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1 bility in a wider range of Gram negative and Gram positive bacteria.
2     Its antibacterial activity is limited to gram positive bacteria.
3  covalently attached to the peptidoglycan of gram positive bacteria.
4 gulates the biosynthesis of phospholipids in Gram-positive bacteria.
5  sensitive and highly selective detection of Gram-positive bacteria.
6 en acquired by horizontal gene transfer from gram-positive bacteria.
7 c streptococci and is likely conserved among Gram-positive bacteria.
8 ss regulator Spx is ubiquitously found among Gram-positive bacteria.
9  secretion systems in many Gram-negative and Gram-positive bacteria.
10 tial target for evaluating antimicrobials in gram-positive bacteria.
11 omplementing the method's proven utility for Gram-positive bacteria.
12 ring elongation in rod-shaped and ovococcoid Gram-positive bacteria.
13  whose hosts are Bacillus cereus and related Gram-positive bacteria.
14 dable in vitro activity against a variety of Gram-positive bacteria.
15 oups by their hosts, either Gram-negative or Gram-positive bacteria.
16 xhibits potent antimicrobial effects against Gram-positive bacteria.
17 iscuous plasmids and their preference toward Gram-positive bacteria.
18 anding the biology of tectiviruses infecting Gram-positive bacteria.
19 hat displays nanomolar activity against many Gram-positive bacteria.
20 e opposite trend was observed in the case of Gram-positive bacteria.
21 vidin, recognizing almost none of the tested Gram-positive bacteria.
22 obal regulator of transcription in low G + C Gram-positive bacteria.
23 wn function that is well conserved in low-GC Gram-positive bacteria.
24 he CTC protein, a feature typical to various Gram-positive bacteria.
25 ive peptide/protein pairs we engineered from Gram-positive bacteria.
26 wn tropism of RNA bacteriophages may include gram-positive bacteria.
27 nificant antimicrobial effect, especially in gram-positive bacteria.
28 uses (bacteriophages) specifically infecting Gram-positive bacteria.
29 izes many types of PAMPs that originate from gram-positive bacteria.
30  peptides, and vulnerability to infection by Gram-positive bacteria.
31 epeat glycoproteins (SRRPs) are conserved in Gram-positive bacteria.
32 ich is linked to cell growth and division in Gram-positive bacteria.
33 , Staphylococci, and Streptococci, and other Gram-positive bacteria.
34 ates initiation of DNA replication in low-GC Gram-positive bacteria.
35  The most commonly identified organisms were gram-positive bacteria.
36 e pathway that produces phosphatidic acid in Gram-positive bacteria.
37 negative bacteria, but neither is present in Gram-positive bacteria.
38 gh which the stringent response functions in Gram-positive bacteria.
39 ossessed weak antibacterial activity against Gram-positive bacteria.
40  elements are now thought to occur widely in gram-positive bacteria.
41 elevant for the killing of Gram-negative and Gram-positive bacteria.
42 tic with rapid bactericidal activity against gram-positive bacteria.
43 yclic depsipeptide antibiotic active against Gram-positive bacteria.
44 , but they are ineffective against resistant gram-positive bacteria.
45 est basins displayed an increase in only the gram-positive bacteria.
46 nst fluoroquinolone resistant MRSA and other Gram-positive bacteria.
47  cell wall biosynthesis and pathogenicity in Gram-positive bacteria.
48 mids carrying antibiotic resistance genes in Gram-positive bacteria.
49 le is known about flagellin glycosylation in Gram-positive bacteria.
50 tibiotics, which inhibit the growth of other Gram-positive bacteria.
51 ins to the peptidoglycan of the cell wall of gram-positive bacteria.
52 used by staphylococci, enterococci and other Gram-positive bacteria.
53 y key roles in several cellular processes in Gram-positive bacteria.
54 nctionalize the peptidoglycan layers of many Gram-positive bacteria.
55 ed in PHPT homologues from Gram-negative and Gram-positive bacteria.
56 ons caused by Staphylococcus aureus or other Gram-positive bacteria.
57 ning a new mechanism of protein anchoring in Gram-positive bacteria.
58 h regulates many amino acid-related genes in Gram-positive bacteria.
