ライフサイエンスコーパス: G-protein alpha subunit

1 ng RGS in close proximity with its substrate G protein alpha subunit.

2 ning requires Pins or related proteins and a G protein alpha subunit.

3 by mutations in the GNAS exons encoding the G protein alpha subunit.

4 sis has only one gene, GPA1, for a canonical G protein alpha subunit.

5 to xanthine nucleotides in a heterotrimeric G protein alpha subunit.

6 ed by the G protein beta subunit to bind the G protein alpha subunit.

7 eceptors (GPCRs) and GTP replaces GDP on the G protein alpha-subunit.

8 the Gpr1 receptor that is coupled to Gpa2, a G-protein alpha subunit.

9 nes may be the result of a difference in the G-protein alpha subunit.

10 4) muscarinic receptors fused with the G(15) G-protein alpha-subunit.

11 ing proteins that specifically interact with G protein alpha subunits.

12 or protein-protein interactions differ among G protein alpha subunits.

13 by enhancing endogenous GTPase activities of G protein alpha subunits.

14 ecule, and there are several such regions in G protein alpha subunits.

15 elerating proteins (GAPs) for heterotrimeric G protein alpha subunits.

16 by increasing the rate of GTP hydrolysis on G protein alpha subunits.

17 asma membrane localization of heterotrimeric G protein alpha subunits.

18 g proteins (GAPs) for G(i) and/or G(q) class G protein alpha subunits.

19 were reconstituted with purified recombinant G protein alpha subunits.

20 celerates the rate of GTP hydrolysis by some G protein alpha subunits.

21 S) proteins directly control the activity of G protein alpha subunits.

22 naling by stimulating the GTPase activity of G protein alpha subunits.

23 ctional regulation of activity by homologous G protein alpha subunits.

24 ne proteins, G protein-coupled receptors and G protein alpha subunits.

25 encode positive regulators of heterotrimeric G protein alpha subunits.

26 catalyzed binding of GTP gamma S to purified G protein alpha subunits.

27 is to participate in the folding of nascent G protein alpha subunits.

28 hat NUCB1 might interact with heterotrimeric G protein alpha subunits.

29 at collectively bind the four subfamilies of G protein alpha subunits.

30 otide exchange factor that activates certain G protein alpha-subunits.

31 by acting as GTPase-activating proteins for G protein alpha-subunits.

32 rotein-2 (RAMP2), and the role of individual G protein alpha-subunits.

33 localization or GAP activity toward purified G-protein alpha subunits.

34 ng of the GDP-bound conformation of specific G-protein alpha subunits.

35 forms, VSV and VGV, to interact with various G-protein alpha subunits.

36 region for protein binding to heterotrimeric G-protein alpha subunits.

37 oteins by stimulating the GTPase activity of G-protein alpha subunits.

38 o function as GTPase-activating proteins for G-protein alpha subunits.

39 antibodies that recognize various classes of G-protein alpha-subunits.

40 the four completely sequenced Dictyostelium G-protein alpha-subunits.

41 ological effects by signaling through either G-protein alpha subunit 12 or beta-arrestin 2.

42 Conversely, GNAS (G-protein alpha subunit), a PKA activator that is geneti

43 e receptor signaling by binding to activated G-protein alpha-subunits, accelerating GTP hydrolysis.

44 The four classes of heterotrimeric G-protein alpha subunits act as molecular routers inside

45 nosine diphosphate ribosylation of the small G protein alpha-subunit activating CFTR with consequent

46 of neutrophils in the absence of receptor or G protein alpha subunit activation.

