ライフサイエンスコーパス: Francisella

1 e type of cells that are first infected with Francisella.

2 ng MglA/SspA and FevR (PigR) interactions in Francisella.

3 ion against the live vaccine strain (LVS) of Francisella.

4 mmatory pathways in the extreme virulence of Francisella.

5 a mechanism of evasion for cytosol-invasive Francisella.

6 fferent cellular stress response pathways in Francisella.

7 rated, inflammatory response advantageous to Francisella.

8 n of the outer membrane component lipid A in Francisella.

9 contribution of mast cell/TLR regulation of Francisella.

10 ling CRISPR-Cpf1 (CRISPR from Prevotella and Francisella 1) to a CRISPR RNA (crRNA) array flanked wit

11 cking for the virulence factors expressed by Francisella and how these factors are secreted and deliv

12 ted effectors mediating interactions between Francisella and its host significantly advances our unde

13 ses against DNA viruses and bacteria such as Francisella and Listeria.

14 bI enoyl-ACP reductase enzyme inhibitors for Francisella and other select agents.

15 we identified the early interactions between Francisella and the host following two different routes

16 ation in response to Legionella, Salmonella, Francisella, and Listeria.

17 including Burkholderia, Shigella, Listeria, Francisella, and Mycobacterium species.

18 An anti-Francisella antibody (FB11) was used for the detection t

19 stress resistance by affecting secretion of Francisella antioxidant enzymes SodB and KatG.

20 e we used a murine model of infection with a Francisella attenuated live vaccine strain (LVS), which

21 entified in many biothreat agents, including Francisella, Brucella, Bacillus, Burkholderia, and Yersi

22 ic receptors alter the intracellular fate of Francisella by delivering bacteria through phagocytic pa

23 ilure to upregulate pfkfb3 We also show that Francisella capsule is required for this process.

24 iated uptake delayed maturation of the early Francisella-containing phagosome (FCP) and restricted ph

25 hesis and required for rapid escape from the Francisella-containing phagosome (FCP).

26 Francisella contains only three response regulators, mak

27 inhibition further supporting the binding of Francisella DnaK to alkaline phosphatase.

28 However, Francisella-encoded factors and mechanisms responsible f

29 Francisella encodes a NIS synthetase FslA/FigA and an or

30 We detected a Francisella endosymbiont in 174 ticks (70%), and Rickett

31 (+) T cell responses and that elucidation of Francisella epitopes that elicit high-avidity CD4(+) T c

32 However, the Francisella factors and the mechanisms through which F.

33 The Francisella FTT0831c/FTL_0325 gene encodes amino acid mo

34 response making the host more susceptible to Francisella growth.

35 acid phosphatase secretion by intracellular Francisella has not been shown.

36 ts establish NLRP3 as a cytosolic sensor for Francisella in human cells, a role not observed in mouse

37 e receptor 2 agonists during rapid growth of Francisella in vitro and in vivo.

38 m likely evolved from a pathogenic strain of Francisella, indicating that tick endosymbionts can evol

39 In summary, virulent Francisella induces a unique pulmonary inflammatory resp

40 gain more insight into the host response to Francisella infection during the acute stage, transcript

41 mine the IL-1beta response of human cells to Francisella infection.

42 Francisella infections are characterized by a delayed im

43 The importance of the MEP pathway to Francisella is demonstrated by the fact that MEP pathway

44 in the current study, we identified a novel Francisella-like endosymbiont (FLEs-Hd) from the tick Ha

45 lla tularensis, as well as Coxiella-like and Francisella-like endosymbionts (CLEs and FLEs, respectiv

46 Francisella-like endosymbionts (FLEs) with significant h

47 sella philomiragia, Francisella persica, and Francisella-like endosymbionts found in ticks.

48 bors, including Francisella philomiragia and Francisella-like endosymbionts found in ticks.

49 These results suggest that the attenuated Francisella LVS induces significant host cell signaling

50 of FITC-dextran and amiloride inhibition of Francisella LVS uptake.

