ライフサイエンスコーパス: H chain

1 t Ig miniloci encoding the nurse shark omega H chain.

2 layed a preference for binding to HLA-C free H chain.

3 the cell surface in association with the BCR H chain.

4 aGal that carry two copies of the knocked in H chain.

5 cript levels of CXCL13, IgG H chain, and IgM H chain.

6 d, and their modifications were localized to H chain.

7 e: All B cells start out with a 56R anti-DNA H chain.

8 VJ whose products may not associate with the H chain.

9 cts residues in the alpha2 domain of one B27 H chain.

10 ery rare alpha helix in its third CDR of the H chain.

11 neutralizing or modifying DNA binding of the H chain.

12 ycosylation site, except for the CDR3 of the H chain.

13 in the intracellular tail of the HLA class I H chain.

14 patient, and thus ferritin consists only of H chains.

15 or LILRB2 than HLA class I heterotrimers and H chains.

16 1 L chains could only do so with full-length H chains.

17 OVA into the C terminus of anti-receptor Ab H chains.

18 pha1, alpha2, and alpha3 domains of both B27 H chains.

19 nti-DNA binding when expressed with anti-DNA H chains.

20 nd canine lens fiber cell L-chains and human H-chains.

21 nces far greater than the length of a single HS chain.

22 model, two FGFs and two FGFRs bind a single HS chain.

23 ructure and distribution of domains along an HS chain.

24 hat can be located at any position within an HS chain.

25 co-receptors require sulfated domains in the HS chains.

26 well as difficulties in separating isomeric HS chains.

27 d on specific structural features within the HS chains.

28 egree of sulfation that were internal to the HS chains.

29 pendent of the sulfation pattern of the bulk HS chains.

30 the highest binding affinity toward isolated HS chains.

31 of HSPG function by removing 6S from intact HS chains.

32 factor/cytokine binding and signaling by its HS chains.

33 om glucosamine in highly sulfated regions of HS chains.

34 n by binding IAPP via their heparan sulfate (HS) chains.

35 ctors and receptors through heparan sulfate (HS) chains.

36 populations were identified by neurofilament H-chain 200, I-B(4) isolectin (IB4), or tropomyosin rece

37 CD98 H chain (4F2 Ag, Slc3a2) was discovered as a lymphocyte-

38 The increased Sdc2 HS chains 6-O sulfation is driven by a specific N-termin

39 a, which is similar in size to L (60-69) and H chain (70-79) CRS.

40 igher proportion expresses the nontransgenic H chain allele.

41 Rearrangements on both H chain alleles exhibit junctional diversity consistent

42 t limit the contribution of B cells with Dmu H chain alleles to the repertoire.

43 B cells exhibit V(D)J rearrangements on both H chain alleles, yet allelic exclusion is tightly mainta

44 Overall, the BCR H chain alone is sufficient to identify clonal relations

45 c reticulum by Ii binding to either the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin comp

46 We then apply this method to Ab H chain amplicons to sequence the first, to our knowledg

47 AICDA- and POL eta-mediated mutations, 1470 H chain and 1313 kappa- and lambda-chain rearrangements

48 e alpha1/alpha2/alpha3 domains of the H2D(d) H chain and beta(2)-microglobulin (beta2m) and is the fu

49 ress single copies of the unrearranged human H chain and L chain Ig gene loci.

50 ock-in mice carrying functionally rearranged H chain and L chain variable region genes isolated from

51 Ig transgenic mice that express the VH186.2 H chain and recognize a common foreign Ag (the hapten 4-

52 ridomas are clones that have inactivated the H chain and secrete only L chains.

53 election for productive rearrangements in Ig H chains and also by cultivation studies.

54 lum before exiting in association with MHC-I H chains and beta2-microglobulin as a trimolecular compl

55 chains could associate with both full-length H chains and Dmu, whereas secretion-incompetent lambda1

56 unction of B27 FHC dimers with other class I H chains and identified contact residues in KIR3DL2.

57 ritin from cataractous lenses contained more H-chain and bound 11-fold more iron than ferritin from n

58 Da) differed from the 21-kDa standard canine H-chain and from the 12-kDa modified H-chain present in

59 fferences in the characteristics of ferritin H-chain and its distribution in canine cataractous lense

60 FGF and one FGFR bind to the free end of the HS chain and dimerization require these ends to join, br

61 Finally, P. aeruginosa bound to HS chains and N-glycans coated on plastic surfaces, show

62 rminal domain increases 6-O sulfation of its HS chains and promotes Sdc2-VEGFA(165)-VEGFR2 complex fo

63 elated with transcript levels of CXCL13, IgG H chain, and IgM H chain.