59 s and is known to possess selectivity toward Gram-positive bacteria.
60 e essential for function and conserved among Gram-positive bacteria.
61 ) is an important cell wall polymer found in gram-positive bacteria.
62  broad scope of activities against different Gram-positive bacteria.
63 nent required for proper cell growth in many Gram-positive bacteria.
64 es level differentiation of the investigated Gram-positive bacteria.
65 copeptide with bactericidal activity against gram-positive bacteria.
66 enuate the inflammatory responses induced by Gram-positive bacteria.
67 crobial activity against S. aureus and other Gram-positive bacteria.
68 conditions and many preferentially targeting Gram-positive bacteria.
69 to catalyze both reactions of the process in Gram-positive bacteria.
70 and subsequent release of vesicular cargo in Gram-positive bacteria.
71 igenetic regulation of cellular functions in Gram-positive bacteria.
72 he virulence of numerous medically important Gram-positive bacteria.
73  determinants dispersed and maintained among Gram-positive bacteria.
74  fatty acid and phospholipid biosynthesis in Gram-positive bacteria.
75 stance determinants and adaptations in other Gram-positive bacteria.
76 r background for cultures with non-S. aureus Gram-positive bacteria.
77 ntimicrobial or quorum signaling peptides in Gram-positive bacteria.
78 EVs have now been described for a variety of Gram-positive bacteria.
79  interaction with the peptidoglycan layer of Gram-positive bacteria.
80 ues are late cell division proteins found in Gram-positive bacteria.
81  differentiate between viable and non-viable Gram-positive bacteria.
82 y and potency against both Gram-negative and Gram-positive bacteria.
83 th P. aeruginosa and other gram-negative and gram-positive bacteria.
84 nterococcus faecalis as a model organism for Gram-positive bacteria.
85 hibitory concentration (MIC) values] against Gram-positive bacteria.
86 e Au(I) complexes for both Gram-negative and Gram-positive bacteria.
87 f complex rhamnose-containing CWPSs in other Gram-positive bacteria.
88 ensor was highly efficient in the capture of Gram-positive bacteria.
89  functionally homologous to the WTA of other Gram-positive bacteria.
90 y both multidrug-resistant Gram-negative and Gram-positive bacteria(1).
91                   All bacteria detected were gram-positive bacteria (100%), most commonly: Staphyloco
92 fective drug target for resistant strains of Gram-positive bacteria.2 In addition, because sortase A
93 gulase-negative staphylococci not included): Gram-positive bacteria, 58%; Gram-negative bacteria, 78%
94             The most frequent pathogens were gram-positive bacteria (91.3%), including coagulase-nega
95 d in 70% of patients, with a predominance of Gram-positive bacteria (93%).
96                                           In Gram-positive bacteria, a subset of surface proteins rel
97                                 Furthermore, Gram-positive bacteria acutely activate Hippo-Yorkie sig
98     16S rRNA gene pyrosequencing showed that Gram-positive bacteria affiliated with the Firmicutes an
99 or of coproporphyrinogen oxidase (CgoX) from Gram-positive bacteria, an enzyme essential for heme bio
100                                      Most of Gram-positive bacteria anchor surface proteins to the pe
101 tase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many su
102 DnaD protein is essential in low G+C content gram positive bacteria and is involved in replication in
103  representative of monomeric RmlD enzymes in Gram-positive bacteria and a subset of Gram-negative bac
104  the formation of competence-induced pili in Gram-positive bacteria and corroborate the remarkable st
105 ignaling', exists in other Gram-negative and Gram-positive bacteria and displays species-specificity.
106 assays showed antimicrobial activity against Gram-positive bacteria and fission yeast.
107 n a synthetic community of Gram-negative and Gram-positive bacteria and fungi.
108 on-classically secreted effector proteins in Gram-positive bacteria and further inspire the developme
109 ibiotic activity (MIC = 15.6 mug/mL) against Gram-positive bacteria and growth reduction of Gram-nega
110 biosensors for in vivo metabolite imaging in Gram-positive bacteria and have validated the first dinu
111              Here, we characterized GPs from Gram-positive bacteria and heterokont algae acting on be
112  on the biogenesis and functions of EVs from Gram-positive bacteria and identify key areas for future
113 translocons, found in both gram-negative and gram-positive bacteria and in some archaea.
