ライフサイエンスコーパス: GRF

1 GRF also detects DNA or RNA transposable elements charac

2 GRF helps improve the annotation for various DNA transpo

3 GRF is an open source available from Github.

4 GRF is more sensitive than Inverted Repeat Finder in TIR

5 GRF sensitively identifies terminal inverted repeats (TI

6 GRF:AN3 was predicted to induce SbARF3/ETT expression an

7 GRFs and ARFs regulate genes involved in cytokinin and b

8 4.8%, and 58.5% for those with 0, 1, and >=2 GRF, respectively (log-rank: 16.10, df = 2, P = 0.0003),

9 GFR) at baseline of >=60 ml/min, 6,276 had a GRF of <60 ml/min.

10 Our results demonstrate how a GRF-GIF chimera in conjunction with a ternary vector sys

11 ing type switch-activating protein Sap1 is a GRF in S. pombe, demonstrating the general applicability

12 One line, bearing a single copy of a GRF-hGH transgene, has been characterized in detail, and

13 y, the IQ motif of GRF1 determines whether a GRF protein can induce LTD.

14 e or alter its spatial relationship abrogate GRF binding.

15 Systematic analysis of additional GRFs suggests a network architecture that rationalizes t

16 We find that plants with altered GRF dosage are differentially sensitive to the manipulat

17 On multivariate analysis, GRF was associated with survival in this retrospective c

18 rove the fracture prediction in Chinese; and GRF of BMD from people of European descent cannot help i

19 RFs and that of the model with both CRFs and GRF for BMD prediction.

20 between a GROWTH-REGULATING FACTOR (GRF) and GRF-INTERACTING FACTOR (GIF) protein to improve regenera

21 eractions identified here between miR396 and GRF and PLT transcription factors are necessary to estab

22 retrogradation was observed in both NRF and GRF with MPP added of all levels.

23 r different coding regions of human SOS1 and GRF genes were used to screen expression of these genes

24 tion of Ras by the mammalian GEFs, Sos1, and GRF/CDC25Mm.

25 ed the booting/heading stage, while ARFs and GRFs were downregulated suggesting these TF families as

26 dephosphorylation pathway, and MAF3-like and GRFs genes, may be considered as markers of growth compe

27 ng tissues, a process mediated by miR396 and GRFs.

28 ns of 8.3 and 6.1 kb, whereas an Arabidopsis GRF gene occupies a single domain of 27 kb.

29 nding, loci exhibiting Pol II readthrough at GRF binding sites are depleted for upstream NNS signals.

30 diction in Chinese perhaps partially because GRF of BMD from people of European descent may not contr

31 showed that, adding fracture GRF and FN-BMD GRF to the model with CRFs, the area under the receiver

32 re GRF and by the Model with CRFs and FN-BMD GRF, respectively, as compared to 65.5% in the Model wit

33 Although both GRF proteins transduce calcium signals emanating from NM

34 stically significant survival differences by GRF.

35 GRF1 are key to the induction of HFS-LTP by GRF proteins.

36 CDC25 domain in the induction of TBS-LTP by GRF proteins.

37 of synaptic plasticity that are regulated by GRF proteins in the CA1 hippocampus, specificity is enco

38 We identified a pathway regulated by GRF transcription factors that represses stem cell-promo

39 reveals that the specific sequences bound by GRFs have diverged substantially across evolution, corre

40 -REGULATING FACTOR 4 (GRF4) and its cofactor GRF-INTERACTING FACTOR 1 (GIF1) substantially increases

41 GULATING FACTORs (GRFs) with their cofactors GRF-interacting factors (GIFs), offer great potential fo

42 This autoinhibitory activity contrasts GRF-ZF domains of other DNA-processing enzymes, which ty

43 genes that qualify as targets of this DELLA-GRF regulatory module.

44 actors determine mRNA output and then derive GRFs for target genes in the CLB2 gene cluster that are

45 Finally, we show that a dicot GRF-GIF chimera improves regeneration efficiency in citr

46 Each GRF protein contains a Dbl homology (DH) domain.

47 ecrease of starch retrogradation, especially GRF.

48 examine the contribution of these essential GRFs to transcription genome-wide, by using ts mutants t

49 emory Network (BD-LSTM) was used to estimate GRF waveforms from inertial waveforms.

50 y, FG skewed the direction of the GVS-evoked GRF vector towards the axis of baseline postural instabi

51 PLC domains, contains a GTP exchange factor (GRF CDC25) domain and two C-terminal Ras-binding (RA) do

52 protein between a GROWTH-REGULATING FACTOR (GRF) and GRF-INTERACTING FACTOR (GIF) protein to improve

53 hat members of the GROWTH-REGULATING FACTOR (GRF) family act as players in this network.

