ライフサイエンスコーパス: GABA-gated

1 ients required for the inhibitory effects of GABA-gated and serotonin-gated chloride channels on C. e

2 Blocking glycine- and GABA-gated anion currents had opposing effects on sponta

3 e expression of bovine beta1 subunits formed GABA-gated C1- channels.

4 ropic receptor subunits (LCCH3 and GRD) form GABA-gated cation channels when heterologously expressed

5 tes than in the synaptic terminals, and that GABA-gated channels in the dendrites may generate a hype

6 Cl(-) gradient such that Cl(-) flow through GABA-gated channels is reversed and excites rather than

7 Studies of acetylcholine-, glutamate- and GABA-gated channels using rapid agonist application now

8 e an inhibitory chloride conductance through GABA-gated channels, and thereby achieve their sedative-

9 The inhibition of gamma-aminobutyric acid (GABA)-gated chloride currents by the protein kinase C (P

10 odulating the broadly expressed major insect GABA-gated chloride channel resistant to dieldrin (Rdl).

11 A GABA-gated chloride channel subunit from Drosophila mela

12 subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins

13 Resistance to Dieldrin gene, Rdl, encodes a GABA-gated chloride channel subunit that is targeted by

14 ting and readily detoxified modulator of the GABA-gated chloride channel.

15 convulsants and insecticides that block the GABA-gated chloride channel.

16 GABA-gated chloride channels (GABAARs) trafficking is in

17 reases antagonism of homologous invertebrate GABA-gated chloride channels (resistance to dieldrin (RD

18 AR) types C (GABACR) and A (GABAAR) are both GABA-gated chloride channels that are distinguished by t

19 Rho(1) receptor-channels (rho(1)Rs) are GABA-gated chloride channels that exhibit slow kinetics,

20 brane proteins, such as Ca(2+) ion channels, GABA-gated chloride channels, and glutamate receptors, i

21 Chloride influx through GABA-gated chloride channels, the primary mechanism by w

22 uch as voltage-dependent sodium channels and GABA-gated chloride channels.

23 erved here, however, was inconsistent with a GABA-gated chloride conductance mechanism.

24 These results suggest that PS inhibits GABA-gated chloride currents by enhancing receptor desen

25 here is an increase in the peak amplitude of GABA-gated chloride currents compared with wild-type rec

26 Additionally, GABA-gated chloride currents in HEK 293 cells expressing

27 urons, the dileucine motif peptide increases GABA-gated chloride currents of native GABA(A) receptors

28 lls, an effect accompanied by an increase in GABA-gated chloride currents.

29 tudies of presynaptic inhibition mediated by GABA-gated Cl channels and then focus on presynaptic nic

30 nflux of Cl(-) probably occurred through the GABA-gated Cl(-) channel because the effects of H(2)O(2)

31 l's receptive field, while synaptic terminal GABA-gated Cl(-) channels generate the hyperpolarization

32 This would allow dendritic GABA-gated Cl(-) channels to generate the depolarization

33 ral basis of anion selectivity of Drosophila GABA-gated Cl(-) channels, the permeation properties of

34 Chloride influx through GABA-gated Cl(-) channels, the principal mechanism for i

35 (GABA(A)Rs) represent a family of pentameric GABA-gated Cl(-)/HCO(3)(-) ion channels which mediate in

36 In contrast, picrotoxin, which blocks the GABA-gated Cl- channel, did not inhibit the secondary ri

37 dominantly in the retina and forms homomeric GABA-gated Cl- channels that are clearly different from

38 the benzodiazepine (BDZ) lorazepam (LZM) on GABA-gated Cl- current, assessed using whole cell patch

39 ated by reduced diazepam potentiation of the GABA-gated current and GABA potentiation of [3H]flunitra

40 Under control conditions, GABA-gated current deactivated biexponentially, with tau

41 nversely correlated with BDZ potentiation of GABA-gated current, assessed using whole cell patch clam

42 GABA-gated currents (I(GABA)) were measured before and a

43 Isoflurane enhanced GABA-gated currents at anesthetic concentrations but the

44 e with only minimal effects of isoflurane on GABA-gated currents at concentrations associated with lo

45 Inhibition of GABA-gated currents by furosemide, a selective inhibitor

46 In contrast, ethanol had no effect on GABA-gated currents even at lethal concentrations, i.e.

47 s for the effects of isoflurane on NMDA- and GABA-gated currents has revealed both EC50 and Hill slop

48 THDOC (100 nM) significantly potentiated GABA-gated currents in cells transfected with combinatio

49 We report here that NO analogs reduce GABA-gated currents in cultured retinal amacrine cells v

50 d enhanced sensitivity to AP potentiation of GABA-gated currents in DGGCs, but not in CA1 pyramidal c

51 pregnan-20-1 (THDOC)-induced potentiation of GABA-gated currents in transfected HEK 293 cells and in

52 In contrast, GABA-gated currents of the NTS were inhibited by the div

53 THDOC potentiation of GABA-gated currents was greater in cerebellar granule ce

54 significant difference in La3+ modulation of GABA-gated currents was observed between alpha1beta3gamm

55 EC50 and Hill slope for the potentiation of GABA-gated currents were significantly greater than thos

56 which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated

57 e extent of furosemide-induced inhibition of GABA-gated currents.

58 ults indicate that La3+ has a dual action on GABA-gated currents: it decreases desensitization and in

59 eta subunits have been reported to be either GABA-gated or capable of forming anion-selective channel