ライフサイエンスコーパス: GMP

1 GMP accumulate in the BM in SpA and, unexpectedly, at ex

2 GMP, common in many human cancers but of uncertain origi

3 transformation, with the fastest cycling 3% GMPs acquiring malignancy with near certainty.

4 party, allogeneic, off-the-shelf bank of 330 GMP-grade EBV-CTL lines from specifically consented heal

5 The umami-enhancing nucleotide 5'-GMP was detected only in cooked samples, concentration b

6 The highest concentration of 5'-GMP was detected in cooked L. trivialis samples (17 mg/1

7 In order for AUC to be validated for a GMP environment, stringent requirements need to be satis

8 gap and allow AUC to be routinely used in a GMP environment.

9 e selected from leukapheresis product with a GMP-compliant cell separation system and placed in 5-day

10 tty acids (FAs), purine nucleotides (AMP and GMP), a vitamin (pyridoxal-5P), and a cofactor (heme) in

11 on structure reveals the presence of ATP and GMP at the canonical sites of the Bateman domains, the l

12 r nucleotide analogs (hypoxanthine, IMP, and GMP) that we compare with the phosphate-bound enzyme.

13 ted for consistency and reproducibility, and GMP capable data acquisition software needs to be develo

14 tation of an automated, high-throughput, and GMP compliant subunit LC-MS method for monitoring antibo

15 Conclusion: Procedures for fully automated GMP-compliant production of (89)Zr-mAbs were developed o

16 regions designated as the LID, GMP-binding (GMP-BD), and CORE domains and is in an open configuratio

17 Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or ti

18 Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to

19 Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sens

20 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor

21 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor(

22 Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for

23 Cyclic GMP-AMP synthase (cGAS) is a sensor of cytoplasmic DNA t

24 Cyclic GMP-AMP synthase (cGAS) is best known as a cytosolic inn

25 Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberra

26 CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that direc

27 3',3'-cyclic GMP-AMP (cGAMP) is the third cyclic dinucleotide (CDN) t

28 GMP-AMP synthase, which produces 2'3'-cyclic GMP-AMP (cGAMP) that binds to and activates stimulator o

29 c dinucleotide second messenger 2',3'-cyclic GMP-AMP (cGAMP)(1-4).

30 rs, notably lysophosphatidic acid and cyclic GMP-AMP (cGAMP).

31 ampus that breaks down cyclic AMP and cyclic GMP.

32 nucleic acid sensor pathways, such as cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

33 Detection of viral DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defence leadi

34 ed not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin

35 infections and is quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection immune

36 mRNA upregulation to DAI/ZBP1, or by cyclic GMP-AMP synthase (cGAS), despite its presence in the cel

37 Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes)

38 cytoplasm of chromatin-binding cGAS (cyclic GMP-AMP synthase).

39 ctivated caspases are known to cleave cyclic GMP-AMP synthase (cGAS).

40 osolic DNA-sensing pathway comprising cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of IFN ge

41 se (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by

42 ric oxide, soluble guanylate cyclase, cyclic GMP (cGMP), and PKG.

43 among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-ST

44 synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I interfer

45 a full-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nano

46 bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumou

47 duced endothelial NO synthase (eNOS), cyclic GMP (cGMP), and protein kinase G (PKG) activity independ

48 The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected

49 plifier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cyclases.

50 calization but is unable to hydrolyze cyclic GMP (cGMP).

51 Here, we identify cyclic GMP-AMP synthase (cGAS) and interferon-inducible protein

52 eral dinucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-mediate

53 ith DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP).

54 Thus FGF signaling lowers cyclic GMP production in the growth plate, which counteracts bo

55 transition responsible for the major cyclic GMP-dependent physiological effects of NO.

56 ve inhibition of the second messenger cyclic GMP-AMP production.

57 e production of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimulator of

58 d apical and basolateral secretion of cyclic GMP (cGMP) under baseline, unstimulated conditions.

59 ctivated to catalyse the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ATP(3).

