ライフサイエンスコーパス: GABA transporter

1 n AgRP neuron-specific deletion of vesicular GABA transporter.

2 s efflux is mediated through reversal of the GABA transporter.

3 ependent synaptic release or reversal of the GABA transporter.

4 ins, such as synaptophysin and the vesicular GABA transporter.

5 (gamma-aminobutyric acid), and the vesicular GABA transporter.

6 ociated protein, and SLC6A11, a postsynaptic GABA transporter.

7 not involve presynaptic component vesicular GABA transporters.

8 prolonged or totally unaffected by block of GABA transporters.

9 d selected recombinant GABA(A) receptors and GABA transporters.

10 c processes expressing Kir4.1, glutamate and GABA transporters.

11 released through the reversal of astroglial GABA transporters.

12 (ir) neurons express vesicular glutamate or GABA transporters.

13 hway is independent of potassium channels or GABA transporters.

14 responsible for this current is regulated by GABA transporters.

15 p < 0.001), and GABA transporters (-0.51 [-0.92, -0.09], adj.

16 is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1).

17 AAV-DN1 impairs GABA(A)R alpha2 subunit and GABA transporter 1 (GAT-1) clustering, but increases GAB

18 Its encoded GABA transporter 1 (GAT-1) is responsible for the reupta

19 In addition, puncta of GABA transporter 1 (GAT-1) were localized to GABAergic s

20 of the perisynaptic plasma membrane such as GABA transporter 1 (GAT1), were not present.

21 m using tiagabine, which blocks the synaptic GABA transporter 1, and so increases endogenous GABA lev

22 ic acid decarboxylase-65 (GAD65), GAD67, and GABA transporter 1.

23 ng enzyme glutamic acid decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and g

24 ng enzyme glutamic acid decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and g

25 gamma-Aminobutyric acid (GABA) transporter 1 (GAT1)(1) regulates neuronal excitat

26 Postnatal expression of the plasmalemmal GABA transporter-1 (GAT-1), GAT-3, and the vesicular GAB

27 evidence, to a dysfunction of the astrocytic GABA transporter-1 (GAT-1).

28 number, location, and lengths of inhibitory GABA transporter-1 immunoreactive axo-axonic structures

29 ER export motifs (in concatemers of SERT and GABA transporter-1) supported recruitment of both SEC24C

30 nner by NO-711, a selective inhibitor of the GABA transporter-1.

31 Notably, we demonstrated that GABA transporter 2, encoded by Slc6a13, acted downstream

32 governing a wide range of functions, express GABA transporter 3 (Gat3), an astrocyte-specific GABA tr

33 increased expression of a GABA transporter, GABA transporter 3 (GAT3), in the hippocampus of the Mec

34 unction in glia can be partially replaced by GABA transporter 3.

35 ter-1a, the betaine/GABA transporter and the GABA transporter-4.

36 biosynthetic enzyme for GABA, the vesicular GABA transporter, a transcription factor that determines

37 tonic currents in the vlPAG are dependent on GABA transporter activity and are modulated by agonists

38 GAT-1 is a sodium- and chloride-coupled GABA transporter and a member of the neurotransmitter:so

39 mately 40%, whereas the density of vesicular GABA transporter and bassoon coimmunoreactive axon termi

40 s of the glycine transporter-1a, the betaine/GABA transporter and the GABA transporter-4.

41 opulations of cells were immunoreactive to a GABA transporter and, thus, likely GABAergic.

42 ppocampal cultures that endogenously express GABA transporters and on mammalian cells stably expressi

43 led coexpression of SNAP-25, VGAT (vesicular GABA transporter), and GAD65/67 (glutamic acid decarboxy

44 3) Glutamate decarboxylase 67, vesicular GABA transporter, and parvalbumin, but not calbindin, ar

45 extracellular calcium and was blocked by the GABA transporter antagonist SKF-89976a (5 microm).

