ライフサイエンスコーパス: G-quadruplex

1 e proton T(1) values for a water-soluble DNA G-quadruplex.

2 onal spectra for several proteins and an RNA G-quadruplex.

3 specifically to human telomeric antiparallel G-quadruplex.

4 o distribute between a monomeric and dimeric G-quadruplex.

5 ires interaction of TRF2 with a p21 promoter G-quadruplex.

6 onic metallohelices with human telomeric RNA G-quadruplex.

7 able exons that contain splice site-proximal G-quadruplexes.

8 to switch between inter- and intramolecular G-quadruplexes.

9 e metabolites and functionality of the bound G-quadruplexes.

10 ed through RNA secondary structures known as G-Quadruplexes.

11 e property of individual human telomeric DNA G-quadruplexes.

12 telomeric G-quadruplex from other telomeric G-quadruplexes.

13 ains do not preferentially interact with DNA G-quadruplexes.

14 typical B-form DNA to single-stranded DNA to G-quadruplexes.

15 ution of, and replication through, telomeric G-quadruplexes.

16 structure-forming sequences, exemplified by G quadruplex and H-DNA motifs, across the genome in both

17 31 is a 31-nt DNA aptamer, consisting of the G-quadruplex and a duplex domain, which is able to effec

18 On the basis of predicting a stable G-quadruplex and a secondary structure, we truncated 19

19 pregnanol derivatives that recognize the MYC G-quadruplex and BCL2 i-motif promoter DNA structures lo

20 sed RGG box-dependent binding to the SC1 RNA G-Quadruplex and is required for outgrowth of neurites.

21 , specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally

22 ructures of (i) Pseudorabies virus (PRV) RNA G-quadruplex and ligand complex, (ii) PRV DNA G-quadrupl

23 mers by modifying their sequences upon their G-quadruplex and secondary structures.

24 These studies show that T-oligo can form a G-quadruplex and that the antitumor effects of T-oligo m

25 with a high affinity to human telomeric RNA G-quadruplex and that their binding selectivity consider

26 The modified 40-nt aptamer, with a stable G-quadruplex and two modified loops, exhibited a 100 tim

27 G-rich G-quadruplexes and C-rich i-motifs are the most well-cha

28 tential to form secondary structures such as G-quadruplexes and i-motifs, respectively.

29 r cells, proved to be able to stabilize both G-quadruplexes and R loops and showed a potent cell kill

30 RGG domain of FMRP as important for binding G-quadruplexes and the transport of G-quadruplex-contain

31 e method in different structural contexts of G-quadruplexes and their complexes.

32 ence of EXO1, forks accumulate at stabilized G-quadruplexes and ultimately collapse.

33 ative DNA structures, like Z DNA, triplexes, G quadruplexes, and I motifs.

34 -quadruplex and ligand complex, (ii) PRV DNA G-quadruplex, and (iii) an i-motif of human telomeric se

35 ee isomers of [Ru(bqp)(2)](2+) with i-motif, G-quadruplex, and double-stranded DNA.

36 FNAs mainly include DNAzymes, G-quadruplexes, and mismatched base pairs and nanomateri

37 physical barriers such as structured genes, G-quadruplexes, and other obstacles.

38 Using an anti-G-quadruplex antibody, we showed that T-oligo can form G

39 o any conformational form of human telomeric G-quadruplex (antiparallel, hybrid, parallel monomers or

40 ng assay for HBeAg, which takes advantage of G-quadruplex aptamers for enhanced binding and stability

41 king interactions, double-helical stems, and G-quadruplexes are immediately obvious.

42 G-Quadruplexes are noncanonical four-stranded DNA second

43 Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are sug

44 Together, these findings position G-quadruplexes as a primary candidate for the NONO-recru

45 ified translational inhibitory elements with G-quadruplexes as marks for mRNA decay in P-bodies.

46 Guanine-quadruplex (G-quadruplex) assemblies provide a useful platform for s

47 d cephaeline for investigating mechanisms of G-quadruplex-associated alternative splicing.