51 fashion to in vivo observations, addition of Francisella lysate to exogenous alkaline phosphatase (ti

52 Various in vitro models of Francisella-macrophage interactions have been developed,

53 alkaline phosphatase as well as reduction of Francisella-mediated alkaline phosphatase inhibition fur

54 owever, to establish an intracellular niche, Francisella must overcome the oxidative stress posed by

55 on with the fish-specific bacterial pathogen Francisella noatunensis, primary leukocytes from adult z

56 demonstrated that the Cas9 endonuclease from Francisella novicida (FnCas9) is capable of targeting en

57 A resolution crystal structures of Cas9 from Francisella novicida (FnCas9), one of the largest Cas9 o

58 tion of the DNA-sensing AIM2 inflammasome by Francisella novicida and contributed to the activation o

59 rm to explore the intracellular lifestyle of Francisella novicida and discovered that the iglC gene i

60 we characterized the pantothenate pathway in Francisella novicida and F. tularensis and identified an

61 acement, we screened the Cpf1 nucleases from Francisella novicida and Lachnospiraceae bacterium ND200

62 two model intracellular bacterial pathogens, Francisella novicida and Salmonella typhimurium.

63 Using Francisella novicida as a model organism, a bacterial li

64 scape of nuclease-dead Cas12a (dCas12a) from Francisella novicida as it inspects and binds to its DNA

65 We describe a rare case of Francisella novicida bacteremia following a near-drownin

66 Here we report that Francisella novicida Cas9 (FnCas9) shows a very high spe

67 ococcus pyogenes, Staphylococcus aureus, and Francisella novicida complexed with guide RNAs (gRNAs) (

68 sistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion or pharmacological

69 egulator gene (wzz) from the related species Francisella novicida Immunization with VHMW-TT provided

70 ays and superior antibiotic activity against Francisella novicida in cell culture.

71 Francisella novicida is a rare cause of human illness de

72 stem of the intracellular bacterial pathogen Francisella novicida is involved in enhancing envelope i

73 ) and E. coli panE functionally complemented Francisella novicida lacking any KPR.

74 Here we show that the type II-B FnCas9 from Francisella novicida possesses novel properties, but its

75 We identified growth conditions under which Francisella novicida produces abundant OMV.

76 ainst foreign DNA, the CRISPR-Cas9 system of Francisella novicida represses expression of an endogeno

77 and they fail to provide protection against Francisella novicida upon adoptive transfer.

78 we demonstrate that the Cas protein Cas9 of Francisella novicida uses a unique, small, CRISPR/Cas-as

79 coccus thermophilus II-A CRISPR1 (Cas9), and Francisella novicida V-A (Cpf1) systems.

80 ida (herein referred to by its earlier name, Francisella novicida) attenuated strains, the DeltaiglB

81 of a lipid A phosphate with galactosamine in Francisella novicida, a model organism for the study of

82 so synthesized by Francisella tularensis and Francisella novicida, but unlike R. pickettii or L. pneu

83 ium and transfection of LPS, AIM2 activators Francisella novicida, mouse cytomegalovirus and DNA, and

84 We used a model intracellular pathogen, Francisella novicida, to begin characterizing the type I

85 ve bacteria vs the closely related bacterium Francisella novocida.

86 IglE is exported to the Francisella outer membrane as an approximately 13.9-kDa

87 The virulence factors mediating Francisella pathogenesis are being investigated, with an

88 tanding of the functions of these enzymes in Francisella pathogenesis.

89 owth by binding directly to promoters on the Francisella Pathogenicity Island (FPI) and positively re

90 These factors activate Francisella pathogenicity island (FPI) gene expression,

91 pe VI secretion system (T6SS) encoded by the Francisella pathogenicity island (FPI) is critical for t

92 F. novicida DeltaiglB, a Francisella pathogenicity island (FPI) mutant, is defici

93 pothetical protein encoded by the duplicated Francisella pathogenicity island (FPI).

