ライフサイエンスコーパス: Fmoc

1 Fmoc-4-(1-chloroethyl)-phenylalanine (5) was synthesized

2 Fmoc-based solid-phase synthesis methodology was used to

3 Fmoc-D-Hyv(O-TBDMS) was used for the synthesis of the co

4 Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest m

5 Fmoc-N-epsilon-(Hynic-Boc)-Lys is a highly versatile tec

6 Fmoc-O-(2-bromoisobutyryl)-serine tert-butyl ester (10)

7 Fmoc-protected amino acids were condensed into appropria

8 Fmoc-protected DOTAla suitable for solid phase peptide s

9 Fmoc-Trp(C2-BODIPY)-OH contains a BODIPY (4,4-difluoro-4

10 airs of deuterated alanines by using 60-100% Fmoc-l-Ala-d(4) at selected sequence positions.

11 essed in a detailed thermodynamic study of a Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, eluted

12 omers were measured by frontal analysis on a Fmoc-L-Trp imprinted polymer, using different organic mo

13 sic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound.

14 tected phospho-mannosides are coupled with a Fmoc protected threonine derivative, followed by the use

15 ical synthesis of the fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH (3-4 d), the preparation of the l

16 ryptophan (Trp)-based fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH and its incorporation into peptid

17 -fluorenylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50) value of approxima

18 A nonproteinogenic amino acid, Fmoc-Se-phenylselenocysteine (SecPh), can be prepared in

19 The first amino acid-Fmoc-O-TIPS-beta-tyrosine-was prepared in 78% yield (two

20 onstituent Fmoc-protected nucleoamino acids (Fmoc-Ser(B)-OH, where B = thymine, cytosine, and uracil)

21 i.e., Fmoc-modified individual amino acids, Fmoc-modified di- and tripeptides, and Fmoc-modified tet

22 c anthraquinone derivatives with the N(alpha)Fmoc-l-Lys and ethynyl group were synthesized from the i

23 emodin with both the ethynyl and the N(alpha)Fmoc-l-Lys groups showed an antioxidant activity-enhanci

24 Aloe-emodin derivative with N(alpha)Fmoc-l-Lys shows the highest inhibition values by 94.11

25 equired for the deprotection of the N(alpha)-Fmoc group.

26 Herein, we report the synthesis of N-alpha-Fmoc-L-gamma-carboxyglutamic acid gamma,gamma'-tert-buty

27 in we report the facile synthesis of N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine 1

28 henylethyl-2-cyanoethyl)-L-serine 1, N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-threonin

29 hyl-2-cyanoethyl)-L-threonine 2, and N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine

30 An Fmoc group, an effective drug-interactive motif, is also

31 This amino acid has been prepared as an Fmoc-protected building block and may readily be incorpo

32 N-Terminal Ser residues containing an Fmoc carbamate are converted into 2-(9'-fluorenylmethylo

33 luorescent amino acids can be obtained in an Fmoc-protected form for convenient use as building block

34 probe are expanded with the synthesis of an Fmoc-protected amino acid derivative (5), which contains

35 mers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinted polymer were investigated over a wi

36 oc and Cbz strategy and semiorthogonal to an Fmoc strategy.

37 tecting group strategy for linear PAAs to an Fmoc/Alloc/Boc strategy.

38 peltin E (1, 5) were synthesized by using an Fmoc-based solid-phase strategy in 7 steps, in 20% and 2

39 were also inhibited by ACA, ONO-RS-082, and Fmoc-anthranilic acid, whereas the Na(+)/citrate transpo

40 thesized from N-tosyl-3-haloazaindoles 1 and Fmoc-protected tert-butyl iodoalanine 2 via a Negishi co

41 derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (1b).

42 orthogonally protected with Alloc/allyl and Fmoc groups.

43 psules with shell walls bearing both Boc and Fmoc triggering groups.