47 his issue, Slessareva et al. now show that a G protein alpha subunit acts at the endosome to stimulat

48 ssed in HEK293 cells, but co-expression of a G protein alpha subunit allows strong PM localization of

49 ed with constitutively active mutants of the G protein alpha subunits alpha s, alpha i1, and alpha o

50 as GTPase-activating proteins (GAPs) for the G-protein alpha-subunits alpha(i) and alpha(q), lack suc

51 The G-protein alpha subunit, alpha(13), regulates cell growt

52 The N termini of two G protein alpha subunits, alphaq and alpha11, differ fro

53 trimeric guanine nucleotide binding protein (G protein) alpha-subunit (alphas), to alanine (alphas-R2

54 in maintaining the membrane attachment of a G protein alpha subunit, alphaz, which is myristoylated

55 influences of dexamethasone on the levels of G-protein alpha-subunits, an effect that may contribute

56 unit is selectively associated with specific G protein alpha subunits and is localized preferentially

57 hare a common RGS domain that interacts with G protein alpha subunits and mediates their biological r

58 coupled to Galphaq and Galphai, and chimeric G protein alpha subunits and murine fibroblasts deficien

59 from that seen in analogous mutants of other G protein alpha subunits and suggests that either regula

60 Large G protein alpha subunits and their attendant regulators

61 ungus Aspergillus nidulans, a heterotrimeric G protein alpha-subunit and an RGS domain protein, encod

62 neurite outgrowth 1) can tether MOR with the G protein alpha-subunit and subsequently regulate the re

63 nt residue (Glu259) is strictly conserved in G protein alpha-subunits and is predicted to be importan

64 One signaling cascade involves a conserved G-protein alpha subunit and cAMP, and senses nutrients d

65 al landscape and the switching function of a G-protein alpha subunit and the influence of a GPCR in t

66 AMP signaling is dependent on receptor (with G-protein alpha subunits and adenylyl cyclase) internali

67 ne triphosphatase activity of heterotrimeric G-protein alpha subunits and are thus recognized as key

68 toxin (PTX) resulted in ADP-ribosylation of G-protein alpha subunits and inhibition (>80%) of lympho

69 eins bind to the inhibitory G(i) subclass of G-protein alpha subunits and slow the release of bound G

70 For example, this domain interacts with G-protein alpha subunits and Src-like kinases and can fu

71 accelerate GTP hydrolysis by heterotrimeric G-protein alpha subunits and thus inhibit signaling by m

72 mbinants expressing individual PTX-resistant G-protein alpha subunits and treated with PTX, and quinp

73 The GTP bound form of the g-protein alpha-subunit and in some cases the free betag

74 g infrequently occurring mutants of trimeric G-protein alpha-subunits and GPCRs.

75 lysis of two protein families (LacI/PurR and G protein alpha subunit), and compared our method with t

76 one was identified as Gnas, which encodes a G protein alpha subunit, and there is clinical and bioch

77 muli, including protein kinase C, forskolin, G protein alpha subunits, and G protein betagamma subuni

78 ein betagamma subunits, wild-type or mutated G-protein alpha subunits, and active protomers of pertus

79 Since rods and cones have different G-protein alpha subunits, and since this subunit (Talpha

80 duced feeding are mediated through different G-protein alpha-subunits, and provide further evidence f

81 G protein alpha-subunits appear to be capable of interac

82 Most heterotrimeric G protein alpha subunits are covalently modified by palm

83 The C termini of G protein alpha subunits are critical for binding to the

84 Many G protein alpha subunits are dually acylated with myrist

85 functional abundances of G proteins because G protein alpha subunits are misfolded and degraded rapi

86 ded to bitter stimuli, suggesting that other G-protein alpha subunits are involved.

87 encoding members of the Galpha(q) family of G protein alpha subunits, are the driver oncogenes in uv

88 palmitoyltransferase activity, assayed using G-protein alpha subunits as a substrate, was found to be

89 nsitive to MOR-1 AS ODN effects, none of the G-protein alpha-subunit AS ODN probes were effective.