54 of miR396 and its Growth-Regulating Factor (GRF) target genes resulted in reduced syncytium size and

55 ween PpnGRF5-1 and growth-regulating factor (GRF)-interacting factors (GIFs) were experimentally vali

56 abidopsis thaliana growth-regulating factor (GRF)] gene family, which encodes putative transcription

57 ring trans-acting general regulatory factor (GRF) binding sites.

58 keratinocytes, termed gamma response factor (GRF).

59 nts with 0, 1, and >=2 genomic risk factors (GRF: absence of PF; presence of SF or PGx).

60 gated the role of Growth-Regulating Factors (GRFs) and of microRNA miR396 in UV-B-mediated inhibition

61 genes, including growth-regulating factors (GRFs) and transcripts for proteins participating in diff

62 since copurified GROWTH-REGULATING FACTORs (GRFs) varied throughout the growing leaf.

63 chel2 (WUS2), and GROWTH-REGULATING FACTORs (GRFs) with their cofactors GRF-interacting factors (GIFs

64 interacting with GROWTH-REGULATING FACTORs (GRFs).

65 lators, including GROWTH REGULATING FACTORs (GRFs).

66 e also find that general regulatory factors (GRFs) bind to partially unwrapped nucleosomes at these p

67 s accumulation of growth regulatory factors (GRFs) known to interact with ANGUSTIFOLIA (SbAN3), a mas

68 s, including the general regulatory factors (GRFs) Reb1p, Rap1p, and Abf1p, and Pol III transcription

69 bf1 and Rap1 are general regulatory factors (GRFs) that contribute to transcriptional activation of a

70 for one or more General Regulatory Factors (GRFs), most frequently Abf1 and Reb1, and that these fac

71 to investigate whether genetic risk factors (GRFs) for fracture and bone mineral density (BMD) identi

72 for GRF1, we identified another gene family, GRF-interacting factor (GIF), which comprises three memb

73 from results for the Gaussian random field (GRF) with the same two-point correlation function (for w

74 ing companies offer genetic relative-finder (GRF) services that compare the DNA of consenting partici

75 Here, we developed Generic Repeat Finder (GRF), a tool for genome-wide repeat detection based on f

76 l rice flour (NRF) and glutinous rice flour (GRF) at three levels (400, 800 and 1200 ppm) and their e

77 nd Stat1alpha homodimers fail to compete for GRF binding in EMSA, and pIgammaRE does not cross-compet

78 r-evoked balance responses, most notably for GRFs and MG-EMG.

79 rences in patterns of ground reaction force (GRF) and load rate (LR) among runners with running-relat

80 ltaneous reduction in ground reaction force (GRF) through the feet.

81 for the estimation of ground reaction force (GRF) waveforms.

82 lues of peak vertical ground reaction force (GRF), stance time, contact length and vertical centre of

83 (hip, knee, ankle), ground reaction forces (GRF), and moments (hip and knee) of a SL-DJ task using a

84 Ground reaction forces (GRFs) and plantar flexor (soleus and medial gastrocnemiu

85 substrate to measure ground reaction forces (GRFs) with micrometre and nanonewton precision in behavi

86 sured kinematics and ground reaction forces (GRFs), musculoskeletal modeling, and inverse dynamics to

87 The results showed that, adding fracture GRF and FN-BMD GRF to the model with CRFs, the area unde

88 xplained by the Model with CRFs and fracture GRF and by the Model with CRFs and FN-BMD GRF, respectiv

89 Our findings indicate that discoveries from GRF services may be common and that the consequences for

90 Vestibular-evoked responses recorded from GRFs and EMG were quantified in terms of signal coupling

91 Such a 'gene regulation function' (GRF) generally cannot be measured because the experiment

92 measured using the SANS, SAPS, BPRS, and GSF/GRF.

93 n of ERF/AP2, C2H2 zinc finger, homeodomain, GRF, TCP, zinc finger homeodomain, BES, and STERILE APET

94 Peak horizontal GRF and mechanical work per step were lower when POFT oc

95 be expected to overestimate peak horizontal GRF and mechanical work per step.

96 Tgr rats had reduced hypothalamic GRF and mRNA, in contrast to the increased GRF expressio

97 t regarding their decision to participate in GRF services.

