ライフサイエンスコーパス: GTPase

1 GTPase-activating protein and VPS9 domain-containing pro

2 the FLCN:FNIP2 (FLCN-interacting protein 2) GTPase activating protein (GAP) complex, and prevents Ra

3 C negatively regulates mTORC1 by acting as a GTPase-activating protein (GAP) towards the small GTPase

4 hyphal apical dome (HAD) where it acts as a GTPase-activating protein for FgRab8 which is required f

5 Since homodimerization by a GTPase-active human septin also creates hexamers that ex

6 ng as a model the RAB13 RNA, which encodes a GTPase important for vesicle-mediated membrane trafficki

7 1 mediated anchorage-independent growth in a GTPase-independent manner through an adaptor function.

8 structure suggested that C9orf72-SMCR8 is a GTPase-activating protein (GAP), and we found that C9orf

9 MglB, a GTPase-activating protein, forms a cluster that responds

10 NF1 encodes neurofibromin, a GTPase-activating protein for RAS proto-oncogene GTPase

11 These findings reveal a GTPase-independent role for Rac1 in mediating a PI3K-ind

12 cies where (i) the Cdc3 subunit is an active GTPase and (ii) Cdc10-less hexamers natively co-exist wi

13 Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers and cytosk

14 Here, we reveal that sequential ATPase and GTPase activities license release factors Rei1 and Yvh1

15 guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP) activity, and effector b

16 s a complex protein that includes kinase and GTPase domains.

17 LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence b

18 multi-domain protein containing a kinase and GTPase.

19 ne nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs).

20 factors, ribosome-recycling factor (RRF) and GTPase elongation factor G (EF-G), synergistically split

21 Rho of Plants (ROPs) are GTPases that regulate polarity and patterned wall deposi

22 indicate that KNR6 can interact with an Arf GTPase-activating protein (AGAP) and its phosphorylation

23 ctivation of the ADP-ribosylation factor ARF GTPase by the SEC7 domain of ARF guanine-nucleotide exch

24 Here, we investigated the roles of small Arf GTPases during enterovirus infection.

25 ine nucleotide exchange factor for small Arf GTPases.

26 suggesting functional specialization of Arl3-GTPases in T. brucei These results establish the functio

27 RGS proteins primarily act as GTPase accelerators for activated Galpha subunits of G-p

28 t is open for binding to membrane-associated GTPase Arl6 and a large positively charged patch likely

29 ROOT HAIR DEFECTIVE3 (RHD3) is an atlastin GTPase involved in homotypic fusion of endoplasmic retic

30 ion of sheet-like ER, the action of atlastin GTPases must be tightly regulated.

31 FtsZ is a bacterial GTPase that is central to the spatial and temporal contr

32 and mutually antagonistic cross talk between GTPases, along with the conservative membrane binding, g

33 complex morphological landscape generated by GTPase regulation rather than being the result of intrin

34 We identified the Cdc42 GTPase exchange factor FGD5 as a downstream target of Ti

35 results in inhibition of FAK and Rac1/Cdc42-GTPase signaling critical for cell migration.

36 ncounter structure (ERMES) and the conserved GTPase Gem1, factors previously implicated in lipid exch

37 dentify one such factor, IQ motif containing GTPase activating protein-1 (IQGAP1), which enhances Rho

38 responds to a greatly diminished cooperative GTPase activity in comparison to native Drp1.

39 ing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effe

40 movement, and association of Cdc42-directed GTPase-Activating Proteins with secretory vesicles incre

41 Recently, we have reported that two distinct GTPases, the mechanoenzyme, dynamin2 (Dyn2), and the sma

42 Dynamin GTPases (Dyn1 and Dyn2) are indispensable proteins of th

43 g the allosteric activation of the essential GTPase Initiation Factor 2 (IF2) during translation init

44 sor, ADENOSINE PHOSPHATE RIBOSYLATION FACTOR GTPase ACTIVATION PROTEIN DOMAIN3, as root clock regulat

45 ns together with the ADP ribosylation factor GTPase exchange factors GNOM and BIG3 in regulating PIN

46 , the protein ADAP1 (ADP-ribosylation factor GTPase-activating protein [ArfGAP] with dual pleckstrin

47 state, the BBSome is bound to an Arf-family GTPase (ARL6/BBS3) that recruits the BBSome to ciliary m

48 RAC1, a Rho family GTPase, is an essential mediator of HDAC6 function, and

49 gulators, including the conserved Rho-family GTPase Cdc42, but the mechanisms underlying polarity reo

50 uniquely broad specificity toward ARF family GTPases in in vitro assays.