46 elivery of saporin-conjugated anti-vesicular GABA transporter antibodies (SAVAs) in vitro as well as

47 indicate that highly homologous subtypes of GABA transporters are sorted differently when expressed

48 - and Cl--dependent gamma-aminobutyric acid (GABA) transporters are known to exist in the rat and mou

49 ygous variants in SLC6A1, encoding the GAT-1 GABA transporter, are associated with seizures, developm

50 Our data establish a role for GABA transporters as regulators of neuronal excitability

51 GABA transporter blockade also caused desensitization by

52 icular monoamine transporter 2 and vesicular GABA transporter, but they lacked immunostaining for any

53 hat transcriptional control of the vesicular GABA transporter by NO regulates GABA transmission and a

54 hat valproate increases the turnover rate of GABA transporters by an allosteric mechanism.

55 y enhance the activity of neuronal and glial GABA transporters by up to 10%.

56 The GABA transporter can reverse with depolarization, causin

57 monoamine transporter 2) and VGAT (vesicular GABA transporter), consistent with vesicular storage of

58 GABA transporters control extracellular GABA levels by c

59 GABA transporters control extracellular GABA, which regu

60 vironment in which their uniquely positioned GABA transporters control the degree of GABA(A)R activat

61 GABA transporters control the effect of extracellular GA

62 SNAP5114 alone reduced by half the GABA transporter current in NEC, whilst it abolished it

63 In patch-clamped astrocytes, the GABA transporter current was abolished by combined appli

64 Here, the GABA transporter current was directly investigated in th

65 s reduced by the activity of GAT-1 and GAT-3 GABA transporters, demonstrating that alterations of GAB

66 ditionally, blockade of both GAT-1 and GAT-3 GABA transporters did not unmask this tonic current.

67 ansport systems and imply that monoamine and GABA transporters evolved by selection and conservation

68 amate acid decarboxylase (GAD) and vesicular GABA transporter expression, these findings put intracor

69 dysplastic cortex and striking reductions in GABA transporter expression.

70 e, reveal a potential mechanism of increased GABA transporter expression/activity in the neighboring

71 coupling of ion and substrate fluxes in the GABA transporter family.

72 Members of the gamma-aminobutyric acid (GABA) transporter family are polytopic membrane proteins

73 These data suggest that the GABA transporter fine-tunes its function in response to

74 cloning and functional characterization of a GABA transporter from C. elegans (ceGAT-1) and on the fu

75 Recent evidence suggests that GABA transporter function can be regulated, although the

76 kinase C (PKC), shown previously to modulate GABA transporter function, exerts its modulatory effects

77 The GABAA receptor, GABA transporter, GABA transaminase, parvalbumin, and re

78 ation, we observed increased expression of a GABA transporter, GABA transporter 3 (GAT3), in the hipp

79 Aergic interneurons, and GABA(A)-, vesicular GABA transporter-, GAD65-, and GAT3-immunoreactive struc

80 the glutamate transporter EAAC-1 (25%), and GABA transporter GAT-1 ( approximately 10%).

81 significant decrease in the primary neuronal GABA transporter GAT-1 and in both subunits of the GABA(

82 The GABA transporter GAT-1 belongs to the neurotransmitter:s

83 Tonic current induced by application of the GABA transporter GAT-1 blocker NO711 (1-[2([(diphenylmet

84 ion is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and

85 The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitt

86 It was previously shown that the rat GABA transporter GAT-1 is located in the presynaptic mem

87 The GABA transporter GAT-1 mediates electrogenic transport o

88 a" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in

89 ed by the loss-of-function of the astrocytic GABA transporter GAT-1 that does not necessarily derive

90 decreased whole-brain protein levels of the GABA transporter GAT-1, the glutamate transporter GLT-1,

91 labeled by cholecystokinin and the neuronal GABA transporter GAT-1, which project axo-somatic and ax

92 in HEK 293 cells stably transfected with the GABA transporter GAT-1.

93 tores of calcium or by blocking the neuronal GABA transporter GAT-1.

94 on I(h) but depends strongly on the neuronal GABA transporter GAT-1.

