ライフサイエンスコーパス: GM-CSF receptor

1 Lyn, but not Hck, was physically coupled to GM-CSF receptor.

2 of PD-1 and recruitment of PD-1-SHP-2 to the GM-CSF receptor.

3 was blocked by inhibiting activation of the GM-CSF receptor.

4 rovides a key brake on signaling through the GM-CSF receptor.

5 ations in GM-CSF that reduced binding to the GM-CSF receptor.

6 coding the ligand-binding alpha chain of the GM-CSF receptor.

7 acking the common beta chain (Beta c) of the GM-CSF receptor.

8 that is independent of signaling through the GM-CSF receptor.

9 ng through the isolated alpha subunit of the GM-CSF receptor.

10 c-Abl bound to the betac chain of IL-3/IL-5/GM-CSF receptors.

11 than up-regulation of surface expression of GM-CSF receptors.

12 r IL-5 share a common ss-chain with IL-3 and GM-CSF receptors.

13 main confers signal specificity for IL-3 and GM-CSF receptors.

14 restricted to cells or tissues that express GM-CSF receptors.

15 , indicating that they express high-affinity GM-CSF receptors.

16 locyte-macrophage colony-stimulating factor (GM-CSF) receptor.

17 locyte macrophage colony stimulating factor (GM-CSF) receptor.

18 d the IL-3 receptor shares with the IL-5 and GM-CSF receptors a common signal transducing beta-chain.

19 Ablation of the GM-CSF receptor alleviated the monocyte response and inh

20 Wild-type and GM-CSF receptor alpha (Csf2ra)-deficient mice reconstitu

21 populations of hematopoietic and endothelial GM-CSF receptor alpha (GM-CSFRalpha)-positive cells.

22 d cell line WT-19 transfected with the human GM-CSF receptor alpha and beta subunits (GM-CSFRalpha an

23 The gene encoding the GM-CSF receptor alpha subunit (CSF2RA) is located on X a

24 protein of 198 amino acids, designated GRAP (GM-CSF receptor alpha subunit-associated protein), was i

25 Variant and mutated GM-CSF receptor alpha subunits, along with the beta subu

26 tin with protein kinase CbetaII (PKCbetaII), GM-CSF receptor alpha-chain, and two actin-associated pr

27 locyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha-chain (CSF2RA) deficiency is a ra

28 way and the role of the alpha subunit of the GM-CSF receptor (alpha GMR) in modulating transporter ac

29 ound that an elevated proportion of immature GM-CSF receptor-alpha(R) subunit-expressing cells were p

30 cellular portion of the alpha subunit of the GM-CSF receptor (alphaGMR) to search for interacting pro

31 hose late interactions occurring between the GM-CSF receptor and activated eosinophil signaling molec

32 ining the interaction between ICAM-1 and the GM-CSF receptor and highlight the importance of targetin

33 Therefore, the physical coupling of Lyn to GM-CSF receptor and its early activation are required fo

34 this chimera to bind human cells through the GM-CSF receptor and prevent apoptosis.

35 cDNAs encoding varying portions of the human GM-CSF receptor and/or beta chains.

36 null cells had minimal expression of G- and GM-CSF receptors and no detectable M-CSF receptors.

37 show that the LNCaP cells express functional GM-CSF receptors and that prostatic carcinomas have prom

38 t forms a complex with the beta-chain of the GM-CSF receptor, and this interaction involves the first

39 roduce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells.

40 receptor, such as monocytes, as well as for GM-CSF receptor-bearing myeloid cell lines, HL60 (promye

41 ng increased tyrosine phosphorylation of the GM-CSF receptor beta chain (betac), STAT5, and other sig

42 Mice that lack the GM-CSF receptor beta chain (GM-CSFRbeta) developed invas

43 putative substrates SHPTP-2, Stat-5, and the GM-CSF receptor beta(c) subunit.