94 is virulence stems from genes encoded on the Francisella pathogenicity island (FPI).

95 The Francisella pathogenicity island, required for bacterial

96 onal iglI, iglJ, or pdpC, three genes of the Francisella pathogenicity island.

97 neighbors, such as Francisella philomiragia, Francisella persica, and Francisella-like endosymbionts

98 ave been reported to play important roles in Francisella phagosomal escape, inhibition of the respira

99 screpant results on the timing and extent of Francisella phagosomal escape.

100 mily (MFS) transporters, and the nine-member Francisella phagosomal transporter (Fpt) subfamily posse

101 novicida and other near neighbors, including Francisella philomiragia and Francisella-like endosymbio

102 firmed with MALDI-TOF/MS spectra acquired on Francisella philomiragia ATCC 25015 and on Francisella t

103 Francisella philomiragia is a saprophytic gammaproteobac

104 from each other and near neighbors, such as Francisella philomiragia, Francisella persica, and Franc

105 naplasma, Rickettsia, Ehrlichia, Bartonella, Francisella, Powassan virus, tick-borne encephalitis vir

106 Francisella primarily invades host macrophages, where it

107 We previously identified a Francisella protein, FTN_0818, as being essential for in

108 vides new information to help understand how Francisella regulates its virulence genes in response to

109 An unusual set of Francisella regulators-the heteromeric macrophage growth

110 lasmic membrane protein RipA is required for Francisella replication within macrophages and other cel

111 strains, we combined the control of in vitro Francisella replication within macrophages with gene exp

112 o cope with their intracellular environment, Francisella requires multiple virulence factors, which a

113 n trans from attTn7 under the control of the Francisella rpsL promoter, thereby establishing that the

114 s or pseudogenes was found to differ between Francisella species and F. tularensis subspecies and sub

115 TT1388), which is conserved in all sequenced Francisella species and is the sole KPR in Schu S4.

116 Francisella species express lipid A molecules with uniqu

117 , but unlike R. pickettii or L. pneumophila, Francisella species lack putrescine biosynthetic pathway

118 acillus, presumptively identified as a novel Francisella species via 16S rRNA and multilocus gene seq

119 ctrum could enable (i) the identification of Francisella species, and (ii) the prediction of their vi

120 RipA is conserved among all sequenced Francisella species, and RipA-like proteins are present

121 unknown function but highly conserved among Francisella species, was identified in this screen to be

122 of virulent strain Schu S4 and are unique to Francisella species.

123 ion that had not been previously observed in Francisella species.

124 ure was associated with altered abundance of Francisella-specific transcripts, including those associ

125 pneumoniae) suggesting the inhibition may be Francisella-specific.

126 sed by the intracellular bacterial pathogens Francisella spp. and Brucella spp. to manipulate compone

127 y, promoting cytosolic growth in the case of Francisella spp. and facilitating cellular egress and ce

128 Francisella spp. are highly infectious and virulent bact

129 Because some Francisella strains are very virulent, this species is c

130 Francisella strains exhibit differences in IL-1beta prod

131 Following generation of various Francisella strains expressing well-characterized lympho

132 distinguish between virulent and nonvirulent Francisella strains is desirable.

133 t the same size as the genomes of pathogenic Francisella strains, about one-third of its protein-codi

134 bsp. tularensis CCUG 2112, the most virulent Francisella subspecies.

135 As an intracellular pathogen, Francisella survives and replicates in phagocytic cells,

136 o required for early replication of virulent Francisella Taken together, our data demonstrate that me

137 s been conducted using attenuated strains of Francisella that do not cause disease in humans.

