ライフサイエンスコーパス: FOXO

1 FOXO (forkhead box O) transcription factors are tumor su

2 FOXO activation inversely correlated with JNK/c-JUN sign

3 FOXO deficiency further affected internalization of Haem

4 FOXO inhibition resulted in myeloid maturation and subse

5 FOXO protein expressed in baculovirus system binds to FO

6 FOXO proteins are transcription factors that are involve

7 FOXO transcription factors are critical regulators of ce

8 FOXO transcription factors can repress Cyclin D1 transcr

9 FOXOs are crucial regulators of cellular homeostasis tha

10 FOXOs in turn attenuate Wnt/beta-catenin signaling by di

11 8) with expression levels of Sema 3A, NRP-1, FOXO 3a and MelCAM were studied by Kaplan-Meier analysis

12 compounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effec

13 This pathway relies on DAF-16/FOXO activation in vulval tissues to maintain stress res

14 Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is required

15 ect is partially dependent on gonadal DAF-16/FOXO activity.

16 ed branching, and this delay required DAF-16/FOXO activity.

17 m-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN.

18 ural integrity into old age, and both DAF-16/FOXO and heat shock factor transcription factor HSF-1 ex

19 he PI3K signaling pathway to activate DAF-16/FOXO and promote developmental neurite outgrowth.

20 elegans, the transcription regulators DAF-16/FOXO and SKN-1/Nrf function to promote longevity under c

21 lifespan extension was independent of DAF-16/FOXO and SKN-1/Nrf2 signaling, but tryptophan and severa

22 on resulting in the activation of the DAF-16/FOXO and SKN-1/Nrf2 stress response pathways.

23 tivation of the transcription factors DAF-16/FOXO and SKN-1/Nrf2.

24 n a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS).

25 ke peptide signaling from the gut and DAF-16/FOXO function in AWC.

26 cold sensation in C. elegans, whereby DAF-16/FOXO gets activated via complementary kinase signaling.

27 also demonstrate that the capacity of DAF-16/FOXO in regulating neuron morphology is conserved in mam

28 role is separable from the effect of DAF-16/FOXO on organismal aging.

29 roprotective effect also requires the DAF-16/FOXO partner bar-1/beta-catenin and putative DAF-16-regu

30 gely be explained by perturbations in DAF-16/FOXO target gene expression.

31 also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that w

32 r translocation of the cytoprotective DAF-16/FOXO transcription factor and protected from paraquat-in

33 stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not that of NP

34 factor (IGF) receptor and short lived daf-16/FOXO transcription factor mutants.

35 ible kinase, and specific isoforms of DAF-16/FOXO transcription factor to regulate fat storage.

36 ensitive membrane TRP channel and the DAF-16/FOXO transcription factor, but in more complex organisms

37 via the action of AKT kinases and the DAF-16/FOXO transcription factor.

38 n/IGF-like signaling and its effector DAF-16/FOXO transcription factor.

39 G16L exert their function through the DAF-16/FOXO transcription factor.

40 y signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan.

41 Here, we report a role for DAF-16/FOXO, a transcription factor that is active under condit

42 ch regulates stress induction through DAF-16/FOXO, does not contribute to ESRE gene expression or bin

43 s, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and

44 to the protective role of HLH-30 and DAF-16/FOXO, TOR/LET-363 and the IIS-regulated Zn-finger transc

45 isease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-controlled germline-tumor affecting-1)-dependent pa

46 programs by controlling noise in the DAF-16/FOXO-regulated gene network.

47 lling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

48 of the forkhead transcription factor DAF-16/FOXO.

49 itivity by regulating AKT kinases and DAF-16/FOXO.

50 imuli did not require the function of DAF-16/FOXO.

51 t signals to the transcription factor DAF-16/FOXO.

52 on the conserved transcription factor DAF-16/FOXO.

53 quires the longevity-promoting factor daf-16/FOXO.

54 he canonical PI3K pathway, inhibiting DAF-16/FOXO.

55 activity of the transcription factor DAF-16/FOXO.

56 nd diminished nuclear localization of DAF-16/FOXO.