60 It catalyses the synthesis of cyclic GMP-AMP (cGAMP)(9-12), which stimulates the induction of

61 hway: this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the

62 e responses through the activation of cyclic GMP-AMP synthase (cGAS) and production of the cyclic din

63 cross-presentation and activation of cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-ST

64 dinucleotides (2'3'CDNs) with use of cyclic GMP-AMP synthases (cGAS) from human, mouse, and chicken.

65 ymerization, mediated by nitric oxide-cyclic GMP signaling leading to inhibition of RhoA.

66 The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functio

67 icularly for the DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signalling ef

68 ulfurreducens, specifically regulates cyclic GMP-AMP (3',3'-cGAMP) levels in vivo to stimulate gene e

69 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta produc

70 te the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme.

71 The parasite's cyclic GMP (cGMP)-dependent protein kinase (PKG) is essential a

72 c dsDNA, mainly by the key DNA sensor cyclic GMP-AMP synthase (cGAS), leads to the synthesis of type

73 The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the stimulator of IFN genes

74 I increased expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon genes in w

75 ity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon gene

76 in fragments activate the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) pathway

77 cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULATOR O

78 alpha subunit (Galpha(T).GTP) and the cyclic GMP (cGMP) phosphodiesterase 6 (PDE6), which stimulates

79 we describe a crystalline form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF) domai

80 he host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN genes (STI

81 The cyclic GMP-AMP synthase (cGAS)-cGAMP-STING pathway plays a key

82 itment of cGAS, and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

83 lex virus 1 (HSV-1) triggers both the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

84 leotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

85 rs immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

86 d other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (

87 ught to require signaling through the cyclic GMP-AMP synthase (cGAS)-STING pathway and subsequent act

88 yndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious phenotyp

89 h activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) innate im

90 cal DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.

91 in the present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-ST

92 The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pa

93 roughput screen for inhibitors of the cyclic GMP-AMP synthase/stimulator of interferon genes pathway,

94 ns and inflammatory cytokines through cyclic GMP-AMP synthase, which produces 2'3'-cyclic GMP-AMP (cG

95 2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activates the

96 Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported by dise

97 relevant guanine metabolites, such as dGMP, GMP, and cGMP, as well as guanine-derivative drugs.

98 , the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate)

99 Here we demonstrate that c-di-GMP also intervenes later in development to control diff

100 While c-di-GMP and (p)ppGpp are both synthesized from GTP molecules

101 mathematical model for the dynamics of c-di-GMP and (p)ppGpp in C. crescentus and analyze how the gu

102 Second messengers, c-di-GMP and (p)ppGpp, are vital regulatory molecules in bact

103 ence the cell cycle by influencing both c-di-GMP and (p)ppGpp.

104 Moreover, expression of the c-di-GMP and calcium-regulated, biofilm-promoting brp exopoly

105 the role of two key second messengers, c-di-GMP and cAMP, in this process.

106 The interactions of CdbA with c-di-GMP and DNA appear to be mutually exclusive and residue

107 -di-GMP binding abolish binding to both c-di-GMP and DNA, rendering these protein variants non-functi

108 The interaction between c-di-GMP and the ATPase MshE promotes pilus extension, wherea

109 As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP

110 methodologies for the quantification of c-di-GMP are typically based on chemical extraction, represen

111 i-sigma complex formation and establish c-di-GMP as the central integrator of Streptomyces developmen

112 that such peculiar control reflects on c-di-GMP being a key second messenger that silences energy-co

113 titutions in CdbA regions important for c-di-GMP binding abolish binding to both c-di-GMP and DNA, re

114 compare the mechanisms of c-di-AMP and c-di-GMP binding by the respective receptors that allow these

115 nsights into the molecular evolution of c-di-GMP binding to proteins.

