ライフサイエンスコーパス: Gran

1 y in regular (11 year) and recently reported grand (350-400 year) solar cycles caused by actions of t

2 , discrimination, shocking perseverance, and grand adventure.

3 sponsible for Mendelian disorders provides a grand and unprecedented opportunity for geneticists.

4 e classified into a Murre virus species; and Grand Arbaud virus, Precarious Point virus, and Manawa v

5 d to cover a wide range of hydrophobicities (grand average hydropathy (GRAVY) scores of -0.6 to 1.9).

6 The grand average of all the significantly correlated subtha

7 amino acid structures, isoelectric point and grand average of hydropathy (GRAVY) values of the 7 most

8 The grand-averaged difference in root mean squared voltage b

9 ca and the Bahamas (Abaco, Eleuthera, Exuma, Grand Bahama, Long Island and New Providence).

10 ranged from 0.989 in Long Island to 1.000 in Grand Bahama, with limited haplotype sharing observed am

11 Specifically, in the Labrador Sea/Grand Banks for populations from NA, 26% and 24% of vari

12 A case study was conducted on the Grand Banks of Newfoundland, Canada.

13 logical Guanche individuals originating from Gran Canaria and Tenerife.

14 exposed to the outfall of the Las Palmas de Gran Canaria wastewater treatment plant.

15 rs, here represented by two individuals from Gran Canaria.

16 bsent in the most recently colonized island, Gran Canaria.

17 Mg-metal batteries is investigated through a grand canonical density functional theory (DFT) approach

18 The grand canonical ensemble lies at the core of quantum and

19 d at an atomistic resolution within the semi-grand canonical ensemble using mutation moves to rapidly

20 nt to that of a lattice gas of bosons in the grand canonical ensemble; bromine doping introduces diso

21 ed physiological concentration, although the grand canonical free energy profiles are uphill for HTT

22 et was allowed to fluctuate via the use of a Grand Canonical Monte Carlo (GCMC) methodology.

23 Grand canonical Monte Carlo (GCMC) simulation provides m

24 d vapor adsorption experiments together with Grand Canonical Monte Carlo (GCMC) simulations, and coul

25 uantum mechanics (QM)-based force fields and grand canonical Monte Carlo (GCMC) simulations.

26 ntal observations are consistent with ReaxFF grand canonical Monte Carlo (ReaxFF-GCMC) calculations,

27 equate sampling of Mg(2+) ion binding with a grand canonical Monte Carlo MD method.

28 Enabled by a new grand canonical Monte Carlo method for membrane simulati

29 Grand canonical Monte Carlo simulation reveals that not

30 of 26.7 kJ/mol, which was validated through grand canonical Monte Carlo simulation studies of CH4 ad

31 tical and methodological developments to the grand canonical Monte Carlo simulation technique.

32 Grand canonical Monte Carlo simulations agree that ultra

33 Grand canonical Monte Carlo simulations and single compo

34 CO(2)/H(2)O gas mixtures were determined by grand canonical Monte Carlo simulations at temperature/p

35 hotoelectron spectroscopy, and complementary grand canonical Monte Carlo simulations coupled to a tig

36 Extensive grand canonical Monte Carlo simulations in combination w

37 Grand canonical Monte Carlo simulations of defective can

38 The study starts with grand canonical Monte Carlo simulations on a suite of 10

39 e filling of one site compared to the other: grand canonical Monte Carlo simulations support these ex

40 f Cs migration in partially saturated clays, Grand Canonical Monte Carlo simulations were applied to

41 Grand canonical Monte Carlo simulations were carried out

42 diffraction, density functional theory, and grand canonical Monte Carlo simulations, we show that in

43 area was estimated to be 422 m(2) g(-1) from grand canonical Monte Carlo simulations.