90 Gnasxl determines a variant G protein alpha subunit associated with the trans-Golgi

91 NA to suppress expression of the three known G-protein alpha-subunit-associated RhoA guanine nucleoti

92 This may reflect the concentration of G-protein alpha subunits at synapses.

93 When G-protein alpha subunits binds GTP and Mg(2+), they tran

94 to examine the receptor coupling to purified G protein alpha subunits by the bombesin receptor family

95 bial mechanisms, such as ADP ribosylation of G protein alpha-subunits by cholera and pertussis toxins

96 employing combinations of antibodies against G-protein alpha subunits, calcium-binding proteins, and

97 Inactive forms of all G protein alpha subunits can be produced by mutations eq

98 Second, different G protein alpha subunits can compete with each other for

99 ructural differences between closely related G-protein alpha-subunits can have important consequences

100 Our data suggest that activation of G protein alpha subunits causes them to concentrate in s

101 Alpha-gustducin, a taste cell-expressed G-protein alpha subunit closely related to the alpha-tra

102 Most strikingly, interaction with G protein alpha subunit completely inhibits the enzymati

103 G protein alpha subunits consist of two domains, a GTPas

104 G protein alpha subunits cycle between active and inacti

105 AS ODN probes directed against different G-protein alpha-subunits differentially reduced morphine

106 ranch of the yeast mating pathway in which a G-protein alpha subunit directly activates phosphatidyli

107 enriched GTPase activating protein (GAP) for G-protein alpha subunits, displayed increased microglial

108 demonstrate that the GTP-bound state of the G protein alpha subunit displays no detectable affinity

109 anism, given that the GDP-bound form of many G protein alpha subunits does not contain bound Mg2+.

110 mosensory sensilla, which suggests that this G-protein alpha subunit does not participate in olfactor

111 main functionally suppresses the activity of G-protein alpha subunits, eNOS, and Src-like kinases, su

112 eptor alleles expressed in cells lacking the G protein alpha subunit exhibit a higher equilibrium bin

113 ptahelical receptors among the four Gq class G-protein alpha subunits expressed in mammals.

114 e functional roles subserved by G(alpha)z, a G protein alpha subunit found predominantly in neuronal

115 e on the cloning and characterization of two G protein alpha-subunits from pea: PGA1 and PGA2.

116 ation comes from investigations of the large G-protein alpha subunit from yeast (Gpa1) and the three

117 itherto undescribed defect in human platelet G-protein alpha-subunit function leading to impaired pla

118 Here we demonstrate that the heterotrimeric G protein alpha subunit G(s)alpha is required in cells o

119 The imprinted mouse gene Gnas produces the G protein alpha-subunit G(S)alpha and several other gene

120 The G protein alpha-subunit G(s)alpha is required for hormon

121 ytochemistry using antisera specific for the G-protein alpha subunits G(alphai), G(alphaq), and G(alp

122 Disruption of the Dictyostelium G-protein alpha-subunit G alpha 3 (g alpha 3-) blocks de

123 d expressing this receptor together with the G-protein alpha-subunit G alpha(16).

124 The G-protein alpha-subunit G(s)alpha is required for the in

125 The downstream promoter for the stimulatory G protein alpha-subunit (G(s)alpha) is unmethylated, alt

126 These products include stimulatory G protein alpha-subunit (G(s)alpha), the G protein requi

127 n of Gnas, the gene encoding the stimulatory G-protein alpha subunit (G(s)alpha), leads to distinct p

128 To probe conformational changes in the G-protein alpha-subunit (G(alpha)) associated with activ

129 Solution NMR studies of a (15)N-labeled G-protein alpha-subunit (G(alpha)) chimera ((15)N-ChiT)-

130 l changes in an isotope-labeled, full-length G-protein alpha-subunit (G(alpha)) chimera (ChiT) associ

131 ciency of beta(2)AR interaction with various G-protein alpha-subunits (G(xalpha)), we expressed fusio

132 binding assay, and binding was inhibited by G protein alpha subunit, G alpha i1.

133 e in expression of muscarinic receptors, the G protein alpha-subunit, G-alphai2, and the inward recti

134 nylyl cyclase inhibitory guanine nucleotide (G) protein alpha subunit, G alpha(i2).