51 cellular membrane fusion requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimid

52 ator of the oncogenic activity of RAC-family GTPases in human and murine lung cancer.

53 ator of the oncogenic activity of RAC-family GTPases in lung cancer development.

54 Rho family GTPases regulate an array of cellular processes and are

55 ne nucleotide exchange factor for Rho family GTPases that also activates the ERK/MAPK pathway.

56 process known to be downstream of Rho family GTPases.

57 are reviewed, with an emphasis on Rho-family GTPases operating at the plasma membrane.

58 ired in vitro show activation of RhoA family GTPases.

59 1 or 2 alleles of the mitochondrial fission GTPase Drp1 and demonstrate that these mitochondrial dat

60 mics of the GFP-tagged mitochondrial fission GTPase dynamin-related protein 1 (Drp1) both in vitro an

61 utions in GBP2, associated with loss of GBP2 GTPase activity, attenuated the anti-MNV effects of GBP2

62 guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in the Rho and Ra

63 esulted in shorter protofilaments and higher GTPase, similar to the effect of the known bottom capper

64 ific target, suggesting a role for this host GTPase-activating protein in Coxiella infections.

65 action inhibitors, and activators increasing GTPase activity of mutant RAS proteins.

66 s, MHC class II genes, and IFN-gamma-induced GTPases, with antimicrobial function.

67 Interferon-inducible GTPase 1 (IIGP1) is a mouse-specific ISG and belongs to

68 2 is a ~32 kDa protein first purified by its GTPase-activating protein (GAP) activity toward ARL2 and

69 3K, Rac1 mediated cell migration through its GTPase activity, whereas independently of PI3K, Rac1 med

70 found implications for the study of this key GTPase in cancer, particularly because a large number of

71 mputational modeling to assess whether known GTPase dynamics can give rise to a sufficient diversity

72 KRAS GTPases are activated in one-third of cancers, and KRAS(

73 OPA1, a large GTPase of the dynamin superfamily, mediates fusion of th

74 in 2 (GBP2) is an interferon-inducible large GTPase which is crucial to the protective immunity again

75 The large GTPase Dynamin 2 (Dyn2) is known to increase the invasiv

76 dynamin family members MxA and MxB are large GTPases that convey resistance to a variety of infectiou

77 enes DExD/H-box helicase 58, MX dynamin-like GTPase 1, and IFN-induced protein with tetratricopeptide

78 We demonstrate that the small Ras-like GTPase MglA stimulates T4P formation in its GTP-bound st

79 hF, a signal recognition particle (SRP)-like GTPase, has been found to regulate the flagellar number

80 oplast lines overexpressing the tubulin-like GTPase protein gene FtsZ1 from Arabidopsis thaliana.

81 ited by a four-member sub-family of Ras-like GTPases known as RGK (Rad, Rem, Rem2, Gem/Kir) proteins.

82 Ral (Ras-like) GTPases are directly activated by oncogenic Ras GTPases.

83 Ral (Ras-like) GTPases play an important role in the control of cell mi

84 results, along with prior literature linking GTPase activity to cell morphology, support the hypothes

85 ial division, with ER tubulation and mechano-GTPase activities.

86 that MxB is an inner mitochondrial membrane GTPase that plays an important role in the morphology an

87 g anaphase causes the active form of the MEN GTPase Tem1 to accumulate at the dSPB.

88 The cognate MglA GTPase activating protein (GAP) MglB, which localizes ma

89 odulated by the Ca(2+)-binding mitochondrial GTPase Miro.

90 l as reduced expression of the mitochondrial GTPase MFN2 in the NAc.

91 actin cytoskeleton, and the small, monomeric GTPases Rac and Rho are important regulators of actin.

92 T-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT.

93 ented interaction with neurofibromin 1 (NF1)-GTPase-activating protein (GAP), providing a mechanism f

94 an evolutionary conserved putative nucleolar GTPase belonging to the HSR1_MMR1 subfamily of GTPases.

95 effectors, generating a positive feedback of GTPase activation and membrane recruitment.