114  of gut microbiota with reduced abundance of gram-positive bacteria and increased abundance of gram-n
115 ancomycin, an antibiotic that acts mainly on gram-positive bacteria and is restricted to the gut, pot
116  is present in a subset of gram-negative and gram-positive bacteria and is the founding member of a n
117 ins are related to class IIa bacteriocins of Gram-positive bacteria and kill members of the Bacteroid
118 lecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-n
119 uld be used for the quantitative analysis of Gram-positive bacteria and might be applied potentially
120  youngest basins had increased abundances of gram-positive bacteria and saprotrophic fungi at higher
121 us of Zg16(-/-) animals had a higher load of Gram-positive bacteria and showed bacteria with higher m
122 rium spp. have demonstrated EV production in Gram-positive bacteria and shown the great importance EV
123 e reductase) protein family, is conserved in Gram-positive bacteria, and interacts with RNA polymeras
124                                           In Gram-positive bacteria, and particularly the Firmicutes,
125 gram-negative bacteria, lipoteichoic acid in gram-positive bacteria, and phospholipomannan in fungi.
126 isteria monocytogenes, as well as many other Gram-positive bacteria, and which highlights a more gene
127 protein family, which is spread widely among gram-positive bacteria; and suggests approaches to targe
128                                              Gram positive bacteria are the major contributor of bact
129                                              Gram-positive bacteria are decorated by a variety of pro
130                      Because the features of Gram-positive bacteria are fundamentally different relat
131                            EVs purified from Gram-positive bacteria are implicated in virulence, toxi
132                          Surface proteins in Gram-positive bacteria are incorporated into the cell wa
133 he serine-rich repeat (SRR) glycoproteins of Gram-positive bacteria are large, cell wall-anchored adh
134                                              Gram-positive bacteria are prominent members of plant-as
135             Many amino acid-related genes in Gram-positive bacteria are regulated by the T box ribosw
136   However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells posse
137 obacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protopo
138 anscription in innate immunity, and identify Gram-positive bacteria as extracellular stimuli of Hippo
139 A similar mechanism probably operates in the gram-positive bacteria as well, but these systems have b
140 ver, treated cattle had reduced abundance of gram-positive bacteria at the genus level.
141 nally, we discover aminoacyl-PGs not only in Gram-positive bacteria but also in Gram-negative C. jeju
142 none oxidoreductases (Sdh) are widespread in Gram-positive bacteria but little is known about the cat
143 n shows broad antibacterial activity against Gram-positive bacteria, but is also hemolytic and cytoto
144 ions and is evolutionarily conserved in many Gram-positive bacteria, but its function in M. tuberculo
145 a potent antibiotic against a broad range of Gram-positive bacteria, but its medical applications hav
146 er regulator of carbon source utilization in gram-positive bacteria, but the CcpA regulon remains ill
147 bumin (ALA) and oleic acid and kills several Gram-positive bacteria by a mechanism that bears resembl
148           It permeates the cell membranes of Gram-positive bacteria by binding to the cell wall precu
149                             A broad range of gram-positive bacteria cause serious infections in the c
150                                              Gram-positive bacteria cause the majority of skin and so
151                                              Gram-positive bacteria colonize mucosal tissues, withsta
152 al functions of specific compounds, and that Gram-positive bacteria considered to be obligate aerobes
153                             The cell wall of Gram-positive bacteria contains abundant surface-exposed
154                        The cell wall of most Gram-positive bacteria contains equal amounts of peptido
155                                         Many Gram-positive bacteria coordinate cellular processes by
156                                           In Gram-positive bacteria, CPS linkage is to either the cyt
157                        The virulence of many Gram-positive bacteria depends on cholesterol-dependent
158 th antibiotics that target Gram-negative and Gram-positive bacteria develop ameliorated psoriasiform
159  call NDA-1, contributes to the reduction of Gram-positive bacteria during early development and thus
160                                      In some gram-positive bacteria (e.g. Staphylococcus aureus), sor
161 ies have shown that ADEPs are active against Gram-positive bacteria (e.g., MRSA, VRE, PRSP (penicilli
162 itory concentration (MIC) was much lower for Gram positive bacteria (Enterococcus spp. and Staphyloco
163                             However, in many Gram-positive bacteria, especially in fermicutes, RNAP i
164 oronate chemistry allows potent labelling of Gram-positive bacteria even in the presence of 10% serum
165                                           In Gram-positive bacteria, extracellular protein appendages
166 amined PrsA proteins encoded by a variety of Gram-positive bacteria for functional complementation of
167 rgest inhibition zones were observed against Gram-positive bacteria for halloysite samples.
