ライフサイエンスコーパス: FMRP

1 FMRP deficiency increases p110beta protein levels and ac

2 FMRP depletion increased mRNA m(6)A levels in the nucleu

3 FMRP downregulation induced by CRISPR/Cas9 and shRNA tec

4 FMRP has been confirmed to bind voltage-gated potassium

5 FMRP has KH0, KH1, KH2, and RGG domains, which are thoug

6 FMRP is a RNA-binding protein predominantly resident in

7 FMRP is an RNA-binding protein involved in the control o

8 FMRP is both an RNA- and channel-binding regulator, with

9 FMRP regulates leak closure in wild-type (WT), but not F

10 FMRP regulates the translation of numerous mRNAs within

11 FMRP upregulates and downregulates the activity of micro

12 FMRP(LCR) posttranslational modifications by phosphoryla

13 FMRP-null PNs lose activity-dependent synaptic modulatio

14 FMRP-null PNs reduce synaptic branching and enlarge bout

15 nucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and m

16 behavioral plasticity occurs normally after FMRP knockdown, but performance rapidly deteriorated in

17 anscripts, particularly those that were also FMRP targets.

18 Overall, our study defines an FMRP-dependent cell-autonomous miR pathway that selectiv

19 on targets of FMRP were distinct and that an FMRP mutant that is unable to bind ribosomes still promo

20 led a novel mechanism by which Gp1 mGluR and FMRP mediate protein translation and neural network acti

21 spectrum disorder (ASD) including RBFOX1 and FMRP.

22 t Mdm2 acts as a translation suppressor, and FMRP is required for its ubiquitination and down-regulat

23 that PFC dysfunction may persist as long as FMRP is absent and therefore can be rescued after develo

24 ion of FXS synaptic phenotypes by astroglial FMRP.

25 idence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, l

26 s show that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, p

27 we showed that selective loss of astroglial FMRP in vivo up-regulates a brain-enriched miRNA, miR-12

28 Although the selective loss of astroglial FMRP only modestly increases spine density and length in

29 pstream open reading frame to suppress basal FMRP production.

30 triguing new mechanistic connections between FMRP, innate immunity, and abnormal development.

31 and suggest a role for interactions between FMRP and HTT in the pathogenesis of fragile X syndrome.

32 advances focus on discovering links between FMRP roles to determine whether FMRP has a multitude of

33 t data, we examined the relationship between FMRP binding and genetic association with schizophrenia,

34 Both FMRP and FXR2P regulate neurogenesis, a process affected

35 Analysis of the brain FMRP transcriptome has revealed hundreds of potential mR

36 Although connections between burgeoning FMRP functions remain unknown, recent advances have exte

37 genetic risk is truly related to binding by FMRP or is alternatively mediated by the sampling of gen

38 ty to normalize multilevel defects caused by FMRP loss.

39 Regulation of this machinery by FMRP could support complex behaviours in humans througho

40 BET protein and chromatin reader targeted by FMRP.

41 dy reinforces the evidence that targeting by FMRP captures a subpopulation of genes enriched for gene

42 Regulation of axonal translation by FMRP may shape the structure and function of the axonal

43 Canonically, FMRP functions as an mRNA-binding translation suppressor

44 To clarify FMRP's binding to its target mRNAs, we produced a shared

45 we use conditional tagging of FMRP and CLIP (FMRP cTag CLIP) to examine FMRP mRNA targets in hippocam

46 n in regulating basal and activity-dependent FMRP synthesis, and they demonstrate the therapeutic pot

47 Despite FMRP importance for proper brain function, its overall e

48 ioral, and cognitive levels in two different FMRP-deficient mouse models.

49 These findings demonstrate differential FMRP-dependent regulation of mRNAs across neuronal cell

50 We identified distinct FMRP-containing granules in the growing axons of Atoh1(+

51 ears ago, studies continue to reveal diverse FMRP functions.

52 inal low-complexity disordered region (i.e., FMRP(LCR)).

53 use conditional knock-out mice to eliminate FMRP only in the PFC alone of adult mice.