64 a peptidic linker to the N terminus of mAb1 H chain, and paired mutations at the CH1-CL interface mA

65 eric antibodies and unique functional heavy (H)-chain antibodies (HCAbs).

66 Developmental processes leading to H chain antibody expression are unknown.

67 Human MHC class I H chains are encoded by the HLA-A, HLA-B, and HLA-C gene

68 tion, or by enforced expression of the SMB19 H chain as a transgene, results in significant protectio

69 his inference usually relies on only the BCR H chain, as most current protocols do not preserve H:L c

70 an antibody that recognizes heparan sulfate (HS) chains attached to multiple HSPGs without diminishin

71 red BCR datasets, we assessed the ability of H chain-based clonal clustering to identify clones.

72 ersely, L chains were insufficient to refine H chain-based clonal clusters.

73 ing to either the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin complex and appeared to be

74 facilitated an early step in the assembly of H chain-beta(2)m heterodimers, for which tapasin-ERp57 o

75 e symmetric FGF2-HS2-FGFR2 model, two acidic HS chains bind in a basic canyon located on the top face

76 of the unfolded protein response, including H chain binding protein (BiP; GRP78), C/Ebp homologous p

77 onitor IgG Abs, fluoresceinated IgG constant H chain-binding polyclonal F(ab')2 (IgHPolyFab) is used

78 0-kDa IgY comprised of two differently sized H chains bound to L chains and apparently often noncoval

79 njury factors through their heparan sulfate (HS) chains, but the importance of HSPGs in liver injury

80 tion, they exchange the gene encoding the Ig H chain C region by class switch recombination (CSR).

81 Using a transgene of the entire H chain C region locus, we demonstrate in this study tha

82 rAbs with a dockerin domain fused to the rAb H chain C terminus are efficiently secreted by mammalian

83 a H chain genes in a transgene of the entire H chain C-region locus.

84 H chain cDNA libraries were constructed from the RNA der

85 was achieved through mutations in the third H chain CDR (HCDR3) that conferred a markedly faster on-

86 H chain CDR sequences bore numerous replacement mutation

87 tic categorical selection of CDR-3 of the Ig H chain (CDR-H3) content in peritoneal cavity (PerC) B c

88 ition of the perinatal liver CDR-3 of the Ig H chain (CDR-H3) repertoire is marked by a paucity of N

89 naturally occurring somatic mutations in the H chain CDR2 region that conferred a markedly prolonged

90 lly activated B cell clones bear hydrophobic H chain CDR3s (HCDR3s) and are disseminated to most lymp

91 Nucleotide sequencing of H chain CDR3s of DEX-specific plasmablasts, sorted posti

92 hose activated by cytokines that regulate Ig H chain class switching to IgE.

93 The immunoglobulin heavy (H) chain class switch is mediated by a deletional recomb

94 elatively high arginine (Arg) content in the H chain complementarity determining region (H3), suggest

95 unit residues 46-53 of murine H-2L(d) MHC-I H chain, complexed with mAb 64-3-7, demonstrates solvent

96 ntigenic peptide, beta(2)-microglobulin, and H chain connected by flexible linkers.

97 onformational changes occur in a loop in the H chain constant domain.

98 regions, each of which is associated with a H chain constant region gene.

99 ation using a transgene of the entire murine H chain constant region locus.

100 sgenic lines, germline transcription of some H chain constant regions genes is severely impaired.

101 timulation with R-spondin and its binding to HS chains decorating syndecan-1 are indispensable for op

102 r HS polymerization, we demonstrate that the HS chains decorating syndecan-1 mediate aberrant Wnt pat

103 ed, and suggest the presence of intermediate H chain-deficient PLCs.

104 Disulfide-dependent B27 H chain dimers and multimers are stronger ligands for LI

105 hypothesis that additional levels of somatic H chain diversification may exist.

