ライフサイエンスコーパス: GPC

1 GPC protects inner medullary cells against the perturbin

2 GPC-4D enabled characterization of Glu-PLGA in its conce

3 GPC-B1 is a NAC transcription factor and has a paralogou

4 rating this secondary mutation into Candid#1 GPC, we hope to minimize the likelihood of reversion and

5 Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are

6 mouse model of lethal infection, rMACV/Cd#1-GPC was fully attenuated, more immunogenic than Candid#1

7 V with the Candid#1 glycoprotein (rMACV/Cd#1-GPC) exhibited growth properties similar to those of Can

8 Here, we generated rCl-13(GPC/VGKS) by introducing the corresponding revertant mut

9 e, and a detailed characterization of rCl-13(GPC/VGKS) can provide novel insights into the mechanisms

10 In addition, rCl-13(GPC/VGKS) grew to high titers in cultured cell lines and

11 Further analysis revealed that rCl-13(GPC/VGKS) infected fewer splenic plasmacytoid dendritic

12 within GP2 of rCl-13 and we show that rCl-13(GPC/VGKS) was unable to persist in mice.

13 ain of Cl-13 GP2 resulted in a virus, rCl-13(GPC/VGKS), that failed to persist in mice despite exhibi

14 entire alpha-fetoprotein (AFP), glypican-3 (GPC-3), melanoma-associated gene-A1 (MAGE-A1) and New Yo

15 ) of LASV (GPC spanning residues 441 to 449 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437))

16 In contrast, a recombinant LCMV expressing a GPC whose processing into GP1 and GP2 was mediated by fu

17 Furthermore, a GPC shown recently to predict incident coronary heart di

18 the K33A, F49A, and C57A mutations abolished GPC-mediated cell entry and therefore could not allow fo

19 extracts from yeast and plants could acylate GPC with acyl groups from acyl-CoA.

20 All enzymes utilize acyl-CoA to acylate GPC, forming lyso-PC, and they show broad acyl specifici

21 epitope involved in binding of two adjacent GPC monomers and preserved the prefusion trimeric confor

22 K465V and G467K mutations did not affect GPC processing, virus RNA replication, or gene expressio

23 d plants carrying knock-out mutations of all GPC-1 and GPC-2 genes exhibited delayed senescence but n

24 Trimethyl-amines (GPC and glycine-betaine) are characterized by strong har

25 Differences among GPC-antibody interactions highlighted specific residues

26 arrying knock-out mutations of all GPC-1 and GPC-2 genes exhibited delayed senescence but normal anth

27 However, virus assembly and GPC incorporation into budded virions were unaffected.

28 nteen FUBC and 5 FUBC were drawn for GNB and GPC to yield 1 positive result.

29 To elucidate the importance of the GPB and GPC receptors relative to the well-described EBA-175/GPA

30 get the LASV surface glycoprotein (GPC), and GPC-B competition group antibodies often show potent neu

31 rved for polymer 2 over polymer 1 by NMR and GPC.

32 orter gene expression levels from the NP and GPC loci were confirmed with recombinant trisegmented LC

33 gment (rLCMV/TransS), where the viral NP and GPC open reading frames replaced one another.

34 roducts encoded by the S RNA segment (NP and GPC) were swapped to generate rLCMV/TransS.

35 targets for JCV infection are astrocytes and GPCs and that infection is associated with progressive m

36 was noted primarily in human astrocytes and GPCs rather than oligodendrocytes, which instead express

37 r that was chimeric for human astrocytes and GPCs.

38 0/20:4), 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4), sulfate, and gamma-glutamylalanine.

39 l entry into cells is mediated by arenavirus GPC that consists of an SSP, the receptor-binding GP1, a

40 ors of S1P-mediated processing of arenavirus GPC as a novel antiviral strategy.

41 iency and subcellular location of arenavirus GPC processing.

