ライフサイエンスコーパス: GTC

1 GTC ingestion with caffeine also significantly decreased

2 The HD-induced deficit ranged from -27% (GTC maximum at -100 mV in Ba(2+)) to -41% (sodium transi

3 recognize the sequences 3'-T(C/T)G-5' and 3'-GTC-5', respectively.

4 that the Cys4 motif contacts cytosine of 5'-GTC-3' and may also contribute to thymine recognition.

5 length of the template on the 3'-side of 5'-GTC-3' increases.

6 ound CTP selects the remaining base G, of 5'-GTC-3', by base pairing.

7 Bacteriophage T7 DNA primase recognizes 5'-GTC-3' in single-stranded DNA.

8 e altered proteins recognize the sequence 5'-GTC-3' in the template and deliver preformed primer to T

9 Upon recognition of the sequence, 5'-GTC-3' by the zinc motif, the catalytic site condenses t

10 recognizes a core trinucleotide sequence, 5'-GTC-3', on single-stranded DNA at which it catalyzes the

11 At the sequence, 5'-GTC-3', the primase synthesizes the dinucleotide pppAC;

12 translocate to primase recognition sites, 5'-GTC-3', or to dissociate from the molecule to which it i

13 On meta-analysis, GTCs with caffeine decreased BMI (-0.55; 95% CI: -0.65,

14 oops are favored in CAG (89%), CTG (89%) and GTC (69%) while GAC favors triloops.

15 ays on hairpin substrates containing CTG and GTC triplet sequences revealed that A3A prefers cytidine

16 nt base stacking, we find that CAG, CTG, and GTC triplets predominantly form even-membered loops that

17 and slipping dynamics for CAG, CTG, GAC and GTC hairpins.

18 isease-related expansion whereas the GAC and GTC sequences do not, these stability differences can in

19 expansion were found also for CGG, GTG, and GTC.

20 al injury homed to the renal parenchyma, and GTC-treated mice showed reduced renal oxidative stress,

21 e was 94% for WSI and GTC and 94% for TM and GTC.

22 terobserver concordance between WSI, TM, and GTC was 91%.

23 nterobserver concordance was 94% for WSI and GTC and 94% for TM and GTC.

24 tive correlation between Kir4.1 currents and GTCs.

25 g profiles of (CAG)10, (CTG)10, (GAC)10 and (GTC)10 strands are determined at low and physiological s

26 Anti-GTC-90 antibodies inhibit the in vitro Golgi transport a

27 0 repeats) of CTG.CAG and CGG.CCG as well as GTC.GAC by primer extensions in vitro using DNA polymera

28 g RNAs and reduced the stability of tRNA(Asp(GTC)) We also demonstrate the importance of m(5)C in pla

29 uced tDR derived from the 3' end of tRNA-Asp-GTC, activated autophagic flux in kidney cells and its s

30 Mechanistically, tRNA-Asp-GTC-3'tDR assembled stable G-quadruplex structures and s

31 Thus, tRNA-Asp-GTC-3'tDR plays a role in regulating RNA autophagy, whic

32 Here, we showed that tRNA-Asp-GTC-3'tDR, a hypoxia-induced tDR derived from the 3' end

33 stantial renoprotective function of tRNA-Asp-GTC-3'tDR.

34 ber of infected cells was comparable between GTC-d11- and HepG2.2.15-derived viruses when inoculated

35 tivation energies than corresponding [(CAG):(GTC)] duplexes of the same length.

36 oid triplet repeat disorders mediated by CAG/GTC replication slippage.

37 under the influence of green tea catechins (GTC), which are suggested to offer chemopreventive and t

38 ecent data suggest that green tea catechins (GTCs) reduce acute UVR effects, but human trials examini

39 Green tea catechins (GTCs) with or without caffeine have been studied in rand

40 nges from +1.02 kcal/mol for GCG/CTC and CCG/GTC to +1.95 kcal/mol for TCC/ATG.