57 tive feedback loop between miR-34 and DAF-16/FOXO.

58 ead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only protein (FBXO) expression.

59 he uPA inhibitor UK122, dexamethasone, and a FOXO inhibitor.

60 TLR3 activates innate immune responses in a FOXO-dependent manner.

61 The life span extension required a FOXO transcriptional factor DAF-16 but not HSF-1.

62 w that bacterial pathogens potently activate FOXO transcription factors in cultured human respiratory

63 of reactive oxygen species (ROS), activates FOXOs through JNK-mediated phosphorylation.

64 Active FOXO was also detectable in human bronchial tissue obtai

65 JNK1) kinase activity, which in turn affects FOXO localization through a compensatory dephosphorylati

66 These data reveal a molecular role for AKT/FOXO and JNK/c-JUN in maintaining a differentiation bloc

67 through suppression of cytokine-mediated Akt/FOXO inhibition, and blunting of cathepsin-L-mediated ly

68 defense and mitochondrial uncoupling to Akt/FOXO signaling, these results have implications in obesi

69 We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML).

70 Although FOXOs were localized in the nucleus and showed increased

71 eficial predominance of the adiponectin-AMPK-FOXO-signaling axis over the sustained JNK-elevation and

72 ated lower levels of proteasome activity and FOXO expressions than their WT counterparts.

73 hibits regeneration independently of age and FOXO signaling via the TOR pathway.

74 s and molecules, including TGFbeta, AKT, and FOXO transcription factors (TFs).

75 efore, NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the men

76 Sirtuin deacetylases and FOXO (Forkhead box, class O) transcription factors have

77 nts, and correlates with PTEN expression and FOXO nuclear localization.

78 ched for the FOXO transcription factors, and FOXO acetylation was elevated in Hdac3 knockout (KO) and

79 l progenitor cells had deficits in HDAC3 and FOXO recruitment and gene expression.

80 IIS and FOXO also regulate important neuronal and adult behaviou

81 signaling, via phosphoinositide 3-kinase and FOXO, intrinsically controls the competence of cap cells

82 onal programs associated with metabolism and FOXO and Hippo signaling were affected, analogous to wha

83 ated with activation of the AMPK pathway and FOXO transcription factors, inhibition of the mTORC1 and

84 Diapause is a complex phenotype, and FOXO emerges as a prime candidate for activating many of

85 ema 3A modulates phosphorylation of PTEN and FOXO 3a and expression of MelCAM, leading to suppression

86 Overexpression of PTEN and FOXO 3a enhances Sema 3A-induced attenuation of breast c

87 -mediated MelCAM expression through PTEN and FOXO 3a.

88 of phosphatase and tensin homolog (PTEN) and FOXO 3a.

89 -3beta and mammalian target of rapamycin and FOXO proteins FOXO1, FOXO3A, and FOXO4 and decreased per

90 ylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at severa

91 tions for the role of insulin signalling and FOXO activation in diabetic wound healing.

92 e that Akt (protein kinase B) signalling and FOXO transcription factors form part of a common signall

93 hat integration of beta-catenin, sirtuin and FOXO signaling protects from the early phases of mutant

94 Down-regulating RUNX1 and FOXOs simultaneously causes widespread oxidative stress,

95 As FOXOs and PGC-1alpha are essential for memory and long-t

96 eased catabolic (TNF-alpha, TWEAK/Fn14 axis; FOXO-1, Atrogin-1 and MuRF1; Myostatin) and increased an

97 Both FOXO and 4E-BP delay muscle functional decay and extend

98 cellular survival programs that involve both FOXO-regulated transcription and cap-independent transla

99 orticoid receptor signaling or forkhead box (FOXO) 1/3 inhibition abolished the rapamycin-induced uPA

100 These 10 genes activated by FOXO are highly up-regulated during diapause and are thu

101 et containing genes potentially regulated by FOXO.