138 Less is known about how Francisella traffics within macrophages or exits into th

139 st simultaneous measurement of both host and Francisella transcriptome changes that occur during in v

140 Moreover, in reconstituted 293T cells, Francisella triggers assembly of the NLRP3 inflammasome

141 (VOCs) emitted in culture by bacterial taxa Francisella tularensis (F. tularensis) subspecies novici

142 Francisella tularensis (Ft) is a highly infectious intra

143 The bacterium Francisella tularensis (Ft) is one of the most infectiou

144 Francisella tularensis (Ft), the Gram-negative facultati

145 ymbionts (FLEs) with significant homology to Francisella tularensis (gamma-proteobacteria) have been

146 onstrated that targeting fixed (inactivated) Francisella tularensis (iFT) organisms to FcR in mice i.

147 w-derived macrophages (BMDMs) to inactivated Francisella tularensis (iFt)-containing immune complexes

148 Francisella tularensis and Anaplasma phagocytophilum alt

149 aureus (MRSA) and priority pathogens such as Francisella tularensis and Burkholderia pseudomallei.

150 Rhizoferrin is also synthesized by Francisella tularensis and Francisella novicida, but unl

151 r nodosus and FtPilE from the human pathogen Francisella tularensis at 2.3 and 1 A resolution, respec

152 Francisella tularensis bacteria acquired from infected c

153 O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent o

154 Schu S4 strain of the intracellular pathogen Francisella tularensis by host macrophages involves CR3/

155 urface exposed and required for virulence of Francisella tularensis by subverting the host innate imm

156 The facultative intracellular pathogen Francisella tularensis can persist in water, amoebae, an

157 Francisella tularensis causes a lethal human disease kno

158 Francisella tularensis causes lethal pneumonia following

159 Inhalation of Francisella tularensis causes pneumonic tularemia in hum

160 The intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that

161 R recruitment, we evaluated Escherichia coli-Francisella tularensis chimeric variants of tmRNA and Sm

162 Infection with Francisella tularensis elicits innate and adaptive immun

163 The intracellular pathogen Francisella tularensis encodes a disulfide bond formatio

164 he identification of novel inhibitors of the Francisella tularensis FabI target.

165 In both cases, forward primer for Francisella tularensis holarctica genomic DNA was surfac

166 Francisella tularensis in an intracellular bacterial pat

167 thetic knee joint infections (PJI) caused by Francisella tularensis in Europe (one in Switzerland and

168 re required for intracellular replication of Francisella tularensis in J774A.1 macrophages.

169 ion of the lipid A 1-phosphatase, LpxE, from Francisella tularensis in Y. pestis yields predominantly

170 Francisella tularensis induces the synthesis of prostagl

171 used by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and thei

172 We study the pathogenesis of Francisella tularensis infection with an experimental mo

173 ences in the epidemiology of F. novicida and Francisella tularensis infections.