44 r solid-phase synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding recently used Fmo

45 the unsaturated side chains of the Boc- and Fmoc-protected derivatives of enyne and diyne coupling p

46 into peptide chains by coupling N-(Cbz- and Fmoc-alpha-aminoacyl)benzotriazoles with amino acids, wh

47 Mixed anhydrides from BOP-Cl and Fmoc-alphaalphaAA-OH are used for anchoring alphaalphaAA

48 lving iterative PyBOP-mediated couplings and Fmoc deprotections, is rapid (about 5 d), operationally

49 used protease digestion of glycoproteins and Fmoc chemistry.

50 lete peptide coupling reactions in 6 min and Fmoc-removal reactions in 4 min under temperature-contro

51 The use of Nap and Fmoc as temporary protecting groups made it possible to

52 hybrid peptides derived from Fmoc-Neu2en and Fmoc-Glu(OtBu)-OH.

53 tionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions

54 aziridines was achieved with Boc, tosyl, and Fmoc groups.

55 cids, Fmoc-modified di- and tripeptides, and Fmoc-modified tetra- and pentapeptides.

56 as well as benzylidene-, silyl-, Troc-, and Fmoc-protecting groups do not get affected during the ne

57 m-Abc(2K) and o-Abc(2K) are prepared as Fmoc-protected derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) a

58 ffected to base-sensitive substrates such as Fmoc-protected alaninal, citral, 5-cholesten-3-one, urid

59 -butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2-5 steps.

60 nd by delivering S-220 via a self-assembling Fmoc-based hydrogel that has suitable properties for SCI

61 c acid (Hmp)/2-methylpiperidine (2-MP) based Fmoc chemistry procedure to prepare the C-terminal Hmp p

62 tives such as HOBt or Oxyma during the basic Fmoc-removal treatment were found to be very effective f

63 ing blocks for solid-phase synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding rece

64 ith common N-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, as well as various OH protecting

65 h as acetates (Ac, Piv) and carbamates (Boc, Fmoc), respectively.

66 So, all compounds but Fmoc-L-Trp(OPfp) find three different types of adsorptio

67 of the purified isoxazolidinones followed by Fmoc protection affords enantiomerically pure Fmoc-beta(

68 Metal complex decomposition followed by Fmoc protection affords the enantiomerically pure amino

69 Acidolytic deprotection followed by Fmoc-protection provided building blocks suitable for so

70 scently labeled ADM analogues synthesized by Fmoc/t-Bu solid phase peptide synthesis were used to ana

71 te (Alloc), and 9-fluorenylmethyl carbonate (Fmoc), different patterns of O-sulfation can be installe

72 A diverse set of (fluorenylmethoxy)carbonyl (Fmoc) protected amino alcohols was found to load rapidly

73 or 9-fluorenylmethoxycarbonyl chloroformate (Fmoc-Cl).

74 nt, namely, 9-fluorenylmethyl chloroformate (Fmoc-Cl).

75 self more readily deblocked than the classic Fmoc analogue.

76 s of this approach, a lysine-hynic conjugate Fmoc-N-epsilon-(Hynic-Boc)-Lys was synthesized for incor

77 Effective syntheses of constituent Fmoc-protected nucleoamino acids (Fmoc-Ser(B)-OH, where

78 -chlorotrityl chloride resin by conventional Fmoc-based solid-phase peptide synthesis.

79 itions, 5 mol % catalyst efficiently couples Fmoc amino acids without notable racemization.

80 pared as the protected amino acid derivative Fmoc-Sox-OH and integrated into peptide sequences.

81 ) are prepared as Fmoc-protected derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (

82 The model dipeptide Fmoc-Tyr(All)-Tyr(All) was used to explore different rea

83 Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest C

84 ut are prone to alpha-C epimerization during Fmoc solid-phase peptide synthesis.

85 undesirable side reaction that occurs during Fmoc solid-phase peptide synthesis (SPPS).

86 nctional molecules from three aspects, i.e., Fmoc-modified individual amino acids, Fmoc-modified di-

87 An efficient Fmoc-based solid-phase peptide synthetic strategy is the

88 Here we describe a simple and efficient Fmoc solid-phase peptide synthesis (SPPS)-based method f

89 as common peptide fragments bound to either Fmoc or the surface linker.