102 proposed mechanism in which the beta-catenin FOXO and SIRT1 proteins may together regulate gene expre

103 anner, NFIL3 repressed expression of certain FOXO targets--e.g., FAS, GADD45alpha (growth arrest and

104 Depending on the circumstance, FOXO (Forkhead O) (FOXO1, FOXO3, and FOXO4) transcriptio

105 orkhead transcription factor of the O class (FOXO)3A, known Akt targets that are related to cell surv

106 In conclusion, FOXO transcription factors are involved in the cellular

107 Under stress conditions FOXO transcription factors activate 4E-BP expression amp

108 SIRT1 and SIRT2 deacetylate FOXO factors to regulate FOXO function.

109 Rather than decreased FOXO activity, we observed that FOXOs are active in appr

110 hway that mediates ROS-induced JNK-dependent FOXO regulation.

111 ma 3A controls NRP-1-mediated PTEN-dependent FOXO 3a activation.

112 For example, distinct FOXO-regulated transcriptional programs stimulate cell d

113 identified an interaction between Drosophila FOXO (dFOXO) and the zinc finger transcription factor Kr

114 Here, we show that Drosophila FOXO (dFOXO) regulates the expression of core small RNA

115 Here we show that Drosophila FOXO binds the PDCD4 promoter and stimulates the transcr

116 Collectively, our results identify E2F1/FOXO cooperation as a regulatory mechanism that places E

117 re identified as specific activators of E2F1/FOXO transcription, acting to enhance E2F1-induced apopt

118 pes and by the association of a reduced E2F1/FOXO transcriptional program with poor prognosis.

119 The E2F1/FOXO axis is frequently blocked in cancer, as evidenced

120 Here, we report that knockdown of endogenous FOXO proteins in hippocampal and cerebellar granule neur

121 at least partially by repressing endogenous FOXO signaling.

122 d Akt and ERK phosphorylations, and enhanced FOXO-1 and p27(kip1) levels in Caco-2 cells.

123 nostat with a PI3K inhibitor led to enhanced FOXO-dependent apoptosis.

124 ection against oxidative stress by enhancing FOXO-driven Sod2 transcription.

125 For example, FOXO proteins are context-dependent tumour suppressors t

126 ression by deacetylating the forkhead factor FOXO in response to stress and nutrient deprivation.

127 e activity of the longevity-promoting factor FOXO through a noncanonical mechanism that implicates th

128 The transcription factor FOXO and its target 4E-BP remove damaged proteins at lea

129 c network, the forkhead transcription factor FOXO has been shown to interact with diverse transcripti

130 suppressor PTEN, or the transcription factor FOXO in the subperineurial glia.

131 d redistribution of the transcription factor FOXO.

132 e deduced the forkhead transcription factor (FOXO) family to be a downstream mechanism through which

133 on the forkhead box O transcription factor (FOXO), which is negatively regulated by the insulin-sign

134 regulation of forkhead transcription factor (FOXO).

135 The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, includ

136 Forkhead transcription factors (FOXOs) alter a diverse array of cellular processes inclu

137 Forkhead O transcription factors (FOXOs) have been implicated in glucose and lipid homeost

138 Here, we find that forkhead family (FOXO) transcription factors are critical for activation

139 regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and

140 f chondrogenic commitment, reveal a role for FOXO transcription factors during lipid starvation, and

141 ion experiments revealed a critical role for FOXO transcription factors in mediating these proliferat

142 ro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo

143 t al. identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.

144 The members of the class O forkhead (FOXO) transcription factor family, including FOXO3a, act

145 Importantly, in mammals, four FOXO genes have overlapping and different functions, and

146 to generate isogenic controls rescued HDAC3-FOXO-mediated impairments in gene expression.

147 ear factor interleukin 3-regulated) hindered FOXO transcription factor access to chromatin at the TRA

148 To gain insight into how FOXOs select specific genes for regulation, we performed

149 Here, we identify FOXO transcription factors as E2F1 target genes that act

150 IIS/FOXO neuron-specific targets are distinct from canonical

151 ng, we identified both the wild-type and IIS/FOXO mutant adult neuronal transcriptomes for the first

152 ific targets are distinct from canonical IIS/FOXO-regulated longevity and metabolism targets, and are

153 Together, neuron-specific and canonical IIS/FOXO-regulated targets enable the coordinated extension

154 and C. elegans, but the neuron-specific IIS/FOXO targets that regulate these functions are still unk

155 s reveal that the Ryk-ICD pathway may impair FOXO protective activity in mutant polyglutamine neurons

156 ial respiration not previously implicated in FOXO localization.