98 f the 23,196 respondents had participated in GRF services only for non-specific reasons that included

99 c GRF and mRNA, in contrast to the increased GRF expression which accompanies GH deficiency in other

100 evolutionary transition from Cbf1 as a major GRF in pre-whole-genome duplication (WGD) yeasts to Reb1

101 reveal that most members of the nine-member GRF (GROWTH REGULATORY FACTOR) transcription factor fami

102 xpression profiling revealed that the miR396-GRF regulatory system can alter the expression of 44% of

103 Functionally, we establish that the NEIL3 GRF domain inhibits glycosylase activity against monoadd

104 The raw net GRF is normalized by time and then averaged across at le

105 Binding of GRF is tyrosine phosphorylation-dependent, and mutations

106 uggests that limb length is a determinant of GRF moment arm magnitude and that unless muscle moment a

107 This work demonstrated that estimation of GRF waveforms is feasible across a range of running velo

108 ant dwarfism by local feedback inhibition of GRF.

109 nd Rap1 or Abf1, but not affected by loss of GRF binding.

110 de and timing of impact and active phases of GRF waveforms differed in runners with history of tibial

111 monstrate here that the C-terminal region of GRF proteins has transactivation activity.

112 We surveyed a convenience sample of GRF service participants to understand the prevalence of

113 ay help improve mechanistic understanding of GRF and LR and identify gait retraining foci for specifi

114 to unravel, facilitate subsequent binding of GRFs, and constitute a dynamic cycle of nucleosome depos

115 volutionary transitions in the repertoire of GRFs.

116 her Ras exchange factor, CDC25Mm, or p140Ras-GRF.

117 uticle sequestration and planting, producing GRFs of 1-7 uN.

118 g implemented as a parallelized C++ program, GRF was faster and more sensitive than the existing inve

119 A Ras-GRF mutant containing the PH domain from Ras-GTPase-acti

120 es defective LTP induction in adolescent Ras-GRF knockout mice, consists of NMDA glutamate receptor a

121 vation is reduced in the brains of adult Ras-GRF knockout mice and neuronal damage is enhanced.

122 tion of cells is not sufficient to allow Ras-GRF activation by calcium.

123 domains function cooperatively to allow Ras-GRF activation.

124 calcium channels, an event that is also Ras-GRF-independent.

125 Sos and Ras-GRF are two families of guanine nucleotide exchange fact

126 cleotide exchange factors (GEFs) such as Ras-GRF; however, there is no Ca(2+)-dependent mechanism for

127 activation of a single Ras homologue by Ras-GRF/Cdc25Mm or other Ras guanine nucleotide exchange fac

128 of Ras-GRF function together to connect Ras-GRF to multiple components in the particulate fractions

129 In contrast, Ras-GRF proteins are expressed primarily in central nervous

130 the phosphorylation state of endogenous Ras-GRF.

131 inst specific domains of hSOS1 and human Ras-GRF gene products.

132 In contrast, neither Ras-GRF protein influences synaptic plasticity in prepubesce

133 main redistributes a large percentage of Ras-GRF from the particulate to the cytosolic fraction of ce

134 minal PH, coiled-coil, and IQ domains of Ras-GRF function together to connect Ras-GRF to multiple com

135 Remarkably, this form of Ras-GRF is constitutively activated.

136 Here, using a set of Ras-GRF knock-out mice, we show that Ras-GRF2 contributes pr

137 necessary for particulate association of Ras-GRF, it is not sufficient for targeting the core catalyt

138 Moreover, the postnatal appearance of Ras-GRF-dependent LTP and LTD coincides with the emergence o

139 g to an IQ domain near the N terminus of Ras-GRF.

140 te, at least in part, the specificity of Ras-GRF/CDC25Mm for Ha-Ras protein.

141 n that the neuronal exchange factor p140 Ras-GRF becomes activated in vivo in response to elevated ca

142 ism for Ras activation, mediated by p140 Ras-GRF.

143 ce; however, at this developmental stage Ras-GRF (guanine nucleotide-releasing factor) proteins are n

144 phosphorylation state of epitope-tagged Ras-GRF.

145 ls NMDARs signal through Sos rather than Ras-GRF exchange factors, implying that Ras-GRFs endow NMDAR

146 campal-dependent behavior, implying that Ras-GRF proteins contribute to forms of synaptic plasticity

147 We found that Ras-GRF/Cdc25Mm activates Ha-Ras, but does not activate N-Ra

148 ransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in exchange-

149 Consistent with this function for Ras-GRFs and the known neuroprotective effect of CREB activi

150 Similar phenotypes are seen with mutant Ras-GRFs containing point mutations in either the PH or coil

151 Ras-GRF exchange factors, implying that Ras-GRFs endow NMDARs with functions unique to mature neuron

152 H) was targeted to growth hormone-releasing (GRF) neurons in the hypothalamus of transgenic rats.

153 eractors and, at the same time, that several GRF genes are targets of DELLA-modulated transcription a

154 xpressing miR396-resistant copies of several GRFs are less sensitive to this inhibition.