168 ased on self-assembly of vancomycin (Van) on Gram-positive bacteria for imaging bacterial infection.
169 doxin reductase, a protein essential in many Gram-positive bacteria for maintaining the thiol-redox b
170 nel to other methods of identification of 20 Gram-positive bacteria, four antimicrobial resistance ge
171 ficiently removes multiple Gram-negative and Gram-positive bacteria, fungi and endotoxins from whole
172                         The cell envelope of Gram-positive bacteria generally comprises two types of
173                                   Given that Gram-positive bacteria genomes encode a variety of sorta
174 ding Eukaryota, Homo sapiens, Viridiplantae, Gram-positive Bacteria, Gram-negative Bacteria and Virus
175 nd has broad-spectrum activity that includes gram-positive bacteria, gram-negative bacteria, anaerobe
176 numerous antibiotic resistance plasmids from Gram-positive bacteria, Gram-negative phage and the mobi
177                             The cell wall of Gram-positive bacteria has been shown to mediate environ
178 though riboflavin precursor derivatives from Gram-positive bacteria have been characterized, some lev
179 o differences in cell wall structure, EVs in Gram-positive bacteria have been disregarded for decades
180                                              Gram-positive bacteria have developed secretion systems
181              Nonetheless, Listeria and other Gram-positive bacteria have evolved an impressively dive
182                Regulators of PBP activity in Gram-positive bacteria have yet to be discovered but are
183                           The highest ranked Gram-positive bacteria (high priority) were vancomycin-r
184                              The presence of Gram-positive bacteria in foodstuffs is a chronic worldw
185 ndant in the smokers at baseline and so were Gram-positive bacteria in the non-smokers (P <0.01).
186  has been widely used to treat infections of Gram-positive bacteria including Clostridium difficile a
187  antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogen
188  cultures in patients with Gram-negative and Gram-positive bacteria, including 8/60 (13.3%) patients
189 found that auranofin is active against other Gram-positive bacteria, including Bacillus subtilis and
190  shown to play a role in the pathogenesis of Gram-positive bacteria, including E. faecium We previous
191 psin was bactericidal against a diversity of Gram-positive bacteria, including human pathogens such a
192                                              Gram-positive bacteria, including major clinical pathoge
193 aining domains are unexpectedly prevalent in Gram-positive bacteria, including many clinically releva
194 crobial activity against multidrug-resistant Gram-positive bacteria, including MRSA and VRE, rapid ti
195 robial agent; it performed well against many Gram-positive bacteria, including multidrug resistant st
196                  It has been found mainly in Gram-positive bacteria, including pathogenic bacteria li
197 hat rTCP96 aggregates both Gram-negative and Gram-positive bacteria, including Staphylococcus aureus
198 y used antibiotics against gram-negative and gram-positive bacteria, including Staphylococcus aureus,
199                                         Many Gram-positive bacteria, including the human pathogen Lis
200 loped to overcome the acquired resistance in Gram-positive bacteria, intrinsic resistance in Gram-neg
201 ial activity against model Gram negative and Gram positive bacteria is reported for selected compound
202 at cyclic-di-adenosine monophosphate in live Gram-positive bacteria is a vita-PAMP, engaging the inna
203             The peptidoglycan that surrounds Gram-positive bacteria is affixed with a range of macrom
204 c IgG booster responses to Gram-negative and Gram-positive bacteria is contained solely within the B
205   Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness
206                     Vancomycin resistance in Gram-positive bacteria is due to production of cell-wall
207                   Amino acid availability in Gram-positive bacteria is monitored by T-box riboswitche
208   However, iron-sulfur cluster biogenesis in Gram-positive bacteria is not so well characterized, and
209 or example, increasing drug resistance among gram-positive bacteria is responsible for approximately