44 combined with oscillating chemical potential Grand Canonical Monte Carlo/molecular dynamics simulatio

45 dynamics and oscillating chemical potential grand canonical Monte Carlo/molecular dynamics to invest

46 Here, we apply the recently developed grand canonical potential kinetics (GCP-K) formulation o

47 In this article we make use of a grand canonical screening approach recently proposed to

48 tion of surface spectroscopic techniques and grand-canonical electronic-structure calculations in ord

49 Using grand-canonical electronic-structure calculations, we di

50 osition pathways of LiBH4 nanoclusters using grand-canonical free-energy minimization based on total

51 nic structure methods and characterized with Grand-canonical Monte Carlo simulations for methane upta

52 and U measured in periphyton from springs in Grand Canyon (United States) and were compared to U conc

53 w paleocanyon that was carved in the eastern Grand Canyon 25 to 15 million years ago (Ma), negating t

54 consistent with a 5 to 6 Ma age for western Grand Canyon and Marble Canyon.

55 Projected temperature for the Grand Canyon area, however, is expected to rise by as mu

56 (4)He/(3)He thermochronometry data from the Grand Canyon basement that tightly constrain the near-su

57 that geological observations do not require Grand Canyon carving coeval with Colorado River integrat

58 Flowers and Farley propose that the Grand Canyon is 70 million years old.

59 Similar data for the western Grand Canyon provide evidence that it was excavated to w

60 Groundwater is a critical resource in the Grand Canyon region, supplying nearly all water needs fo

61 d precipitation and temperature data for the Grand Canyon region.

62 nterior-basin deposits near the mouth of the Grand Canyon show that no paleocanyon existed in that ar

63 at hundreds of spring locations in and near Grand Canyon supports important ecosystems in this mostl

64 hronometry to propose that the western paleo-Grand Canyon was nearly as deep 70 million years ago (Ma

65 ions from Arizona and Utah, separated by the Grand Canyon, to dissect genetic variation controlling V

66 tarkly contrasting models for the age of the Grand Canyon-70 versus 6 million years-can be reconciled

67 s that H3K27me3-marked large DNA methylation grand canyons represent a set of very-long-range loops a

68 ge (>7.3 kb) DNA methylation nadirs (termed "grand canyons") can form long loops connecting anchor lo

69 rovisioned at Stingray City Sandbar (SCS) in Grand Cayman have altered diel activity patterns and dec

70 by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidopsis MED13) are required for

71 t decisions by agricultural companies in the Gran Chaco and Chiquitano, a region that has become the

72 single- or few-layered nanosheets remains a grand challenge and becomes the bottleneck to essential

73 he ecosystem services they provide present a grand challenge and major opportunity as we direct our r

74 rically functionalized polyoxometalates is a grand challenge as it could lead to new molecular nanoma

75 The grand challenge before us is to sustainably meet humanit

76 sic microbiology and medicine, but remains a grand challenge due to the fact that many species adopt

77 hanging climate and dwindling resources is a grand challenge facing mankind.

78 tanding of human intelligence is perhaps the grand challenge for 21st-century science, with broad imp

79 synthesizability of inorganic materials is a grand challenge for accelerating their discovery using c

80 knowledge across the Tree of Life remains a grand challenge for biodiversity science.

81 eural circuits through network training is a grand challenge for biomedicine and engineering applicat

82 neered and industrial environments remains a grand challenge for geomicrobiology.

83 Rebuilding marine life represents a doable Grand Challenge for humanity, an ethical obligation and

84 cules that target allosteric sites remains a grand challenge for ligand discovery.

85 the neural correlates of consciousness is a grand challenge for neuroscience.

86 rochemical window in solid electrolytes is a grand challenge for the synthesis of battery materials.

87 ing the combination of these properties is a grand challenge for the synthesis of sulfide-based solid

88 This grand challenge has mostly proved ineffective because of

89 er in response to environmental stimuli is a grand challenge in active materials, structures, and rob

90 reserving 3D context, represents an enduring grand challenge in biology.

91 enome of an organism into its phenotype is a grand challenge in biology.

92 proteins from first principles represents a grand challenge in chemistry and structural biology.

93 pologies at the molecular level represents a grand challenge in chemistry.