116 conserved motifs with high affinity for c-di-GMP binding, the findings here suggest that c-di-GMP can

117 usly showed that the signaling molecule c-di-GMP binds BldD, a master repressor, to control initiatio

118 C-di-GMP binds to the dedicated pseudoreceiver domain Rec1, t

119 binding, the findings here suggest that c-di-GMP can regulate both motility and biofilm formation thr

120 Thus, c-di-GMP cannot only stabilize domain interactions, but also

121 The elucidation of the CSP.c-di-GMP complex structure by NMR identified a linear c-di-GM

122 Maintenance of low c-di-GMP concentrations by these phosphodiesterases was requi

123 entified as critical to maintaining low c-di-GMP concentrations generated after initial phagocytosis

124 rate a fluorescent biosensor to measure c-di-GMP concentrations in thousands of individual bacteria d

125 rmation by P. putida through changes in c-di-GMP content and altered expression of structural element

126 (2020) demonstrates that c-di-GMP controls spore formation in Streptomyces venezuelae

127 pilus extension, whereas low levels of c-di-GMP correlate with enhanced retraction.

128 ling an unusual, partially intercalated c-di-GMP dimer bound at the RsiG-sigma(WhiG) interface.

129 ing motif, in which a self-intercalated c-di-GMP dimer is tightly bound by a network of H bonds and p

130 Our results indicate that c-di-GMP directly controls MshE activity, thus regulating MSH

131 (CSP) that was derived from a CheY-like c-di-GMP effector protein.

132 associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs) have been iden

133 he ribbon-helix-helix family that binds c-di-GMP in Myxococcus xanthus.

134 RsiG binds c-di-GMP in the absence of sigma(WhiG), employing a novel E(X

135 Further studies demonstrate that c-di-GMP is essential for RsiG to inhibit sigma(WhiG).

136 terial usage of the cyclic dinucleotide c-di-GMP is widespread, governing the transition between moti

137 which cues degradation of intracellular c-di-GMP leading to transcription of the swarming program.

138 ons, that SpoT can effectively decrease c-di-GMP levels in response to nitrogen starvation just as we

139 lysed the influence of L-amino acids on c-di-GMP levels in the plant-beneficial bacterium Pseudomonas

140 cascade leading to changes in cellular c-di-GMP levels remains unknown, certain L- and D-amino acids

141 AmrZ itself has been shown to modulate c-di-GMP levels through the control of many genes encoding en

142 phase and biofilm formation, while low c-di-GMP levels unleash T6SS and T4SS to advance plant coloni

143 otility and promoted biofilm formation, c-di-GMP levels were decreased in Deltapa2072, and biofilm fo

144 ent signaling system, increase cellular c-di-GMP levels, and signal the onset of the cell cycle.

145 ucture: while DeltarbdA showed elevated c-di-GMP levels, restricted motility and promoted biofilm for

146 There is limited information on c-di-GMP metabolism, particularly on regulatory mechanisms go

147 daptation though incremental changes in c-di-GMP network proteins acquires knowledge from past experi

148 P. aeruginosa is able to differentiate c-di-GMP output using structurally highly related proteins th

149 cyclases (DGCs) CdgB and CdgC, and the c-di-GMP phosphodiesterases (PDEs) RmdA and RmdB, are poorly

150 ory mechanisms governing control of EAL c-di-GMP phosphodiesterases.

151 her affinity than FleQ and propose that c-di-GMP produced by AdrA modulates flagella synthesis throug

152 interacts with several GGDEF proteins (c-di-GMP producers), but mutants of Bd1971 do not share the d

153 on and dispersal is mediated by LapD, a c-di-GMP receptor, and LapG, a periplasmic protease, which to

154 define the sensor enzymes important to c-di-GMP regulation.

155 c-di-GMP, thus revealing a link between c-di-GMP signaling and chromosome biology.

156 t endogenously expressed CSP intercepts c-di-GMP signaling and effectively inhibits biofilm formation

157 ated, but the specific cues that impact c-di-GMP signaling are largely unknown.

158 ere, we present a strategy to intercept c-di-GMP signaling pathways by directly targeting the second

159 tested for their capacity of targeting c-di-GMP signaling.

160 ng role between cellular metabolism and c-di-GMP signalling in P. putida.