106 The truncated/V(H)-less mouse H chain Dmu forms precursor B cell receptors with the su

107 olecules (i.e., appropriate HLA alpha1alpha2 H chain domains fused with a mouse alpha3 domain and cov

108 However, the physiologic role of H chain editing (V(H) replacement and rearrangement on t

109 H chain editing is shown to involve VH replacement at th

110 In the process of immunoglobulin heavy (H) chain editing, these secondary rearrangements are med

111 two unmodified L chain subunits and a single H chain ending in glycine, but the second H chain termin

112 The human H chains expressed with these L chains also have relativ

113 ice, consistent with central deletion of 2F5 H chain-expressing B cells.

114 Because Igmu H chain expression was decreased in Emu-deficient pre-B

115 gene in a variant cell line lacking Emicro, H chain expression was lost, and interactions between V(

116 ior cavity of a genetically engineered human H-chain ferritin (HFn).

117 Overexpression of human H-chain ferritin (HuHF) is known to impart a degree of p

118 ic ferritins and instead resembles an animal H-chain ferritin center.

119 Three fluorescence variants of human H-chain ferritin were prepared in which Trp34 was introd

120 mposed of 24 subunits of two types, ferritin H chain (FHC) and ferritin L chain (FLC).

121 ly to HLA-B27 (B27) beta2-microglobulin free H chain (FHC) dimers than other HLA-class I molecules re

122 (beta2m) and peptide and (beta2m free) free H chain (FHC) forms including B27 dimers (termed B27(2))

123 reveals that L363 depends on both the L and H chains for binding to the glycolipid-mCD1d complex, al

124 The binding sites on HS chains form non-random, heterogeneous networks.

125 reB and lambda5 proteins, together with Igmu-H chains, form precursor BCRs (preBCRs).

126 a2-microglobulin-associated B27 and B27 free H chain forms (FHC), including disulfide-bonded H chain

127 I, whereas LILRB2 bound both folded and free H chain forms.

128 A mAb directed to TbKHC1, an orphan kinesin H chain from Trypanosoma brucei, inhibited T. musculi ex

129 H chains from these misclustered clones contained more d

130 this study, we generate KI models expressing H chains from two other HIV-1 Abs, 4E10 (another self-/p

131 heme oxygenase-1 (HMOX1; HO-1) and ferritin H chain (FTH) via a mechanism that involves the transcri

132 The IgM H chain gene organization of cartilaginous fishes consis

133 s for a brief period following successful Ig H chain gene rearrangement.

134 both truncated transgenes express the micro H chain gene well, they undergo very low or undetectable

135 lasma cells (AxJ) that express the identical H chain gene whose RNA is processed in different ways.

136 of its C-terminal domain (CTD) on the IgG2a H chain gene, comparing two mouse cell lines representin

137 ts works poorly in the context of the gamma1 H chain gene, resulting in expression of gamma1 H chains

138 used the VH3-09 (or closely related VH3-20) H chain gene, whereas no PF anti-matDsg1 used these gene

139 f the secreted form of the IgH mRNA from the H chain gene.

140 uction in class switch recombination for all H chain genes and the varied reduction in germline trans

141 ecial roles for some 3' enhancers; different H chain genes are affected by different 3' enhancer dele

142 reduction in germline transcription for some H chain genes could be caused by (i) insertion site effe

143 nd I exons for the murine gamma1 and gamma2a H chain genes in a transgene of the entire H chain C-reg

144 The chromosomal distribution of H chain genes in an Ig genotype can be inferred through

145 we name "initiator B cells." Analysis of BCR H chain genes isolated from these cells revealed evidenc

146 ombination and germline transcription of all H chain genes.

147 matosus, using the autoreactive germline D42 H chain (glD42H) site-directed transgenic NZB/W mouse.

148 In contrast, the conserved MHC class I H chain glycan played a minor role in CRT recruitment in

149 2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine residue at its no

150 ent and usage of the endogenous, nontargeted H chain (HC) allele.

151 surface expression was coincident with MHC-I H chain (HC) expression and was downregulated upon pertu

152 R signaling (BCR) because ablation of either H chain (HC) expression or BCR signaling causes B cells

153 bunit Igalpha or the VDJ segment of the IgH (H chain [HC]).

154 hain forms (FHC), including disulfide-bonded H chain homodimers (termed B27(2)).