94 tatistics in complex nonlinear systems are a grand challenge in climate, material, and neuroscience a

95 -correlation functionals has long remained a grand challenge in density functional theory (DFT), as i

96 dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction.

97 A grand challenge in material science is to understand the

98 anostructures and identical composition is a grand challenge in materials chemistry.

99 A grand challenge in materials research is to understand c

100 has been developed to address the number one grand challenge in metabolomics, which is the large-scal

101 specific functions, diseases and traits is a grand challenge in modern genetics.

102 stable multidimensional solitary waves is a grand challenge in modern science.

103 s of metastable inorganic solids, which is a grand challenge in solid-state chemistry, requires the d

104 tionship to solid-state phase formation is a grand challenge in synthesis science.

105 n from large-scale functional data sets is a grand challenge in systems biology.

106 The grand challenge in the development of atomically dispers

107 It remains a grand challenge in the field of chemistry to synthesize

108 A grand challenge is to develop a general cancer screening

109 Modern chemistry's grand challenge is to significantly improve catalysts fo

110 It is currently a grand challenge of chemistry, materials science, and eng

111 In silico catalyst design is a grand challenge of chemistry.

112 ell as climate atmosphere ocean science is a grand challenge of contemporary science with important s

113 us providing instrumental technology for the grand challenge of engineering N2-fixing cereals.

114 n as a complementary solution to address the Grand Challenge of global food security and environmenta

115 oxo clusters and related materials remains a grand challenge of inorganic chemistry.

116 Cities will play a key role in the grand challenge of nourishing a growing global populatio

117 stly arising from feed production, is thus a grand challenge of sustainability science.

118 A grand challenge of systems biology is to predict the kin

119 liquids, and offering the potential to solve grand challenge problems.

120 A grand challenge that crosses synthetic chemistry and bio

121 veloped a new microgel array to address this grand challenge through robotic printing of complex stem

122 It is a grand challenge to develop a truly effective medication

123 izer use and loss to the environment poses a grand challenge to farmers and society, and necessitates

124 However, it has been a grand challenge to maintain the viability, functionality

125 It remains a grand challenge to replace platinum group metal (PGM) ca

126 A grand challenge to solve a large-scale linear inverse pr

127 mising their crystalline superiority holds a grand challenge to unveil their pristine electrocatalyti

128 Desikan-Killiany-Tourville, and MICCAI 2012 Grand Challenge).

129 Control of these complex systems is a grand challenge, for example, in mitigating the effects

130 Princeton University Health Grand Challenge, US National Institutes of Health (NIH),

131 efficient Z-scheme photocatalysts remains a grand challenge.

132 films at submicrometer resolution presents a grand challenge.

133 t unite all lineages (the tree of life) is a grand challenge.

134 edict such representative features remains a grand challenge.

135 round of the D3R (Drug Design Data Resource) Grand Challenge.

136 and their ecological determinants remains a grand challenge.

137 ever, in silico vaccine prediction remains a grand challenge.

138 trocatalysts at the atomic level, which is a grand challenge.

139 choose, an aspiration of the Dial-a-Molecule Grand Challenge.

140 roton-exchange-membrane fuel cells remains a grand challenge.

141 and fabricate biological machines remains a grand challenge.

142 Protein structure prediction is a grand challenge.

143 uld accelerate progress toward meeting this "grand challenge."

144 rrelated quantum matter with applications in grand-challenge problems.

145 Special attention will be paid to the grand-challenge related to detection, quantification and

146 which can offer some solutions to society's grand challenges associated with sustainability and ener

147 Grand Challenges Canada (Government of Canada), Saving B

148 Grand Challenges Canada (Saving Brains).

149 Bill & Melinda Gates Foundation, Grand Challenges Canada, and the UK Medical Research Cou

150 Grand Challenges Canada, Bill & Melinda Gates Foundation

151 Grand Challenges Canada, Bill & Melinda Gates Foundation

152 Grand Challenges Canada, the Bill & Melinda Gates Founda

153 Bill & Melinda Gates Foundation, Grand Challenges Canada, UK Medical Research Council.

154 National Institutes of Health, Grand Challenges Canada.

155 MQ Transforming Mental Health and Grand Challenges Canada.

156 Canadian Institutes of Health Research; Grand Challenges Canada; Ontario SPOR Support Unit and t

157 ment to define this conversion as one of the Grand Challenges for Biology in the 21st Century.