161 c-di-GMP signals are integrated into the genetic differentiat

162 and DeltarmdB strains revealed that the c-di-GMP specified by these enzymes has a global regulatory r

163 he complex metabolic pathways governing c-di-GMP synthesis and degradation are highly regulated, but

164 st that the regulation of chemotaxis by c-di-GMP through MapZ orthologs/homologs is widespread in pro

165 is a monofunctional PDE that hydrolyzes c-di-GMP to 5'pGpG.

166 EF-EAL domain arrangement, RmdA cleaves c-di-GMP to GMP and exhibits residual DGC activity.

167 otype from proteins containing putative c-di-GMP turnover and Per-Arnt-Sim (PAS) sensory domains.

168 ed proteins that can contain degenerate c-di-GMP turnover domains.

169 cted on the basis of predicted impaired c-di-GMP turnover function: DeltafimX showed increased, Delta

170 o acids have been described to modulate c-di-GMP turnover in some bacteria.

171 ny genes encoding enzymes implicated in c-di-GMP turnover.

172 e pools appears to determine changes in c-di-GMP turnover.

173 est that, as opposed to other bacteria, c-di-GMP turns down the T6SS in A. tumefaciens thus impacting

174 Additionally, c-di-GMP was found to be localized at the outer boundary of m

175 We also show that SadB binds c-di-GMP with higher affinity than FleQ and propose that c-di

176 CSP binds c-di-GMP with submicromolar affinity.

177 lso demonstrate that elevated levels of c-di-GMP within the cell decrease the activity of the Type IV

178 In C. crescentus, c-di-GMP works as a major regulator of pole morphogenesis and

179 regulated by 3',5'-cyclic diguanylate (c-di-GMP) and requires production of the type IV mannose-sens

180 cyclic dimeric guanosine monophosphate (c-di-GMP) by posttranscriptionally repressing expression of c

181 -3,5-cyclic di-guanosine monophosphate (c-di-GMP) determines when Streptomyces initiate sporulation.

182 he protein levels of two cyclic di-GMP (c-di-GMP) diguanylate cyclases (DGCs), GcpA and GcpL, are rep

183 secondary messenger cyclic dimeric-GMP (c-di-GMP) in response to environmental conditions.

184 Cyclic diguanylate (c-di-GMP) is a broadly conserved intracellular second messeng

185 Cyclic di-GMP (c-di-GMP) is a second messenger that modulates multiple respo

186 '-5') cyclic diguanosine monophosphate (c-di-GMP) phosphodiesterase MbaA.

187 al second messenger cyclic diguanylate (c-di-GMP) regulates a wide range of cellular functions from b

188 lular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls ma

189 lator cyclic diguanylate monophosphate (c-di-GMP) through changes in the activity and localization of

190 messenger, 3-5 cyclic diguanylic acid (c-di-GMP) to the master repressor, BldD.

191 We present the structure of the RsiG-(c-di-GMP)(2)-sigma(WhiG) complex, revealing an unusual, parti

192 ously reported that cyclic diguanylate (c-di-GMP), synthesized by diguanylate cyclase A (DgcA), induc

193 via the second messenger cyclic di-GMP (c-di-GMP).

194 econd messengers such as cyclic di-GMP (c-di-GMP).

195 cyclic dimeric guanosine monophosphate (c-di-GMP).

196 e PTS (Ntr) system influences (p)ppGpp, c-di-GMP, GMP and GTP concentrations.

197 In the absence of c-di-GMP, ShkA predominantly adopts a compact domain arrangem

198 structure of a ternary complex between c-di-GMP, sigma(WhiG), and its anti-sigma factor, RsiG.

199 ts, instead having an elevated level of c-di-GMP, suggesting that the role of Bd1971 is to moderate t

200 mosome organization and is modulated by c-di-GMP, thus revealing a link between c-di-GMP signaling an

201 ex structure by NMR identified a linear c-di-GMP-binding motif, in which a self-intercalated c-di-GMP

202 r data support a role for the predicted c-di-GMP-binding protein LapD in inhibiting LapG-dependent di

203 Our data suggest that the major c-di-GMP-controlled targets determining the timing and mode o

204 t the restrictive temperature prevented c-di-GMP-induced cAMP synthesis as well as c-di-GMP-induced s

205 i-GMP-induced cAMP synthesis as well as c-di-GMP-induced stalk gene transcription.