210        Inflammation caused by infection with Gram-positive bacteria is typically initiated by interac
211      The mechanism of persister formation in Gram-positive bacteria is unknown.
212  that modulates QS in both Gram-negative and Gram-positive bacteria, is phosphorylated by LsrK, and t
213 d cell shape, and, in the case of pathogenic Gram-positive bacteria, it lies at the interface between
214             By contrast, Ntox28 domains from Gram-positive bacteria lack C-terminal Gly-Tyr-Gly-Ile m
215             Horizontal gene transfer between Gram-positive bacteria leads to a rapid spread of virule
216 -1'-enyl, 2-acyl phospholipids) in anaerobic Gram-positive bacteria led to studies on the physical ch
217                                              Gram-positive bacteria like Bacillus and phytopathogen R
218             Export of cell surface pilins in Gram-positive bacteria likely occurs by the translocatio
219  in mechanism of action on gram-negative and gram-positive bacteria may be less pronounced than forme
220 peptides when the flies were challenged with Gram-positive bacteria Micrococcus luteus In this settin
221                                        Among Gram-positive bacteria, mortality was highest for methic
222 tive bacteria (n = 210) outnumbered those by Gram-positive bacteria (n = 142).
223 t activity and antibacterial effects against Gram-positive bacteria, namely methicillin-susceptible S
224                  The O-acetylating enzyme in Gram-positive bacteria, O-acetyltransferase A (OatA), is
225 Pseudoalteromonas sp. strain CF6-2) can kill Gram-positive bacteria of diverse peptidoglycan (PG) che
226 sensitive and resistant Gram-negative and/or Gram-positive bacteria of new amphiphilic 3',4'-dialkyl
227                         In contrast to other Gram-positive bacteria, only one single sortase enzyme,
228 s no cross-reactivity with other mollicutes, Gram-positive bacteria, or Gram-negative bacteria.
229                                              Gram-positive bacteria, particularly coagulase-negative
230                                           In Gram-positive bacteria, PCATs function both as maturatio
231                                           In Gram-positive bacteria, peptidoglycan is tens of nanomet
232             The DnaB primosomal protein from Gram-positive bacteria plays a key role in DNA replicati
233                                  Most low GC Gram-positive bacteria possess an essential walKR two-co
234 enteen CRBSIs were recurrent; infection with gram-positive bacteria predicted recurrence.
235                                              Gram-positive bacteria process and release small peptide
236 here enhances our understanding of how other Gram-positive bacteria produce essential components of t
237                                         Many Gram-positive bacteria produce lantibiotics, genetically
238 role in CMP-pseudaminic acid biosynthesis in Gram-positive bacteria provides a foundation to investig
239 function are broadly conserved among diverse Gram-positive bacteria, PrsA2 exhibits unique specificit
240 ream biological effects of EVs released from gram-positive bacteria remain poorly characterized.
241                  Antimicrobial resistance in gram-positive bacteria remains a challenge in infectious
242                             Adhesive pili in Gram-positive bacteria represent a variety of extracellu
243 highest activities against Gram-negative and Gram-positive bacteria, respectively.
244  for half a century but the possibility that Gram-positive bacteria secrete extracellular vesicles (E
245 basis for formation of the 100S complexes in Gram-positive bacteria, shedding light on the mechanism
246                  Here we extend our study to Gram-positive bacteria showing that coupling game-theory
247 al strains, including both Gram-negative and Gram-positive bacteria, showing great potential for appl
248               In many Gram-negative and some Gram-positive bacteria, small regulatory RNAs (sRNAs) th
249 cond messenger predicted to be widespread in Gram-positive bacteria, some Gram-negative bacteria, and
250  rhinosinusitis (CRS) has been linked to the gram-positive bacteria Staphylococcus aureus (S. aureus)
251             They showed activity against two Gram-positive bacteria Staphylococcus aureus and Enteroc
252                           We have found that Gram-positive bacteria Staphylococcus aureus and Enteroc
253  found to specifically inhibit the growth of Gram-positive bacteria Staphylococcus aureus with MIC(50
254                                        Among Gram-positive bacteria, Staphylococcus aureus were predo
255 antibacterial properties, especially against Gram-positive bacteria such as S. aureus.