95 opy to quantify astroglial expression of the GABA transporter GAT-3 and astrocyte synaptic proximity

96 In our model, down-regulation of the GABA transporter GAT-3 in thalamic astrocytes mediated t

97 Moreover, GABA transporters GAT-1 and GAT-3 appear to control extr

98 The gamma-aminobutyric acid (GABA) transporter GAT-1 is a prototype of neurotransmitt

99 1) gene encodes the gamma-aminobutyric acid (GABA) transporter GAT-1, the deficiency of which is asso

100 Here, we examined the role of the astrocytic GABA transporter (GAT) in sleep regulation using Drosoph

101 is demonstrated for GAT1, the most important GABA transporter (GAT) subtype.

102 67, GABA(A), GABA(B,) and GABA(C) receptors, GABA transporters (GAT) 1-3 and vesicular GAT in the bra

103 Immunohistochemical staining for GABA transporters (GAT-1 and GAT-3) revealed a low level

104 ) and GAD(67) isoforms), the plasma membrane GABA transporters (GAT-1 and GAT-3), and the vesicular G

105 f two high affinity gamma-aminobutyric acid (GABA) transporters (GAT-1 and GAT-3) in the rat hippocam

106 d decarboxylase (GAD-65 and GAD-67), and the GABA transporter, GAT-1.

107 enhanced extracellular GABA reuptake via the GABA transporter, GAT-1.

108 viously unrecognized role for the astrocytic GABA transporter, GAT-3.

109 this report, we have localized the other two GABA transporters, GAT-2 and GAT-3, in transfected MDCK

110 The rat brain GABA transporter GAT1 and other members of this family a

111 cient removal of synaptic transmitter by the GABA transporter GAT1 depends on the previous binding of

112 d this hypothesis by examining the rat brain GABA transporter GAT1 endogenously expressed in hippocam

113 ts, the N-terminal cytoplasmic domain of the GABA transporter GAT1 regulated substrate transport rate

114 We show that the trafficking of the GABA transporter GAT1 resembles the trafficking of neuro

115 cells stably expressing the cloned rat brain GABA transporter GAT1.

116 tion systems expressing the cloned rat brain GABA transporter GAT1.

117 iated currents, and charge movements for the GABA transporter GAT1.

118 meation of substrates during function of the GABA transporter GAT1.

119 on of the rat brain gamma-aminobutyric acid (GABA) transporter GAT1 expressed endogenously in hippoca

120 in is the rat brain gamma-aminobutyric acid (GABA) transporter GAT1.

121 that intracellular domains of the rat brain GABA transporter (GAT1) contribute to the transport proc

122 targets-PDE6, ACE2, osteopontin (SPP1) and a GABA transporter (GAT1)-we discover undocumented phospho

123 f this process for both wild-type and mutant GABA transporters (GAT1) expressed in Xenopus oocytes us

124 The GABA transporters (GAT1, GAT2, GAT3, and BGT1) have most

125 gene and transfected with the cDNA for a rat GABA transporter, GAT1, cloned downstream of a T7 RNA po

126 s differentially regulated by two astrocytic GABA transporters, GAT1 and GAT3, which are localized ne

127 es is released through an astrocyte-specific GABA transporter GAT3/4, and significantly enhances toni

128 In the adult cerebral cortex, GABA transporters (GATs) are expressed by both neurons a

129 Here, we show that blocking GABA transporters (GATs) in acute rat brain slices conta

130 vestigated the role of neuronal and/or glial GABA transporters (GATs) in modulating these inhibitory

131 dge on how e[GABA] is regulated by different GABA transporters (GATs) in vivo is limited.

132 Astrocytic uptake of GABA through GABA transporters (GATs) is an important mechanism regul

133 GABA transporters (GATs) play a critical role in the tra

134 The GABA transporters (GATs) regulate the concentration of G

135 es a protein of high similarity to mammalian GABA transporters (GATs).

136 gamma-Aminobutyric acid (GABA) transporters (GATs) are sodium- and chloride-depen

137 c expression of glutamate transporter genes, GABA transporter genes, and extracellular matrix protein

138 plasmic, the existence of an islet vesicular GABA transporter has been postulated.