206 also controlled by a complex network of c-di-GMP-metabolizing enzymes.

207 virulence was due to overproduction of c-di-GMP-regulated cellulose, as deletion of the cellulose sy

208 We identified a class of c-di-GMP-responsive proteins, represented by the AraC-like tr

209 mechanism of a previously unrecognized c-di-GMP-responsive transcription factor and provide insights

210 For this, we developed a c-di-GMP-sequestering peptide (CSP) that was derived from a C

211 n one causing a significant increase in c-di-GMP.

212 its activity is directly controlled by c-di-GMP.

213 tors have been shown to be regulated by c-di-GMP.

214 g pathway, FleQ, has been shown to bind c-di-GMP.

215 se in the level of the second messenger c-di-GMP.

216 how that the protein levels of two cyclic di-GMP (c-di-GMP) diguanylate cyclases (DGCs), GcpA and Gcp

217 Cyclic di-GMP (c-di-GMP) is a second messenger that modulates mult

218 e intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and c

219 nitiation via the second messenger cyclic di-GMP (c-di-GMP).

220 e use of second messengers such as cyclic di-GMP (c-di-GMP).

221 ersal eubacterial second messenger cyclic di-GMP impacts the production of T6SS toxins and T6SS struc

222 homologs associated with bacterial cyclic di-GMP signaling.

223 ffold that selectively responds to cyclic di-GMP synthesized by a neighbouring cGAS/DncV-like nucleot

224 that GacB is inhibited directly by cyclic di-GMP, which provides evidence for cross-regulation betwee

225 ms, such as the unexpected role of cyclic-di-GMP in host sensitivity to phage N4, and more generic de

226 DgcB (GGDEF enzyme) that produces cyclic-di-GMP in response to an unknown stimulus.

227 Finally, bacterial cyclic-di-GMP induces an alternative active STING conformation, ac

228 The bacterial second messenger cyclic-di-GMP is a widespread, prominent effector of lifestyle cha

229 e history strategies by regulating cyclic-di-GMP levels, global transcriptional responses, biofilm pr

230 onstrate, for the first time, that cyclic-di-GMP may play a role in mediating catabolite repression,

231 cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C) through destabi

232 e feedback between mechanosensors, cyclic-di-GMP signaling, and production of adhesive polysaccharide

233 uenching study revealed binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase a

234 ond to theophylline, hypoxanthine, cyclic-di-GMP, and folinic acid from libraries of ~22,700 sequence

235 Here, we show that cyclic-di-GMP-AMP (cGAMP) synthase (cGAS) is the primary sensor th

236 motile-sessile switch mediated by cyclic-di-GMP-by two domains that sense, respond to, and control t

237 Laventie et al. (2019) describe a cyclic-di-GMP-dependent pathway used by the opportunistic pathogen

238 hosphodiesterase domains acting on cyclic-di-GMP.

239 latory proteins associated with the cylic di-GMP signaling messenger produced swarming and biofilm ph

240 UPR is triggered by bacterial cyclic dimeric GMP, in a STING-dependent manner, and that this response

241 he bacterial second messenger cyclic dimeric GMP.

242 acellular secondary messenger cyclic dimeric-GMP (c-di-GMP) in response to environmental conditions.

243 is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture.

244 x of Vrg4, revealing the molecular basis for GMP recognition and transport.

245 Here we review the requirements for GMP validation of data acquisition software and illustra

246 TPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP, and that AtPTPN positively regulated

247 Identification of glycomacropeptide (GMP) and beta-lactoglobulin (beta-lg) present in cheese

248 (Ntr) system influences (p)ppGpp, c-di-GMP, GMP and GTP concentrations.

249 elopoiesis and transcriptome analysis of HSC/GMP cell populations revealed enrichment of neutrophil-

250 However, its implementation in GMP-compliant commercial quality control (QC) laboratori

251 hree distinct regions designated as the LID, GMP-binding (GMP-BD), and CORE domains and is in an open

252 r under laboratory conditions or at 50-liter GMP scale in different lots.