96 RAB27B is a member of the Rab family of GTPases that allows controlled release of secretory gran

97 Septins are a unique family of GTPases, which were discovered 50 years ago as essential

98 Pase belonging to the HSR1_MMR1 subfamily of GTPases.

99 se-activating protein for RAS proto-oncogene GTPase (RAS).

100 Additional ablation of the oncogenic GTPase Rac1 partially reduced progression of Hace1(-/-)

101 We anticipate that similar organelle- or GTPase-induced conformational changes could regulate the

102 s are maintained until a wave of oscillatory GTPase activities from the cell front reaches the rear,

103 potential virus-specific differences in Rab GTPase requirements and glycosylphosphatidylinositol (GP

104 nteraction between Dyn2 and a regulatory Rab GTPase that may play an important role in hepatocellular

105 ynamin2 (Dyn2), and the small regulatory Rab GTPase, Rab10, work independently at distinct steps of l

106 LRRK2 recruits the Rab GTPase Rab8A to damaged endolysosomes as well as the ESC

107 o illuminated, including a system of >40 Rab GTPases and associated regulatory proteins, where GPVI-m

108 ARF1), bridging integrator 1 (BIN1), and Rab GTPases RAB7L1 and RAB8A are important regulators of HIV

109 , and they are endowed with a variety of Rab GTPases (16 out of 43 tested).

110 bed the potential involvement of several Rab GTPases in HSV-1 entry and suggest that endocytic entry

111 This process depends on Ulk1, Rab GTPases and SNARE complexes implicated in secretory but

112 Sec17/alphaSNAP, and Sec18/NSF families; Rab-GTPases (Rabs); and Rab effectors.

113 nucleotide exchange factor activity for Rab1 GTPase.

114 Silencing of Rab9 or Rab11 GTPases, which are involved in the retrograde transport

115 he periphery is required for directing RAB13 GTPase activity to promote cell migration.

116 ked to cancer progression, such as the RAB13 GTPase and the NET1 guanine nucleotide exchange factor,

117 interaction experiments identified the Rab7 GTPase-activating protein TBC1D5 as a candidate CstK-spe

118 ave-pinning reaction-diffusion model for Rac GTPase activity.

119 cally, Htl regulates the activity of Rho/Rac GTPases in nascent myotubes and effects changes in the a

120 s prenylation of proteins including the Rac1 GTPase in axons, counter to the canonical view of prenyl

121 We conclude that the RAC1-GTPase is a key downstream node of RAS and that genetic

122 Here, we demonstrate that the Rag GTPase acts in both the amino-acid-sensing and growth fa

123 actor signaling pathways converge on the Rag GTPase to inhibit TORC1 activity through the regulation

124 including tumors, are more sensitive to Rag GTPase-dependent nutrient sensing.

125 lysosome in the absence of amino acids, Rag GTPases, growth factors, and Rheb.

126 e-specific mechanism that is mediated by Rag GTPases.

127 plex 1 (mTORC1) localization through the Rag GTPases is a critical step for its activation by Rheb GT

128 Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subse

129 no-acid-mediated activation of RagC and RagD GTPases, but is insensitive to RHEB activity induced by

130 i-allelic variants in RALGAPA1 (encoding Ral GTPase activating protein catalytic alpha subunit 1) in

131 Molecularly, upregulation of Ral GTPase activity and Sox9 expression underlies the observ

132 tor Rgl2-mediated nucleotide exchange of Ral GTPase.

133 Ral GTPases have been implicated as critical drivers of cell

134 n-1 is the principal direct effector of Rap1 GTPases that regulates platelet integrin activation in h

135 SYNGAP1 is a Ras GTPase-activating protein that underlies the formation a

136 FliI immunoprecipitates showed abundant Ras GTPase-activating-like protein (IQGAP1), which in immuno

137 eregulation of the previously documented Ras GTPase activities.

138 activated Ras by blocking recruitment of Ras GTPase-activating protein (RasGAP) to the plasma membran

139 ified by Rab5A, a small G protein of the Ras GTPase superfamily.

140 Here we show a role for the Ras GTPase, R-Ras, in the functional adaptation of high endo

141 Ras GTPases act as molecular switches to control various cel

142 ases are directly activated by oncogenic Ras GTPases.