90 glutamic acid gamma,gamma'-tert-butyl ester (Fmoc-Gla(O(t)Bu)(2)-OH), a suitably protected analogue f

91 , Fmoc-L-tryptophan pentafluorophenyl ester (Fmoc-L-Trp(OPfp)), and their antipodes.

92 rogen in the presence of a tert-butyl ester, Fmoc protection of the lactam, and a lanthanide-catalyze

93 lated amino acids and peptides (see example, Fmoc=9-fluorenylmethoxycarbonyl).

94 The final Fmoc-protected (2S,5R)-6-azido-5-hydroxylysine derivativ

95 dard solid-phase 9-fluorenylmethoxycarbonyl (Fmoc) chemistry.

96 is following the 9-fluorenylmethoxycarbonyl (Fmoc) strategy, which we demonstrate by the synthesis of

97 ted into CD52 by 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

98 e preparation of 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1-aminoalkylphosphinic acids.

99 levulinoyl (Lev) ester, fluorenylmethyloxy (Fmoc)- and allyloxy (Alloc)-carbonates, and 2-methyl nap

100 oups N(alpha)-9-fluorenylmethyloxycarbonate (Fmoc), 2-methylnaphthyl ether (Nap), levulinoyl ester (L

101 synthesis of N-9-fluorenylmethyloxycarbonyl (Fmoc) alpha-amino diazoketones.

102 alled by using 9-fluorenylmethyloxycarbonyl (Fmoc) and allyloxycarbonyl (Alloc) as a versatile set of

103 ified with the 9-fluorenylmethyloxycarbonyl (Fmoc) group possess eminent self-assembly features and s

104 oxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

105 corporation of a fluorenylmethyloxycarbonyl (Fmoc) motif at the interfacial region of PEG5K-VE2 led t

106 chanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with

107 em (e.g., from 4.74 for Fmoc-Trp to 2.53 for Fmoc-Gly)).

108 he octanol-water system (e.g., from 4.74 for Fmoc-Trp to 2.53 for Fmoc-Gly)).

109 u)(2)-OH), a suitably protected analogue for Fmoc-based solid-phase peptide synthesis.

110 an-2-carboxylic acid as a building block for Fmoc solid phase peptide synthesis.

111 threonine, and tyrosine building blocks for Fmoc-based solid-phase peptide synthesis to allow conven

112 found that three types of sites coexist for Fmoc-L-Trp but only two types of sites for Fmoc-D-Trp, e

113 nfluence on the site density (especially for Fmoc-D-Trp) than does HBD.

114 namic properties of copolymers imprinted for Fmoc-l-tryptophan and prepared by two different methods.

115 en egg yolk together with the Nbz linker for Fmoc chemistry solid phase synthesis of the glycopeptide

116 these peptides, we employed a new linker for Fmoc-based thioester peptide synthesis.

117 hest energy sites (sites that exist only for Fmoc-L-Trp), increasing the concentration of acetic acid

118 eta-methoxyaspartate, suitably protected for Fmoc solid phase peptide synthesis.

119 amic acid (Gla), appropriately protected for Fmoc-based solid-phase peptide synthesis (SPPS), is desc

120 enic amino acids appropriately protected for Fmoc-based solid-phase peptide synthesis is described.

121 are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

122 is totally stable to conditions required for Fmoc-SPPS.

123 r Fmoc-L-Trp but only two types of sites for Fmoc-D-Trp, except at the lowest acetic acid concentrati

124 The highest energy sites for Fmoc-L-Trp in MeCN are inactive in CH(2)Cl(2), CHCl(3),

125 c-based oligomerization is also suitable for Fmoc-based oligomerization.

126 -D-glucitol-gamma-glutamate 20, suitable for Fmoc-strategy solid-phase peptide synthesis (SPPS), was

127 We report a one-step synthesis for Fmoc-fluorosulfated tyrosine.

128 eine residue under basic conditions used for Fmoc deprotection.

129 The K(d) values for Fmoc-VPRpTPVGGGK-NH2 and Ac-VPRpTPV-NH2 were determined

130 of alpha/delta hybrid peptides derived from Fmoc-Neu2en and Fmoc-Glu(OtBu)-OH.