157 The integration of individual FOXO and sirtuin family members into various aspects of

158 Lapatinib-induced FOXO transcription factors, normally tumor-suppressing,

159 insulin-like peptides (ILPs) and influenced FOXO subcellular localization, resulting in the down-reg

160 cies, where AKT acts, in part, by inhibiting FOXO tumor suppressors.

161 trometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting

162 Recently, insulin/FOXO signaling has been implicated in the regulation of

163 of JAK2V617F mutation, suggesting that JAK2-FOXO signaling has a different effect on progenitors com

164 an and stress, distinct from the insulin/JNK/FOXO pathway.

165 we performed a screen for genes that modify FOXO activation of TRAIL, a death receptor ligand capabl

166 s the pharmacological approaches to modulate FOXO function.

167 Moreover, FOXO/4E-BP signaling in muscles decreases feeding behavi

168 aging and longevity pathways including mTOR, FOXO and MAPK, most of which also demonstrated associati

169 moters during HCMV reactivation, as mutating FOXO binding sites in alternative MIE promoters decrease

170 morphogenesis, both of which require normal FOXO function.

171 Nuclear FOXO proteins act as tumor suppressors by transcriptiona

172 be partially reversed by maintaining nuclear FOXO but not by increasing PGC-1alpha.

173 The resulting nuclear FOXO increases expression of target genes, including mit

174 wnstream signaling molecules forkhead box O (FOXO) and p70 S6 kinase in a tissue and blood meal-speci

175 Evasion of forkhead box O (FOXO) family of longevity-related transcription factors-

176 The forkhead box O (FOXO) family of transcription factors is a conserved fam

177 DAF-16 transcription factor (forkhead box O (FOXO) homologue), whose global targets were identified i

178 habditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target o

179 ed to be abnormally elevated forkhead box O (FOXO) signaling in the ETC-deficient ISCs, as geneticall

180 Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an essential regulat

181 Forkhead box O (FOXO) transcription factors control diverse cellular fun

182 ession program downstream of Forkhead box O (FOXO) transcription factors during 3D breast epithelial

183 Forkhead box O (FOXO) transcription factors favor both T cell quiescence

184 keletal progenitors activate forkhead box O (FOXO) transcription factors, which bind to the Sox9 prom

185 the activation of mammalian forkhead box O (FOXO) transcription factors.

186 ifferentiation by modulating Forkhead box O (FOXO), target of rapamycin, and Hippo signaling pathways

187 ivated protein kinase (AMPK)-forkhead box O (FOXO)-signaling axis stemming from at the least three sy

188 knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene ex

189 ted AKT, GSK3beta, and forkhead box class O (FOXO)1 in CON and IUGR fetal livers.

190 d transcription factor Forkhead box class O (FOXO)3a and VEGF expression.

191 Forkhead transcription factor class O (FOXO)3a, which plays a critical role in a wide variety o

192 Forkhead box transcription factor family O (FOXO) transcription factors are key regulators of cellul

193 ertebrate model organisms, Forkhead box "O" (FOXO) transcription factors and sirtuin deacetylases are

194 se genes via deacetylation and activation of FOXO family transcription factors.

195 loroacetate (DCA), would blunt activation of FOXO gene targets and reduce statin myopathy.

196 rial pathogens resulted in the activation of FOXO transcription factors in alveolar and bronchial epi

197 nous expression of Pak1 in the background of FOXO knockdown in both primary neurons and postnatal rat

198 eflects direct and indirect contributions of FOXO, EcR, Rbf and additional transcription factors thro

199 of endogenous Pak1 phenocopies the effect of FOXO knockdown on neuronal polarity.

