ライフサイエンスコーパス: Fc receptor

1 with its cognate cellular recycling neonatal Fc receptor.

2 as a previously unrecognized immunoglobulin Fc receptor.

3 ic response in vivo when engaging activating Fc receptors.

4 f full-length Tau fibrils into microglia via Fc receptors.

5 nia (HIT) from cellular activation involving Fc receptors.

6 ate or avoid effector cell functions through Fc receptors.

7 o the activated endothelium via cell surface Fc receptors.

8 of affinities for activatory and inhibitory Fc receptors.

9 nk between the innate pentraxins and humoral Fc receptors.

10 to antibodies binding to their low affinity Fc receptors.

11 gs and found FcRL4 and FcRL5 to be bona fide Fc receptors.

12 s and interact with CD68(+) immune cells via Fc receptors.

13 acquired antigens via convalescent serum and Fc receptors.

14 c anti-HLA antibodies triggering their CD16a Fc receptors.

15 it vaccine that elicits neutralizing but not Fc receptor-activating or complement-binding responses.

16 Indeed, Fc receptor activation is accompanied by increased expre

17 with Pf-specific immunoglobulin G (IgG) and Fc receptor activation to control parasitemia.

18 Upon Fc receptor activation, Src-family kinase signaling lead

19 R binding assay sensitively detected greater Fc receptor activity to pandemic H1N1 hemagglutinin afte

20 e MHC fold has also been modified to perform Fc-receptor activity (e.g., FcRn) and for roles in host

21 and myosin 1f, are specifically localized to Fc-receptor adhesions and required for efficient phagocy

22 sion on murine neutrophils, and by different Fc-receptor affinities for IgG across species.

23 ll molecule conjugate Fc-CGS retained potent Fc receptor and A(2A)R interactions and showed superior

24 xplained the ability of its two ligands, the Fc receptor and complement C1q, to bind to the top of it

25 mune protection is mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

26 ation and opsonization of pathogen result in Fc receptor and macrophage activation.

27 dritic cells (DC), which was mediated by the Fc receptor and was specific to trastuzumab.

28 tly nonneutralizing antibodies that activate Fc receptors and bind complement, and a glycoprotein D s

29 at Asn-297 is critical for interactions with Fc receptors and complement and that glycosylation at As

30 Signal integration between activating Fc receptors and inhibitory signal regulatory protein al

31 grin (CD11b), and activated conformations of Fc receptors and integrins, have been proposed to report

32 Cell-cell signaling via both Fc receptors and NK-activating receptors led to measurab

33 one hand not engage conventional activating Fc receptors and on the other hand interact normally wit

34 r tyrosine kinase that signals downstream of Fc receptors and plays a transduction role in antibody e

35 crease affinity at acidic pH to the neonatal Fc receptor, and to reduce effector functions.

36 n of the expression of complement receptors, Fc receptors, and F-actin formation after ANE treatment.

37 Expression of complement receptors, Fc receptors, and F-actin in ANE-treated neutrophils is

38 Fc receptors are crucial for innate immune activation.

39 Fc receptors are the cellular mediators of antibody func

40 ns and in particular, their interaction with Fc receptors as effectiveness of antibodies often depend

41 ng a primary infection facilitate entry into Fc receptor bearing cells during secondary infection, re

42 tibody-dependent enhancement of infection in Fc receptor-bearing cells at subneutralizing concentrati

43 rimary infection facilitate virus entry into Fc receptor-bearing cells during a subsequent secondary

44 nd EpCAM and a constant domain that recruits Fc receptor-bearing cells, notably monocytes, dendritic

45 s capable of enhancing the DENV infection of Fc receptor-bearing cells.

46 t the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes.

47 reduction of viral replication and enhanced Fc receptor binding and were consistent with transcripti

48 Human Fc receptor binding assays and analysis of antibody-cell

49 fully human anti-CD73, we demonstrated that Fc receptor binding augmented the production of proinfla

50 rstanding of known functional differences in Fc receptor binding between IgG1 and IgG4.

51 Removal of complement and/or Fc receptor binding did not affect h2G7 efficacy.

52 agers with a human IgG1 Fc part competent in Fc receptor binding resulted in an almost 10-fold superi

53 In all of the mAbs, Fc receptor binding was abrogated by Trx activity, with

54 ities, the ADCs have been engineered to lack Fc-receptor binding.