44 ted eosinophils, we have identified that the GM-CSF receptor beta-chain (GMRbeta) interacted with ICA

45 locyte-macrophage colony-stimulating factor (GM-CSF) receptor-beta-deficient (Csf2rb(-/-)) mice that

46 tions displayed increased phosphorylation of GM-CSF receptor betac subunit in response to stimulation

47 SF (Gmcsf) or the beta common subunit of the GM-CSF receptor (betac) are inactivated display normal s

48 We show that the common beta chain of the GM-CSF receptor (betac) is dispensable for Nras(G12D/+)

49 ute myeloid leukemia progenitors bearing the GM-CSF receptor, but not normal marrow progenitors.

50 tors in human fetal liver that expressed the GM-CSF receptor CD116 and the transcription factor MYB.

51 n the presence of at least 100 high affinity GM-CSF receptors/cell and the absence of overexpressed a

52 usly mapped the Lyn-binding site of the IL-5/GM-CSF receptor common beta (beta c) subunit.

53 e eosinophil peroxidase, CCR3, the IL-3/IL-5/GM-CSF receptor common beta-chain, and the transcription

54 DCs constitutively express higher levels of GM-CSF receptor compared with CD103(+) DCs and are thus

55 The GM-CSF receptor consists of two subunits: GMRalpha, whic

56 locyte-macrophage colony-stimulating factor (GM-CSF) receptor consists of 2 glycoprotein subunits, GM

57 veolar proteinosis in mice transplanted with GM-Csf-receptor-deficient progenitors.

58 locyte-macrophage colony-stimulating factor (GM-CSF) receptors, ectopically expressed in FDCP-mix mul

59 lar macrophage immune function by decreasing GM-CSF receptor expression and downstream PU.1 nuclear b

60 These differences arise from higher GM-CSF receptor expression in myeloid progenitors compar

61 and that prostatic carcinomas have prominent GM-CSF receptor expression.

62 Defects in GM-CSF receptor function disrupt surfactant clearance, c

63 le of N-glycosylation of the beta subunit on GM-CSF receptor function.

64 association of auto-antibodies to GM-CSF or GM-CSF receptor gene mutations with PAP has implicated G

65 nt proteins or the common beta chain for the GM-CSF receptor (GM-CSFR) are causal.

66 inding to the alpha and beta subunits of the GM-CSF receptor (GM-CSFRalpha and betac, respectively).

67 118 through 400 of the alpha subunit of the GM-CSF receptor (GM-R alpha) [IL-3R alpha/GM-R alpha] or

68 pression levels of uPA receptors (uPARs) and GM-CSF receptors (GM-CSFRs) as well as with total uPA le

69 locyte-macrophage colony-stimulating factor (GM-CSF) receptor (GM-CSFr) and the intracellular domain

70 y c-Cbl (henceforth referred to as Cbl) as a GM-CSF receptor (GMR) adaptor protein that targets Src f

71 t exerts its effects by interaction with the GM-CSF receptor (GMR) on the surface of responsive cells

72 ion of mature host defense cells through the GM-CSF receptor (GMR), which is composed of alpha (alpha

73 ociation between the tyrosine phosphorylated GM-CSF receptor (GMR)-beta c chain and Shc in vivo.

74 locyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) consists of an alpha (GMRalpha) a

75 locyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) is a heterodimeric receptor expre

76 locyte-macrophage colony-stimulating factor (GM-CSF) receptor has several isoforms that result from a

77 om mice with the ubiquitous transgenic human GM-CSF receptor (hGM-CSFR) were used for the analysis.

78 ared by IL-3 and granulocyte-macrophage CSF (GM-CSF) receptors (IL-3R and GM-CSFR).

79 GM-CSF receptor immunoreactivity was found on neurons wi

80 icantly decreased membrane expression of the GM-CSF receptor in alveolar macrophages.

81 Inhibition of TBK1 signaling in TAMs or GM-CSF receptor in cancer cells impedes BCBM development

82 ishes the actin-linkage of integrins and the GM-CSF receptor in dendritic cells.