200 Finally, we explore the effects of FOXO knockouts in three different mouse tissues.

201 ctic muscles that enhanced the expression of FOXO transcription factors and NADPH oxidase 4 (Nox4), a

202 ed proteasome activity and the expression of FOXO transcription factors in three wild-type (WT) and t

203 FOXO1 inhibition decreased the expression of FOXO/BRD4 target genes.

204 Inactivation of FOXO proteins and elevation of intracellular ROS are cha

205 ACs in murine liver results in inhibition of FOXO target genes and lowers blood glucose, resulting in

206 occurred at least in part via inhibition of FOXO-mediated transcription of genes regulating muscle C

207 creen and discovered selective inhibitors of FOXO-dependent glucose production devoid of lipogenic ac

208 nriched regions predicted the involvement of FOXO transcription factors.

209 Small interfering RNA-mediated knockdown of FOXO in bronchial epithelial cells resulted in reduced e

210 ae that lacked the CA had elevated levels of FOXO activity, whereas a loss-of-function mutation of FO

211 ivity, no change in the expression levels of FOXO target genes were observed.

212 Examination of subcellular localization of FOXO protein via CRISPR-assisted, single-stranded oligod

213 Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing ther

214 acting on chromatin to restrict the menu of FOXO target genes.

215 vity, whereas a loss-of-function mutation of FOXO rescued the effects of CA ablation on final body si

216 iation to the specific signaling pathways of FOXO, mTOR, and Wnt/beta-catenin.

217 Furthermore, regulation of FOXO by RALA and JIP1 is conserved in C. elegans, where

218 Importantly, JNK regulation of FOXO is evolutionarily conserved.

219 In this Review, we overview the role of FOXO proteins in health and disease and discuss the phar

220 tudy, our aim was to investigate the role of FOXO transcription factors in innate immune functions of

221 n response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal a

222 phorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoin

223 RNAi-mediated silencing of FOXO impaired E2F1 binding to the promoters of cooperati

224 epithelial cells, we found that a subset of FOXO target genes was jointly regulated by the transcrip

225 hIP sequencing to identify direct targets of FOXO.

226 Upregulation of FOXO gene targets known to regulate proteasomal and lyso

227 es how oncogenic RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these i

228 The elucidation of a restraining effect of FOXOs on Wnt signaling in bipotential progenitors sugges

229 and lipid homeostasis; however, the role of FOXOs in the development of nonalcoholic fatty liver dis

230 phorylation and cytoplasmic sequestration of FOXOs.

231 soform), as well as nuclear stabilization of FOXOs, well-known CHIP-ubiquitination targets.

232 Injection of bovine insulin or FOXO double-stranded RNA into the previtellogenic, starv

233 accumulated tumor-suppressor proteins (p27, FOXO, p73, and prostate apoptosis response-4 [PAR-4]) an

234 ER2(+) breast cancer by inhibiting HER2-PI3K-FOXO-survivin signaling.

235 indings therefore demonstrate that PTEN-PI3K-FOXO-USP11 constitute the regulatory feedforward loop th

236 tion of the deubiquitinase USP11 by the PI3K/FOXO pathway, and further show that this feedforward mec

237 by acting upstream of the lifespan-promoting FOXO transcription factor DAF-16 and likely upstream of

238 ration of Akt activation in part by reducing FOXO-mediated transcriptional activation of mitochondrio

239 t flies are starvation sensitive, reflecting FOXO-dependent increases in lipolysis that deplete trigl

240 echanisms by which hormonal signals regulate FOXO deacetylation remain unclear, however.

241 d SIRT2 deacetylate FOXO factors to regulate FOXO function.

242 axis, unraveling an epigenetically regulated FOXO/c-Myc axis as a potential target to improve therapy

243 class IIa deacetylase HDAC4, which regulates FOXO activity in Drosophila.

244 erentiation, at least in part, by regulating FOXO factor function on enhancers to activate TP63 and G

245 cating a potential role of AKT in regulating FOXO levels.

246 r this mode of regulation extends to related FOXO family members is unknown.

247 ction in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished beta-cateni

248 regulation of microRNA bantam that represses FOXO-mediated transcription of pro-apoptotic Smac/DIABLO

249 erent functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-

250 are characterized by activation of the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein res

251 ne but not reporter genes dependent on SMAD, FOXO, C/EBP, NF-kappaB, or AP-1.