48 ome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is de

49 two guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the elect

50 promising and desirable features to develop G-quadruplex binders as safe and effective anticancer ag

51 In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused on th

52 Searching for potent and selective G-quadruplex binders, here we describe a small series of

53 tories finds that the Timeless protein has a G-quadruplex binding domain that works together with the

54 To investigate the G-quadruplex binding properties of the new molecules, in

55 rove Au-carbene affinity and specificity for G-quadruplex binding.

56 so sensitive to the well-known intracellular G-quadruplex-binding ligand 360A.

57 , 9CI that selectively recognizes c-MYC Pu22 G-quadruplex both in vitro and ex vivo.

58 nical property of individual human telomeric G-quadruplexes bound to telomestatin, using optical twee

59 nvolve DNA synthesis: DNA replication across G-quadruplexes; break-induced replication; and processin

60 R can dramatically simplify the depiction of G-quadruplexes by automatically detecting G-tetrads and

61 Although G-quadruplexes can be found throughout the genome, telom

62 With 9CI and c-MYC Pu22 G-quadruplex complex as the fluorescent response core, a

63 altered mechanical anisotropy of the ligand-G-quadruplex complex can add additional level of regulat

64 ptamer as the photo-probe, generating the MB/G-quadruplex complex.

65 servation that NONO preferentially binds the G-quadruplex conformation of G-rich C9orf72 repeat RNA,

66 ut rather folds into a compact stacked three-G-quadruplex conformation.

67 ides key insight into rate-limiting steps of G-quadruplex conformational dynamics.

68 ind ribosomes still promoted localization of G-quadruplex-containing messages.

69 binding G-quadruplexes and the transport of G-quadruplex-containing transcripts.

70 A G-quadruplexes, resulting in inhibition of G-quadruplex-dependent alternative splicing.

71 ify chemical compounds capable of regulating G-quadruplex-dependent alternative splicing.

72 s and that it regulates gene expression in a G-quadruplex-dependent fashion.

73 to G-quadruplex motifs, and treatment with a G-quadruplex-disrupting small molecule causing dissociat

74 ing during unwinding, but not the binding of G quadruplex DNA.

75 with the stem-loop structure in RNA and with G quadruplex DNA.

76 gh selectivity, and induced the formation of G-quadruplex DNA along with the related DNA damage respo

77 romoter activity of c-MYC gene that contains G-quadruplex DNA forming sequence in the upstream promot

78 elop a competitive screening method in which G-quadruplex DNA linked magnetic nanoparticles pull down

79 We also found that TraB binds G-quadruplex DNA structures with higher affinity than Tr

80 small molecules that can selectively bind to G-quadruplex DNA structures.

81 herapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.

82 d platinum(II) complex has good affinity for G-quadruplex DNA.

83 e mass spectrometry analysis of proteins and G-quadruplex DNA.

84 Targeting G-quadruplex DNAs for cancer treatment is a very promisi

85 ticles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for determinati

86 the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with peroxidase activity.

87 When replication forks encounter G-quadruplexes, EXO1 resects the nascent DNA proximal to

88 netic and biochemical analyses show that RNA G-quadruplex folding is able to regulate translation and

89 LNA, or beta-l-RNA series exhibit unchanged G-quadruplex folding topology.

90 hibits substantially reduced perturbation of G-quadruplex folding.

91 cate that the binding between the ligand and G-quadruplex follows the induced-fit model.

92 w family of drugs targeting the MYC promoter G-quadruplex for MYC suppression.

93 l approach allows separation of K(+)-induced G-quadruplex formation and subsequent refolding and prov

94 at stabilization of RNA sequences capable of G-quadruplex formation by metallohelices investigated in

95 s and rice, providing direct evidence of RNA G-quadruplex formation in living eukaryotic cells.

96 , there is a lack of direct evidence for RNA G-quadruplex formation in living eukaryotic cells.

97 in GTEx, suggesting that variants affecting G-quadruplex formation within UTRs may also contribute t

98 upercoiling alone is not sufficient to drive G-quadruplex formation.

99 The G-quadruplex formed in the proximal promoter region of t

100 Our investigation has been performed for G-quadruplexes formed by folding of GGG(TTAGGG)3 single

101 cribe not only the basic structural motif of G-quadruplexes formed by, e.g., telomeric DNA sequences,

102 8-dihydroguanine ((oxo)G), and evaluated the G-quadruplex forming ability of such oligonucleotides.