42 to characterize the processing of arenavirus GPC-derived target sequences by human SKI-1/S1P in a qua

43 nhibit S1P-mediated processing of arenavirus GPC.

44 tibiotic therapy can be narrowly targeted at GPC in many acutely infected patients, but those at risk

45 e characterize a genetic interaction between GPC subunits that evolutionarily forces retention of the

46 recently been identified and shown to block GPC-mediated fusion of the viral and cellular endosomal

47 e Sobel test of mediation revealed that both GPCs mediated their respective relations between VF (as

48 tudy, we investigated the processing of BUNV GPC and found that both NSm and Gc proteins were cleaved

49 and grain yield was reduced by 1.0-1.6%, but GPC was increased by 0.50% for cv Yangmai16 and 0.80% fo

50 dispersities (M(w)/M(n) < 1.25) as judged by GPC.

51 This was further supported by GPC-matrix assisted laser desorption ionization time-of-

52 cometry and size average molecular weight by GPC.

53 nding protein that recognizes Glycophorin C (GPC) on the red blood cell (RBC) surface and that its bi

54 ptors glycophorin B (GPB) and glycophorin C (GPC).

55 Here, we show that Can GPC aggregates in the ER of infected cells, forming inco

56 ent in the wild-type pathogenic JUNV, causes GPC retention in the endoplasmic reticulum (ER).

57 r function during the glial progenitor cell (GPC) to astrocyte transition.

58 lls (NSCs), including glial precursor cells (GPCs), of Alzheimer's disease (AD) are unclear.

59 enerated bipotential glial progenitor cells (GPCs) from human embryonic stem cells (hESCs) derived fr

60 by engrafting human glial progenitor cells (GPCs) into neonatal immunodeficient and myelin-deficient

61 , we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice.

62 chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells deriv

63 able to treatment by glial progenitor cells (GPCs), which give rise to astroglia and myelin-producing

64 ow that Gpc1 and Ale1 are the major cellular GPC and LPC acyltransferases, respectively.

65 (GPC) in the yeast Saccharomyces cerevisiae GPC can be reacylated by the glycerophosphocholine acylt

66 these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 containing a small disulfide bo

67 To address this, MACV/JUNV chimeric GPCs were assessed for interaction with a group of alpha

68 racterized by gel permeation chromatography (GPC) and (1)H nuclear magnetic resonance (NMR) spectra.

69 sisted of (i) gel permeation chromatography (GPC) and adsorption chromatography using (ii) deactivate

70 s observed by gel permeation chromatography (GPC) and UV-vis spectroscopy, as well as labeling of the

71 lar weight by gel permeation chromatography (GPC) based on polystyrene molecular weight standards, an

72 nalysis, with gel permeation chromatography (GPC) being the most common approach for determining the

73 and versatile gel permeation chromatography (GPC) methodology for molecular weight (MW) characterizat

74 Gel permeation chromatography (GPC), (1)H NMR spectroscopy, and matrix-assisted laser d

75 action (XRD), gel permeation chromatography (GPC), and electron paramagnetic resonance (EPR) spectros

76 ques, such as gel permeation chromatography (GPC), crystallization elution fractionation (CEF), high

77 determined by gel permeation chromatography (GPC).

78 R spectra and gel permeation chromatography (GPC).

79 We used Gaussian Process Classifiers (GPC), a machine learning approach that assigns a predict

80 Proteoliposomes containing the cleaved GPC mediate pH-dependent membrane fusion, a characterist

81 Purified recombinant EDI3 protein cleaves GPC to form glycerol-3-phosphate and choline.

82 However, the critical enzyme cleaving GPC to produce choline, the initial step in the pathway

83 es of positive FUBC for gram-positive cocci (GPC) but not GNB.