252 Although implicated as tumor suppressors, FOXO genetic inactivation has not been observed in human

253 ulated mTORC1 activation, protein synthesis, FOXO nuclear exclusion, GLUT4 translocation, and glucose

254 etic mobility shift assay data revealed that FOXO 3a regulates MelCAM at the transcriptional level.

255 Thus, our data suggest that FOXO transcription factors play a salutary role in the p

256 ing in bipotential progenitors suggests that FOXO activation by accumulation of age-associated cellul

257 an decreased FOXO activity, we observed that FOXOs are active in approximately 40% of AML patient sam

258 These data suggest that FOXOs modulate proteasome activity, and thus represents

259 The FOXO family of transcription factors elicits cell cycle

260 The FOXO transcription factors control proliferation and apo

261 The FOXO transcription factors, including the brain-enriched

262 n, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.

263 -2-signaling pathway and is regulated by the FOXO transcription factor DAF-16, which contributes to t

264 n-6, a subunit of the 19S proteasome, by the FOXO transcription factor DAF-16.

265 In cancer, the FOXO family of transcription factors functions as tumor

266 These findings define the FOXO proteins and Pak1 as components of a cell-intrinsic

267 inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabeti

268 d that ROS signaling cascade facilitates the FOXO-3a/FBXO-mediated BK-beta(1) degradation and leads t

269 y, thus identifying a novel function for the FOXO transcription factors in a unique aspect of neural

270 ortex in vivo, reveals a requirement for the FOXO transcription factors in the establishment of neuro

271 3-associated promoters were enriched for the FOXO transcription factors, and FOXO acetylation was ele

272 ivity of downstream effectors, including the FOXO family of transcription factors.

273 The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 li

274 naling in pituitary gonadotrope cells is the FOXO subfamily of forkhead transcription factors.

275 or production, which activate members of the FOXO family of transcription factors.

276 ons and transcriptional dysregulation of the FOXO genes are infrequent in human cancers, it remains u

277 t shock-induced nuclear translocation of the FOXO orthologue DAF16.

278 of FOXO4 and increase the expression of the FOXO target genes MnSOD and catalase.

279 ignaling is dependent on the activity of the FOXO transcription factor DAF-16 and the nuclear hormone

280 ity, as a critical direct target gene of the FOXO transcription factors.

281 Suppression of the FOXO-3a/FBXO pathway prevented vascular BK-beta(1) degra

282 mall molecules prove the druggability of the FOXO-DBD and provide a structural basis for modulating t

283 denced by the specific downregulation of the FOXO-dependent E2F1 transcriptional program in multiple

284 cer growth in vivo, partly by repressing the FOXO/c-Myc axis, unraveling an epigenetically regulated

285 the Ryk-ICD fragment and its binding to the FOXO co-factor beta-catenin.

286 This effect of insulin utilizes the FOXO-dependent regulation of the thor gene, which encode

287 ses do not require insulin signaling via the FOXO homolog DAF-16 or the insulin/IGF-1-receptor homolo

288 hosphorylate conserved AKT motifs within the FOXO family and that PP2A is entwined in a dynamic inter

289 l cell morphology during development through FOXO.

290 regulates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes

291 and AKT2 appeared to regulate growth through FOXO proteins, but not through either GSK3beta or mTOR.

292 on and nuclear translocation of HDAC4 and to FOXO deacetylation.

293 ein expressed in baculovirus system binds to FOXO response element present in the Vg gene promoter.

294 y defective signalling downstream of pAKT to FOXO and GSK3 in fs188 and fswt cells, which also correl

295 N signaling, and leukemic cells resistant to FOXO inhibition responded to JNK inhibition.

296 aling by diverting beta-catenin from TCF- to FOXO-mediated transcription.

297 antagonize the primary effects on ageing via FOXO in mouse and via SKN-1 in worm.

298 ucose culture conditions was associated with FOXO-3a/FBXO-dependent increase in BK-beta(1) degradatio

299 tly necessary for normal wound healing, with FOXO and S6K as their respective effectors.

300 owed that mir-228 and mir-235 synergise with FOXO transcription factor DAF-16 in the insulin signalin