131 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helica

132 Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the p

133 anine (5) was synthesized in four steps from Fmoc-tyrosine.

134 e tert-butyl ester (10) was synthesized from Fmoc-Ser(OTrt)-OH in three steps.

135 hogonal protection schemes (up to five from: Fmoc, Boc Alloc, pNZ, o-NBS, and Troc), together with th

136 moc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluorophenyl ester (Fmoc-L-Trp(OP

137 L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluorophenyl ester (Fm

138 iently synthesized by using the glycosylated Fmoc-asparagine as a key building block.

139 ein present a thorough evaluation of a green Fmoc removal protocol.

140 linker at a Lys residue epsilon-amine, (ii) Fmoc-SPPS elongation of a desired solubilizing sequence,

141 (2K(Boc))-OH (1c) as ordinary amino acids in Fmoc-based solid-phase peptide synthesis.

142 scent amino acids can be readily obtained in Fmoc-protected form for convenient use as building block

143 ide fragments and have used them as units in Fmoc solid-phase peptide synthesis.

144 rcially available building blocks, including Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlor

145 solid-phase peptide synthesis to incorporate Fmoc-hydroxyproline (4R-Hyp).

146 t-butylated beta-amino acid (betaFa) and its Fmoc- and Boc-protected forms were designed and synthesi

147 using a mixture of 70%/30% unlabeled/labeled Fmoc-protected residues.

148 using three complementary strategies: linear Fmoc solid-phase peptide synthesis (SPPS) using several

149 nductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA

150 Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical

151 a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever r

152 of racemates, including mandelic acid (Man), Fmoc-phenylalanine, 1,1'-bi-2-naphthol (binol), and TTSB

153 This SAM1 linker is applied in the manual Fmoc-based solid-phase peptide synthesis of Leu-enkephal

154 In this method, Fmoc-protected C-terminal cysteine esters are anchored t

155 plate is highest for the imprinted molecule (Fmoc-L-Trp).

156 N-Fmoc-(2S,3S,4R)-3,4-dimethylglutamine (6) was synthesize

157 erein the first synthesis of a C-activated N-Fmoc-protected trans-(2S,3S)-3-aminotetrahydrofuran-2-ca

158 ng to single diastereoisomers of N-Boc and N-Fmoc protected spiroisoxazolinoproline amino acids.

159 Chiral N-Tfa- and N-Fmoc-protected (alpha-aminoacyl)benzotriazoles 1a-j unde

160 The crystalline N-Fmoc-cis-4-fluoropyrrolidine-2-carbonyl fluoride 2a is a

161 n of a dideuterated methionine equivalent, N-Fmoc-(4,4-(2)H(2))methionine, to the desired labeled AHL

162 e area, was synthesized in the presence of N-Fmoc and O-Et protected phosphoserine and phosphotyrosin

163 further demonstrated by the preparation of N-Fmoc-alpha-amino diazoketones also from alpha-amino acid

164 The synthesis of N-Fmoc-O-(N'-Boc-N'-methyl)-aminohomoserine in 35% overall

165 he preparation of a diastereomeric pair of N-Fmoc-protected dipeptidyl diazoketones.

166 ntroduce a new general tool, Fmoc-Ddae-OH, N-Fmoc-1-(4,4-dimethyl-2,6-dioxocyclo-hexylidene)-3-[2-(2-

167 OSu furnished fully protected (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine in overall 20% yield.

168 applied to the synthesis of the respective N-Fmoc-protected alpha-amino diazoketones from L-isoleucin

169 otection of free amino phosphinates as the N-Fmoc derivative was achieved by in situ trimethylsilylat

170 The N-Fmoc-protected epsilon-amino acid was synthesized in hig

171 Three N-Fmoc unnatural amino acids (1-3) that contain varying li

172 VKDVYI-NH(2) (8), were achieved utilizing N-(Fmoc-alpha-aminoacyl)benzotriazoles.

173 The overall affinity of Fmoc-L-trp in CH(2)Cl(2), CHCl(3), and THF is dominated

174 n contrast, in MeCN, the overall affinity of Fmoc-L-Trp is dominated by adsorption on the highest ene

175 The overall affinity of Fmoc-L-Trp is dominated by the contribution of the low-d

176 Analogues of Fmoc-Orn(Mtt)-OH can be incorporated into a growing pept

177 g-Pro-Asp-Phe): (i). side-chain anchoring of Fmoc-Asp-OAl via its free beta-carboxyl as a p-alkoxyben

178 residue, which was selected on the basis of Fmoc-tBu SPPS compatibility and photolysis efficiency.