135 This report describes the Dictyostelium G-protein alpha-subunit, G alpha3, and demonstrates that

136 We found that the G-protein alpha subunit Galpha(i2) is present in most bi

137 The G protein alpha subunit (Galpha) is composed of two dist

138 The pheromone-responsive G protein alpha subunit (Galpha) of yeast down-regulates

139 activated by exchange of GDP for GTP at the G protein alpha subunit (Galpha), most notably by G prot

140 ins by substituting GTP for GDP bound to the G protein alpha subunit (Galpha), thereby generating two

141 AMP from ATP and is activated by stimulatory G protein alpha subunits (Galpha(s)) and by forskolin (F

142 e Factor (GEF) that activates heterotrimeric G protein alpha subunits (Galpha) and serves as an essen

143 ein signaling (RGS) proteins that deactivate G protein alpha subunits (Galpha).

144 The inhibitory G protein alpha-subunit (Galpha(z)) is an important modu

145 a cycle of GTP binding and hydrolysis on the G protein alpha-subunit (Galpha).

146 rase 8A (Ric8A) is an essential regulator of G protein alpha-subunits (Galpha), acting as a guanine n

147 led receptor (GPCR)-independent regulator of G protein alpha-subunits (Galpha), acting as a guanine n

148 usly showed that guanine nucleotide-binding (G) protein alpha subunit (Galpha)-interacting vesicle-as

149 te xanthine nucleotide-selective unspecified G-protein alpha-subunit (Galpha).

150 accelerate the intrinsic GTPase activity of G-protein alpha-subunits (Galpha) and thus shorten the t

151 In functional studies, the use of a chimeric G protein alpha-subunit, Galpha(qo5), demonstrated that

152 The GTPase activities of two G protein alpha subunits, Galpha12 and Galpha13, are sti

153 ers of the Galpha12 family of heterotrimeric G proteins alpha subunits, Galpha12 and Galpha13, regula

154 xchange factor that binds the heterotrimeric G-protein alpha-subunits, Galpha12 and Galpha13.

155 ic binding of a C-terminal fragment from the G protein alpha subunit (GalphaCT) to trap a light activ

156 The heterotrimeric G protein alpha subunit, Galphai3, has also been localiz

157 elanomas (UMs), but somatic mutations in the G protein alpha subunits Galphaq and Galpha11 (encoded b

158 occupied receptors and the receptor-coupled G-protein alpha subunits Galphaq and Galphai in caveolae

159 Interestingly, the N termini of two G protein alpha subunits, Galphaq and Galpha11, differ f

160 ly, we have reported that the heterotrimeric G protein alpha-subunit, Galphaq/11, can mediate insulin

161 lerators of the intrinsic GTPase activity of G protein alpha subunits (GAPs), thus controlling the re

162 Besides the sole prototypical G protein alpha subunit gene, GPA1, the Arabidopsis thal

163 s-of-function mutation in the heterotrimeric G protein alpha-subunit gene Gnai3 have fusions of ribs

164 Ta strain containing a deletion of GPA1, the G protein alpha-subunit gene; however, STE4(SD13) had no

165 ole prototypical heterotrimeric GTP-binding (G) protein alpha subunit gene, GPA1, lack both ABA inhib

166 -DNA null mutations in the sole prototypical G-protein alpha-subunit gene, GPA1.

167 ines of the sole prototypical heterotrimeric G-protein alpha-subunit gene, GPA1.

168 Mutations in G protein alpha subunit genes altered the responses of b

169 tive GDP-bound complex of the heterotrimeric G protein alpha subunit Gi alpha 1 has been investigated

170 e crystal structure of the complex between a G protein alpha subunit (Gi alpha 1) and its GTPase-acti

171 In this report, G protein alpha subunits Gi1alpha, Gsalpha, and Goalpha

172 Mice lacking the heterotrimeric G protein alpha subunit Gialpha2 develop chronic colitis

173 We have identified a new gene encoding the G protein alpha subunit, gna-3, from the filamentous fun

174 ine 243 to histidine (R243H) mutation in the G-protein alpha subunit GNAO1 in breast carcinoma tissue

175 enes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNAS) are found in approximate

176 as caused by the hyperactivation of a single G-protein alpha subunit, Gnas.