84 ococci (CoNS) and other Gram-positive cocci (GPC) directly from VersaTREK blood culture bottles was e

85 tification of clustered Gram-positive cocci (GPC) in blood cultures and on appropriate antibiotic tre

86 microbial, with aerobic gram-positive cocci (GPC), and especially staphylococci, the most common caus

87 id was notable for many Gram-positive cocci (GPC), but cultures of BAL fluid and subcarinal lymph nod

88 to bacteremia caused by Gram-positive cocci (GPC), susceptible Gram-negative bacteria (sGNB), resista

89 omponent of the mature glycoprotein complex (GPC) and plays important roles not only in GPC expressio

90 in the viral envelope glycoprotein complex (GPC) is responsible for attenuation raise the prospect o

91 The glycoprotein complex (GPC) of arenaviruses, composed of stable signal peptide,

92 of the viral envelope glycoprotein complex (GPC), thereby raising concerns regarding the potential f

93 nst the MACV glycoprotein precursor complex (GPC) and murine hybridoma technology to generate 25 mous

94 layed arenaviral glycoprotein spike complex (GPC) mediates host cell recognition and is an important

95 rain yield, and grain protein concentration (GPC) varied depending on cultivar and accumulated heat s

96 ve identified EDI3, a key enzyme controlling GPC and choline metabolism.

97 en utilized in conjunction with conventional GPC detectors to analyze a series of broad MWD PS standa

98 lx/Cr, Glu/Cr, Gln/Cr, Asc/Cr, and decreased GPC/Cr and decreased left thalamic tNAA/Cr, NAA/Cr were

99 ferentiation phenotype in microRNA-deficient GPCs, overexpression of these targets in wild-type GPCs

100 Detailed GPC and NMR analyses demonstrate that branching density

101 The time evolution of the dual-detection GPC data, concentration of active catalyst, and monomer

102 -TOF mass spectrometry, and triple-detection GPC.

103 on chromatography with quaternary detection (GPC-4D) has been previously applied to other polymers, a

104 rs was obtained from solubility differences, GPC, and DOSY-NMR studies.

105 Each GPC-B antibody recognized an overlapping epitope involve

106 ly, we employed our sensor to show efficient GPC processing of a panel of pathogenic and nonpathogeni

107 transfected with plasmids expressing either GPC or both Gn and Gc revealed that Gn is posttranslatio

108 gate whether the regional extent of elevated GPC+PC were greater in BD-I patients with rapid cycling

109 We found significantly elevated GPC+PC levels in ACC, putamen and caudate of RC BD-I pat

110 ell fusion activity of ectopically expressed GPC to approximately 20% of wild-type levels.

111 rogates the ability of ectopically expressed GPC to mediate membrane fusion at endosomal pH.

112 e fusion activity of recombinantly expressed GPC.

113 nsmembrane domain of G2 may be important for GPC-mediated membrane fusion and its inhibition.

114 inpatients with blood cultures positive for GPC in the pre-PCR (15 January 2009 to 14 January 2010)

115 year after neonatal xenograft, the forebrain GPC populations of implanted mice were largely, and ofte

116 al polymerization, and the MWs obtained from GPC were further confirmed via nuclear magnetic resonanc

117 Further, GPC-1 inhibition increased PC-3 tumor size in NCr nude m

118 Glycerophosphocholine (GPC) is high in cells of the renal inner medulla where h

119 Glycerophosphocholine (GPC) metabolites modulate atherosclerosis and thus risk

120 free fatty acids and glycerophosphocholine (GPC) in the yeast Saccharomyces cerevisiae GPC can be re

121 ifically, a decreased glycerophosphocholine (GPC) to phosphocholine (PC) ratio was reported in breast

122 Concentrations of glycerophosphocholine (GPC) were found to be significantly higher in the renal

123 ivity coefficients of glycerophosphocholine (GPC), taurine, and myo-inositol.

124 erapy), increased PC, glycerophosphocholine (GPC) and tCho levels (p<0.04).

125 promoted by the virus envelope glycoprotein GPC.

126 mediated by the virus envelope glycoprotein GPC.