179 s allows for orthogonal on-resin cleavage of Fmoc and Alloc protecting groups during solid-phase synt

180 ores were then "reopened" by the cleavage of Fmoc groups with a piperidine solution.

181 s analogues are reported by a combination of Fmoc-based solid-phase peptide synthesis (SPPS) and beta

182 Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit exce

183 gmuir isotherm model, except for the data of Fmoc-L-Trp(OPfp) that are best modeled by a simple Langm

184 isting questions impeding the development of Fmoc-modified simple biomolecules are discussed, and cor

185 sotherm parameters of the two enantiomers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinte

186 the Nle(epsilon-N3) or the incorporation of Fmoc-Nle(epsilon-N3)-OH during the stepwise build-up of

187 d phase using l-Ser and a racemic mixture of Fmoc- trans-2-aminocyclohexanecarboxylic acid predominan

188 piperidine solution as well as the number of Fmoc moieties within the pores.

189 haride, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical pro

190 ed by UV/visible spectroscopy, and a plot of Fmoc released versus time showed a sigmoidal shape.

191 cient synthetic route for the preparation of Fmoc-protected l-gamma-carboxyglutamic acid, which is am

192 is scalable, and enables the preparation of Fmoc-protected unnatural amino acids in three steps.

193 the alkanethiol SAM (after de-protection of Fmoc-HWRGWVA) was 1.2x10(-6)M.

194 or the synthesis and Diels-Alder reaction of Fmoc-protected azopeptides has been developed and used t

195 uki-Miyaura cross-coupling (SMC) reaction of Fmoc-protected bromo- or iodophenylalanines is reported.

196 is formed by coupling the diazonium salt of Fmoc-Phe(pNH(2))-OAllyl to a MBHA-polystyrene resin prev

197 F(2) laser single photon ionization (SPI) of Fmoc-derivatized peptides covalently bound to surfaces.

198 e development of more efficient syntheses of Fmoc-protected amino acids.

199 Synthesis of Fmoc-3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-D-gluci

200 chiral complex, the asymmetric synthesis of Fmoc-Gla(O(t)Bu)(2)-OH was completed in nine steps from

201 A one-step synthesis of Fmoc-protected aryl/heteroaryl-substituted phenylalanine

202 An efficient synthesis of Fmoc-protected mpAbc was executed in which the biaryl co

203 w-density highest energy sites while that of Fmoc-D-Trp is dominated by the most abundant, low-energy

204 ed and then functionalized with two types of Fmoc (9-fluorenylmethyloxycarbonyl) terminated silanes w

205 t one peptide (8), which required the use of Fmoc chemistry.

206 The use of Fmoc-OSU as a traceless capping agent resulted in cleane

207 nosylamine 2 by readily available N- (Cbz or Fmoc-alpha-aminoacyl) benzotriazoles under microwave irr

208 hylene(diNosyl)-spermine(triBoc) with Dde or Fmoc orthogonal protecting groups.

209 For the original Fmoc removal cocktail (solvents ratio of 1:1), we evalua

210 We show that PEG2k-Fmoc-NLG alone is effective in enhancing T-cell immune r

211 delivery of paclitaxel (PTX) using the PEG2k-Fmoc-NLG nanocarrier leads to a significantly improved a

212 In addition, PEG5K-Fmoc-VE2/DOX mixed micelles showed more sustained releas

213 antitumor activity was demonstrated by PEG5K-Fmoc-VE2/DOX in both drug-sensitive (4T1.2 and PC-3) and

214 umor accuulation for DOX formulated in PEG5K-Fmoc-VE2 micelles.