41 we obtained GPSC-derived tubular-like cells (GTCs) that were functional in vitro, as demonstrated thr

42 .(1)(,)(2) In hagfishes, gland thread cells (GTCs) each produce a silk-like proteinaceous fiber calle

43 a combination of myoclonic and tonic-clonic (GTC) seizures.

44 Cog1/ldlBp, Cog2/ldlCp, Cog3/Sec34, and Cog5/GTC-90), three homologues of yeast Sec34/35 complex subu

45 zed include (a) the Golgi transport complex (GTC), identified in an in vitro membrane transport assay

46 kDa), which we term Golgi transport complex (GTC).

47 lished interobserver ground truth consensus (GTC) diagnosis for 499 previously diagnosed cases propor

48 zure or generalized tonic-clonic convulsion (GTC).

49 d respective glutamate transporter currents (GTCs) were induced by photolytic or synaptic glutamate r

50 h the triplet repeat sequences d(GAC)n and d(GTC)n also form hairpins, repeats of the double-stranded

51 nits than with odd numbers, whereas d(GAC).d(GTC) repeats showed no such alternation despite having t

52 RCTs that evaluated GTCs with or without caffeine and that reported BMI, bod

53 Studies that evaluated GTCs without concomitant caffeine administration did not

54 la/Val455, with 3 individuals homozygous for GTC (Val) in both groups.

55 d TM methods and interobserver variance from GTC, following College of American Pathology guidelines.

56 lity whereas opposing hairpins in a (GAC) . (GTC) duplex would have unmatched stability, introducing

57 ity, introducing frustration in the (GAC) . (GTC) opposing hairpins that could encourage their resolu

58 or work implicated the instability of a (GAC*GTC)5 tract in the cartilage oligomeric matrix protein (

59 A transcribed plasmid containing (GAC*GTC)49 repeats led to large deletions (>3 repeats) after

60 We postulate that small instabilities of GAC*GTC repeats are achieved through replicative slippage, w

61 anscription, the genetic instability of (GAC*GTC)49 repeats did not significantly differ from the opp

62 The genetic instability of (GAC*GTC)n (where n = 6-74) was investigated in an Escherichi

63 in, we report the first genetic study on GAC*GTC repeat instability describing two types of mutationa

64 eas large deletion events are found when GAC*GTC repeats are transcribed.

65 Relative to the GAC/GTC class not associated with disease, the order of fold

66 Comparing CAG/CTG loop structures with GAC/GTC structures, having similar hydrogen bonding but diff

67 eviously identified neutral polymorphism GCC/GTC coding for Ala/Val455, with 3 individuals homozygous

68 y used APRs include ACA, ACC, ATC, GCC, GCG, GTC and CAC, some of which were translation enhancers in

69 found to be CTG > GAC approximately = CAG > GTC for 10 repeats.

70 t-negative missense mutation (codon 22 GGC-->GTC; V22G) of the signaling adaptor protein Uncoordinate

71 e efficient than infection of wild-type GTC (GTC-wt), and the number of infected cells was comparable

72 The frequency of haplotype GTC (-881G/-826T/-297C) was significantly higher among A

73 The haplotype GTC of NFKBIA gene is associated with higher risk of ARD

74 ter adjustment for covariates, the haplotype GTC remained significantly associated with increased ris

75 Crude analysis showed that the haplotype GTC was significantly associated with higher risks of AR

76 A novel full-length GTC TFO was designed to bind simultaneously in parallel

77 ue 433, in the M4 domain) the database lists GTC which encodes a valine, while our putative 'wild-typ

78 50 mg encapsulated green tea extract (540 mg GTC) with 50 mg vitamin C or placebo twice daily for 3 m

79 In mice, GTCs injected after ischemic renal injury homed to the r

80 Protein-binding assays showed that 1 microM GTC TFO inhibited binding of nuclear transcription facto

81 of sequence motifs d(TGTCT(n)G) and d(TGT(n)GTC).