55 trial robustly boosted HIV-1 gp120-specific Fc receptor-binding antibodies and ADCC against HIV-1-in

56 visualize lung macrophages activated through Fc receptors by antibody-coated glass slides.

57 d IgE but independent of FcgammaRII, type II Fc receptors, C-type lectin receptors, and sialic acid-b

58 mokine, IL, TNF, MHC, immunoglobulin-binding Fc receptor, calcium-binding S100, matrix metalloprotein

59 zation of different ligands such as mannose, Fc receptor, CD11c/CD 18, DEC-205 and DC-SIGN on DC for

60 agocytosis of IgG-opsonized bioparticles and Fc receptor CD16 and CD32 surface levels, a function, to

61 The Fc receptor CD16 is present on essentially all CD56(dim)

62 This process is facilitated by the Fc receptor CD16a on human NK cells.

63 oved in knockout mice lacking the inhibitory Fc receptor CD32b, nor against a Deltasmac P. berghei pa

64 d that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with

65 cells modified to express the high-affinity Fc receptor (CD64) and CD86, the natural ligand of CD28

66 Apart from CHIR-AB, which functions as an Fc receptor, CHIR ligands are unknown.

67 were higher in patients with a high affinity Fc-receptor compared to those with a lower affinity Fcga

68 Our data suggest that the antibody/Fc-receptor complex functionally mimics viral receptor i

69 some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger

70 Serum ADCC activity was analyzed using Fc receptor cross-linking, NK cell activation, and influ

71 e associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity

72 the immune system, which could be rescued by Fc receptor-dependent Ab opsonization.

73 oth muscle cell proliferation in vitro in an Fc receptor-dependent manner, and antibody-deficient mic

74 o the lung in naive mice in a mast cell- and Fc receptor-dependent manner.

75 ed breadth but may effect protection through Fc receptor-dependent processes, such as antibody-depend

76 antibodies induced death of AML cells in an Fc receptor-dependent way in the absence of cytotoxic le

77 zed MAb dosages in viral-receptor-dependent, Fc-receptor-dependent, and both-receptors-dependent vira

78 The ablation of activating IgG Fc receptors did not ameliorate injury, implicating sube

79 Fc receptors endocytose modified nucleic acids bound to

80 stituents and produced interferon-gamma upon Fc-receptor engagement but not following combined interl

81 lation alters the affinity of antibodies for Fc receptors, evidence suggests that glycosylation is a

82 IgE possess a very high affinity for cognate Fc receptors expressed by tumor-associated macrophages (

83 the spike, and mediates viral entry into IgG Fc receptor-expressing cells through canonical viral-rec

84 parasitic infestation, often mediated by IgE Fc receptor-expressing macrophages.

85 sease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatu

86 ng the binding affinity of the Fc to diverse Fc receptor family members.

87 Blocking the IgA Fc receptor FcalphaRI abrogated phagocytosis and NET for

88 onstrated previously that triggering the IgA Fc receptor (FcalphaRI) on neutrophils results in neutro

89 essed, and the role of the high-affinity IgE Fc receptor (FcepsilonRI) in allergic sensitization was

90 IgE antibodies bind the high-affinity IgE Fc receptor (FcepsilonRI), found primarily on mast cells

91 tibodies interact with the high affinity IgE Fc receptor, FcepsilonRI, and activate inflammatory path

92 ations of which are mediated through its two Fc receptors, FcepsilonRI and CD23 (FcepsilonRII).

93 ic peptide receptor A IgG4 with the neonatal Fc receptor, Fcgamma receptors, and complement-activatin

94 (TF-CAR-NK) cells that co-express CD16, the Fc receptor (FcgammaIII) to mediate antibody-dependent c

95 protective epitopes and characterized their Fc receptor (FcgammaR) dependence in vivo in FcgammaR hu

96 variable, affecting binding to phagocyte IgG-Fc receptors (FcgammaR).