253 ne (N-Ac-Tyr) or guanosine-5'-monophosphate (GMP) was investigated at various pH values.

254 t the coassembly of guanosine monophosphate (GMP) with an azobenzene-containing DNA intercalator prod

255 response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGA

256 Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recog

257 lic mtDNA by cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS).

258 allenge, we have characterized C. neoformans GMP synthase, the second enzyme in the guanylate branch

259 g molecules modulating the nitric oxide (NO)-GMP-phosphodiesterase (PDE) pathway, the evaluation of n

260 Thus, the balance of GMP and MDP differentiation shapes the myeloid cell repe

261 thod has been developed for the detection of GMP and beta-lg by staining acrylamide gel after tricine

262 ite application, despite the current lack of GMP validation.

263 nucleotides, impacting the cellular pools of GMP, GDP and GTP.

264 Transcriptome analysis of GMPs revealed enrichment in gene signatures of self-rene

265 dmap and challenge the current definition of GMPs.

266 q-based broad-range genetic quality tests on GMP-compliant human leucocyte antigen (HLA)-homozygous h

267 material under good manufacturing practice (GMP) conditions.

268 ssessment under good manufacturing practice (GMP) guidelines.

269 g an optimized, good manufacturing practice (GMP)-compliant manufacturing process.

270 ully automated, good-manufacturing-practice (GMP)-compliant production procedure for the (89)Zr label

271 expanded under good manufacturing practices (GMP) conditions, and administered intravenously at eithe

272 alidation in a Good Manufacturing Practices (GMP) environment.

273 erived from granulocyte monocyte precursors (GMPs) and could develop into granulocytes in the presenc

274 s, we uncover an axis whereby CD34(+)PRLR(+) GMPs inhibit CD56(+) lineage development through TGF-bet

275 MEP), and granulocyte-macrophage progenitor (GMP) cells, accompanied by increased cell cycle arrest i

276 and late granulocyte-macrophage progenitor (GMP) cells.

277 rough the granulocyte-macrophage progenitor (GMP) compartment showing that AXL(+)SIGLEC6(+) pre-DCs m

278 am of the granulocyte/macrophage progenitor (GMP).

279 wed toward granulocyte-monocyte progenitors (GMP) during joint and intestinal inflammation in experim

280 defined granulocyte macrophage progenitors (GMPs) and acquisition of self-renewal potential in a non

281 ty among granulocyte-macrophage progenitors (GMPs) determines their probability of transformation.

282 (CLPs), granulocyte-macrophage progenitors (GMPs), megakaryocyte-erythrocyte progenitors (MEPs), pre

283 Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) pro

284 Granulocyte-monocyte progenitors (GMPs) have been previously defined for their potential t

285 rm glomeruloid microvascular proliferations (GMP), accompanied by only modest endothelial cell death.

286 able synthesis module, which also allows the GMP production of other radiolabeled mAbs.

287 guide eosinophil lineage commitment from the GMP and suppress the neutrophil program, promoting eosin

288 fies an urgent need for AUC operation in the GMP environment.

289 Both products had to meet the GMP-compliant quality standards with respect to yield, r

290 To meet the GMP-compliant quality standards, only the radiochemicall

291 Here we report the crystal structure of the GMP bound complex of Vrg4, revealing the molecular basis

292 Our dissection of the GMP hierarchy led us to further identify a previously un

293 ed the early committed progenitor within the GMPs responsible for the strict production of neutrophil

294 domain arrangement, RmdA cleaves c-di-GMP to GMP and exhibits residual DGC activity.

295 dye 'coomassie brilliant blue' (CBB) towards GMP.

296 substantial variability even between the two GMP lots.

297 0) on a >10 g scale with >99.8% purity under GMP conditions.

298 re similar to isolated yields obtained using GMP protocols for manual (89)Zr labeling of mAbs.

299 talbumin (a-la) and beta-lg appear red while GMP stains blue.

300 s have proposed lineage heterogeneity within GMPs, it is unclear if committed progenitors already exi