215 (DOX) could be effectively loaded into PEG5K-Fmoc-VE2 micelles at a DLC of 39.9%, which compares favo

216 More importantly, DOX-loaded PEG5K-Fmoc-VE2 micelles showed an excellent safety profile wit

217 ug resistant cell line, suggested that PEG5K-Fmoc-VE2 may have the potential to reverse multidrug res

218 MTT assay showed that PEG5K-Fmoc-VE2/DOX exerted significantly higher levels of cyto

219 matic interfacial self-assembly of peptides (Fmoc-Tyr(H(2) PO(3) )-OH) with magnetic nanoparticles (M

220 yrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluoroph

221 lly protected trinucleotide phosphoramidite (Fmoc-TAG; Fmoc = 9-fluorenylmethoxycarbonyl) was develop

222 ion of D-Hyv(O-TBDMS) with Fmoc-OSu produced Fmoc-D-Hyv(O-TBDMS) in 26% yield from D-Val.

223 improved synthesis of orthogonally protected Fmoc-Dyp-acetonide (9) and of several Fmoc-d-Hot horizon

224 e scale, and the resulting racemic protected Fmoc-DSA subunit was separated by supercritical fluid ch

225 moc protection affords enantiomerically pure Fmoc-beta(2)-amino acids, which are useful for beta-pept

226 been developed for preparing optically pure, Fmoc-protected diethylene glycol-containing ( R)- and (

227 e of a ligand, the reaction provided racemic Fmoc-protected amino alcohols with excellent regioselect

228 valent grafting of peptides with a removable Fmoc or acetylated N-termini via their C-termini to prod

229 The optimized protocol used to remove Fmoc from Gly residue was proved by the synthesis of Leu

230 ]-OH (11), starting with the papain-resolved Fmoc-DAgl(Boc).

231 alogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-try

232 tected Fmoc-Dyp-acetonide (9) and of several Fmoc-d-Hot horizontal lineTap-ketals for solid-phase pep

233 After simple Fmoc deprotection, the glycans were printed on NHS-activ

234 e incorporated into the peptides by standard Fmoc solid phase peptide synthesis.

235 chain elongation of the peptide by standard Fmoc/tBu solid-phase chemistry; (iii). removal of the N-

236 rrogate amino acids are amenable to standard Fmoc peptide synthesis strategy, and the resulting compo

237 esized by solid-phase methods using standard Fmoc chemistry and purified by RP-HPLC; all intermediate

238 solid-phase peptide synthesis using standard Fmoc chemistry.

239 d into a neurotensin analogue using standard Fmoc-based protocols.

240 aged phospho-peptide sequence using standard Fmoc-based SPPS procedures.

241 as well as full compatibility with standard Fmoc solid-phase peptide synthesis (SPPS).

242 lding blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.

243 ng strategy that is compatible with standard Fmoc solid-phase peptide synthesis.

244 nctionality that is compatible with standard Fmoc-based peptide synthesis.

245 provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemose

246 eld, which can be readily used in subsequent Fmoc solid-phase peptide synthesis.

247 -(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSU), to generate a series of sequence-specific tru

248 This was accomplished by synthesizing Fmoc-Cys(NDBF)-OH and incorporating that residue into pe

249 ted trinucleotide phosphoramidite (Fmoc-TAG; Fmoc = 9-fluorenylmethoxycarbonyl) was developed to scan

250 chemistry; (iii). removal of the N-terminal Fmoc group; (iv). coupling of Trt-Cys(Xan)-OH; (v). sele

251 The Fmoc group in P6 peptide makes several hydrophobic inter

252 The Fmoc protection strategy also allows for selective modif

253 The Fmoc-D-Hyv(O-TBDMS) diastereomers were separated by prep

254 base-triple formation with 4 T/U bases; the Fmoc-K(2M) derivative can be used directly in solid phas

255 he unique cation-free "basket" formed by the Fmoc-G-PNA conjugate can serve as an attractive componen

256 s of the solid were completely filled by the Fmoc-protected organosilanes.