97 s dependent on the high-affinity IgG-binding Fc receptor (FcgammaRI) and the low-affinity IgG-binding

98 s effect was broadly recapitulated for other Fc receptors (FcgammaRI, FcgammaRIIA, FcgammaRIIB, and F

99 complement receptors (CR1, CR3, and CR4) and Fc receptors (FcgammaRII and FcgammaRIII) in a concentra

100 The uniquely human activating Fc receptor FcgammaRIIA promotes glomerular neutrophil a

101 cs, such as binding to placentally expressed Fc receptors FcgammaRIIa and FcgammaRIIIa, and Fc region

102 Genetic variants of the inhibitory Fc receptor FcgammaRIIb have been associated with system

103 ignaling is suppressed by the inhibitory IgG Fc receptor FcgammaRIIb; therefore, we reasoned that a t

104 ssed the inhibitory fragment crystallizable (Fc) receptor FcgammaRIIB following activation and multip

105 The inhibitory low-affinity IgG Fc-receptor FcgammaRIIB is co-expressed on allergic effe

106 as long been known that the ITIM-bearing IgG Fc receptor (FcgammaRIIb, RIIb) is expressed on liver si

107 Genetic deficiency of the inhibitory Fc receptor, FcgammaRIIB (CD32b), has been shown to augm

108 ineate the effects of IgG and its inhibitory Fc receptor, FcgammaRIIb, on both de novo allergen sensi

109 Gs with enhanced affinity for the activating Fc receptor FcgammaRIIIA due to afucosylated Fc glycans

110 ibodies for their increased activity through Fc receptors (FcgammaRIIIa).

111 h is mediated in part through the activatory Fc receptor, FcgammaRIIIA.

112 (FcgammaRI) and the low-affinity IgG-binding Fc receptor (FcgammaRIV).

113 y to systemic anaphylaxis that relies on IgG Fc receptors (FcgammaRs).

114 The IgM Fc receptor (FcmuR) is the newest FcR, and coligation of

115 We identified the immunoglobulin M Fc receptor (FcmuR), also known as the Fas apoptotic inh

116 CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to typ

117 earance after vaccination was dependent upon Fc receptor (FcR) expression.

118 This implicates Fc-Fc receptor (FcR) interactions in affinity maturation, w

119 has accumulated supporting the importance of Fc receptor (FcR) ligation in antibody-mediated patholog

120 Little is known of the impact of Fc receptor (FcR) polymorphism in macaques on the bindin

121 ptor 3 (CR3), used by promastigotes, and the Fc receptor (FcR), used by amastigotes.

122 Accumulating evidence indicates a role for Fc receptor (FcR)-mediated effector functions of antibod

123 Here, the role of PLA(2)IValpha in Fc receptor (FcR)-mediated phagocytosis was investigated

124 Targeting an antigen to Fc receptors (FcR) can enhance the immune response to th

125 ved, although it has been suggested that the Fc receptor FcRn may be involved in active antibody tran

126 The neonatal Fc receptor FcRn plays a critical role in the traffickin

127 e types of receptors, including the neonatal Fc receptor (FcRn) and Fcgamma receptors (FcgammaRs), wh

128 gments lack the ability to bind the neonatal Fc receptor (FcRn) and have reduced half-lives.

129 Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor.

130 gG antibodies on the binding to the neonatal Fc receptor (FcRn) as well as on FcRn-dependent pharmaco

131 G, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endoc

132 methionine residues and the loss of neonatal Fc receptor (FcRn) binding and complement-dependent cyto

133 onal studies by antigen binding and neonatal Fc receptor (FcRn) binding correlated very well with the

134 hree-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known l

135 The neonatal Fc receptor (FcRn) controls IgG transport from the mothe

136 The neonatal Fc receptor (FcRn) directs the transfer of maternal immu

137 across the placenta by binding the neonatal Fc receptor (FcRn) expressed within the endosomes of the

138 Neonatal Fc receptor (FcRn) has a key role in the homeostasis of

139 The endothelial cellular neonatal Fc receptor (FcRn) has been suggested to play a central

140 maintained the binding affinity for neonatal Fc receptor (FcRn) in a pH-dependent manner.

141 involvement of immune complexes and neonatal Fc receptor (FcRn) in the emergence of ADAs in the case

142 In light of the fact that the neonatal Fc receptor (FcRn) is a key regulator of albumin homeost

143 The neonatal Fc receptor (FcRn) is a major regulator of IgG and album

144 Neonatal Fc receptor (FcRn) is the homeostatic receptor responsib

145 We also identify that the neonatal Fc receptor (FcRn) is upregulated in the cornea followin

146 eins for lysosomal degradation, the neonatal Fc receptor (FcRn) located at the brush border of the ap

147 e found that PVIgGs associated with neonatal Fc receptor (FcRn) on the cell membrane, and the PVIgG-F

148 Silencing neonatal Fc Receptor (FcRn) or CAMK4 prevented the podocyte-damag

149 is delivered to fetuses through the neonatal Fc receptor (FcRn) pathway, which physiologically transf

150 interaction of the IgG1 Fc with the neonatal Fc receptor (FcRn) plays a critical role in maintaining

151 t affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt b

152 lf-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region

153 The neonatal Fc receptor (FcRn) that mediates IgG and albumin recycli

154 The neonatal Fc receptor (FcRn) transports IgG across barriers, for e

155 The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (I

156 d formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.