143 rgeted tumors revealed inhibition of the RAS-GTPase, Hedgehog, and Notch pathways, along with evidenc

144 eration, suggesting that these non-redundant GTPases function in the same pathway to mitigate ribosom

145 Immunity-related GTPase M (IRGM) in human locates at the inner membrane o

146 Secretion-associated Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII

147 inery are coordinated by the tubulin-related GTPase FtsZ, which was found to form treadmilling filame

148 1 and mitofusin 1, two other dynamin-related GTPases that mediate fusion, become proteolytically inac

149 ific ISG and belongs to the immunity-related GTPases (IRGs) family.

150 mediates the recruitment of immunity-related GTPases and destruction of the vacuole.

151 Atg16L1 is an effector of the Golgi resident GTPase Rab33B.

152 s a critical step for its activation by Rheb GTPase.

153 Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-linked

154 th its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neura

155 n mutants influenced p120(ctn)-dependent Rho GTPase phosphorylation and shifted cells towards differe

156 ates unique and sequential functions for Rho GTPase adaptors in regulating MAPK pathways.

157 1) and the ICAM-1(+) neutrophils involve Rho GTPase to promote NETosis.

158 ase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca(2+).

159 lation, which required the activation of Rho GTPase and focal adhesion kinase.

160 etwork analyses identified enrichment of Rho GTPase, extracellular matrix, focal adhesion and cytoske

161 tenin) and RHO guanosine triphosphatase [RHO GTPase, RHO], two signaling pathways previously shown to

162 Rho GTPases are central regulators of the cytoskeleton and,

163 RHO GTPases are key regulators of the cytoskeletal architect

164 ections, parasitic infections, activated Rho GTPases, and endoplasmic reticulum (ER) stress.

165 roteins or for other G-proteins, such as Rho GTPases.

166 These findings suggest that distinct Rho GTPases may act as context-dependent integrators of chem

167 a guanine nucleotide exchange factor for Rho GTPases that is overexpressed in many cancers and involv

168 e nucleotide exchange factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics.

169 x neural systems presented new roles for Rho GTPases, filled by new family members.

170 up-regulated genes in the cell-cycle and Rho-GTPase pathways.

171 pendent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its binding partner ARH

172 thma.Conclusions: We found enrichment of Rho-GTPase pathways in obese asthmatic Th cells, identifying

173 s Yap activation by lats1/2 knockdown or Rho-GTPase stimulation mimicked Yap overexpression and induc

174 anine nucleotide exchange factor for the Rho-GTPase CDC42, which is known for its role in the assembl

175 library screen of all human kinases and Rho-GTPases in a patient-derived NF1(-/-) Schwann cell line

176 RhoA GTPase regulated the activation of S100A4 via rhotekin,

177 sin heavy chain, which was catalysed by RhoA GTPase via the RhoA-binding protein, rhotekin.

178 contractile stimulation is activated by RhoA GTPase.

179 tatins, is a key downstream effector of RHOA GTPases.

180 CA4P activates the actin-regulating RhoA-GTPase/ ROCK pathway, which is required for full vascula

181 h in turn promote the nanoclustering of ROP6 GTPase that acts downstream of TMK1 to regulate cortical

182 Tubulin, a Rossmann GTPase, demonstrates the potential of the beta2-Asp to t

183 We found that the organization of septin GTPases, which are essential for appressorium-mediated i

184 Rab27b is one of several GTPases essential to the endosomal-lysosomal pathway and

185 ctive, these results demonstrate that simple GTPase dynamics can generate complex multistability in w

186 lial cell line, we show that RanGTP, a small GTPase that dictates nuclear transport, regulates ciliar

187 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compa

188 iated Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP binding, recr

189 Rab6, a small GTPase that regulates a number of endosomal trafficking

190 Decades ago, Rap1, a small GTPase very similar to Ras, was observed to suppress onc

191 y elevated levels of activated Rac1, a small GTPase widely implicated in cytoskeleton reorganization,

192 by phosphorylating and destabilizing a small GTPase, Rho1.

193 b6, the most abundant Golgi associated small GTPase, consists of 2 equally common isoforms, Rab6A and

194 o family members, including Rac family small GTPase 1 (RAC1), were identified as candidates.