127 target the arenavirus envelope glycoprotein (GPC) have recently been identified and shown to block GP

128 The arenavirus envelope glycoprotein (GPC) retains a stable signal peptide (SSP) as an essenti

129 act on the tripartite envelope glycoprotein (GPC) through its unusual stable signal peptide subunit t

130 act on the arenavirus envelope glycoprotein (GPC) to prevent membrane fusion.

131 gions within the virus surface glycoprotein (GPC) and nucleoprotein (NP) are the main targets of the

132 marily target the LASV surface glycoprotein (GPC), and GPC-B competition group antibodies often show

133 The glycoprotein (GPC) gene is primarily responsible for attenuation of th

134 ecombinant LCMV containing the glycoprotein (GPC) gene of LASV within the backbone of the immunosuppr

135 The glycoprotein, GPC, is the sole antigen expressed on the viral surface

136 Unlike other viral envelope glycoproteins, GPC contains a myristoylated stable signal peptide (SSP)

137 rthermore, secreted members of the glypican (GPC) family are selectively expressed in these tumours,

138 ycosylphosphatidylinositol-linked glypicans (GPCs), the basement membrane proteoglycan perlecan (HSPG

139 V (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-436)) that displayed hi

140 harply downregulated relative to normal hESC GPCs; NKX2.2, OLIG2, SOX10, MYRF, and their downstream t

141 For example, heterotypic GPC complexes are unable to support virion entry.

142 (80-96%) and characterized by NMR, ESI-HRMS, GPC, IR, and X-ray data: p-carboxyphenylsiloxanes in cry

143 Human GPCs and astrocytes were infected more readily than olig

144 In human GPCs (hGPCs) derived from 3 mHTT hESC lines, transcripti

145 w methods for generating and isolating human GPCs, the myelin disorders may now be compelling targets

146 efficient engraftment and expansion of human GPCs in murine hosts has led to the development of human

147 Engraftment of human GPCs in normally myelinated and immunodeficient mice res

148 this report, we demonstrate that the hybrid GPC complexes are properly assembled, proteolytically cl

149 The iC-GPC assay (iCubate, Huntsville, AL) provides a molecular

150 A preliminary evaluation of the iC-GPC assay using 203 clinical or seeded specimens demonst

151 We identified GPC and NP regions containing T cell epitopes and HLA ha

152 strong than those with the newly identified GPCs.

153 n disulfide bonds, which results in impaired GPC processing into G1 and G2.

154 Additionally, the decreased cell growth in GPC-1 knockdown PC-3 cells was rescued by coculturing wi

155 n yield, as well as the observed increase in GPC due to heat stress.

156 unique pH-sensing intersubunit interface in GPC, but atomic-level structural information is unavaila

157 (GPC) and plays important roles not only in GPC expression and processing but also in the membrane f

158 udies have suggested that SSP is retained in GPC through interaction with a zinc-binding domain (ZBD)

159 cible deletion of all canonical microRNAs in GPCs in vitro led to a block in the differentiation to a

160 ymatic activity, increased the intracellular GPC/PC ratio, and decreased downstream lipid metabolites

161 s demonstrated through a series of isocratic GPC separations using narrow MWD polystyrene (PS) standa

162 d for interaction with a group of alpha-JUNV GPC monoclonal antibodies (MAbs) and mouse antisera agai

163 s loop causing interference, mouse anti-JUNV GPC antisera that solely neutralized pseudovirions beari

164 rgeted GP1, with those that neutralized JUNV GPC-pseudovirions competing with each other for RBS bind

165 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)),

166 combinant Candid#1 (rCan) virus bearing K33S GPC is viable and retains its attenuated genotype under

167 increase fitness in rCan, reversion in K33S-GPC rCan is likely to be lethal.