82 of the duplex by pushing out the T-bases of GTC's so that the opposite faces of each phenoxazone are

83 The beneficial effect of GTC on cancer cells could be confirmed by SECM, and the

84 A 5-25-fold higher frequency of GTC(val) to TTC(phe) transversions at codon 157 was foun

85 ons for oligomers containing GTTC instead of GTC are also consistent with the T-base displacement mod

86 Six weeks after ischemic injury, kidneys of GTC-treated mice had less fibrosis and inflammatory infi

87 Loops of GTC compared with CTG melt 9 degrees C lower and slip 6-

88 -90) that allowed us to identify a number of GTC-90 cDNAs.

89 The membrane-associated pool of GTC-90 is localized to the Golgi apparatus.

90 s, we systematically examined the scaling of GTC and slime-thread dimensions with body size within bo

91 The administration of GTCs with caffeine is associated with statistically sign

92 e evolution of extreme size and allometry of GTCs.

93 We found that the length of GTCs varied between 40 and 250 um and scaled positively

94 stematic review and meta-analysis of RCTs of GTCs on anthropometric variables, including body mass in

95 for the CXG TR sequences than for the GAC or GTC TR sequences.

96 Oral GTC (1080 mg/d) with vitamin C over 3 mo did not signifi

97 , while slippage rates decrease in the order GTC > CAG approximately GAC > CTG.

98 bilities (in low salt) increase in the order GTC < CAG < GAC < CTG, while slippage rates decrease in

99 of similar length but opposing orientation (GTC*GAC)53 containing plasmid led to small instabilities

100 antly differ from the opposing orientation, (GTC*GAC)53.

101 these results, we recommend 70% ethanol over GTC-TCEP for RNA preservation of mycobacterial cultures.

102 A Val1483Ile polymorphism (GTC to ATC; allele frequency of A = 0.10) was associated

103 fter genetic upregulation of Kir4.1, somatic GTCs were found to be decreased.

104 ents but increased the amplitudes of somatic GTCs.

105 tional base pairs at the ends will stabilize GTC/GTC binding sites, and to d(TGTCAATTG) in which two

106 ved from a d11-introduced genotype C strain (GTC-d11) was ~10-fold more efficient than infection of w

107 equence information from the 90-kDa subunit (GTC-90) that allowed us to identify a number of GTC-90 c

108 Subcellular fractionation indicates that GTC-90 exists in both membrane and cytosolic pools, with

109 Hydrodynamic properties suggest that GTC is approximately 800 kDa and nonglobular.

110 Current data do not suggest that GTCs alone positively alter anthropometric measurements.

111 lanar phenoxazone chromophore inserts at the GTC site by pushing out the T-base while the terminal G

112 which the planar phenoxazone inserts at the GTC site with a loop-out T base whereas the G base at th

113 The binding step of the GTC-d11 virus onto the cell surface was responsible for

114 TGTC) and d(TGTCTTTTGTCA) in stabilizing the GTC/GTC binding site for juxtaposing the two G bases for

115 with the genomic sequence suggests that the GTC-90 mRNA is alternatively spliced.

116 tosolic pool associated exclusively with the GTC complex.

117 r DNA were detected after infection with the GTC-d11 virus.

118 nged codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113

119 ed overall higher RNA quantities compared to GTC-TCEP and RNA integrity was maintained at -20 degrees

120 odons 73(GCC to ACC, Ala to Thr), 76 (GCC to GTC, Ala to Val), 85(GCT to ACT, Ala to Thr), 98(CAC to

121 t inserts ((CTG.CAG), (CGG.CCG), (GAA.TTC), (GTC.GAC), and (GTG.CAC)) of different lengths, orientati

122 d more efficient than infection of wild-type GTC (GTC-wt), and the number of infected cells was compa

123 ance was determined through assay of urinary GTC metabolite epigallocatechin glucuronide.

124 anol as simpler alternative to commonly-used GTC-based storage of mycobacteria at - 80 degrees C was

125 ease and a common A2M polymorphism, Val1000 (GTC)/Ile1000 (ATC), which occurs near the thiolester act

126 considerable reduction in ACTD affinity when GTC is replaced by GTTC in an oligomer, in line with the

127 placebo-controlled trial to examine whether GTCs protect against clinical, histologic, and biochemic

128 d, followed by interobserver comparison with GTC.