157 enhance interactions with the human neonatal Fc receptor (FcRn) without loss of the oligomeric struct

158 he placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allerge

159 ent interaction between IgG and the neonatal Fc receptor (FcRn), as FcRn is the main homeostatic regu

160 on of the relevant receptor, namely neonatal Fc receptor (FcRn), by Calu-3 cell layers simulating the

161 tated by interaction with the human neonatal Fc receptor (FcRn), that promotes it as a highly attract

162 Here, involvement of the neonatal Fc receptor (FcRn), which mediates IgG recycling and tra

163 Genetic deletion of the neonatal Fc receptor (FcRn), which rescues albumin and IgG from l

164 sured by their interaction with the neonatal Fc receptor (FcRn), which salvages IgG from intracellula

165 at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting against inf

166 by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of aller

167 s pH-dependent interaction with the neonatal Fc receptor (FcRn).

168 ributed to its interaction with the neonatal Fc receptor (FcRn).

169 requires interaction of Fc with the neonatal Fc receptor (FcRn).

170 on proteins interact with the human neonatal Fc receptor (FcRn).

171 inding and neonatal fragment crystallizable (Fc) receptor (FcRn) binding demonstrated no difference b

172 The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling mechanism t

173 o determine the contribution of the neonatal Fc-receptor (FcRn) in rat brain efflux employing two dif

174 Neonatal Fc-receptor (FcRn), the major histocompatibility complex

175 ing downstream of the B-cell receptor (BCR), Fc receptors (FcRs), and toll-like receptors.

176 -glycan in optimizing the interface with the Fc receptor for efficient binding.

177 egalovirus glycoprotein gp68 functions as an Fc receptor for host IgGs and can form antibody bipolar

178 FcalphaRI (CD89), the human Fc receptor for IgA, is highly expressed on neutrophil g

179 Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in

180 Fc receptor for IgG IIA (FcgammaRIIA)-mediated platelet

181 Cell surface Fc receptor for IgM antibody (FcmuR) is the most recentl

182 However, the role of the putative Fc receptor for IgM, known as Toso/Faim3, has to this po

183 red interactions between the antibody Fc and Fc receptors for IgG (FcgammaRs) to confer protection fr

184 , we found that the rapid loss of activating Fc receptors from the surface and their subsequent prote

185 Fc receptor function of FCRL4 was demonstrated by bindin

186 ngs, and gene sets involved in phagocytosis, Fc receptor function, complement, and Ig regulation are

187 Besides intracellular Fc receptor function, tripartite motif 21 (TRIM21) E3 li

188 ridge the innate pentraxins and the adaptive Fc receptor functions.

189 The glycoprotein VI (GPVI)-Fc receptor gamma (FcRgamma) chain is the major platelet

190 s deficient in Mincle or its adapter protein Fc receptor gamma chain (FcRgamma) produced severely red

191 r tyrosine-based activation motif receptors: Fc receptor gamma chain, which is noncovalently associat

192 rane sequence that interacts with the common Fc receptor gamma subunit to initiate immune signaling.

193 The glycoprotein (GP) VI/Fc receptor gamma-chain complex is a central regulator o

194 n platelets, plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activa

195 In human platelets, Fc receptor gamma-chain IIa (FcgammaRIIa) has been ident

196 uced FcgammaRI effector functions, including Fc receptor gamma-chain signaling and intracellular calc

197 ased activation motif (ITAM) adaptor protein Fc receptor gamma-chain, even though the canonical ITAM

198 he immunoglobulin (Ig) receptor GPVI and the Fc receptor gamma-chain, which has an immunoreceptor tyr

199 ine phosphorylation events downstream of the Fc receptor gamma-chain-associated immunoreceptor tyrosi

200 by the loss of transcription factor PLZF and Fc receptor gamma-chain.

201 ed T-cell receptor signaling, which utilizes Fc-receptor gamma-chain FcRgamma-Syk.