168 rts, alpha-HB was a positive correlate and L-GPC a negative correlate of insulin sensitivity, with al

169 alpha-HB and L-GPC are independent predictors of worsening glucose tole

170 To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measure

171 GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational coho

172 ivity was examined, alpha-HB inhibited and L-GPC stimulated glucose-induced insulin release in INS-1e

173 each standard deviation of predictor), and L-GPC was a negative predictor (0.64 [0.48-0.85] and 0.67

174 in accuracy when substituting alpha-HB and L-GPC with 2-h OGTT glucose concentrations.

175 a-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glu

176 we compared three crystal structures of LASV GPC complexed with GPC-B antibodies of varying neutraliz

177 of the glycoprotein precursor (GPC) of LASV (GPC spanning residues 441 to 449 [GPC(441-449)]), LCMV (

178 subunits in a native-like Lassa virus (LASV) GPC trimer expressed in insect cells.

179 /LASV-GPC were shown to increase rCl-13/LASV-GPC infectivity in mice.

180 cells, but in contrast to Cl-13, rCl-13/LASV-GPC was unable to establish persistence in immunocompete

181 e GP2 cytoplasmic domain (CD) of rCl-13/LASV-GPC were shown to increase rCl-13/LASV-GPC infectivity i

182 of the Armstrong strain of LCMV (rCl-13/LASV-GPC) exhibited Cl-13-like growth properties in cultured

183 w door to widespread application of VSV-LASV-GPC as a safe and efficacious oncolytic chimeric virus w

184 had two brain tumors, intratumoral VSV-LASV-GPC injection in one tumor (glioma or melanoma) led to c

185 n contrast, a novel chimeric virus (VSV-LASV-GPC) containing genes from both the Lassa virus glycopro

186 g residues 441 to 449 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)),

187 t vesicular stomatitis virus expressing MACV GPC (VSV-MACV) as well as against authentic MACV.

188 GP1 provided enhanced neutralization of MACV GPC when this loop was removed.

189 Abs) and mouse antisera against JUNV or MACV GPC.

190 sulfide bonded loop (loop 10) unique to MACV GPC, suggesting that this loop may block MAbs interactio

191 V (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-43

192 the number and relative proportion of mouse GPCs fell as a function of time, concomitant with the mi

193 mately replaced the host population of mouse GPCs, ultimately generating mice with a humanized glial

194 The multisubunit GPC glycoprotein spike complex displayed on the arenavir

195 Mice allografted with murine GPCs showed no enhancement of either LTP or learning.

196 With respect to the obtained (1)H NMR, GPC, and contact angle results, the possibility for furt

197 aracterized using a variety of methods (NMR, GPC, IR, DLS, etc.).

198 We find that nonmyristoylated GPC mutants of the Candid #1 strain of Junin virus displ

199 We identified novel GPCs strongly associated with multiple CVD risk factors

200 We identified several novel GPCs that were associated with multiple CVD risk factors

201 ral loads and CCHF-induced disease, the NP + GPC vaccinated animals were significantly protected.

202 date a new molecular mechanism of adult NSCs/GPCs on neurogenesis and demonstrate a regulatory role f

203 Shh itself was elevated in hippocampal NSCs/GPCs.

204 deficits of Ptc1-Gli1 signaling induced NSCs/GPCs into asymmetric division, which results in an incre

205 anolamine as acyl donors in the acylation of GPC.

206 iral agents that target this novel aspect of GPC membrane fusion may be useful in the treatment of ar

207 Degradation of GPC is catalyzed by the glycerophosphocholine phosphodie

208 f 4.1R to bind to the cytoplasmic domains of GPC, Duffy, and XK.

209 We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such

210 s to high NaCl- and urea-induced increase of GPC.

211 While inhibition of GPC-1 expression in PC-3 cells decreased cell growth and

212 hat its binding correlates with the level of GPC on the RBC surface.

213 Increased levels of GPC+PC suggest alterations in the membrane phospholipids

214 9242 efficiently prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomen

215 The in vitro reconstitution of GPC-mediated membrane-fusion activity offers unprecedent

216 here are few studies elucidating the role of GPC-1 in prostate cancer progression.