177 Recently, it has been shown that the G protein alpha subunit Gpa1 can promote signaling at en

178 sed mass spectrometry to show that the yeast G protein alpha subunit Gpa1 is ubiquitinated at Lys-165

179 The yeast G protein alpha subunit Gpa1 represents a rare example o

180 potential third pathway is initiated by the G-protein alpha subunit Gpa1.

181 ngal pathogen Cryptococcus neoformans, three G protein alpha subunits (Gpa1, Gpa2 and Gpa3) have been

182 for proteins that interact with Arabidopsis G protein alpha-subunit (GPA1).

183 les the one described for the heterotrimeric G-protein alpha subunit (GPA1) null mutant gpa1.

184 olated a knock-out mutant of the Arabidopsis G-protein alpha subunit (gpa1-5) and analysed its transc

185 PR89) and interact with the sole Arabidopsis G protein alpha subunit, GPA1, but also have intrinsic G

186 f the G protein; promotes degradation of the G protein alpha subunit, Gpa1, in vivo; and catalyzes Gp

187 Arabidopsis, in addition to one prototypical G protein alpha subunit, GPA1, there are three extra-lar

188 ponses in null mutants of the sole canonical G-protein alpha subunit, GPA1.

189 The Saccharomyces cerevisiae G protein alpha subunit Gpa1p is involved in the respons

190 The G protein alpha subunit (Gpa1p) is tandemly modified at

191 ductively interact with the endogenous yeast G protein alpha subunit, Gpa1p, or a mutant Gpa1p subuni

192 ling pathway that directly interact with the G protein alpha-subunit Gpa2p in the yeast Saccharomyces

193 e show that a signaling module formed by the G protein alpha subunit, Gqalpha, and one of its downstr

194 In this study, we report that immunoreactive Gs protein alpha-subunits (Gs alpha) localize to nuclei

195 The stimulatory G protein alpha subunit Gsalpha binds within a cleft in

196 complex with its stimulatory heterotrimeric G protein alpha subunit (Gsalpha) and forskolin was dete

197 The stimulatory G protein alpha-subunit (Gsalpha) couples the beta-adren

198 GNAS1, the gene encoding the heterotrimeric G protein alpha-subunit (Gsalpha) that couples multiple

199 sed in taste receptor cells that contain the G protein alpha subunit gustducin, implying that they fu

200 coupled receptor (GPCR) linked directly to a G protein alpha subunit have been employed for a number

201 t, two different constitutive mutants of the G protein alpha subunit have been reported.

202 lves a signal mediated by the heterotrimeric G protein alpha subunit homolog encoded by GPA2.

203 The gene encoding a G-protein alpha subunit homolog, GPA1, was disrupted by

204 und that GPA2, one of the two heterotrimeric G protein alpha subunit homologs in yeast, regulates pse

205 vated Galpha(q/11) subunits, implicates this G protein alpha subunit in the modulatory pathway.

206 tify the site of ubiquitination in Gpa1, the G protein alpha subunit in yeast Saccharomyces cerevisia

207 ine the cellular trafficking function of the G protein alpha subunit in yeast, Gpa1.

208 ies have implicated the carboxyl terminus of G protein alpha subunits in both mediating receptor-G pr

209 enon, the authors investigated the levels of G protein alpha subunits in platelets and lymphocytes of

210 s to characterize the relative expression of G protein alpha subunits in rat colonocytes, colonocyte

211 fied two genes, gna-1 and gna-2, that encode G protein alpha subunits in the filamentous fungus Neuro

212 perone for several classes of heterotrimeric G protein alpha subunits in vertebrates.

213 was examined by reconstitution with various G protein alpha-subunits in heterotrimeric form with Gbe

214 the abundance of mRNA and/or protein of six G protein alpha-subunits in human CD4(+) and CD8(+) T ce

215 act as GTPase-activating proteins (GAPs) for G protein alpha-subunits in vitro.