155 The H-chain identified in cataractous fiber cells (29 kDa) d

156 xpressing the inherently autoreactive VH4-34 H chain (identified by the 9G4 mAb) and 9G4(+) plasma Ig

157 A series of control elements within the Ig H chain (Igh) locus has been implicated in regulating th

158 B cells produce Ig H chain (IgH) mRNA and protein, primarily of the membran

159 b repertoires, amplicons are created from Ab H chain (IgH) transcripts and sequenced on a high-throug

160 cell expression of CD32B or CD32C, and IgG1 H chain (IGHG1) and kappa-chain (IGKC) polymorphisms det

161 ance of arginines in CDR3 of the Ig variable H chain (IgVH).

162 saminoglycans, specifically heparan sulfate (HS) chains immobilized onto magnetic nanoparticles.

163 als, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is

164 ance triggered by self-reactivity of the 2F5 H chain impedes BnAb induction.

165 Deletion of CD98 H chain in B cells leads to complete failure of B cell p

166 Using a biomarker to track a self-reactive H chain in peripheral blood, we found evidence of simila

167 is prevented by chaperone association of the H chain in the endoplasmic reticulum.

168 The higher content of H-chain in assembled ferritin allows this molecule to se

169 The H-chain in both species was truncated, and its concentra

170 In addition, the accumulation of H-chain in deeper fiber layers of the lens may be part o

171 yndecan-4 acts as a receptor for TG2 via its HS chains in two ways: by increasing TG2-cell surface tr

172 This suggests that additional H chain information could be leveraged to refine clonal

173 he asymmetric FGF2-HS1-FGFR2 model, a single HS chain interacts with the FGF2-FGFR2 protein complex t

174 Sequence analysis of the third CDR of the H chain intervals obtained by PCR amplification of V(H)

175 nto the PLC, but impacted the recruitment of H chains into the PLC, and glycan-deficient H chains wer

176 The ferroxidase activity of the ferritin H chain is critical to store iron in its Fe3+ oxidation

177 The capacity to class switch the Ig H chain is critical to the effectiveness of humoral immu

178 The selection of Ab H chains is difficult to study because of the large dive

179 6-O-sulfation (6S) of glucosamine within HS chains is critical for many of these ligand interacti

180 Interaction of heparanase with HS chains is regulated by specific substrate sulfation s

181 rinization and selection of a strain-matched H chain isotype are critical to generate ideal surrogate

182 TA-1-based surrogate Abs with a murine IgG2c H chain isotype were created.

183 zation of its classical Ig gene content (two H chain isotypes, mu and omega, and four L chain isotype

184 exploiting two targeted IgH transgenic mice (H chain knock-in [HKI]) that produce large numbers of fo

185 tional H chain rearrangements in an anti-DNA H chain knock-in mouse, B6.56R.

186 Induction of cGVH in anti-DNA H chain knockin (3H9KI) transgenic mice results in speci

187 rease in "double-producers," suggesting that H chain/L chain combinations with superior signaling pro

188 n level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA(165) binding

189 ther demonstrate that heparanase cleavage of HS chains leads to increased ability to support FGF2-dep

190 he potential randomization of cognate heavy (H) chain/light (L) chain pairing, which could occur to a

191 t attenuation of IL-7R signaling returns the H chain loci to an inaccessible state; this process has

192 usage of the endogenous (i.e., nontargeted) H chain locus and evidence of vigorous L chain editing;

193 ic model, we report here that editing at the H chain locus appears to occur exclusively in bone marro

194 Breaks in switch regions of the H chain locus cause isotype switching and have been exte

195 ore how the underlying genetic makeup of the H chain locus influences the formation of particular DJ

196 the same recombinatorial machinery, but the H chain locus is accessible at the pro-B cell stage, whe

197 cated at the most distal 3' region of the Ig H chain locus, has multiple regulatory functions that co

198 hat happen to successfully rearrange another H chain may be favored in the periphery.

199 lpha and gamma mRNAs made up the majority of H chain mRNAs in the adventitia.

200 The most highly sulfated regions of HS chains, N-sulfated (NS) domains, play prominent roles

201 ansgenic mouse expresses a transgene-encoded H chain of an anti-DNA Ab.

202 Therefore, Abs to the H chain of HLA-E may be responsible for some of the HLA-

203 The H chain of L363 features residue Trp-104, which mimics t

204 The H chain of these homodimeric antibodies consists of one

205 interaction is specifically mediated by the HS chains of perlecan.