83 encoding the alpha and beta subunits of the GM-CSF receptor in LNCaP cells, and the presence of the

84 e we established the absence of a functional GM-CSF receptor in murine nociceptors, and suggest an in

85 locyte-macrophage colony-stimulating factor (GM-CSF) receptor in the human prostate carcinoma cell li

86 Indeed, the human GM-CSF receptor is a good target because it is overexpre

87 The GM-CSF receptor is composed of two subunits, alpha and b

88 GM-CSF-receptor is increased on HSCs and multipotent pro

89 nd that the chimeric protein binds the human GM-CSF receptor, is endocytosed, and appears to reach th

90 ge signaling through the KGF receptor/GM-CSF/GM-CSF receptor/JAK-STAT axis.

91 alveolar macrophage-reconstitution of global GM-CSF receptor knockout mice as well as cell-type-speci

92 rred in HIV-1-infected donors despite normal GM-CSF receptor levels.

93 o with rGM-CSF via the upper airway restored GM-CSF receptor membrane expression as well as PU.1 prot

94 GM-CSF-receptor occupancy at 0.7 nmol/L GM-CSF-ligand co

95 t the induction of apoptosis correlates with GM-CSF-receptor occupancy at low ligand concentrations.

96 s on receptor-binding affinity, induction of GM-CSF receptor oligomerization and signaling capacity.

97 etitively inhibited binding of GM-CSF to the GM-CSF receptor on HL-60 cells and demonstrated antagoni

98 ude that recombinant GM-CSF-Bcl-XL binds the GM-CSF receptor on human monocyte/macrophage cells and b

99 l measurements of the number and affinity of GM-CSF receptors on cells from the same samples showed n

100 y to be explained by an increased density of GM-CSF receptors on these cells.

101 M-CSF, although some may have had defects in GM-CSF receptor or signal-transduction mechanisms.

102 t human lymphocytes expressing high affinity GM-CSF receptors responded to alpha GMR antibody with in

103 locyte-macrophage colony-stimulating factor (GM-CSF) receptors share a common beta chain (beta(c)), a

104 red with normal, hPAP-iPS-Mphis had impaired GM-CSF receptor signaling and reduced GM-CSF-dependent g

105 Restoration of GM-CSF receptor signaling corrected the surfactant clear

106 Abrogation of GM-CSF receptor signaling in adoptive transfer recipient

107 Despite abundant lung GM-CSF and intact GM-CSF receptor signaling, PPAR-gamma was not sufficient

108 n 293T cells transfected with alpha and beta GM-CSF receptor subunits (alphaGMR and betaGMR), GM-CSF-

109 d that depended on the ectopic expression of GM-CSF receptor subunits by tumors.

110 e to mutations in CSF2RA or CSF2RB, encoding GM-CSF receptor subunits); secondary PAP results from va

111 chemoattractant for native cells bearing the GM-CSF receptor, such as monocytes, as well as for GM-CS

112 This leads to increased GM-CSF receptor/Syk signalling, and to the induction of

113 y of the biochemical properties of mammalian GM-CSF receptors that are required for efficient binding

114 ed the requirement for signaling through the GM-CSF receptor to initiate and sustain this MPD by gene

115 We conducted dynamic kinetic analyses of GM-CSF receptors to define the role of GMRbeta in the in

116 ression of the common beta-chain of the IL-3/GM-CSF receptor was down-regulated in Stat-5-activated m

117 that the interaction between ICAM-1 and the GM-CSF receptor was essential for GM-CSF-induced eosinop

118 dition, the common beta subunit of IL-3/IL-5/GM-CSF receptor was tyrosine phosphorylated in the clone

119 pDC that expressed the GM-CSF receptor were increased in breast tumors compared

120 orylation of c-Kit and the beta-chain of the GM-CSF receptor were not observed, SCF and GM-CSF in com

121 Binding studies indicated that human GM-CSF receptors were present on all of the human GI and