ライフサイエンスコーパス: HLH domain

1 kk1 kinase activity but does not require the HLH domain.

2 hey encode share homology primarily in their HLH domain.

3 nce the in vivo conformation of the adjacent HLH domain.

4 brogated by deletion of 51 aa within the TEL HLH domain.

5 FIGLA binding to the TCF3 helix-loop-helix (HLH) domain.

6 d region of TEL termed the helix-loop-helix (HLH) domain.

7 ection comprising a unique helix-loop-helix (HLH) domain.

8 two functional domains: a helix-loop-helix (HLH) domain (also known as pointed domain) located at th

9 ed isoforms of the IKKalpha mRNA lacking its HLH domain and both its LZip and HLH domains, respective

10 cluster residing immediately adjacent to the HLH domain and of the serines in the NEMO/IKKgamma-bindi

11 lation of the serine cluster adjacent to the HLH domain and phosphorylation of the NBD/gammaBD.

12 C9 physically interacts with TEL through the HLH domain and that the interaction leads to modulation

13 4a but not p19/ARF promoter activity via its HLH domain, and that Id1 inhibits transcriptional activa

14 he evolution of HLH genes, the structures of HLH domains, and the elaborate activities of HLH protein

15 regulated by heterodimerization through the HLH domain, as a result of formation of functional or no

16 ents such heterodimeric interactions via the HLH domain between bHLH and bHLHZip proteins.

17 am target activation is linked to the XNgnr1 HLH domain, demonstrating a novel role for this domain i

18 The HLH domain dictates dimerization to create homo- and het

19 eucine383>leucine (I383>L) in helix 2 of the HLH domain, extends the LZ domain from four to five hept

20 dissociate a DNA recognition function of the HLH domain from its role in protein dimerization.

21 LH domain provides further evidence that the HLH domain, highly conserved among ETS family members, i

22 In contrast to the conventional HLH-HLH domain interaction formed in the MyoD/E12 heterodime

23 studies have indicated that the well defined HLH domain is both necessary and sufficient for dimeriza

24 The HLH domain is involved in protein-protein interaction wi

25 icted to represent a null allele because the HLH domain is missing and the reading frame for the prot

26 Helix 1 of the Mash1 HLH domain is necessary for Mash1 to be able to promote

27 The HLH domain is necessary for the transactivation activity

28 igomerization of TEL-ABL mediated by the TEL HLH domain is required for tyrosine kinase activation, c

29 The helix-loop-helix (HLH) domain is employed by many transcription factors th

30 of Ets proteins through the highly conserved HLH domain may represent a previously unrecognized pheno

31 Smad3 physically interacted with the HLH domain of MyoD, and this interaction correlated with

32 meras containing the b domain of ato and the HLH domain of sc also induced ch organ formation, but to

33 Chimeric proteins containing the HLH domain of SREBP-1 and the leucine zipper from either

34 Interaction mapping showed that the basic-HLH domain of TAL1 was both necessary and sufficient for

35 Mutational analyses showed that the HLH domain of TAL1 was necessary and sufficient for its

36 Transformation of Ba/F3 cells required the HLH domain of TEL and the kinase activity of the PDGF be

37 DGF beta R self-association, mediated by the HLH domain of TEL, would lead to constitutive activation

38 at UBC9 binds to TEL exclusively through the HLH domain of TEL.

39 Previously, we demonstrated that the HLH domain of the class II basic HLH (bHLH) protein SCL/

40 Both the C-terminal and HLH domains of Dermo-1 were essential for its repression

41 TEL/PDGF beta R that is dependent on the TEL HLH domain provides further evidence that the HLH domain

42 Deletion of the ID2 HLH domain rendered ID2 ineffective at inhibiting CLOCK-

43 ies just carboxyl-terminal to helix 2 of the HLH domain, represents the most highly conserved region

44 lacking its HLH domain and both its LZip and HLH domains, respectively.

45 s depend on target and DBD contexts, such as HLH domains that can act as either activators or repress

46 and sufficient to convert a muscle-specific HLH domain to one able to rescue hematopoiesis.

47 nus of TEL, containing the helix-loop-helix (HLH) domain, to the transmembrane and cytoplasmic domain

48 oss-linking the protomers at the intersected HLH domain via engineered disulfide bonds.

49 A mutant Id2 protein lacking the HLH domain was not capable of suppressing myogenin-media

50 While the MyoD HLH domain without the basic domain failed to interact w