206 Heparanase promotes tumor growth by cleaving HS chains of proteoglycan and releasing HS-bound angioge

207 -glomerulus via binding to heparan sulphate (HS) chains of proteoglycans and co-associated with synde

208 The heparan sulfate (HS) chains of proteoglycans are a key regulatory compone

209 roglobulin reduced the expression of class I H chain on the cancer targets by >97%, but it did not re

210 lved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with

211 This variable domain of an H chain-only Ab (VHH or nanobody) significantly inhibite

212 ized H and L chains, with exceptions such as H chain-only Abs in camels or natural Ag receptors in sh

213 he formation of fully functional and diverse H chain-only antibodies in L(-/-) animals.

214 t the immature B cell stage, produce diverse H chain-only antibodies in serum.

215 with viral epitopes generates high affinity H chain-only antibodies, which, because of their smaller

216 bination, which facilitate the generation of H chain-only Ig-secreting plasma cells.

217 The generation of H chain-only IgG is caused by the loss of constant (C) g

218 acking clonotypes of anti-insulin B cells in H chain-only VH125Tg/NOD mice showed that BTK-dependent

219 eens were largely composed of the transgenic H chain paired with a spectrum of L chains, predominantl

220 xamined the molecular characteristics of the H chain portion of the Ag receptor.

221 canine H-chain and from the 12-kDa modified H-chain present in fiber cells of noncataractous lenses.

222 transcription factor Bright up-regulates Ig H chain production from select V region promoters and re

223 The accumulation of Ig gamma H chain protein was also diminished, but unexpectedly th

224 It is unclear if additional rounds of H chain rearrangement are driven by BCR specificity.

225 ese findings favor a single, early window of H chain rearrangement in B6.56R that precedes the expres

226 e manner in which B cells undergo additional H chain rearrangements in an anti-DNA H chain knock-in m

227 asin enhance beta(2)m and MHC class I heavy (H) chain recruitment to the PLC, with the ERp57 binding

228 Without combinatorial events, the shark IgM H chain repertoire is based on junctional diversity and,

229 This editing mechanism acts on the natural H chain repertoire; endogenous H chains with anti-DNA fe

230 They also have a simplified heavy (H) chain repertoire: All B cells start out with a 56R an

231 Light (L) chains that edit anti-DNA heavy (H) chains rescue B-cell development by suppressing DNA b

232 Remarkably, the H chain sequences isolated from individual lipogranuloma

233 how Sle2(z) impacts B cell tolerance, two Ig H chain site-directed transgenes, 3H9 and 56R, with spec

234 anscriptional level as opposed to effects on H chain stability.

235 The individual light (L) and heavy (H) chain subunits from the main and basic peaks were ana

236 ctivation-induced cytidine deaminase, clonal H chain switch, and an inverted lambda/kappa ratio of Ig

237 FHsiRNA decreased ferritin H-chain synthesis, but doubled ferritin L-chain synthesi

238 le H chain ending in glycine, but the second H chain terminated in lysine for one isoform and alpha-a

239 hain gene, resulting in expression of gamma1 H chains that is <1% the wild-type level.

240 in three prominent CR regions (CRR) on L and H chains that overlap but do not coincide with Ab CDR.

241 endogenous heparan sulfate proteoglycan with HS chains that is critical for junctional complex assemb

242 ertoire, which uses a short third CDR of the H chain, the anti-DEX response relies more intensely on

243 endent and correlate with positively charged H chain third CDR.

244 erential expansion of clones bearing certain H chain third complementary region (HCDR3) lengths.

245 sing most progenitor B cells expressing this H chain to be eliminated at the pre-B cell checkpoint.

246 erated mAb against Treml4 and engineered its H chain to express three different Ags (i.e., OVA, HIV G

247 disulfide-linked complexes and bring the mu H chain to the cell surface as part of the BCR but is in

248 g(H) transcription (Bright), up-regulates Ig H chain transcription 3- to 7-fold in activated B cells

249 elated with a reduction in mRNA encoding the H chain transcription factor, OBF-1/BOB-1/OCA-B.