174 Francisella tularensis is a bacterium replicating within

175 Francisella tularensis is a category A biodefence agent

176 Francisella tularensis is a facultative bacterial pathog

177 Francisella tularensis is a facultative intracellular ba

178 Francisella tularensis is a facultative intracellular ba

179 Francisella tularensis is a facultative intracellular ba

180 Francisella tularensis is a facultative intracellular ba

181 Francisella tularensis is a facultative intracellular, G

182 Francisella tularensis is a Gram-negative bacterium and

183 Francisella tularensis is a gram-negative bacterium that

184 Francisella tularensis is a Gram-negative coccobacillus

185 Francisella tularensis is a Gram-negative, facultative i

186 Francisella tularensis is a highly infectious bacterium

187 Francisella tularensis is a highly infectious intracellu

188 Francisella tularensis is a highly infectious intracellu

189 Francisella tularensis is a highly virulent Gram-negativ

190 Francisella tularensis is a potential bioterrorism agent

191 Francisella tularensis is a remarkably infectious facult

192 Tularemia caused by Francisella tularensis is a zoonotic infection of the No

193 Francisella tularensis is able to survive and replicate

194 Francisella tularensis is an important human pathogen re

195 Pulmonary exposure to Francisella tularensis is associated with severe lung pa

196 A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cell

197 Francisella tularensis is classified as a category A pri

198 A licensed vaccine against Francisella tularensis is currently not available.

199 The adaptive immune response to Francisella tularensis is dependent on the route of inoc

200 The bacterium Francisella tularensis is recognized for its virulence,

201 Francisella tularensis is the causative agent of the deb

202 Francisella tularensis is the causative agent of tularem

203 Francisella tularensis is the causative agent of tularem

204 Francisella tularensis is the causative agent of tularem

205 The highly infectious and zoonotic pathogen Francisella tularensis is the etiologic agent of tularem

206 Francisella tularensis is the etiological agent of tular

207 IKKs in myeloid cells in vivo in response to Francisella tularensis Live Vaccine Strain (Ft. LVS) inf

208 We employed Francisella tularensis live vaccine strain (LVS) to stud

209 of mice infected with sublethal doses of the Francisella tularensis live vaccine strain (LVS).

210 ammation, priming with glycolipid (FtL) from Francisella tularensis live vaccine strain induces splen

211 hown that priming with glycolipid (FtL) from Francisella tularensis live-vaccine strain (i) induces F

212 The Francisella tularensis pathogenicity island (FPI) encode

213 Francisella tularensis produces a lipopolysaccharide (LP

214 the production of IL-4, effectively control Francisella tularensis replication.

215 Following inhalational exposure to Francisella tularensis SCHU S4, a small initial number o

216 virulence determinants from the select agent Francisella tularensis SCHU S4.

217 study, we describe novel inhibitors against Francisella tularensis SchuS4 FabI identified from struc

218 llular bacterial pathogens, such as virulent Francisella tularensis spp. tularensis (Ftt).

219 n lung tissue from mice exposed to virulent (Francisella tularensis ssp tularensis SchuS4).

220 , which encode putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200.

221 -flight (MALDI-TOF) mass spectrometry on the Francisella tularensis subsp. holarctica LVS defined thr

222 Two Francisella tularensis subsp. novicida (herein referred

223 In this study, we demonstrated that Francisella tularensis subsp. novicida, for which a comp

224 species, including the opportunistic microbe Francisella tularensis subsp. novicida, there are consid

225 b O-PS gene cluster from the highly virulent Francisella tularensis subsp. tularensis (type A) strain

226 n Francisella philomiragia ATCC 25015 and on Francisella tularensis subsp. tularensis CCUG 2112, the

227 Francisella tularensis subsp. tularensis is a highly inf

228 Inactivation of both copies of iglE rendered Francisella tularensis subsp. tularensis Schu S4 avirule

229 Francisella tularensis subsp. tularensis Schu S4 is a zo

230 scribe the isolation and characterization of Francisella tularensis subsp. tularensis strain Schu S4

231 In Francisella tularensis subsp. tularensis, DsbA has been

232 AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida)

233 onal exposure to lethal doses of aerosolized Francisella tularensis subspecies tularensis, strain SCH

234 taxonomical level with the identification of Francisella tularensis subspecies.

235 almonella, Yersinia pestis, and the virulent Francisella tularensis subspecies.

236 cus efforts on the highly virulent bacterium Francisella tularensis tularensis.

237 ts ortholog FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required

238 elates of vaccine-induced protection against Francisella tularensis using murine splenocytes and furt

239 The Gram-negative bacterium Francisella tularensis utilizes its antioxidant armature

240 Thus, IglE is essential for Francisella tularensis virulence.

241 of animals as early as 4 hrs post-exposure, Francisella tularensis was associated with an almost com

242 rticularly good antibacterial effect against Francisella tularensis, a Category A biowarfare pathogen

243 Francisella tularensis, a Gram-negative bacterium, is th

244 spp., Toxoplasma gondii, Coxiella burnetii, Francisella tularensis, and Neospora caninum, estimate c

245 lian pathogens such as Coxiella burnetii and Francisella tularensis, as well as Coxiella-like and Fra

246 We found that viable Francisella tularensis, as well as Salmonella enterica b

247 Francisella tularensis, Bacillus anthracis, and Yersinia

248 In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fit

249 anisms (Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella spp., Burkholderia spp.