139 ns through conditional deletion of vesicular GABA transporter has no effect on spontaneous IPSCs reco

140 inhibitory synapses, identified by vesicular GABA transporter immunoreactive puncta.

141 indicated by the colocalization of vesicular GABA transporter immunoreactivity predominantly in extra

142 xin 1A inhibits GABA uptake of an endogenous GABA transporter in neuronal cultures from rat hippocamp

143 transporter type 1 (GAT-1) is the principal GABA transporter in the brain, and it plays a crucial ro

144 Inhibition of mGAT1, the most abundant GABA transporter in the brain, enhances GABA signaling a

145 its, glutamic acid decarboxylase (GAD) and a GABA transporter in the brains of female rhesus macaques

146 Here we report the immunolocalization of a GABA transporter in the tobacco hornworm, Manduca sexta

147 ent of glutamate receptors, calcium, and the GABA transporter in this GABA uptake and release.

148 These data suggest a role for the vesicular GABA transporter in transplantation-mediated plasticity.

149 nsport blocker NO-711 to examine the role of GABA transporters in shaping synaptic responses mediated

150 hrough neuronal and glial uptake mechanisms, GABA transporters in the pia-arachnoid may help to regul

151 en calcium-permeable glutamate receptors and GABA transporters in these cells.

152 , the most abundant gamma-aminobutyric acid (GABA) transporter in the central nervous system, reveale

153 is one of the major gamma-aminobutyric acid (GABA) transporters in the brain and is responsible for r

154 ase) 65 and 67 isoforms, and VGAT (vesicular GABA transporter) in interneurons from the stratum radia

155 t in inhibitory neurons expressing vesicular GABA transporter, in the spinal cord of FK506-treated ma

156 r glutamate transporter 3 with the vesicular GABA transporter, indicating that GABA, glycine and glut

157 emmal and vesicular gamma-aminobutyric acid (GABA) transporters influence neurotransmission by regula

158 ) receptors, and were prolonged by the GAT-1 GABA transporter inhibitor NO711 (10 microm).

159 extracellular GABA levels, thus tiagabine, a GABA transporter inhibitor, was evaluated as a control t

160 mmalian GABA transporters, we found that the GABA transporter is localized to subsets of centrally de

161 The highly homologous GABA transporter isoforms, GAT-2 and GAT-3, localize to

162 Our results show that GABA transporters limit the extent of inhibitory transmi

163 Instead, these cells express the membrane GABA transporters mGAT1 (Slc6a1) and mGAT4 (Slc6a11) and

164 ese results raise the possibility that other GABA transporters might rely analogously upon conserved

165 t of valproate on a gamma-aminobutyric acid (GABA) transporter (mouse GAT3) expressed in Xenopus laev

166 utamate transporter 2), and VGAT- (vesicular GABA transporter) mRNA in specific subregions of the CEA

167 The distribution of gamma-aminobutyric acid (GABA) transporter mRNAs (mGATs) was studied in mouse bra

168 Thus, the GABA transporter normally operates near its equilibrium

169 ve feedback through the interplay of Glu and GABA transporters of adjacent astroglia can result in sh

170 Selective inhibition of GAT-1 GABA transporters on amacrine cells increases this tonic

171 gamma-Aminobutyric acid (GABA) transporters on neurons and glia at or near the sy

172 cell type-specific deletion of the vesicular GABA transporter or by expression of botulinum toxin in

173 o-localizations between pSTAT5 and vesicular GABA transporter or vasopressin were observed, whereas a

174 Plasma membrane GABA transporters participate in neural signaling throug

175 y elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA t

176 blocking action potentials or the vesicular GABA transporter, phasic and tonic currents decreased in

177 GABA transporters play an important but poorly understoo

178 activity recordings, we found that vesicular GABA transporter-positive (VGAT(+)) dPAG neurons fire ac

179 presynaptic endings; GAD-positive, vesicular GABA transporter-positive inhibitory endings are unaffec

180 , correlating with increased VGAT (vesicular GABA transporter) puncta.