202 e lectin 2, the receptor for podoplanin, and Fc receptor gammaII A, a low-affinity receptor for immun

203 unctional polymorphism in the inhibitory IgG-Fc receptor gene FcgammaRIIB influences intravenous immu

204 ass I and class II HLA, B-cell receptor, and Fc receptor genes.

205 Meanwhile, MAb binds to cell surface IgG Fc receptor, guiding viral entry through canonical viral

206 tallizable (Fc) domain to the human neonatal Fc receptor (hFcRn).

207 t with the human cellular recycling neonatal Fc receptor (hFcRn).

208 lactosylated IgA1 complexed with soluble IgA Fc receptor I (sCD89) and/or anti-hypogalactosylated-IgA

209 Polymorphisms in the immunoglobulin G Fc receptor II (FcGR) and tumor necrosis factor-alpha (T

210 expressing both hPF4+ and human platelet IgG Fc receptor IIA (FcgammaRIIA), infusion of the HIT-like

211 hisms within the gene encoding the human IgG Fc receptor IIA (hFcgammaRIIA) are associated with an in

212 s is based on the structures of low affinity Fc receptor in complex with Fc.

213 nd mouse pentraxins recognize major forms of Fc receptors in solution and on cell surfaces with affin

214 nces of the engagement of type I and type II Fc receptors in the context of infectious, autoimmune, a

215 The role of Fc receptors in the induction and progression of Crgn is

216 rm that PRN694 prevents T-cell receptor- and Fc receptor-induced cellular and molecular activation, i

217 igand-1 (PSGL-1, CD162), cytokine receptors, Fc receptors, integrins including alphaM integrin (CD11b

218 w, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of

219 the Fab domain to signal transduction via Fc-Fc receptor interactions.

220 our understanding of antibody recognition by Fc receptors is based on the structures of low affinity

221 ced IgG signaling through type I and type II Fc receptors is required for the control of proinflammat

222 d-type, but not Fcgamma-receptor or neonatal Fc-receptor knock-out mice.

223 receptor antagonist or a solubilized BMPR1a-FC receptor ligand trap prevents trabecular and cortical

224 ences in antibody subclass, specificity, and Fc receptor ligation using pseudovirus entry and multipl

225 Fc receptor-like (FCRL) 4 is an immunoregulatory recepto

226 Fc receptor-like (FCRL) 5 regulates B cell Ag receptor s

227 Fc receptor-like (FcRL) proteins are a family of cellula

228 In contrast, Syk and Fc receptor-like 1 were downregulated.

229 n the FCRL3 gene led to higher expression of Fc receptor-like 3 (FcRL3) on Treg cells and that FcRL3+

230 sine-based dual regulatory potential termed "Fc receptor-like 5" (FCRL5) was investigated to explore

231 sion of CD11c, low levels of CD21, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some c

232 ipartite motif (TRIM) 21 as an intracellular Fc receptor linking cytosolic antibody recognition to th

233 e dependent on the CD4 activation, which was Fc receptor mediated.

234 refore, we hypothesized that vaccine-induced Fc receptor-mediated (FcR-mediated) Ab function is indic

235 ed as a novel mechanism in the modulation of Fc receptor-mediated cell activation in autoimmune disea

236 interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate im

237 ng specificities determines the magnitude of Fc receptor-mediated effector functions.

238 may not depend on complement activation and Fc receptor-mediated effector functions.

239 Equally cross-reactive Fc receptor-mediated functional activities, including AD

240 macrophages, expression of Fcgr3-rs inhibits Fc receptor-mediated functions, because WKY bone marrow-

241 lity, mediated partly through differences in Fc receptor-mediated macrophage activation.

242 associated with decreased apoptotic cell and Fc receptor-mediated macrophage clearance.

243 rgn1 BMDMs showed a significant reduction in Fc receptor-mediated oxidative burst, phagocytosis of op

244 acts with the common Fc-gamma chain but that Fc receptor-mediated phagocytosis and signaling are defe

245 The roles of Fc receptor-mediated protective antibody responses are g

246 ve roles in regulating TCR and high-affinity Fc receptor-mediated signaling and cellular function.