103 The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter

104 we confirmed their binding to pseudoknot and G-quadruplex forming RNAs as well as their ability to re

105 A single G-quadruplex forming sequence from the human telomere ca

106 etic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5' and 3' UTRs a

107 Potential G-quadruplex forming sequences (PQSs) in promoters have

108 oughout the genome are enriched in potential G-quadruplex-forming DNA sequences.

109 g an in vitro assay, we show that a putative G-quadruplex-forming sequence (PQFS) in the first intron

110 G-rich promoter element that is a potential G-quadruplex-forming sequence (PQS) in NEIL3 is a site f

111 However, we identified a specific G-quadruplex-forming sequence at the heavy-strand promot

112 experiments have identified a non-canonical G-quadruplex-forming sequence containing bulges within t

113 when OG is formed in guanine-rich, potential G-quadruplex-forming sequences (PQS) in promoter-coding

114 e porphyrin dyes are first attached to short G-quadruplex-forming sequences and then reacted with per

115 ultiple sequence alignments, we observe that G-quadruplex-forming sequences are a general feature of

116 Such a mechanism enables G-quadruplex-forming sequences to act as long-range sens

117 ploying both telomeric and oncogene promoter G-quadruplex-forming sequences.

118 Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, her

119 hat Delta1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes.

120 plicing enhancer motifs and a propensity for G-quadruplex (G-Q) formation, linking the defective spli

121 We find that PARP3 regulates G quadruplex (G4) DNA in response to DNA damage, which s

122 reviously showed that CST binds and disrupts G-quadruplex (G4) DNA in vitro, suggesting that CST may

123 replication stress and DNA damage by way of G-quadruplex (G4) DNA secondary structure.

124 Here, we map differentially enriched G-quadruplex (G4) DNA structure-forming regions (DeltaG4

125 G-quadruplex (G4) DNA structures can form physical barri

126 Formation of G-quadruplex (G4) DNA structures in key regulatory regio

127 The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of po

128 ing domain that exhibits specific binding to G-quadruplex (G4) DNA structures.

129 efficiently to both double-stranded DNA and G-quadruplex (G4) DNA.

130 a structural transition of the sequence to a G-quadruplex (G4) fold that positions the AP in a loop f

131 , oxidation sensitivity and a propensity for G-quadruplex (G4) folding, both of which depend upon seq

132 nce-based computational model to predict DNA G-quadruplex (G4) formation.

133 G-quadruplex (G4) is a noncanonical secondary structure

134 Here, we examined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeti

135 G-quadruplex (G4) sequences are abundant in untranslated

136 Importantly, G-quadruplex (G4) stabilizing compounds induce chromosom

137 G-Quadruplex (G4) structures are four-stranded noncanoni

138 Four-stranded G-quadruplex (G4) structures form through self-recogniti

139 opensity to adopt four-stranded tetrahelical G-quadruplex (G4) structures that are overrepresented in

140 e (G), but G-rich DNA can form four-stranded G-quadruplex (G4) structures, which plays important role

141 ences that have been previously annotated as G-quadruplex (G4) structures.

142 the capability of assembling into tetrameric G-quadruplex (G4) structures.

143 ence potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1.

144 G-quadruplex (G4)-containing substrates mimicking the ma

145 ch DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures.

146 G-quadruplexes (G4) are alternative nucleic acid structu

147 G-quadruplexes (G4) are noncanonical secondary structure

148 Guanine-rich oligonucleotides can form G-quadruplexes (G4), which are stabilized by the hydroge

149 Repeated Element (OGRE), potentially forming G-quadruplexes (G4).

150 can adopt non-canonical structures known as G-quadruplexes (G4).

151 nusual three-dimensional structures known as G-quadruplexes (G4).