250 Ig L and H chain transcription increased significantly, and heavy

251 The decrease in H chain transcripts correlated with a reduction in mRNA

252 rize the maturation of the repertoire of IgA H chain transcripts in circulating blood B cells during

253 CR, we amplified, cloned, and sequenced IgG4 H chain transcripts of PBMCs from 10 children with aller

254 of 60 wk, somatic mutation frequency of IgA H chain transcripts reached 25% of the adult values but

255 We found that IgA H chain transcripts were present in cord blood as early

256 Thus, naturally occurring H chain transcripts without C(H)1 (V(H)DJ(H)-hinge-C(H)2

257 , which, through alternative RNA splicing of H chain transcripts, begins to be coexpressed with IgM a

258 E, but also reduce IgE(+) B cell numbers and H chain transcripts.

259 mice bearing the autoreactive site-directed H chain transgene 3H9.

260 as revealed in mice expressing a targeted Ig H chain transgene encoding BCRs with "multireactivity" f

261 BL/6 (B6) controls, each expressing the AM14 H chain transgene in the presence or absence of the IgG2

262 56R/56R mice that possessed the 56R anti-DNA H chain transgene inserted into both HC loci.

263 Introduction of an anti-insulin BCR H chain transgene restores diabetes in btk-deficient NOD

264 ralizes or alters self-reactivity of the 56R H chain transgene.

265 of NOD mice was restricted using a fixed Ig H chain transgene.

266 We isolated two lines of mice in which the H chain transgenes were truncated at their 3' ends.

267 We addressed this question using a H chain transgenic (Tg) mouse model that lacks secreted

268 as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-a

269 Immunization of young TC.AM14 H chain transgenic mice with IgG2a(a) anti-chromatin imm

270 r of unselected mutations, we immunized B1-8 H chain transgenic mice with nitrophenyl to stimulate ni

271 iting frequencies of DNA Abs in the 3H9H/56R H chain transgenic mice, but the level of IgG2a anti-DNA

272 In site-directed anti-dsDNA H chain transgenic mice, loss of VprBP function in B cel

273 ficient to break B cell tolerance in V(H)3H9 H chain transgenic mice.

274 Using the anti-DNA H chain-transgenic mouse, 56R, we find that B cells with

275 the D-glucosamine residue in an immobilized HS chain using D-glucosaminyl 3-O-sulfotransferase.

276 somatic hypermutation (ac-Nglycs) within Ig H chain V region (IGHV) genes as alternative selective p

277 is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequence

278 To study the selection of individual Ab H chain V region genes (V(H)), we performed CDR3 spectra

279 Analysis of the rearranged H chain V region genes of mAbs isolated from seven of th

280 ras, we demonstrate the dominant role of the H chain V region in TSHR recognition.

281 urally occurring somatic mutations in the Ab H chain V region of Fab19, a well-described neutralizing

282 time in blood, in the case of B-CLL with Ig H chain V region-unmutated BCR and <30% CD38(+) cells in

283 sis of B-1a, B-1b, and B-2 cell IgH V region H chain (V(H)) genes revealed increased usage of V(H)11

284 d more diverse variable gene segments of the H chain (V(H)) use in both the young and aged mice as co

285 P1 HA-elicited mAbs were encoded by distinct H chain variable and L chain variable gene segment rearr

286 n the pathogenesis of OA, we analyzed the Ig H chain variable region (V(H)) genes of B cells recovere

287 The degradation of ferritin H-chain was blocked by both siRNAs, whereas only FHsiRNA

288 Histologic analysis revealed that the H-chain was distributed differently throughout cataracto

289 H chains into the PLC, and glycan-deficient H chains were impaired for tapasin-independent and tapas

290 In addition, HS chains were shown to contain significantly increased

291 residue capping the non-reducing end of the HS chain, where no further degradation can occur in the

292 me uptake was specifically inhibited by free HS chains, whereas closely related chondroitin sulfate h

293 on sugar residues along the heparan sulfate (HS) chain which results in a structural heterogeneity th

294 etory delta transcript resulted in two delta-H chains, which incorporated Cmu1 and variable domains.

295 n the natural H chain repertoire; endogenous H chains with anti-DNA features are expressed primarily

296 he human repertoire, and if so, do they edit H chains with anti-DNA signatures?

297 layed unique features in the third CDR of Ig H chains with minor alterations along the immunization c

298 osed primarily of NS domains internal to the HS chain with minor presence of non-reducing end (NRE) N

299 peeling reaction that specifically degrades HS chains with 3-O-sulfated glucosamine at the reducing-

300 antagonist surfen, and enzymatic removal of HS chains with heparinase III treatment as well as by si