247 TK inhibitor that potently inhibits BCR- and Fc receptor-mediated signaling and, thus, subsequent act

248 Fc-receptor-mediated endocytosis and the endosome/autoph

249 Dasatinib completely blocked integrin- and Fc-receptor-mediated neutrophil functions, with the lowe

250 o the related CD1a, CD1b, CD1c, and neonatal Fc receptor molecules were absent from the surfaces of b

251 uires binding of the antibody to a cytosolic Fc receptor named tripartite motif containing 21 (TRIM21

252 rolled, double-blind trial of teplizumab (an Fc receptor-nonbinding anti-CD3 monoclonal antibody) inv

253 ermine whether two courses of teplizumab, an Fc receptor-nonbinding anti-CD3 monoclonal antibody, red

254 The Fc receptor on NK cells, FcgammaRIIIA (CD16), has been e

255 ne marrow chimeras, we found that activating Fc receptors on basophils were required for protective i

256 We investigated the role of Fc receptors on basophils, the antibody isotypes IgG1 an

257 ugh the interaction of the Fc glycan and the Fc receptors on immune cells.

258 tion between RA IgG immune complexes and IgG Fc receptors on immune cells.

259 Immune complex-mediated activation of Fc receptors on infiltrating blood-borne cells and tissu

260 cancer cell growth by engaging high-affinity Fc receptors on monocytes and macrophages; however, the

261 s erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory

262 otein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated p

263 proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the tar

264 entry into cells expressing viral receptor, Fc receptor, or both receptors.

265 Interestingly, the number of mouse Fc-receptor-positive cells was significantly increased i

266 Interestingly, the number of mouse Fc-receptor-positive cells was significantly increased i

267 d through cold ischemia via interaction with Fc-receptor-positive cells.

268 nomic and phenotypic analyses of FCGR3A/CD16 Fc-receptor profiles were compared in CAV-positive (n=52

269 Despite the diversity of the Fc receptor proteins, IgG ligands, and potential respond

270 and then sensitizing mast cells through the Fc receptor, resulting in the secretion of proinflammato

271 enhanced the levels of antibody binding and Fc receptor signaling mediated by HIV-positive-patient-d

272 duction that are likely related to inhibited Fc receptor signaling within macrophages in diseased glo

273 e (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization.

274 use of its role in mediating both B cell and Fc receptor signaling, Bruton's tyrosine kinase (BTK) is

275 hogens by immune cells triggers both TLR and Fc receptor signaling.

276 hesion molecules intrinsic to the activating Fc-receptor signalling pathway, namely immune semaphorin

277 Absent neonatal Fc receptor surface expression led to low serum IgG and

278 ose IgG-opsonized bioparticles by decreasing Fc receptor surface levels, a mechanism previously thoug

279 FcgammaRIIb is an Fc receptor that inhibits B cell activation and, if defe

280 le, and that of the fragment crystallizable (Fc) receptors that bind them, in driving local inflammat

281 By engaging the neonatal Fc receptor the Fc domain extends the in vivo lifespan o

282 Pups used the neonatal Fc receptor to transfer IgG from milk into serum.

283 ntibodies functioned primarily by activating Fc receptors to mediate antibody-dependent cellular cyto

284 man IgGs and attracted immune cells carrying Fc receptors to tumor cells that expressed p185(her2/neu

285 istocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across c

286 Additionally, complement synergizes with the Fc receptor TRIM21 to block transduction by an adenoviru

287 EHRL-4 interacted with cytosolic Fc receptor TRIM21, observed by confocal microscopy and

288 rom inside cells by activating the cytosolic Fc receptor TRIM21.

289 In contrast to other Fc receptors, TRIM21 shows remarkably broad isotype spec

290 tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM21).

291 tivities by engaging two distinct classes of Fc receptors (type I and type II) on the basis of the tw

292 immune complexes, it is also plausible that Fc receptor usage patterns may regulate the immune respo

293 or (TCR), B cell antigen receptor (BCR), and Fc receptors uses the same schematic and similar molecul

294 ouse IgG, which influences IgG activation of Fc receptors, was evaluated by Sambucus nigra lectin blo

295 formed by IgE and its evolutionarily related Fc receptors, we conclude that this mechanism is general

296 n the expression of complement receptors and Fc receptors were examined using an immunofluorescence s

297 hat this effect is dependent on the neonatal Fc receptor, which rescues the dissociated antibody in t

298 x binding mechanism is distinct from that of Fc receptors, which bind through the Fc.

299 sequence (Fcgr3-rs) is a novel rat-specific Fc receptor with a cytoplasmic domain 6 amino acids long

300 ptor I (FcgammaRI or CD64) is the sole human Fc receptor with high affinity for monovalent IgG.