216 tment to the cell cortex by a heterotrimeric G-protein alpha subunit in complex with a TPR-GoLoco mot

217 Here, we studied the internal mobility of a G-protein alpha subunit in its apo and nucleotide-bound

218 ta subunits established the involvement of a G-protein alpha subunit in PMT-activation of PLCbeta1.

219 LGs) that show significant similarity to the G-protein alpha subunit in their C-terminal regions.

220 of ribosylation-resistant (PTX-insensitive) G-protein alpha subunits in brain EC restored their abil

221 expression of 5HT(2C) receptor isoforms with G-protein alpha subunits in fibroblasts were studied, an

222 erized the complete set of genes that encode G-protein alpha subunits in the genome of the malaria ve

223 may accelerate the rate of GTP hydrolysis by G protein alpha subunits, in part, by inserting an amino

224 Pase-accelerating protein (GAP) for multiple G protein alpha subunits, including adenylyl cyclase-inh

225 triphosphatase (GTPase) activity of various G protein alpha-subunits, including the photoreceptor G

226 However, the topological fate of activated G protein alpha subunits is disputed.

227 uanosine 5'-diphosphate (GDP) release by the G protein alpha-subunit is not well understood.

228 luoride (AlF4-) activation of heterotrimeric G-protein alpha-subunits is a well established aspect of

229 ain, which is structurally homologous to the G protein alpha subunit, is tethered to the top of the b

230 or more precisely, GDP dissociation from the G protein alpha-subunit, is the key step towards G prote

231 ults, we conclude that corticosterone alters G protein alpha-subunit levels in the rat hippocampus wi

232 To investigate how G protein alpha subunit localization is regulated under

233 Differential coupling of G-protein alpha subunits may be a means of achieving spe

234 G protein alpha subunits mediate activation of signaling

235 ese results identify Galphai2 as the primary G protein alpha-subunit mediating the detection of volat

236 Of the known Ptx-sensitive G-protein alpha subunits, MN9D-expressed Galphai2, Galph

237 ssion (Col) wild type and the heterotrimeric G-protein alpha subunit mutant, gpa1, which has ABA-hypo

238 way in lobster olfactory receptor neurons, a G protein alpha subunit of the G(q) family and an inosit

239 ionally, Ubl1 physically interacted with two G protein alpha subunits of F.verticillioides, thus impl

240 -RhoGEFs) that link activated heterotrimeric G protein alpha subunits of the G12 family to activation

241 s a structural motif by which heterotrimeric G protein alpha subunits of the Galpha(12) family can bi

242 These clones encoded (1) the G protein alpha subunits of the Gq, Gi, and Go families,

243 lerate the GTPase activity of heterotrimeric G protein alpha subunits of the i, q, and 12 classes.

244 xchange (GEF) activity toward heterotrimeric G protein alpha subunits of the i, q, and 12/13 classes,

245 dies against pertussis toxin (PTX)-sensitive G protein alpha-subunits or with injection of antisense

246 tibodies to the common GTP-binding region of G-protein alpha subunits, or antibodies to different reg

247 sn347 is a conserved residue present in most G protein alpha subunits outside the alphas family, thes

248 The C-terminal regions of the heterotrimeric G protein alpha-subunits play key roles in selective act

249 The carboxyl terminus of the G protein alpha subunit plays a key role in interactions

250 groups reported that the alpha5 helix in the G protein alpha subunit plays a major role during this a

251 The carboxyl terminus of heterotrimeric G protein alpha subunits plays an important role in rece

252 Thus homologous G protein alpha-subunits promote bidirectional regulatio

253 -binding activities of Ras-like proteins and G protein alpha subunit proteins were examined in polyom

254 develop a simplified method for recombinant G protein alpha subunit purification that was applicable

255 We find that the G protein alpha subunit Ras and helical domains-previous

256 antibodies were used to quantitate levels of G protein alpha subunits regulating adenylylcyclase acti

257 action and possible intracellular effects of G protein alpha subunits remain unclear.