54 ivation of the FMR1 gene and loss of encoded FMRP, an RNA binding protein that represses translation

55 This ASO blockade enhanced endogenous FMRP expression in human neurons.

56 Activation of mGluR5 receptors enhances FMRP synthesis.

57 of FMRP and CLIP (FMRP cTag CLIP) to examine FMRP mRNA targets in hippocampal CA1 pyramidal neurons,

58 Virally expressed FMRP restored WT HCN channel-related dendritic propertie

59 it remains unclear, however, to what extent FMRP-BK channel interactions contribute to synaptic and

60 identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding partners.

61 in hippocampal neurons from male and female FMRP KO mice, we find enhanced Cav2.3 protein expression

62 synaptic functions, are highly enriched for FMRP binding targets.

63 oportionately longer lengths, enrichment for FMRP binding and G-quartets, and their genes are under g

64 ut direct demonstration of a requirement for FMRP control of local protein synthesis during behaviora

65 This reveals a new role for FMRP-regulated dendritic local translation in learning-i

66 n the Drosophila FXS disease model, we found FMRP binds shrub mRNA (human Chmp4) to repress Shrub exp

67 Consistently, we found FMRP loss and Shrub overexpression similarly elevate end

68 ntral brain learning/memory center, we found FMRP loss and Shrub overexpression similarly increase co

69 of the non-mRNA binding N-terminal fragment, FMRP(1-298), similarly restored dendritic function.

70 rome (FXS), caused by the loss of functional FMRP, is a leading cause of autism.

71 Among these presynaptic FMRP functions, FMRP interaction with large-conductance calcium-activate

72 RGG/RG domains from Fused in Sarcoma (FUS), FMRP and hnRNPU.

73 Analysis of RGG/RG domains from FUS, FMRP and hnRNPU against a spectrum of contrasting RNAs r

74 d from birth through adulthood, with greater FMRP reductions in the soma than in the neurite, despite

75 expansion (preCGG), cortical and hippocampal FMRP expression is moderately reduced from birth through

76 How FMRP impacts synaptic protein translation and which mRNA

77 How FMRP regulates neuronal development and function remains

78 ous mRNAs within dendritic synapses, but how FMRP recognizes these target mRNAs remains unknown.

79 Understanding how FMRP regulates iontophoresis should reveal new molecular

80 tellectual disability, yet it is unknown how FMRP function varies across brain regions and cell types

81 However, FMRP regulates the transcription of other proteins and p

82 riched miRNA, miR-128-3p, in mouse and human FMRP-deficient astroglia, which suppresses developmental

83 ession and purification of full-length human FMRP, FXR1P, and FXR2P from Escherichia coli in high yie

84 ionally, we find that the RGG motif of human FMRP binds with a high affinity to an RNAG-quadruplex st

85 ing studies with various constructs of human FMRP.

86 elective in vivo inhibition of miR-128-3p in FMRP-deficient astroglia sufficiently rescues decreased

87 partially rescued dendritic abnormalities in FMRP-deficient immature neurons.

88 We uncovered key deficits in FMRP-deficient cells demonstrating abnormal neural roset

89 in hippocampal neurons which is disrupted in FMRP KO mice.

90 ent behavioral plasticity occurs normally in FMRP knockdown animals, but plasticity degrades over 24

91 of genetic rescue of FXS-like phenotypes in FMRP-deficient mice by deletion of the Cpeb1 gene is med

92 yperactivity and aberrant calcium spiking in FMRP KO mice and contribute to FXS, potentially serving

93 RNA metabolic labeling demonstrates that, in FMRP-deficient cortical neurons, mRNA down-regulation is

94 mily of RNA-binding proteins, which includes FMRP and FXR2P.

95 onucleoprotein granule components, including FMRP.

96 onversely, direct injection of an inhibitory FMRP antibody into BCs, or membrane depolarization of BC

97 This study may provide a novel insight into FMRP involvement in the intracellular localization of FU

98 nscriptome and proteome profiles of isogenic FMRP-deficient neurons demonstrate perturbations in syna

99 Neurons lacking FMRP show aberrant mRNA translation and intracellular si

100 circuit, we discovered that neurons lacking FMRP take up dramatically more current-injected small dy

101 physical property of central neurons lacking FMRP that could underlie aspects of FXS disruption of ne

102 ic increase in dye uptake in neurons lacking FMRP.