158 eading their functional implications present grand challenges for plant biology.

159 anel of leading experts, reflecting a set of grand challenges for spatial lifecourse epidemiology in

160 om microbial single cells is one of the last grand challenges in (bio)analytical chemistry.

161 One of the grand challenges in chemistry has been to directly obser

162 Gene expression prediction is one of the grand challenges in computational biology.

163 One of the grand challenges in contemporary chemical biology is the

164 One of the grand challenges in contemporary systems chemistry resea

165 Grand challenges in global change research and environme

166 Health (as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative).

167 reservoir of enzymes that could help address grand challenges in human health, energy, and sustainabi

168 mbination of enabling features to tackle the grand challenges in pressure- and tactile-sensing applic

169 tocatalyts for water splitting is one of the grand challenges in solar energy conversion.

170 gene expression profiles has been one of the grand challenges in systems biology.

171 this field of research and its relevance to grand challenges in the treatment of neurological disord

172 One of the grand challenges of biophysical chemistry is to understa

173 g major needs of the society, especially the grand challenges of energy, health, and environment.

174 The four grand challenges of imaging research-increasing evidence

175 nt-efficient crops are a solution to the two grand challenges of modern agriculture: improving food s

176 mate molecular building blocks is one of the grand challenges of our time.

177 cular profile datasets represents one of the grand challenges of Systems Biology.

178 yploidy toward confronting interdisciplinary grand challenges of the 21(st) century.

179 US National Institutes of Health, Princeton Grand Challenges Program.

180 Future directions and grand challenges to realize these goals are highlighted

181 ine three interdependent, cross-disciplinary grand challenges underpinning this research endeavor.

182 We then examine several environmental "grand challenges" and discuss how urban land teleconnect

183 r conclusions, we present our choice of the "grand challenges" for the preservation and sharing of ch

184 One of the remaining "grand challenges" in chemistry is the development of a n

185 verse group of international experts on the 'grand challenges' in small-molecule drug discovery with

186 Related grand challenges, including shape sensing, finding, and

187 insufficient selectivity and activity remain grand challenges.

188 Human Development and Saving Lives at Birth Grand Challenges.

189 e social dynamics prevent the formation of a grand coalition and therefore full cooperation.

190 ch's Storm-petrel (Hydrobates leucorhous) on Grand Colombier Island in the St.

191 As part of the "Grand Convergence: Aligning Technologies and Realities i

192 One of the grand current research challenges is to improve the ener

193 r minimum) occurred before the current super-grand cycle start.

194 These grand cycle variations are probed by alpha - Omega dynam

195 with a period of 1950 +/- 95 years (a super-grand cycle) are discovered by applying a running averag

196 leads to beating effects responsible for the grand cycles (350-400 years) superimposed on a standard

197 kward for 800 years reveals the two 350-year grand cycles superimposed on 22 year-cycles with the fea

198 r the next millennium predicts further three grand cycles with the closest grand minimum occurring in

199 aternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communic

200 affect fertility of resulting daughters and grand-daughters.

201 up in longevity gains, and avoid a so-called grand divergence in health and longevity.

202 9 level of Sima del Elefante, level TD6.2 of Gran Dolina (H. antecessor) and Sima de los Huesos.

203 Gran Dolina is a cavity infilled by at least 25 m of Ple

204 n the teeth of the Sima del Elefante-TE9 and Gran Dolina-TD6 Atapuerca hominins (1.2-0.8 million year

205 When construction of the Grand Ethiopian Renaissance Dam (GERD) is completed, the

206 Unraveling the grand evolution from nonscalable to scalable optical pro

207 Here, we investigate the grand evolution of the optical properties by comparing t

208 Islands provide the venue of one of nature's grand experiments in evolution.

209 Cassini's Grand Finale orbits provided for the first time in-situ

210 dering at the mesoscopic scale are among the grand fundamental science challenges.