181 dentified a selective reduction of vesicular GABA transporter punctae on parvalbumin positive neurons

182 We also identified a reduction of vesicular GABA transporter punctae specifically on parvalbumin pos

183 closely spaced presynaptic densities without GABA transporters, raising the possibility that neurotra

184 The vesicular GABA transporter recruits UNC-46 to synaptic vesicle pre

185 transporter 3 (Gat3), an astrocyte-specific GABA transporter responsible for maintenance of extra-sy

186 e expression of Agrp, Npy, and the vesicular GABA transporter Slc32a1, and impeded leptin signaling.

187 GABA synthetic enzyme Gad2 and the vesicular GABA transporter (Slc32a1).

188 e show here that snf-11 encodes a functional GABA transporter; SNF-11-mediated GABA transport is Na+

189 Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian ce

190 m:symporters, GAT-1 and other members of the GABA transporter subfamily all contain an extra amino ac

191 fflux from neighboring cells via reversal of GABA transporters, subsequently leading to the stimulati

192 Combined application of NO-711 (a selective GABA transporter subtype 1 (GAT-1) antagonist) and SNAP-

193 GABA transporter subtype 1 (GAT1) knock-out (KO) mice di

194 GABA transporter subtype 1 (GAT1) molecules were counted

195 trocyte-like cells express the high-affinity GABA transporter subtype GAT4 on processes ensheathing n

196 and characterized pharmacologically on mouse GABA transporter subtypes mGAT1-4.

197 olabeled substrates and is applicable to all GABA transporter subtypes.

198 e possibility that the glial cells express a GABA transporter that could regulate GABA levels to whic

199 This neuron coexpresses the vesicular GABA transporter, the calcium-binding protein parvalbumi

200 ther ion-coupled transporters, including the GABA transporter, the dopamine transporter, and the Na+/

201 sorting factor that localizes the vesicular GABA transporter to synaptic vesicles.

202 pinephrine (NE) and gamma-aminobutyric acid (GABA) transporters to METH administration(s) were determ

203 e additional support for the hypothesis that GABA transporters traffic in parallel with neurotransmit

204 GABA transporter type 1 (GAT-1) is the principal GABA tr

205 at modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-ves

206 nantly presynaptically located, is the major GABA transporter under baseline, quiescent conditions.

207 ion with antibodies to MCH and the vesicular GABA transporter (vGABAT).

208 reference for those expressing the vesicular GABA transporter VGAT and primary afferent A-fibre termi

209 nd that CLC-3 colocalized with the vesicular GABA transporter VGAT in the CA1 region of the hippocamp

210 l cortex (mPFC), expression of the vesicular GABA transporter VGAT was unchanged; however, there was

211 transporter, VIAAT (also known as vesicular GABA transporter VGAT) transports GABA or glycine into s

212 urons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking,

213 manner that is independent of the vesicular GABA transporter VGAT.

214 MPOA neurons that express ESR1 and vesicular GABA transporter (VGAT) (MPOA(ESR1 VGAT) neurons) robust

215 ubjects were immunolabeled for the vesicular GABA transporter (vGAT) and GAD67.

216 r inhibitory synapse constituents, vesicular GABA transporter (vGAT) and gephyrin, in the NAc of male

217 identified by the presence of the vesicular GABA transporter (VGAT) and NPY was found in 13-15% of V

218 We used the vesicular GABA transporter (VGAT) as a marker for inhibitory presy

219 m male and female donors that lack vesicular GABA transporter (Vgat) expression disperse and differen

220 Disruption of a putative vesicular GABA transporter (vGAT) homologue DdvGAT reduces secrete

221 lutamate transporter-2 (VGluT2) or vesicular GABA transporter (VGAT) neurons in the spinal dorsal hor

222 at septal OXTr neurons express the vesicular GABA transporter (vGAT) protein and optogenetic stimulat

223 co-staining for synaptophysin and vesicular GABA transporter (VGAT) revealed a group of small-sized

224 f a unique amino acid motif in the vesicular GABA transporter (VGAT) that controls its synaptic local