152 binds directly with DNA guanine quadruplex (G quadruplex, G4) structures in vitro and in cells, whic

153 r complex (Pt-DA) has been incorporated into G-quadruplex G4K(+) borate hydrogels by using borate est

154 Noncanonical tetrahelical nucleic acids, G-quadruplexes (G4Q), and i-motifs have been shown to pl

155 G quadruplexes (G4s) and R loops are noncanonical DNA st

156 G-quadruplexes (G4s) are extremely stable DNA or RNA sec

157 RNA G-quadruplexes (G4s) are secondary structures proposed t

158 G-quadruplexes (G4s) are stable secondary structures tha

159 Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that t

160 The G-quadruplexes (G4s) formed in PDGFR-beta gene promoter

161 The study of G-quadruplexes (G4s) in a cellular context has demonstra

162 The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported

163 e first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo.

164 now exists to support that formation of DNA G-quadruplexes (G4s) is coupled to altered gene expressi

165 unterparts form parallel and/or antiparallel G-quadruplexes (G4s).

166 guanosines strongly tend to fold into stable G-quadruplexes (G4s).

167 We found that an RNA G-quadruplex (GQ) forms in SHR mRNA and is capable of tr

168 G-quadruplex (GQ) stabilizing small molecule (SM) ligand

169 -rich telomere DNA repeats readily fold into G-quadruplex (GQ) structures in vitro, and the presence

170 erences in the formation of non-Watson-Crick G-quadruplex (GQ) structures.

171 d biophysical characterization of folding of G-Quadruplex (GQ)-based light-up aptamers such as Spinac

172 G-quadruplexes (GQs) can adopt diverse structures and ar

173 G-quadruplexes (GQs) formed from four consecutive repeat

174 cus, we have identified a number of putative G-quadruplexes (GQs) forming sequences.

175 G-Quadruplexes (GQs) serve as popular recognition elemen

176 can fold into noncanonical structures called G-quadruplexes (GQs), which exhibit a common stem struct

177 The structural and topological diversity of G-quadruplexes have attracted great attention for decade

178 RNA G-quadruplexes have been suggested to play key roles in

179 To our knowledge, G-quadruplexes have not been reported previously in ribo

180 luence thermal and biological stabilities of G-quadruplex in a position-dependent manner.

181 enanthrene, dppz=dipyridophenazine) bind DNA G-quadruplex in an enantiospecific manner that parallels

182 ly stable species (parallel and antiparallel G-quadruplex in K+ and Na+, respectively).

183 with strong G/C skew and propensity to form G-quadruplex in non-template DNA, corroborating with all

184 on probes selectively targeting the specific G-quadruplex in the mimics.

185 Our study reveals the existence of RNA G-quadruplex in vivo and indicates that RNA G-quadruplex

186 le ligands that specifically target promoter G-quadruplexes in cancer cells.

187 metry to identify proteins that bind to rRNA G-quadruplexes in cell lysates.

188 To modulate biological functions, G-quadruplexes in genome are often non-specifically targ

189 sion and immune evasion through formation of G-quadruplexes in its mRNA.

190 cted immune recognition through formation of G-quadruplexes in LANA mRNA.

191 k for further investigation into the role of G-quadruplexes in paraspeckle formation and function.

192 ultiple conformations coexisting for dimeric G-quadruplexes in solution.

193 We propose the stability of G-quadruplexes in the mtDNA control region, influencing

194 s 10 tandem G-tracts that form highly stable G-quadruplexes in vitro.

195 le to form complex RNA structures termed RNA G-quadruplexes in vitro.

196 plicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery in cells.

197 x ligands and then used with a new series of G-quadruplex interactive bis-triazolyl ligands that are

198 The complex folding energy landscape of DNA G-quadruplexes leads to numerous conformations for this

199 Here, we demonstrate that the G-quadruplex ligand 20A causes growth arrest of cancer c

200 r basis for the retention of potency by this G-quadruplex ligand has been examined using whole transc

201 ing agents, and that the cytotoxicity of the G-quadruplex ligand pyridostatin involves trapping topoi

202 wed the identification of a highly selective G-quadruplex ligand that, when studied in human cancer c

203 A recently developed small-molecule G-quadruplex ligand, the trisubstituted naphthalene diim

204 n of the first dual BCL2/c-MYC gene promoter G-quadruplex ligand.