103 in the midbrain and hypothalamus exhibit low FMRP levels.

104 However, many FMRP targets possess functions that are themselves genet

105 RNA and protein levels and that HTT mediates FMRP regulation of mitochondrial fusion and dendritic ma

106 mediated transcription regulation and mGluR5/FMRP-mediated protein translation regulation through cor

107 Moreover, FMRP preferentially binds mRNAs with optimal codons, sug

108 suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mit

109 ith high confidence ASD risk genes, and near FMRP gene targets are more likely to be in co-localized

110 osophila FXS model is key to discovering new FMRP roles, because of its genetic malleability and indi

111 rn neurons that are prevented by ablation of FMRP in adult-born neurons and rescued by an metabotropi

112 y bulb neurons and cell-specific ablation of FMRP, we investigated whether learning shapes adult-born

113 gulate BK channel activity in the absence of FMRP and determine its ability to normalize multilevel d

114 on and expression observed in the absence of FMRP could contribute to the neuronal hyperactivity that

115 an be attributed to the continued absence of FMRP from the PFC, independent of FMRP status during dev

116 The absence of FMRP in neurons abolishes group 1 metabotropic glutamate

117 these deficits (1) are due to the absence of FMRP in the PFC alone and (2) are not the result of deve

118 dysfunction due to the continued absence of FMRP is necessary to understand the different roles of F

119 The absence of FMRP leads to neuronal and circuit-level hyperexcitabili

120 hyperexcitability observed in the absence of FMRP likely results from its ability to regulate the exp

121 Absence of FMRP results in abnormal neuronal morphologies in a sele

122 neurons based on the presence or absence of FMRP.

123 nction is also due to the ongoing absence of FMRP.

124 tatory hippocampal neurons in the absence of FMRP.

125 mance rapidly deteriorated in the absence of FMRP.

126 in the hippocampal circuit in the absence of FMRP.

127 Moreover, the abundance of FMRP targets in the cytoplasm relative to the nucleus wa

128 and AGO and then showed that the RGG box of FMRP protects a subset of co-bound mRNAs from AGO associ

129 f facilitating molecular characterization of FMRP signaling in future studies.

130 arget mRNAs, we produced a shared dataset of FMRP consensus binding sequences (FCBS), which were repr

131 ce to systematically map the distribution of FMRP expression in the entire mouse brain.

132 We identified the RGG domain of FMRP as important for binding G-quadruplexes and the tra

133 mRNAs by mapping the interacting domains of FMRP, MOV10 and AGO and then showed that the RGG box of

134 strated hypersynchrony and downregulation of FMRP targets.

135 yramidal neurons, selective re-expression of FMRP in astrocytes significantly attenuates abnormal spi

136 cutely introducing an N-terminal fragment of FMRP into BCs normalizes GABA release in the Fmr1-KO syn

137 Loss of function of FMRP causes fragile X syndrome, the most common form of

138 tudies identified important new functions of FMRP in regulating neural excitability and synaptic tran

139 We examined a group of FMRP targets that encode transcriptional regulators, par

140 provide the first in vivo identification of FMRP localization and actions in developing axons of aud

141 A detailed examination of the impact of FMRP loss on cellular processes and neuronal properties

142 absence of FMRP from the PFC, independent of FMRP status during development.

143 Furthermore, initiation of FMRP production in the PFC of adult FX animals rescues P

144 more, we confirmed the direct interaction of FMRP with one candidate, RhoC, by in vitro RNA binding a

145 endent mechanisms and direct interactions of FMRP with a number of ion channels in the axons and pres

146 In the mouse, the lack of FMRP is associated with an excessive translation of hund

147 minent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory an

148 r brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layer

149 How the loss of FMRP alters protein expression and astroglial functions

150 Thus, loss of FMRP causes abnormal synaptogenesis, leading to large nu

151 ell model of FXS that shows complete loss of FMRP expression.