250 ains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderi

251 m four pathogenic bacteria: Yersinia pestis, Francisella tularensis, Burkholderia pseudomallei and Ac

252 protection against infection with attenuated Francisella tularensis, but their role in infection medi

253 FipB, an essential virulence factor of Francisella tularensis, is a lipoprotein with two conser

254 tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's ocul

255 eumonic tularemia is caused by inhalation of Francisella tularensis, one of the most infectious micro

256 to various assemblies of the loblolly pine, Francisella tularensis, rice and budgerigar genomes.

257 the virulent SCHU S4 strain of the bacterium Francisella tularensis, that infects alveolar macrophage

258 ss despite its close genetic relationship to Francisella tularensis, the agent of tularemia.

259 Francisella tularensis, the bacterial cause of tularemia

260 Francisella tularensis, the causative agent of a fatal h

261 Francisella tularensis, the causative agent of tularemia

262 Francisella tularensis, the causative agent of tularemia

263 Francisella tularensis, the causative agent of tularemia

264 Francisella tularensis, the causative agent of tularemia

265 he current study, we developed a model using Francisella tularensis, the causative agent of tularemia

266 Francisella tularensis, the causative agent of tularemia

267 Francisella tularensis, the causative agent of tularemia

268 Francisella tularensis, the etiological agent of tularem

269 In Francisella tularensis, the putative DNA-binding protein

270 ogens, such as the highly virulent bacterium Francisella tularensis, to ensure their replication and

271 Following pulmonary infection with Francisella tularensis, we observed an unexpected but si

272 Francisella tularensis, which is a Gram negative bacteri

273 nd Prevention (CDC) and include the bacteria Francisella tularensis, Yersinia pestis, Burkholderia ma

274 in Bacillus anthracis, Yersinia pestis, and Francisella tularensis.

275 r the intramacrophage growth and survival of Francisella tularensis.

276 llenge with the live vaccine strain (LVS) of Francisella tularensis.

277 _1680/FTT_0166c as a new virulence factor in Francisella tularensis.

278 ed by a Gram-negative coccoid rod bacterium, Francisella tularensis.

279 been reported with Dichelobacter nodosus and Francisella tularensis.

280 uivalent but highly divergent sequences from Francisella tularensis.

281 on by using the live vaccine strain (LVS) of Francisella tularensis.

282 0) in cutaneous and pulmonary infection with Francisella tularensis.

283 by infection by the gram-negative bacterium, Francisella tularensis.

284 infections using Rift Valley fever virus and Francisella tularensis.

285 ress and virulence by the bacterial pathogen Francisella tularensis.

286 ent of tularemia and category A select agent Francisella tularensis.

287 a category A intracellular mucosal pathogen, Francisella tularensis.

288 el organism for the study of highly virulent Francisella tularensis.

289 ellular pathogens Listeria monocytogenes and Francisella tularensis.

290 he highly infectious intracellular bacterium Francisella tularensis.

291 arance of the lethal intracellular bacterium Francisella tularensis.

292 es of the Gram-negative facultative anaerobe Francisella tularensis: F. tularensis subsp. tularensis

293 pectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Ma

294 C3-dependent Francisella uptake alone was insufficient to induce macr

295 C in modulation of host immune responses and Francisella virulence and also highlight strain- and rou

296 analysis of purified OMV/T identified known Francisella virulence factors among the constituent prot

297 ly identified a gene (FTN_0818) required for Francisella virulence that seemed likely involved in bio

298 infection, is also involved in coordinating Francisella virulence; however, its role has been unclea

299 ment is a particularly effective opsonin for Francisella, we asked whether complement-dependent uptak

300 une T lymphocytes control the replication of Francisella within macrophages in vitro by a variety of