256  of complement by FH6-7/Fc on the surface of Gram-positive bacteria such as S. pyogenes will enable p
257                           Pheromones of many gram-positive bacteria, such as Bacillus and Streptococc
258 s exhibited antibacterial activities against gram-positive bacteria, such as Bacillus subtilis and St
259                                     In other gram-positive bacteria, such as Enterococcus faecalis, d
260 ied in multiple pilus gene clusters of other Gram-positive bacteria, suggesting that similar signalin
261                                              Gram-positive bacteria surround themselves with a thick
262 Nocardia exalbida, all the other 725 (99.7%) gram-positive bacteria tested were susceptible to vancom
263 acetic acid) inhibited all Gram-negative and Gram-positive bacteria tested.
264                 They are more active against Gram positive bacteria than Gram negative bacteria; howe
265 treptococcus agalactiae) are beta-hemolytic, Gram-positive bacteria that are common asymptomatic colo
266 ghput scRNA-seq method for Gram-negative and Gram-positive bacteria that can resolve heterogeneous tr
267  Streptococcus agalactiae are beta-hemolytic gram-positive bacteria that colonize the lower genital t
268 treptogramins(2), potent antibiotics against Gram-positive bacteria that inhibit the bacterial riboso
269 tein export systems in mycobacteria and many Gram-positive bacteria that mediate a broad range of fun
270 Bacilli are ubiquitous low G+C environmental Gram-positive bacteria that produce a wide assortment of
271  environmental conditions, including, within Gram-positive bacteria, the stressosome complex that reg
272 SCH-79797, that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting m
273 tibody-conjugated AuNPs can readily identify Gram-positive bacteria through antibody-antigen recognit
274 ncubated with agonists of TLR2 (receptor for gram-positive bacteria), TLR4 (receptor for gram-negativ
275 ns that mediate the attachment of pathogenic Gram-positive bacteria to host cells.
276 rticles (AuNP) modified with monoclonal anti-Gram-positive bacteria to produce an immune-sensor.
277  The more penetrable Zg16(-/-) mucus allowed Gram-positive bacteria to translocate to systemic tissue
278 activated platelets and mediates adhesion of Gram-positive bacteria to various host cells.
279                            Gram-negative and gram-positive bacteria use a variety of enzymatic pathwa
280                                              Gram-positive bacteria use reactive thioester-containing
281                 ZG16 bound to and aggregated Gram-positive bacteria via binding to the bacterial cell
282 ed molecular pattern (PAMP) of extracellular gram-positive bacteria, via ester hydrolysis.
283                                    Unique to Gram-positive bacteria, wall teichoic acids are anionic
284 vation (up to 95%) against Gram-negative and Gram-positive bacteria was observed when curcumin-functi
285         delta, a small protein found in most Gram-positive bacteria was, for a long time, thought to
286                            Gram-negative and Gram-positive bacteria were equally cultured.
287                                              Gram-positive bacteria were responsible for a high propo
288 tions in this study were caused by bacteria; Gram-positive bacteria were responsible for most cases.
289                                              Gram-positive bacteria were sensitive to vancomycin (27/
290 en between structurally similar molecules in gram-positive bacteria while also demonstrating the powe
291 nductance and renders it ineffective against Gram-positive bacteria while nevertheless enhancing its
292 a extracts were more effective in inhibiting Gram-positive bacteria while soybean extract exhibited s
293 oncentrations in different Gram-negative and Gram-positive bacteria, while its hemolytic activity rem
294  resistance seems to be universal across the Gram-positive bacteria, while the type of coselected tra
295 glycopolymers found on the cell wall of many Gram-positive bacteria, whose diverse surface structures
296                           Promysalin acts on Gram-positive bacteria with a mechanism of action involv
297 pound also has high antibacterial potency on Gram-positive bacteria with an MIC versus wild type S. a
298 gle-cell transcriptomes of Gram-negative and Gram-positive bacteria with high purity and low bias, wi
299 e bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria with host lipoprotein carriers in
300 edicine and nanotechnology.It is unclear how Gram-positive bacteria, with a thick cell wall, can rele

 
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