211 he dissolved phases, were collected from the Grand, Kalamazoo, Saint Joseph, and Lower Fox rivers and

212 les from five Lake Michigan tributaries [the Grand, Kalamazoo, St. Joseph, and Lower Fox Rivers, and

213 tic Canada's largest freshwater wetland, the Grand Lake Meadows (GLM) and the associated Saint John/W

214 Epilepsy with grand mal on awakening (EGMA) is a well-defined subtype

215 N2O, and NH3 from a 2006 model year Mercury Grand Marquis flexible fuel vehicle (FFV) operating on E

216 Exposure to low-protein grand-maternal diet leads to decreased ovarian reserve a

217 We used self-reported grand-maternal gestational weight gain, diet, physical a

218 The inverse associations between grand-maternal lifestyle and BMI in grandchildren were m

219 The inverse associations of grand-maternal lifestyle with BMI of offspring were not

220 e with BMI of offspring were not modified by grand-maternal pre-pregnancy BMI, grandchild age, or gra

221 ification is successful in increasing yield (grand mean + 20.3%), but it also results in a loss of sp

222 CP without protein or leucine ingestion, the grand mean +/- SEM plasma 3-HIB concentration decreased

223 We calculated a grand mean for individual seafood items, based on report

224 Farmed fish generally had lower grand mean Hg concentrations than their wild counterpart

225 sirable direction for 98% of variables and a grand mean of [Formula: see text] (SD = 0.13), indicativ

226 /MU was stable but with yield lower than the grand mean.

227 performance (0.21 fewer cognitive errors at grand-mean-centered age 70 years) than those with low ac

228 rom 35 +/- 2 to 14 +/- 1 micromol/L) and the grand median [quartiles] FGF21 concentration increased (

229 ting total solar irradiance estimates during grand minima.

230 further three grand cycles with the closest grand minimum occurring in the forthcoming cycles 26-27

231 e next three decades (2019-2055) to a Modern grand minimum similar to Maunder one.

232 The most recent "grand minimum" of solar activity, the Maunder minimum (M

233 in the cerebral cortex, cerebellum, parotid grand, myocardium, and bowel mostly reflected the (18)F-

234 two dessert bananas of commercial interest (Grand Nain and Gros Michel), alongside a newly created h

235 Cavendish', 'Giant Cavendish', 'Dwarf Red', 'Grand Nain', 'Eilon', 'Gruesa', 'Silver', 'Ricasa', 'Wil

236 "This grand natural scene was a physical correlate of Francis'

237 These results from Gran Negro were compared with those of Brancellao and Mo

238 witchable fluorescent proteins (PS-FPs) open grand new opportunities in biological imaging.

239 males switching to invest in their existing (grand)offspring, thereby increasing their inclusive fitn

240 metabolic dysfunctions in the offspring and grand-offspring of injected males and affects the sperm

241 nd-offspring, and F3 transgenerational great-grand-offspring were observed.

242 ncreases in pathologies in the F2 generation grand-offspring, and F3 transgenerational great-grand-of

243 cts from the National Heart, Lung, and Blood Grand Opportunity Exome Sequencing Project.

244 ed by the 1000 Genomes Project and the NHLBI Grand Opportunity Exome Sequencing Project.

245 rameters on million-year time scales induce "grand orbital cycles," but the behavior and the paleoenv

246 Immunomedics, Amgen, Canceropole Grand Ouest, the GOELAMS/LYSA group and the French Natio

247 al monitoring program carried out within the Gran Paradiso National Park (GPNP, Italy).