155 e chromatin remodeling complex with specific GRFs tightly regulate the transition between cell divisi

156 We concluded that, in the current study, GRF of fracture identified in people of European descent

157 Here, we show that the tandem GRF-ZFs of NEIL3 provide affinity and specificity for DN

158 For TIRs and TDRs, GRF identifies spacers in the middle and mismatches/inse

159 domain, NEIL3 contains two tandem C-terminal GRF-type zinc fingers that are absent in the other NEIL

160 omain of ZCCHC4 is packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal C

161 to characterized STAT proteins suggest that GRF contains a Stat1alpha-like protein; however, non-ICA

162 Here we show that GRFs may instead be inferred from natural changes in cel

163 The GRF magnitudes were generally underestimated by the mach

164 monstrate conserved interactions between the GRF and KNOX families of transcription factors in both m

165 ssDNA binding by the GRF-ZF motifs helps recruit NEIL3 to replication forks c

166 We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which c

167 r ( < 2%) but does not vanish unlike for the GRF.

168 factor which determines EMA, by modeling the GRF and muscle moment arms in the extinct giraffid Sivat

169 The crystal structure of the GRF domain shows that the tandem ZF motifs adopt a flexi

170 possibly other transcription factors of the GRF family.

171 nature of DNA binding and the effect of the GRF-ZF domain on catalysis of base excision and ICL unho

172 Likewise, we found that the GRF protein BGRF1 from barley (Hordeum vulgare) could ac

173 It has been known that the GRF-INTERACTING FACTOR (GIF) transcription co-activator

174 The GRFs are expressed in transit-amplifying cells but are e

175 The GRFs repress PLETHORA (PLT) genes, regulating their spat

176 If unchecked, the expression of the GRFs in the stem cell niche suppresses formative cell di

177 Inactivation of the GRFs increases the meristem size and induces periclinal

178 ates MIR396 in the stem cells to repress the GRFs.

179 Our observations point to GRFs as new multifaceted players in Ribi gene regulation

180 We used GRF to perform TIR/TDR, interspersed-repeat, and MITE de

181 -shoe forces, providing a proxy for vertical GRF and a standard for the identification of gait events

182 reased knee valgus angle, and lower vertical GRF during SL-DJ (p < 0.001).

183 providing good predictions of peak vertical GRF, stance time, contact length and vertical centre of

184 The pIgammaRE x GRF complex also displays a distinctly different electro

185 Collectively, our data unveil the APE2 Zf-GRF domain as a nucleic acid interaction module in the r

186 Moreover, an APE2 Zf-GRF X-ray structure and small-angle X-ray scattering ana

187 he two NEIL3 Zf-GRF motifs (designated as Zf-GRF repeat) are dispensable for its DNA glycosylase and

188 s containing GRXF residues (designated as Zf-GRF).

189 EIL3 in genome integrity via its distinct Zf-GRF repeat in suppressing APE1 endonuclease-mediated ssD

190 Structure-guided Zf-GRF mutations impact APE2 DNA binding and 3'-5' exonucle

191 y is regulated by DNA interactions in its Zf-GRF domain, a region sharing high homology with DDR prot

192 It appears that the two NEIL3 Zf-GRF motifs (designated as Zf-GRF repeat) are dispensable

193 in interaction assays show that the NEIL3 Zf-GRF repeat but not one Zf-GRF motif interacted with APE1

194 ever, the potential function of the NEIL3 Zf-GRF repeat in genome integrity remains unknown.

195 tion, COMET assays show that excess NEIL3 Zf-GRF repeat reduces DNA damage in oxidative stress in Xen

196 e, we demonstrate evidence that the NEIL3 Zf-GRF repeat was associated with a higher affinity for sho

197 ut not on dsDNA is compromised by a NEIL3 Zf-GRF repeat, whereas one Zf-GRF motif within NEIL3 is not

198 that the NEIL3 Zf-GRF repeat but not one Zf-GRF motif interacted with APE1 but not APE2.

199 or AP endonuclease APE2 contains only one Zf-GRF motif mediating interaction with single-strand DNA (

200 sed by a NEIL3 Zf-GRF repeat, whereas one Zf-GRF motif within NEIL3 is not sufficient to prevent such

201 ffinity for shorter ssDNA than one single Zf-GRF motif.

202 the nucleic acid-binding activity of the Zf-GRF domain.

203 e X-ray scattering analyses show that the Zf-GRF fold is typified by a crescent-shaped ssDNA binding

204 d also reveal topologic similarity of the Zf-GRF to the zinc ribbon domains of TFIIS and RPB9.