225 porters (GAT-1 and GAT-3), and the vesicular GABA transporter (VGAT) was evaluated by using immunohis

226 The expression level of vesicular GABA transporter (VGAT) was upregulated, and no change i

227 Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for

228 ing elevates the expression of the vesicular GABA transporter (VGAT) within recurrent collaterals of

229 campal interneurons, expression of vesicular GABA transporter (vGAT), and extracellular GABA release

230 receptor (NR) subunits, GAD65, the vesicular GABA transporter (VGAT), and the neuronal glutamate tran

231 neous withdrawal, those expressing vesicular GABA transporter (VGaT), glutamate transporter 3 (VGluT3

232 as glutamic acid decarboxylase and vesicular GABA transporter (VGAT), markers of GABAergic neurons.

233 pressing the vesicular glutamate (vGLUT2) or GABA transporter (vGAT), then determined whether TH-ir n

234 d optogenetic activation of septal vesicular GABA transporter (vGAT)-containing neurons or their proj

235 est these hypotheses, adult female vesicular GABA transporter (VGAT)-Cre and vesicular glutamate tran

236 significantly more depolarized in vesicular GABA transporter (VGAT)-expressing inhibitory neurons th

237 -expressing excitatory neurons and vesicular GABA transporter (VGAT)-expressing inhibitory neurons, w

238 S induced LTD and LTP in 12-16% of vesicular GABA transporter (VGAT)-expressing inhibitory neurons.

239 ng channelrhodopsin-(ChR2)-EYFP in vesicular GABA transporter (VGAT)-expressing neurons.

240 dorsal horn of the spinal cord, or vesicular GABA transporter (Vgat)-positive GABA neurons in reward-

241 1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).

242 ng into synaptic vesicles (SVs) by vesicular GABA transporter (VGAT).

243 65 and GAD67) and packaging by the vesicular GABA transporter (vGAT).

244 y labeled varicosities followed by vesicular GABA transporter (VGAT).

245 n labeling for both VGLUT3 and the vesicular GABA transporter (VGAT).

246 ivity (IR) (approximately 27%) and vesicular GABA transporter (VGAT)/p38 IR (approximately 41%) was f

247 e transporter 2 (VMAT2)] and GABA [vesicular GABA transporter (VGAT)].

248 ChC cartridges immunoreactive for vesicular GABA transporter (vGAT+), which is present in all cartri

249 Selective siRNA knockdown of the vesicular GABA transporter (vgat, SLC32A1) in histaminergic neuron

250 neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neur

251 ipts not altered in schizophrenia: vesicular GABA transporter (VGAT; a marker of all GABA neurons) an

252 crease in vesicular gamma-aminobutyric acid (GABA) transporter (vGAT) and glutamic acid decarboxylase

253 ctive for vesicular gamma-aminobutyric acid (GABA) transporter (VGAT) in patch and matrix throughout

254 tion of a vesicular gamma-aminobutyric acid (GABA) transporter (VGAT) to horizontal cell processes in

255 (VGLUT1), vesicular gamma-aminobutyric acid (GABA) transporter (VGAT), and vesicular acetylcholine tr

256 The vesicular gamma-aminobutyric acid (GABA) transporter (VGAT), which transports the inhibitor

257 lation of vesicular gamma-aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using h

258 onsible for packaging either GABA (vesicular GABA transporter [vGAT]) or glutamate (vesicular glutama

259 porally target the deletion of the vesicular GABA transporter, Vgat, in developing neurons.

260 tamic acid decarboxylase; GAD, and vesicular GABA transporter; VGaT).

261 VGLUT3 is found together with the vesicular GABA transporter (VIAAT) on synaptic vesicle membranes i

262 th high sequence homology to known mammalian GABA transporters, we found that the GABA transporter is

263 In addition, inhibition of the GAT-1 GABA transporter, which strongly regulates GABA(C) recep

264 n neurons cannot be compensated for by other GABA transporters, while the function in glia can be par

265 ainst a characterized high-affinity M. sexta GABA transporter with high sequence homology to known ma