195 d through the inhibition of Rac family small GTPase 1 and cell division cycle 42 activation, as well

196 nt promising candidates for Rho-family small GTPase inhibitors and therapeutics targeting Ras-driven

197 cers, and inhibition of the Rho family small GTPase signaling has been shown to combat Ras-driven can

198 ggests a possible universal system for small GTPase patterning involving both protein and lipid inter

199 hensive analysis of the alterations in small GTPase proteome during adipogenesis, and we reveal a pre

200 hensive analysis of the alterations in small GTPase proteome regulated by epitranscriptomic modulator

201 P, JBTS17 and RSG1 (REM2- and RAB-like small GTPase 1), whose genes are mutated in ciliopathies.

202 explored how the expression levels of small GTPase proteins are regulated by m(6)A modulators.

203 temically the changes in expression of small GTPase proteins in cells upon genetic ablation of METTL3

204 607:558 ratio is required for optimal small GTPase prenylation, and validate this innovative approac

205 AS isoforms and a subset of prenylated small GTPase family members using a live-cell quantitative spl

206 une receptors, such as CD40, with RAB7 small GTPase on mature endosomes, in addition to signals emana

207 The Rap1 small GTPase pathway has emerged as a commonly disrupted intra

208 which, in turn, bind and activate the small GTPase ARF6.

209 l dendrite branching by regulating the small GTPase ARF6.

210 The small GTPase Cdc42 governs the formation and distribution of i

211 The small GTPase cell division cycle 42 (CDC42) plays essential ro

212 Mutations in the small GTPase gene RAB39b are associated with X-linked macrocep

213 ee peptide substrates derived from the small GTPase K-Ras and the inhibitory alpha-subunit of the het

214 The small GTPase KRAS is localized at the plasma membrane where it

215 otility is under the dependence of the small GTPase MglA, but the underlying molecular mechanisms rem

216 antially increased the coverage of the small GTPase proteome.

217 Such targeting of the small GTPase RAB13 generated tight spatial coupling of mRNA lo

218 Here, we reveal the role of the small GTPase Rab18 as a positive regulator of directional migr

219 The small GTPase RABL3 is an oncogene of unknown physiological fun

220 We find that Sema3A activates the small GTPase Rac1, and that Rac1 activity is required for dend

221 ide exchange factor that activates the small GTPase Rap-1.

222 The small GTPase Ras-related protein Rab-7a (Rab7a) serves as a ke

223 otein phosphatase calcineurin, and the small GTPase Ras1, as well as with divergent stress response r

224 e-activating protein (GAP) towards the small GTPase Rheb.

225 olo-like kinase 1 (PLK1) activates the small GTPase RhoA to assemble a contractile actomyosin ring.

226 Here, we show that the small GTPase RhoJ integrates these opposing signals in directi

227 Proteomic analysis revealed that the small GTPase, Rap1 was overexpressed in lEVs from MetS patient

228 The small GTPase, Ras-related protein Rab-7A (Rab7), is essential

229 complex component MPP5a interacts with small GTPase Rab11 in Golgi to transport cadherin and Crumbs c

230 Small GTPases are essential signaling molecules for regulating

231 Small GTPases of the RAS and RHO families are related signalin

232 Small GTPases of the Rho family are binary molecular switches

233 tive levels of expression of 55 and 49 small GTPases accompanied by adipogenic differentiation in 3T3

234 c endomembrane system is controlled by small GTPases of the Rab family, which are activated at define

235 s regulate a common set of components: small GTPases and the actin cytoskeleton, which implies that t

236 ll-specific ablation of the Rag family small GTPases RagA and RagB impairs amino acid-induced mTORC1

237 ivities of multiple Ras and Rho family small GTPases, but how their activities are integrated and dif

238 ivation of actin regulators, including small GTPases Rac1, Cdc42 and Ras, in the presence or absence

239 )-like 4D (Arl4D), one of the Arf-like small GTPases, functions in the regulation of cell morphology,

240 suppresses the prenylation of multiple small GTPases in the Ras, Rho, and Rab families and inhibits E

241 mber of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is cr

242 The Ras superfamily of small GTPases are guanine-nucleotide-dependent switches essent

243 The members of the Rab family of small GTPases are molecular switches that regulate distinct st

244 The involvement of small GTPases in adipogenesis, however, has not been systemica

245 AS4A/KRAS4B comprise the RAS family of small GTPases that regulate signaling pathways controlling cel

246 members of the Ras and Rho families of small GTPases through membrane trafficking via regulation of t

247 ingly, overall a significant number of small GTPases were down-regulated during adipogenesis.