258 The N-terminal regions of the heterotrimeric G-protein alpha-subunits represent one of the major Gbet

259 13, near GNAS1, which encodes G(s)alpha, the G protein alpha-subunit required for receptor-stimulated

260 luding G(s)alpha, the ubiquitously expressed G protein alpha-subunit required for receptor-stimulated

261 4, a mammalian GTPase-activating protein for G protein alpha subunits, requires its N-terminal 33 ami

262 able to recognize individual heterotrimeric G protein alpha subunits resulted in rapid expansion of

263 eptor induces a conformational change in the G protein alpha subunit, resulting in exchange of guanin

264 ells with AlF4- (activator of heterotrimeric G protein alpha subunits) results in a 3-4-fold increase

265 In this study we defined the G-protein alpha-subunit selectivity of purified Sf9 cell

266 the first demonstration of a heterotrimeric G protein alpha subunit specifically targeted to mitocho

267 vestigate how RGS4, a GAP for heterotrimeric G protein alpha subunits, stimulates GTP hydrolysis.

268 rexpression of the transducin heterotrimeric G protein alpha subunit strongly suggesting the transfor

269 , only the Galpha12 family of heterotrimeric G protein alpha subunits strongly induced the SRE, while

270 Types of G proteins (G protein alpha-subunit subtypes) which mediate the acti

271 AtGPA1 is a unique heterotrimeric G protein alpha subunit that is constitutively GTP-bound

272 d the role of palmitoylation of alpha(13), a G protein alpha subunit that regulates many pathways inv

273 tal structure of Gsalpha, the heterotrimeric G protein alpha subunit that stimulates adenylyl cyclase

274 ) and Galphaolf (Golf) are highly homologous G-protein alpha subunits that activate adenylate cyclase

275 ns accelerate the GTPase activity of certain G protein alpha subunits (the reaction responsible for t

276 ein-coupled receptor and GAIP interacts with G protein alpha subunits, their physical linkage in the

277 thways by accelerating the GTP hydrolysis on G protein alpha subunits thereby promoting termination o

278 exchange at the GDP/GTP binding site of the G-protein alpha-subunits, thus displacing the bound GDP

279 ent of ubiquitination and trafficking of the G protein alpha subunit to its site of degradation.

280 recognize and promote nucleotide exchange on G protein alpha subunits to initiate signal amplificatio

281 p115 RhoGEF can directly link heterotrimeric G protein alpha subunits to regulation of Rho.

282 ular mechanisms that govern the targeting of G-protein alpha subunits to the plasma membrane.

283 he ability of AS ODN probes directed against G-protein alpha-subunits to reduce feeding induced by mo

284 d-type mice, but not in mice lacking the rod G-protein alpha subunit, transducin (Galphat), revealing

285 ificance of N-acylation of a well understood G-protein alpha-subunit, transducin (G alpha(t)), we gen

286 This alpha subunit, like most other G protein alpha subunits, undergoes palmitoylation, the

287 one, dexamethasone, of the levels of several G-protein alpha-subunits was studied during differentiat

288 4, a mammalian GTPase activating protein for G protein alpha subunits, was identified by its ability

289 alpha-gustducin, a primarily taste-specific G protein alpha-subunit, was discovered in 1992 and was

290 s demonstrate AlF(4)(-)-dependent binding to G protein alpha subunits, we tested the ability of G pro

291 erum response factor (SRF) by heterotrimeric G protein alpha subunits were characterized in transfect

292 Endogenous G protein alpha subunits were uncoupled from GPCRs by tr

293 Although most G protein alpha-subunits were similarly expressed in all

294 GNAQ and GNA11 are heterotrimeric G protein alpha subunits, which are mutated in a mutuall

295 typically accelerated by interaction of the G protein alpha subunit with a member of the regulator o

296 Partial coincidence of localization of G protein alpha subunits with caveolin (a marker for cav

297 This is the first report of G protein alpha subunits with overlapping functions in e

298 In addition to the interaction of the G protein alpha subunits with the RH domain, activated R

299 a subunits and the direct association of the G protein alphas subunit with the regulator of G protein

300 ons in the activity/levels of the extralarge G protein alpha-subunit (XLalphas) are implicated in var