205 ening strategy is first optimized with known G-quadruplex ligands and then used with a new series of

206 G-quadruplex ligands exert their antiproliferative effec

207 lity to perform high-throughput screening of G-quadruplex ligands for the development of drug molecul

208 RNAs that have structured 5' UTRs (including G-quadruplexes), many of which are involved in signal tr

209 les such as gold (Au)-carbene that stabilize G-quadruplexes may also interfere with the elongation of

210 n of G-rich C9orf72 repeat RNA, we find that G-quadruplex motifs are abundant and conserved features

211 ctural specificity and provide evidence that G-quadruplex motifs mediate NONO-NEAT1 association, with

212 ding sites on NEAT1 corresponding largely to G-quadruplex motifs, and treatment with a G-quadruplex-d

213 validated TRF2 occupancy at several promoter G-quadruplex motifs, which did adopt quadruplex forms in

214 upon binding as a doublet to one side of the G-quadruplex, much larger translational and orientationa

215 gand, BMPQ-1, which bound to human telomeric G-quadruplex multimers over monomeric G-quadruplexes wit

216 esses occurring at specific locations within G-quadruplex nucleic acids, providing valuable probes fo

217 ngle rearrangements seen between RNA and DNA G-quadruplexes of the same sequence.

218 cruiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand template.

219 ural features of the experimentally observed G-quadruplexes (OQs), highlighting differences in their

220 far the work was limited to the colorimetric G-quadruplex or fluorescent substrate cleaving NAzymes.

221 ed RNA, double-helical DNA, Pauling triplex, G-quadruplex, or DNA structures 'decorated' with protein

222 is introduced in differentiating multimeric G-quadruplexes over monomeric species, which would be ab

223 d grooves of the Oxytricha nova's telomeres' G-quadruplex ( Oxy-GQ), in agreement with high-resolutio

224 similar size have the capability of binding G-quadruplexes, potentially affecting the expression of

225 nism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be ta

226 uggest that genetic variation is enriched in G-quadruplex regions that impede mitochondrial DNA repli

227 G-quadruplexes represent unique roadblocks to DNA replic

228 inally in syn or anti in nonsubstituted hTel G-quadruplex requires a minor structural rearrangement o

229 phaeline as small molecules that disrupt RNA G-quadruplexes, resulting in inhibition of G-quadruplex-

230 oscopy reveals that excitation of TDI in the G-quadruplex results in symmetry-breaking charge separat

231 RNA G-quadruplex (RG4) structures are involved in multiple b

232 reveals different binding landscapes of RNA G-quadruplex (rG4) structures-binding proteins and disco

233 G-quadruplex RNA evicts the PRC2 catalytic core from the

234 Preferential binding of G-quadruplex RNA is conserved, surprisingly using differ

235 a three-layered intramolecular (3+1) hybrid G-quadruplex scaffold, in which three strands are orient

236 ress this question, we studied two different G-quadruplexes, selecting a single conformation by block

237 enables the identification of c-MYC and BCL2 G-quadruplex selective bis-triazole ligands that specifi

238 t these transcripts contain an enrichment of G-quadruplex sequences in their 3' UTRs, suggesting that

239 Herein, we employ an improved version of a G-quadruplex sequencing method (G4-seq) to generate whol

240 e results are supportive of the concept that G-quadruplex small molecules such as CM03 have potential

241 Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against

242 G-quadruplex stabilizers are an established opportunity

243 We used G-quadruplex-stabilizing ligand to define the inhibition

244 pported by treatment of cells with TMPyP4, a G-quadruplex-stabilizing ligand.

245 s associated with increased formation of the G-quadruplex structure during DNA replication.

246 A guanine-deficit G-quadruplex structure formation by a sequence containin

247 Here we report the G-quadruplex structure formed by a 23-nucleotide G-rich

248 Here we demonstrate the presence of a G-quadruplex structure in the 5' untranslated region (UT

249 binding of POT1 to an initially folded 24 nt G-quadruplex structure is four orders of magnitude slowe

250 Here, a (4n - 1) G-quadruplex structure is shown to be capable of binding

251 DI self-assembles into a nearly monodisperse G-quadruplex structure of 16 layers, with strong pai-ove

252 nding capability caused by (oxo)G, a loss of G-quadruplex structure was observed for most oligonucleo

253 tive chemical targeting of the non-canonical G-quadruplex structure within the PARP1 promoter, which

254 two complexes, both comprised of a (4n - 1) G-quadruplex structure, one bound to a linear dinucleoti

255 in aqueous-media, which first implements the G-quadruplex structure-switching biosensing principle in

256 romoter folds into a stacked, three-parallel G-quadruplex structure.