217 in DU-145 cells, suggesting that the role of GPC-1 is cell type-dependent.

218 ortant insights into the biological roles of GPC SSP and implicates it as a good target for the devel

219 n the stable signal peptide (SSP) subunit of GPC, and we demonstrate the utility of this interaction

220 ling deregulation resulting abnormal loss of GPCs may contribute to a cognition decline in AD brains.

221 serum lipidomics to identify a new panel of GPCs, and tested whether any of these GPCs are associate

222 ed metabolites (1-(1-enyl-stearoyl)-2-oleoyl-GPC (P-18:0/18:1) and 1,5-anhydroglucitol) to the produc

223 inhibitors share a common binding pocket on GPC.

224 ystem to decrease expression of GPA, GPB, or GPC via lentiviral short hairpin RNA transduction of ery

225 The cleavage mechanism of orthobunyavirus GPCs and the host proteases involved have not been clari

226 erentiation of S. aureus from CoNS and other GPC within 30 min from the time of blood culture positiv

227 virus (JUNV), have nearly identical overall GPC architecture and share a host receptor, transferrin

228 pport a critical role for PAF-R agonistic Ox-GPCs in the pathophysiology of XPA photosensitivity.

229 aled increased levels of sn-2 short-chain Ox-GPCs along with native PAF.

230 To date, oxidized glycerophosphocholines (Ox-GPCs) with platelet-activating factor (PAF) activity pro

231 Here we provide evidence that these Ox-GPCs play a pivotal role in the photosensitivity associa

232 ied out included sugar estimation, SDS-PAGE, GPC, color, FT-IR, DSC, thermal stability, solubility, e

233 aPG0116-PG0120 (GPA) and DeltaPG0109-PG0118 (GPC) mutants of P. gingivalis.

234 Glycero-3-phosphocholine (GPC), the product of the complete deacylation of phospha

235 d glycerophosphocholine plus phosphocholine (GPC + PC), metabolites that are markers of neuronal viab

236 , glycerophosphocholine plus phosphocholine (GPC+PC)) in bipolar disorder using in vivo proton magnet

237 lasmids encoding the glycoprotein precursor (GPC) and the nucleoprotein (NP) of CCHFV.

238 both the Lassa virus glycoprotein precursor (GPC) and VSV showed no adverse actions within or outside

239 f the viral envelope glycoprotein precursor (GPC) by the cellular subtilisin kexin isozyme 1 (SKI-1)/

240 Hantavirus glycoprotein precursor (GPC) is posttranslationally cleaved into two glycoprotei

241 cleoprotein (NP) and glycoprotein precursor (GPC) loci within the S segment of the prototypic arenavi

242 e same region of the glycoprotein precursor (GPC) of LASV (GPC spanning residues 441 to 449 [GPC(441-

243 us genus-encodes the glycoprotein precursor (GPC) that is proteolytically cleaved to yield two viral

244 expressing the CCHFV glycoprotein precursor (GPC), which encodes CCHFV structural glycoproteins.

245 inding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human ca

246 tions present in Can glycoprotein precursor (GPC).

247 protein (NP) and the glycoprotein precursor (GPC).

248 ety is cryptically disposed in the prefusion GPC complex and may function late in the fusion process

249 With semi-preparative GPC the LMWDF (DP3) fractions in the wheat grain based f

250 by different chemometrics for grain protein (GPC) and amylose content (AC) of BR and proximate compos

251 s the 4.1R-associated transmembrane proteins GPC, Duffy, XK, and Kell readily extractable by nonionic

252 Unlike other class I viral fusion proteins, GPC retains its stable signal peptide (SSP) as an essent

253 tial resolution and absolute quantification, GPC+PC levels from the anterior cingulate cortex (ACC),

254 In this report we show that the recombinant GPC precursor can be produced as a discrete native-like

255 aviral glycoprotein immunogens that resemble GPC as presented on the mature virion surface.

