ライフサイエンスコーパス: GTP cyclohydrolase I

1 y MptA (MJ0775 gene product), a new class of GTP cyclohydrolase I.

2 he first enzyme in its biosynthetic pathway, GTP cyclohydrolase I.

3 ntameric GFRP associate with one molecule of GTP cyclohydrolase I.

4 nd stimulatory complexes is equal to that of GTP cyclohydrolase I.

5 h of the two outer faces of the torus-shaped GTP cyclohydrolase I.

6 otein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin and

7 nase, arginine decarboxylase gene activator, GTP cyclohydrolase I and a repressor of purine biosynthe

8 r in HPS, where activities of the key enzyme GTP-cyclohydrolase I are in the normal range, but total

9 We used a synthetic gene based on mammalian GTP cyclohydrolase I, because this enzyme is predicted t

10 del for the quaternary structure of GFRP and GTP cyclohydrolase I complexes.

11 GTP cyclohydrolase is composed of a highly conserved hom

12 tly increased de novo synthesis for 6BH4 via GTP-cyclohydrolase I concomitant with high levels of 6BH

13 diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, decreased endothelium-dependent va

14 Conversely, both switching off GTP cyclohydrolase I expression as well as inhibiting it

15 GTP cyclohydrolase I feedback regulatory protein (GFRP)

16 phenylalanine through complex formation with GTP cyclohydrolase I feedback regulatory protein (GFRP).

17 involved in 6BH4 biosynthesis/recycling and GTP-cyclohydrolase I feedback regulatory protein were ex

18 Similarly, a GTP cyclohydrolase I (fol2) mutant of yeast (Saccharomyc

19 d a similar situation in Escherichia coli: a GTP cyclohydrolase I (folE) mutant, deficient in pterin

20 um, by targeted transgenic overexpression of GTP-cyclohydrolase I (GCH), prevented hypoxia-induced pu

21 matic l-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH1) transcription; increases str

22 Overexpression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme fo

23 Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of

24 AKR1B1), carbonyl reductase (CBR1 and CBR3), GTP-cyclohydrolase I (GCH1), and 6-pyruvoyltetrahydrobio

25 GTP cyclohydrolase I (GCHI) mediates the first and commi

26 GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dep

27 GTP cyclohydrolase I (GCYH-I) is the first enzyme of the

28 that the first enzyme of the folate pathway, GTP cyclohydrolase I (GCYH-I), encoded in Escherichia co

29 one and those additionally modified with the GTP cyclohydrolase I gene indicate that BH4 is critical

30 drobiopterin bioavailability by upregulating GTP-cyclohydrolase I gene expression and activity, resul

31 ted with fibro-blasts possessing both TH and GTP cyclohydrolase I genes displayed biochemical restora

32 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzy

33 BH4 levels, in part through the induction of GTP cyclohydrolase I (GTPCH I), the rate-limiting enzyme

34 5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were clo

35 Recently the GTP cyclohydrolase I (GTPCH) gene was isolated as the fi

36 Inhibition of GTP cyclohydrolase I (GTPCH) has been used as a selectiv

37 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme

38 enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in bi

39 e a selective and direct-acting inhibitor of GTP cyclohydrolase I (GTPCH), the first and rate-limitin

40 s factor alpha (TNF-alpha) without affecting GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

41 Expression of both iNOS and GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

42 (BH4), secondary to decreased expression of GTP cyclohydrolase I (GTPCH).

43 transfer of human guanosine 5'-triphosphate (GTP) cyclohydrolase I (GTPCH I), the first and rate-limi

44 he key enzyme involved in BH(4) synthesis is GTP-cyclohydrolase I (GTPCH-I), which is stimulated by e

45 ihydro-d-neopterin triphosphate catalyzed by GTP cyclohydrolase I (GTPCHI).

46 sis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulato

47 ng human tyrosine hydroxylase (hTH) or human GTP-cyclohydrolase I [GTPCHI, the rate-limiting enzyme f

48 To examine further the importance of GTP cyclohydrolase I in gene therapy for PD, in vivo mic

49 y a single enzyme, as is known to occur with GTP cyclohydrolase I in the Eucarya and Bacteria, but ra

50 The activity of GTP cyclohydrolase I is inhibited by (6R)-L-erythro-5,6,

51 al restoration in a rat model of PD and that GTP cyclohydrolase I is sufficient for production of BH4

52 st enzyme in the cofactor synthesis pathway, GTP cyclohydrolase I, is activated by phosphorylation an

53 re the induction of tyrosine hydroxylase and GTP cyclohydrolase is not coordinately regulated.

54 Mammalian GTP cyclohydrolase is subject to end-product inhibition

55 molog loss and suggest the importance of the GTP Cyclohydrolase I/Tetrahydrobiopterin pathway.

56 Furthermore, expression of GTP cyclohydrolase I (the rate-limiting enzyme in de nov

57 omato fruit up to 140-fold by overexpressing GTP cyclohydrolase I, the first enzyme of pteridine synt

58 decline by fruit-specific overexpression of GTP cyclohydrolase I, the first enzyme of pteridine synt

59 vitro data demonstrate that NAMDA inhibited GTP cyclohydrolase I, the rate-limiting enzyme for BH4 b

60 h tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 sy

61 ype (X haplotype) in the GCH1 gene, encoding GTP-cyclohydrolase I, the rate-limiting enzyme in biopte

62 cells with Tet-regulated expression of human GTP cyclohydrolase I to regulate intracellular BH4 avail

63 GTP cyclohydrolase I was also required for fitness in mi

64 Because GFRP is a pentamer and GTP cyclohydrolase I was shown here by cross-linking exp

65 hasone prevented the coordinate induction of GTP cyclohydrolase I with NOS2 after exposure to interle