257 material, the process readily delivered the Fmoc-protected free acid derivatives of AHMOD ((2S)-amin

258 ide bond formation techniques, including the Fmoc/tBu strategy for solid phase peptide synthesis, is

259 ectronic structure calculations indicate the Fmoc label is behaving as an ionization tag for the enti

260 herent hydrophobicity and aromaticity of the Fmoc moiety which can promote the association of buildin

261 reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction con

262 nd only Gly required the optimization of the Fmoc removal cocktail composition.

263 ide-catalyzed transamidation reaction of the Fmoc-protected lactam, using ammonia and dimethylaluminu

264 Experimental isotherm data of the Fmoc-tryptophan (Fmoc-Trp) enantiomers were measured by

265 Following PED, the Fmoc group was removed from the N-terminus and any react

266 ents that are commonly used for removing the Fmoc group during SPPS.

267 head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non

268 masking groups, which are orthogonal to the Fmoc one.

269 ablished, and analogs were generated through Fmoc-based solid phase peptide synthesis.

270 eracetylated form of this glycan attached to Fmoc-threonine in an attempted synthesis.

271 (2S,3R, 2R,3S), which were then converted to Fmoc derivatives and used in two separate syntheses.

272 this work, we introduce a new general tool, Fmoc-Ddae-OH, N-Fmoc-1-(4,4-dimethyl-2,6-dioxocyclo-hexy

273 s of the two enantiomers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinted polymer were in

274 mental isotherm data of the Fmoc-tryptophan (Fmoc-Trp) enantiomers were measured by frontal analysis

275 ymers, one imprinted with Fmoc-L-tryptophan (Fmoc-L-Trp) (MIP), the other nonimprinted (NIP), of comp

276 thermodynamic study of a Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, eluted with four differen

277 ated that the protecting groups, namely, Ts, Fmoc, and (t)Bu, can be easily removed selectively.

278 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-G

279 gues were first synthesized using unresolved Fmoc-Agl(N(beta)Me,Boc)-OH, and the diastereomers were s

280 oc protecting groups expanding recently used Fmoc/Boc protecting group strategy for linear PAAs to an

281 Using Fmoc-Cys(Bhc-MOM)-OH, peptides containing a Bhc-protecte

282 e 68 to quinone 70, and carbamoylation using Fmoc-NCO.

283 s synthesized as a shared intermediate using Fmoc solid phase chemistry on a 2-chlorotrityl resin.

284 efficiently incorporated into peptides using Fmoc-chemistry-based solid-phase peptide synthesis, and

285 a diastereomeric mixture of CF3-PsiPro using Fmoc-protected amino acid chloride without base gave the

286 beads is quantified by UV spectroscopy using Fmoc-monitoring of the immobilized dopamine and serotoni

287 The protein is synthesized using Fmoc-based solid-phase peptide synthesis and assembled u

288 for the SPPS of C-terminal thioesters using Fmoc/t-Bu chemistry.

289 The coupling of this amine with various Fmoc amino acids, followed by cleavage of the alpha-amin

290 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmo

291 cell internalization and are compatible with Fmoc solid phase peptide synthesis.

292 ia a thioglycinamide bond is compatible with Fmoc-chemistry solid-phase peptide synthesis.

293 All of them were found fully compatible with Fmoc/ tBu solid-phase peptide synthesis, which allowed f

294 ves can be used alone or in conjunction with Fmoc-Abc(2K(Boc))-OH (1c) as ordinary amino acids in Fmo

295 trityl alcohol and alpha-amine function with Fmoc-OSu furnished fully protected (S)- and (R)-N-Fmoc-S

296 rwise identical polymers, one imprinted with Fmoc-L-tryptophan (Fmoc-L-Trp) (MIP), the other nonimpri

297 port and the amino acids were protected with Fmoc- and tert-butyl groups.

298 kylphosphinic acids, which then reacted with Fmoc-Cl to provide corresponding products in excellent y

299 Reaction of D-Hyv(O-TBDMS) with Fmoc-OSu produced Fmoc-D-Hyv(O-TBDMS) in 26% yield from

300 DOX in comparison to the counterpart without Fmoc motif.