257 ligands with high selectivity for a specific G-quadruplex structure.

258 an telomeric sequence by stabilizing the RNA G-quadruplex structure.

259 sequence content or the formation of an RNA G-quadruplex structure.

260 tability and secondary structures, including G-quadruplex structures (G4s).

261 G-quadruplex in vivo and indicates that RNA G-quadruplex structures act as important regulators of p

262 gues of a lead which was proved to stabilize G-quadruplex structures and increase R loop levels in hu

263 Most importantly, these G-quadruplex structures are still stable at physiologica

264 profiling, we determine that hundreds of RNA G-quadruplex structures are strongly folded in both Arab

265 Here we used DNA G-quadruplex structures as model systems to demonstrate

266 s a DEAH-box helicase that resolves parallel G-quadruplex structures formed in DNA and RNA.

267 Targeting G-quadruplex structures is currently viewed as a promisi

268 tion of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understood.

269 ediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by mea

270 We also show that CST unfolds G-quadruplex structures, thus providing a mechanism for

271 mRNA (pre-mRNA), especially within predicted G-quadruplex structures.

272 ally unwinding RNA:DNA hybrids and resolving G-quadruplex structures.

273 rms are capable of binding to RNA containing G-quadruplex structures.

274 vidly interact with duplex DNA or with other G-quadruplex structures.

275 f telomeres requires the disruption of these G-quadruplex structures.

276 and more salt-dependent binding than to the G-quadruplex surface.

277 or a single Au-carbene binding at the second G-quadruplex surface.

278 they also demonstrated a strong and specific G-quadruplex targeting strategy by conjugating highly sp

279 selective artificial nucleases that degrade G-quadruplex telomeric DNA and exhibit selective DNA bin

280 ding affinity and cleavage reactivity toward G-quadruplex telomeric DNA over duplex DNA.

281 , LOTUS domains exhibit high affinity to RNA G-quadruplex tertiary structures implicated in diverse c

282 hairpin (HP) probes, molecular beacons, and G- quadruplex) that mediate cyclic cascade and role of h

283 ed the conformational ensemble of multimeric G-quadruplexes towards (3+1) hybrid-2 topology, which be

284 The mechanisms by which G-quadruplexes transition from one folded conformation t

285 that includes equilibrium constants for both G-quadruplex unfolding and POT1 binding to the resultant

286 ogy, which became more pronounced as further G-quadruplex units are added.

287 ures a structure with three stacked parallel G-quadruplex units, while another features an unusual du

288 ogenous ribonucleoprotein A1 (hnRNP A1) as a G-quadruplex-unwinding helicase, which unfolds these sta

289 but dislocates and weakens the loops in the G-quadruplex upon ligand binding.

290 We show that stabilization of G-quadruplexes using small molecules destabilizes the i-

291 -beta gene promoter sequence forms a vacancy G-quadruplex (vG4) which can be filled in and stabilized

292 Introducing the term 'clustered damage to G-quadruplexes' we report here on the structural effects

293 molecular mechanism of Au-carbene binding to G-quadruplexes, we employed molecular dynamics simulatio

294 etrad planes changes the conformation of the G-quadruplex, which resembles a balloon squeezed in cert

295 We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit s

296 induce targeted mechanical unfolding of the G-quadruplex while leaving the nanocage unperturbed.

297 However, the design of probes recognizing a G-quadruplex with high selectivity in vitro and in vivo

298 omeric G-quadruplex multimers over monomeric G-quadruplexes with high selectivity, and induced the fo

299 thermore, we determine that NONO binds NEAT1 G-quadruplexes with structural specificity and provide e

300 We find a global enrichment of RNA G-quadruplexes with two G-quartets whereby the folding p