248 ansfer of information, such as the effect of grand parental smoking or exposure to other toxic compou

249 rate and interactive effects of parental and grand-parental ages at breeding on descendants' mortalit

250 e breeding age effects were not modulated by grand-parental larval diet quality or competitive enviro

251 esigned three-stranded coiled coils (TRI and Grand peptides formed using a heptad repeat approach), w

252 to convey a sense that one need not have a "grand plan" to have a successful life in science.

253 f tissue engineering has not full-filled its grand potential of engineering such combinatorial scaffo

254 m 36 patients spanning nine counties and the Grand Princess cruise ship.

255 Cultivars Iceberg and Grand Rapids that were released in the 18th and 19th cen

256 regulate seed germination in photosensitive 'Grand Rapids' lettuce (Lactuca sativa), we investigated

257 stance at this locus originate from cultivar Grand Rapids.

258 rement of single cell secretions have become grand research barriers.

259 loyed in wastewater-dominated reaches of the Grand River (Kitchener, ON) to verify their feasibility

260 h across an urban environment in the central Grand River watershed (Ontario, Canada).

261 ature, land use and surficial geology in the Grand River, Canada, a seventh-order river in an agricul

262 have been reported for several years in the Grand River, in southern Ontario, Canada, in close proxi

263 uscaloosa, Weyburn-Midale, Bass Islands, and Grand Ronde carbon sequestration geologic formations.

264 In this Grand Round we describe a 2-year-old child from the USA

265 In this Grand Round we review the clinical features, epidemiolog

266 In this Grand Round, we present a dramatic case of cutaneous spo

267 In this Grand Round, we present the case of a previously healthy

268 In this Grand Round, we present the case of an otherwise healthy

269 In this Grand Round, we report a case of a 20-year-old active du

270 In this Grand Round, we report eight HIV-negative refugees, who

271 In this Grand Round, we review the clinical features of hypervir

272 In this Grand Round, we review the clinical features, epidemiolo

273 In this Grand Round, we review the clinical features, epidemiolo

274 ere presented during a virtual ophthalmology grand rounds and discussed with the director of clinical

275 This Grand Rounds review describes the evaluation and evidenc

276 The Oncology Grand Rounds series is designed to place original report

277 The Oncology Grand Rounds series is designed to place original report

278 This Grand Rounds summarizes the factors to consider when cou

279 In this Grand Rounds, 2 prominent clinicians debate whether to i

280 In this Grand Rounds, 2 prominent endocrinologists debate the is

281 In this Grand Rounds, the guideline is reviewed and an expert di

282 In this grand rounds, we focus on development, validation, and a

283 In this Neurology Grand Rounds, we use transcranial magnetic stimulation a

284 Residents of Bocozel or Grand Saline who were eligible for the vaccination campa

285 ysics (LUNA) of the Laboratori Nazionali del Gran Sasso (Italy)(8,9).

286 +/- 0.51 D vs 2.03 +/- 1.03 D, P < .001) and Grand Seiko (0.46 +/- 0.45 D vs 0.99 +/- 1.0 D, P < .001

287 e oscillations is found to coincide with the grand solar minimum (the Maunder minimum) occurred befor

288 Grand stability challenges exist when PGM catalyst loadi

289 ations in the hypothalamus-pituitary-adrenal grand stress.

290 ortality displacement, which is the ratio of grand sum deficit to grand sum excess mortality, decreas

291 , which is the ratio of grand sum deficit to grand sum excess mortality, decreased as a function of e

292 Ultimately, this grand synthesis should improve predictive capability of

293 s within both the classical scenario and the Grand Tack scenario of terrestrial planet formation, and

294 tive method, the best estimate of the global grand total is roughly 200 extinctions.

295 ome at physiological pH, this resulting in a grand total of 1151 gene products identified after the c

296 A grand unified model (GUM) is developed to achieve fundam

297 onopoles resulting from symmetry breaking in grand unified theories.

298 Clark argues that predictive coding offers a Grand Unified Theory (GUT) of brain function.

299 oach to evolutionary biology, in lieu of any grand unified theory updated to include microbial genomi

300 cal control agents, these results expand the grand view of the diversity of mycoviruses and provide p