248 41 acts as a GAP for the ARF family of small GTPases.

249 RF (ADP-ribosylation factor) family of small GTPases.

250 may exert conformational control over small GTPases and may add another previously unrecognized laye

251 icking, activity of the Rab3 and Rab27 small GTPases, tumour necrosis factor-alpha (TNF-alpha)-induce

252 specificity for other closely-related small GTPases.

253 RM quantification results for selected small GTPases.

254 elling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleo

255 ut unsuccessful attempts to target the small GTPases directly have resulted in them being classed as

256 The small GTPases H, K, and NRAS are molecular switches indispensa

257 protein, it also colocalizes with the small GTPases Rab11 and Arf6, components of the exocytic pathw

258 the main downstream effector of these small GTPases.

259 Those small GTPases that are targeted by METTL3 and/or ALKBH5 also d

260 to target the currently "undruggable" small GTPases.

261 We considered that FliI interacts with small GTPases and their regulators to mediate assembly of cell

262 nases through direct interactions with small GTPases, including Rap1A and Ras.

263 pment by differentially regulating the small-GTPase RhoA and actin-associated protein Cortactin.

264 We identified the Rab-specific GTPase-activating protein (GAP) RN-tre as necessary for

265 cell morphology, support the hypothesis that GTPase signaling dynamics can generate the broad morphol

266 The GTPase SECRETORY4 (SEC4) positions the exocyst complex d

267 idance, and synaptogenesis by activating the GTPase RAC1 and modulating actin cytoskeleton remodeling

268 42, the G12V and Q61L mutations decrease the GTPase activity.

269 In eukaryotes, the GTPase eIF5B collaborates in the correct positioning of

270 iously unknown functional differences in the GTPase and stalk domains.

271 osomes carrying unique cargos, including the GTPase Rab11, generated in Rab11-positive recycling endo

272 a constitutively active Galpha, lacking the GTPase activity, produced plants with increased height,

273 , but is required for full activation of the GTPase and for efficient cell migration.

274 hondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase M

275 Furthermore, we identify an allele of the GTPase obgE that is synthetically sick in the absence of

276 man neutrophils as well as activation of the GTPase Rac2, both of which are downstream effects of P-R

277 ed by cell-type specific upregulation of the GTPase RhoA and its effector Rho-kinase.

278 5 and pH 7.5, which had little effect on the GTPase activity of PaFtsZ.

279 toylation cycle to couple to and promote the GTPase cycle of ARF6.

280 the architecture of LRRK2, showing that the GTPase and kinase are in close proximity, with the GTPas

281 and kinase are in close proximity, with the GTPase closer to the microtubule surface, whereas the ki

282 and myofibroblasts, HYAL2 interacts with the GTPase-signaling small molecule ras homolog family membe

283 g regulates the activity and mobility of the GTPases Rab5 and Rab11, which in turn determine the post

284 urine biosynthesis proteins but not with the GTPases.

285 y of heterotrimeric G proteins through their GTPase-accelerating protein (GAP) activity, which is con

286 expressing dominant negative forms of these GTPases, suggesting entry is independent of the conventi

287 ers its ability to bind to and activate this GTPase, leading to physiological effects.

288 SUMO3-interacting motif (SIM) in the TOC159 GTPase domain and a SUMO3 covalent SUMOylation site in t

289 l front reaches the rear, inducing transient GTPase oscillations and RhoA activity spikes.

290 BipA is a conserved translational GTPase of bacteria recently implicated in ribosome bioge

291 of ribosomal translation, the translational GTPase elongation factor Tu (EF-Tu) delivers a transfer

292 ausing that is resolved by the translational GTPase GTPBP2, and in its absence causes neuron death.

293 ision, the mechano-guanosine triphosphatase (GTPase) dynamin-related protein (Drp1) severs mitochondr

294 large set encoding guanosine triphosphatase (GTPase) of immunity-associated proteins (GIMAPs).

295 The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense

296 s by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthetic processes.

297 Rho guanosine triphosphatases (GTPases) are master regulators of cell shape and cell mo

298 These two GTPases can be observed to interact transiently on membr

299 , a multidomain [4Fe4S] cluster protein with GTPase activity.

300 n of purine nucleotide biosynthesis and with GTPases that control ribosome assembly or activity.