152 by epigenetic silencing of FMR1 and loss of FMRP expression.

153 Loss of FMRP in mice results in widespread changes in chromatin

154 t was mediated, at least in part, by loss of FMRP interaction with the SK channels (specifically the

155 Functional loss of FMRP leads to sensory dysfunction and severe intellectua

156 We conclude that loss of FMRP results in significant epigenetic misregulation and

157 eural abnormalities arising from the loss of FMRP.

158 utor to the impaired dendritic maturation of FMRP-deficient neurons and suggest a role for interactio

159 We elucidated the mechanism of FMRP's role in suppressing Argonaute (AGO) family member

160 suggests that these two regulatory modes of FMRP may be functionally separated.

161 gether, these findings support the notion of FMRP differential neuronal regulation and strongly impli

162 (FXR1P and FXR2P) are autosomal paralogs of FMRP that are involved in promoting muscle development a

163 ortant, we describe differential patterns of FMRP distribution in both cortical and subcortical brain

164 cits are rescued by initiating production of FMRP in adult conditional restoration mice, suggesting t

165 We sought to determine the role of FMRP and N(6)-methyladeonsine (m(6)A) on nuclear export

166 Our data establish an essential role of FMRP in codon optimality-dependent mRNA stability as an

167 To explore the molecular role of FMRP in this nucleus, we performed proteomic analysis of

168 cessary to understand the different roles of FMRP and to treat patients effectively throughout life.

169 Nevertheless, roles of FMRP in embryonic development of the auditory hindbrain

170 at it is possible to dissociate the roles of FMRP in neural function from developmental dysregulation

171 To determine the specificity of FMRP for the RREs, we performed quantitative in vitroRNA

172 ggesting that the RNA-binding specificity of FMRP is still unknown.

173 r investigate the RNA-binding specificity of FMRP, we developed a new method called Motif Identificat

174 translational regulator FMRP and a subset of FMRP mRNA targets.

175 Here we use conditional tagging of FMRP and CLIP (FMRP cTag CLIP) to examine FMRP mRNA targ

176 the translation and localization targets of FMRP were distinct and that an FMRP mutant that is unabl

177 High-confidence targets of FMRP, derived from studies of multiple tissue types, wer

178 We discover that the N-terminus of FMRP directly binds to a phosphorylated serine motif on

179 have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts t

180 the well-characterized target transcripts of FMRP are synaptic proteins, yet targeting these proteins

181 cells to identify transcripts that depend on FMRP for efficient transport to neurites.

182 r synaptic integration and its dependence on FMRP.

183 k show that elevated PN activity phenocopies FMRP-null defects, whereas PN silencing causes opposing

184 Of these, 94 are potential FMRP targets, by comparative analysis with previously pr

185 in NL and in particular a list of potential FMRP targets, with the goal of facilitating molecular ch

186 nels and mechanisms that mediate presynaptic FMRP actions, it remains unclear, however, to what exten

187 Among these presynaptic FMRP functions, FMRP interaction with large-conductance

188 omparative analysis with previously proposed FMRP targets in mammals.

189 eins, including the syndromic autism protein FMRP, move in basal processes at velocities consistent w

190 Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common ca

191 n with fragile X mental retardation protein (FMRP) and bind to one another's mRNA.

192 luding Fragile X mental retardation protein (FMRP) and the related protein FXR2P.

193 ets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiat

194 Fragile X mental retardation protein (FMRP) binds to and regulates the translation of amyloid-

195 oss of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the most common i

196 oss of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), yet the mechanism

197 coding Fragile X mental retardation protein (FMRP) causes increased mRNA translation and aberrant syn

198 oss of fragile X mental retardation protein (FMRP) expression.

199 nce of Fragile X Mental Retardation Protein (FMRP) from birth results in developmental disabilities a

200 oss of fragile X mental retardation protein (FMRP) in different brain cell types, especially in non-n

201 of the fragile X mental retardation protein (FMRP) in neurons.