256 the MWD of the "bulk" (all polymers, from RI-GPC analysis) provides important mechanistic information

257 ion into myelin-deficient shiverer mice, SCZ GPCs showed premature migration into the cortex, leading

258 the siRNA-mediated knockdown of other SDCs, GPCs, HSPG2, and agrin had no effect on HCV attachment.

259 on-mass spectrometry, we identified 69 serum GPCs within the 450 to 680 m/z range.

260 ionization time-of-flight mass spectroscopy (GPC-MALDI ToF MS), which revealed the exclusive formatio

261 matography with quadruple detection systems (GPC-4D).

262 We also find that GPC containing the uncleaved GP1-GP2 precursor is not su

263 e data demonstrate the paradoxical role that GPC-1 plays in prostate cancer cell growth by interactin

264 hagic fever arenaviruses, we have shown that GPC is unique among class I viral fusion proteins in tha

265 enic New World arenaviruses, suggesting that GPC cleavage represents no barrier for zoonotic transmis

266 The GPC fails to cleave into its G1 and G2 subunits and is t

267 use monoclonal antibodies (MAbs) against the GPC of MACV.

268 initial step in the pathway controlling the GPC/PC ratio, remained unknown.

269 use inhibition of EDI3 activity corrects the GPC/PC ratio and decreases the migration capacity of tum

270 d to higher levels from the NP than from the GPC locus.

271 critical for intracellular transport of the GPC complex to the cell surface and for its membrane-fus

272 Through our studies of the GPC envelope glycoprotein of the hemorrhagic fever arena

273 rrectly predicts efficient processing of the GPC of the newly emergent pathogenic Lujo virus by human

274 the receptor-binding GP1 subcomponent of the GPC spike from Old World but not New World arenaviruses

275 strain also contribute to aggregation of the GPC within the ER.IMPORTANCE The development of vaccines

276 receptors are of greater importance than the GPC receptor, supporting a hierarchy of erythrocyte rece

277 vo Taken together, our data suggest that the GPC SSP plays an essential role in mediating viral entry

278 of putative cleavage sites derived from the GPCs of newly discovered arenavirus by the SKI-1/S1P of

279 These GPCs may be sensitive indicators of obesity-related risk

280 nel of GPCs, and tested whether any of these GPCs are associated, in adolescence, with classical risk

281 also observed in cultured cells, where this GPC increased the binding of Hh to Patched 1 (Ptc1).

282 orkup procedure, as determined by MALDI-TOF, GPC, and (1)H and 2D NMR.

283 ns, affected Ptc1-Gli1 signaling, we treated GPCs with Abeta peptides, we found that high dose of Abe

284 In the tripartite GPC complex, pH-dependent membrane fusion is triggered t

285 overexpression of these targets in wild-type GPCs blocked differentiation.

286 Using GPC as a biomarker, we identified the tissue slices that

287 Using GPC, activity to neutral faces presented during the happ

288 stribution (MWD) of Hf-bound polymers via UV-GPC analysis.

289 EBOV GP-dependent, but not Lassa fever virus GPC-dependent, entry into a variety of cell lines in a d

290 ng at this critical interface in Lassa virus GPC.

291 -13 persistence and also revealed that virus GPC-host interactions yet to be elucidated critically co

292 Wheat GPC genes showed the opposite transcription profile (hig

293 The closest rice homolog to both wheat GPC genes is Os07g37920 which is located on rice chromos

294 The wheat GPC-B1 gene located on chromosome 6B is an early regulat

295 a paralogous copy on chromosome 2B in wheat, GPC-B2.

296 positive patient blood culture bottles with GPC seen in clusters with Gram staining were tested usin

297 ed on rice chromosome 7 and is colinear with GPC-B2.

298 rystal structures of LASV GPC complexed with GPC-B antibodies of varying neutralization potency.

299 ls with TCM from PC-3 cells transfected with GPC-1 shRNA increased the expression of migration marker

300 PC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-436)) that displayed high-affinity binding to HL