202 The Fragile X Mental Retardation Protein (FMRP) is an RNA binding protein that regulates translati

203 Fragile X mental retardation protein (FMRP) is an RNA-binding protein abundant in the nervous

204 Fragile X mental retardation protein (FMRP) is thought to regulate neuronal plasticity by limi

205 oss of fragile X mental retardation protein (FMRP) is thought to underlie cognitive deficits in FXS,

206 Fragile X mental retardation protein (FMRP) is well-studied, as its loss leads to fragile X sy

207 nce of fragile X mental retardation protein (FMRP) leads to defects in plasticity and learning defici

208 Fragile X mental retardation protein (FMRP) loss causes Fragile X syndrome (FXS), a major diso

209 oss of fragile X mental retardation protein (FMRP) on these pathways is brain region specific.

210 gh the fragile X mental retardation protein (FMRP) pathway may underlie synaptic plasticity associate

211 The fragile X mental retardation protein (FMRP) plays an important role in normal brain developmen

212 AD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl

213 Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor

214 hether fragile X mental retardation protein (FMRP) target mRNAs and neuronal activity contributing to

215 ng the Fragile X Mental Retardation Protein (FMRP), an abundant neuronal granule component and transl

216 oss of fragile X mental retardation protein (FMRP), an mRNA binding protein that regulates mRNA trans

217 oss of fragile X mental retardation protein (FMRP), an mRNA binding protein, and the neuronal hyperex

218 ently, fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates local prote

219 Fragile X mental retardation protein (FMRP), an RNA-binding protein, has previously been shown

220 ent on fragile X mental retardation protein (FMRP), the protein that is deficient in the most common

221 Fragile X mental retardation protein (FMRP), the protein that is lacking in fragile X syndrome

222 ion of fragile X mental retardation protein (FMRP), which represses translation of target transcripts

223 of the fragile X mental retardation protein (FMRP), which translationally represses specific messenge

224 ion of Fragile X Mental Retardation Protein (FMRP).

225 of the Fragile X Mental Retardation Protein (FMRP).

226 oss of Fragile X mental retardation protein (FMRP).

227 ressor Fragile X Mental Retardation Protein (FMRP).

228 uiring fragile-X mental retardation protein (FMRP).

229 oss of fragile X mental retardation protein (FMRP).

230 rotein fragile X mental retardation protein (FMRP).

231 ovo SGs by expressing the fragile X protein (FMRP) and found that rather than directly engaging TDP-4

232 erved roles in regulating fragile X protein (FMRP) synthesis.

233 y and interacts with an RNA-binding protein, FMRP, to promote synapse formation; and Top3beta gene de

234 We show that the Fragile X proteins FMRP and FXR1P interact with RNA-editing enzymes (ADAR p

235 ore of the Fragile X related (FXR) proteins (FMRP, FXR2P, and FXR1P) along with mRNA and ribosomes.

236 ere reproducibly identified in two published FMRP CLIP sequencing datasets.

237 More recently, FMRP was shown to directly interact with the voltage-gat

238 ntain ribosomes, the translational regulator FMRP and a subset of FMRP mRNA targets.

239 the loss of the mRNA translational repressor FMRP leads to exaggerated protein synthesis downstream o

240 cking, with synaptic requirements resembling FMRP.

241 We show FMRP controls transport and localization of one target,

242 the mutant defect, demonstrating a specific FMRP requirement.

243 al motifs that have been proposed to specify FMRP binding, the short sequence motifs TGGA and GAC wer

244 In the auditory system, FMRP deficiency alters neuronal function and synaptic co

245 or a genetic reintroduction of an N-terminal FMRP fragment lacking the ability to associate with poly

246 We conclude that FMRP is absolutely required for experience-dependent cha

247 We conclude that FMRP may affect the nuclear export of m(6)A-modified RNA

248 The findings demonstrate that FMRP deficiency results in inefficient oxidative phospho

249 but no direct evidence has demonstrated that FMRP-regulated dendritic protein synthesis affects behav

250 stribution of the FCBS set demonstrates that FMRP preferentially binds to the coding region of its ta

251 Moreover, our findings provide evidence that FMRP can regulate its targets in opposite directions dep

252 Here we find that FMRP serves as a key translational regulator of the volt

253 a protein-protein interaction, we found that FMRP associated with HCN-TRIP8b complexes in both hippoc

254 d dendritic electrophysiology, we found that FMRP regulates HCN channels via a cell-autonomous protei

255 LC-MS/MS analyses, we demonstrate here that FMRP binds directly to a collection of m(6)A sites on mR

256 These results indicate that FMRP affects visual conditioning-induced local protein s

257 These differential patterns indicate that FMRP expression appears to be specific to individual neu

258 These findings indicate that FMRP is an important regulator of protein synthesis foll

259 thods to identify various RREs in mRNAs that FMRP may bind to in vivo.

260 immunoprecipitation in cortical neurons that FMRP is mostly associated with one unique mRNA: diacylgl

261 Single-channel analyses revealed that FMRP loss reduced BK channel open probability, and this

262 Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium

263 We show that FMRP deficiency leads to reduced Htt mRNA and protein le

264 These studies show that FMRP negatively regulates local protein synthesis and is

265 nt and translational repressor, we show that FMRP phase separates in vitro with RNA into liquid dropl

266 Experiments in Fmr1 null mice show that FMRP regulates axonal protein expression but is not requ

267 The results show that FMRP strongly limits the rate of dye entry via a cytosol

268 Here we show that FMRP-deficient immature neurons exhibit impaired dendrit

269 Lastly, we showed that FMRP has a global role in miRNA-mediated translational r

270 We showed that FMRP knockdown and visual conditioning dramatically incr

271 inally, voltage-clamp recordings showed that FMRP modulated I(h) by regulating the number of function

272 We further showed that FMRP-deficient neurons exhibit a number of additional ph

273 agreement with previous studies showing that FMRP couples Group I metabotropic glutamate receptor (Gp

274 Our results strongly suggest that FMRP mediates structural plasticity of olfactory bulb ad

275 sequences in their 3' UTRs, suggesting that FMRP recognizes them to promote RNA localization.

276 and proteome profiling further suggests that FMRP commonly and preferentially regulates protein expre

277 Activation of the FMRP pathway by group I metabotropic glutamate receptors

278 ategy to identify genome-wide targets of the FMRP translational regulator 1 (FMR1), a brain-enriched

279 We find that the FMRP KH0, KH1, and KH2 domains bind weakly to the single

280 These FMRP-deficient related impairments have also been valida

281 However, it remains unclear how these FMRP activities relate to each other and how dysfunction

282 translation to investigate the role of this FMRP messenger RNA target in learning-dependent structur

283 Thus, FMRP serves as a key translational regulator of Cav2.3 e

284 f mRNA species that were reported to bind to FMRP.

285 Transgenic wild-type FMRP reintroduction rescues the mutant defect, demonstra

286 ntial methylation of App mRNA could underlie FMRP binding, message localization and translation effic

287 Of 36 validated FMRP targets, 35 messages contained m(6)A peaks but only

288 Similarly, through common variation, FMRP targets were associated with major depressive disor

289 Furthermore, when FMRP was knocked-down, translocation of exogenously expr

290 s to FXS pathology and support a model where FMRP, by controlling the translation of Dgkkappa, indire

291 local protein synthesis in vivo and whether FMRP knockdown affects protein synthesis-dependent visua

292 inks between FMRP roles to determine whether FMRP has a multitude of unrelated functions or whether c

293 Here we tested whether FMRP knockdown in Xenopus optic tectum affects local pro

294 n effort to determine the mechanism by which FMRP mediates protein translation and neural network act

295 ndividuals are defective in association with FMRP; whereas one of the mutants is also deficient in bi

296 sensor mechanism based on sensory cues, with FMRP loss causing the most common heritable autism spect

297 All FXGs contain FXR2P, with FMRP and/or FXR1P present in circuit-selective subsets.

298 ion channel shown to directly interact with FMRP; this interaction alters the single-channel propert

299 researchers established the causal link with FMRP loss >;25 years ago, studies continue to reveal div

300 teins might form collaborative networks with FMRP and possibly other post-transcriptional regulators

301 redominantly express a single FXG type, with FMRP-containing FXGs the most prevalent in forebrain neu