ライフサイエンスコーパス: His

1 His account of rationalism, in turn, relies on an overly

2 His affiliation is Center for Molecular Medicine, Maine

3 His AFP normalized after surgery.

4 His best corrected visual acuity markedly improved from

5 His body mass index (BMI) is 33.9 and his blood pressure

6 His brain activity, eye movements and hand/foot movement

7 His bundle pacing (HBP) may also improve clinical outcom

8 His bundle pacing (HBP) remains technically challenging

9 His bundle pacing (HBP) results in physiological ventric

10 His bundle pacing corrected wide QRS in 54% of all patie

11 His career spanned almost five decades, resulting in mor

12 His characterization of habits includes two components:

13 His cytomegalovirus was multi-drug resistant, and was tr

14 His earliest surviving anatomical drawings (circa 1485-9

15 His GI symptoms and anemia improved on a multiple-food-e

16 His hair was sparse and coarse.

17 His head circumference was below the third percentile, a

18 His IAIHG and simplified score was compatible with defin

19 His inflammatory parameters were normal, as were his hep

20 His intraocular pressure was normal.

21 His laboratory is focused on understanding the role play

22 His medical history included basal cell carcinoma, rheum

23 His medical history was unremarkable.

24 His metabolic profile was normal.

25 His neuropathology was extensive and involved the medial

26 His past medical history included recurrent gallstone ch

27 His preoperative Disabilities of the Arm, Shoulder, and

28 His profound legacy on targeted therapy and cancer resea

29 His published and private scientific writings are entire

30 His relationship was only apparent in eyes with central

31 His relevant medical history included a hospital admissi

32 His respiratory symptoms resolved but the diarrhea persi

33 His right eye had a normal anterior segment and a thin r

34 His skin prick tests were positive, with a result of 2+t

35 His small-bowel obstruction was managed conservatively o

36 His teaching and research focus on how algorithms can ai

37 His temperature was 37 degrees C, heart rate was 78/min,

38 His visual acuity subsequently declined due to progressi

39 His willing donor (female, aged 53 y) with a Living Kidn

40 His words and message that day have continued to resonat

41 His work is focused on understanding pathogen recognitio

42 His work reflects the emergence of the modern scientific

43 His, Lys, Arg, or Pro residues prohibit cleavage when fo

44 His-1084 did not improve A2ML1's protease inhibition at

45 His-CATB entry was tracked by intracellular flow cytomet

46 exa-coordinated hemes with His/Lys (heme 1), His/Cys (heme 2), and two His/His ligations (hemes 3 and

47 in MPE: Asp(33), His(35), Asp(78), Asn(112), His(124), His(146), and His(158) A swath of positive sur

48 d trigonal bipyramid geometry with His(117), His(257), Asp(116), Asn(216), and a water/hydroxide as l

49 p(33), His(35), Asp(78), Asn(112), His(124), His(146), and His(158) A swath of positive surface poten

50 e also found that residues Glu-179, His-175, His-202, and Glu-276 are directly involved in the coordi

51 We also found that residues Glu-179, His-175, His-202, and Glu-276 are directly involved in t

52 ree conserved amino acid residues (Cys-1865, His-1955, and Asp-1975).

53 tagged intracellular domain of Neuroligin-2 (His-cytNL2) were prepared on hydrophobically functionali

54 to the proximal histidine (His134) of the 2-His-1-carboxylate facial triad, instead of assuming the

55 se to an additional Cys axial ligand at 20K (His/Cys coordination).

56 r residues at this site (Arg(301), Gly(304), His(307), and Met(369)) enable potent activation of the

57 tions in four active-site residues, Phe-316, His-583, Tyr-766, and His-767.

58 s the enzymic metal ligands in MPE: Asp(33), His(35), Asp(78), Asn(112), His(124), His(146), and His(

59 We provide tools to insert 3xHA, His(6)FLAG, His(6)-Biotin-TEV-RGSHis(6), mCherry, GFP, a

60 r pS(T) However, the betaA-betaB loop Asn-55-His and Lys-57-Ser substitutions in the pS3-subunit impr

61 C-S bond cleavage and indicate that Arg-56, His-123, and Cys-364 are critical SufS residues in this

62 ino acid 44; additional escape mutants had a His-to-Arg mutation at amino acid 44 or a duplication of

63 ily adapted to detect any other protein if a His-tag recombinant protein is available.

64 and PmoF1 binds additional Cu(II) ions in a His-rich extension to its PCu(A)C domain.

65 ulations and enzyme assays show the use of a His-Ser dyad to catalyze either elimination or hydrolysi

66 an inverting mechanism, EnvSia156 reveals a His/Asp active center in which the His acts as a Bronste

67 Labeling protein A with a His-tag that binds 5-nm Ni-nanogold allowed cryo-EM tomo

68 as a stammer insert, directly adjacent to a (His)(3) metal binding site alters catalytic activity.

69 h unique cleavage specificity (cutting after His) that coordinates immune responses in the caterpilla

70 of histidine residues at alpha-His-20, alpha-His-50, and beta-His-2 to aspartate were significantly d

71 of conversion of histidine residues at alpha-His-20, alpha-His-50, and beta-His-2 to aspartate were s

72 on of histidine to hydroxyaspartate at alpha-His-50 and beta-His-2 is also significantly higher in or

73 sual catalytic dyad composed of Cys(145) and His(41) residues.

74 , Asp(78), Asn(112), His(124), His(146), and His(158) A swath of positive surface potential on either

75 wo highly conserved histidines, His(232) and His(237) We found that different mutagenic perturbations

76 atalytic site residues Lys-249, Arg-270, and His-271 resulted in activity loss.

77 n the C-linker-CNBD (Glu(478), Gln(482), and His(559)) that form direct interactions with residues Ar

78 ite residues, Phe-316, His-583, Tyr-766, and His-767.

79 cal basis for the selection of Lys, Arg, and His over other cationic amino acids for incorporation in

80 and hemodynamic effects of LVs with BiV and His bundle (HB) pacing in CRT patients.

81 dated it by mutation of coordinating Cys and His residues, revealing that a triad of residues (R48C,

82 ioventricular septum was mapped via EAM, and His bundle (HB) electrograms, selective, and nonselectiv

83 vel amyloid formed by interdigitated Gln and His residue side chains belonging to the prion-like doma

84 Pulldown assays with purified GST-l-PGDS and His(6)-Rab4 indicated that both proteins interact direct

85 rd protonation), low pH (acidic residues and His protonated), and highly acidic environments in which

86 in the negatively charged thiolate state and His(41) is doubly protonated and positively charged, ins

87 ely form covalent adducts with Lys, Tyr, and His residues, given that these agents were cell permeabl

88 to form covalent adducts with Lys, Tyr, and His residues.

89 We found that Asp-30 of WW1 and His-75 of WW2 interact through a hydrogen bond and, toge

90 The reporter anti-His antibodies, which were modified with primers that in

91 proteins relies on immunoblotting with anti-His antibodies.

92 154-apoA-IV Lys-149, and apoA-II Lys-30-apoE His-227.

93 y DEPC in addition to other residues such as His, Lys, and Cys, providing very good structural resolu

94 onal challenge is programming the system, as His bundle pacing may have specific configurations and r

95 ntibodies with unmutated Ala-Val-Tyr and Asn-His-Ser motifs, which recognize both erythrocyte I/i sel

96 mbrane proteins that possess a catalytic Asp-His-His-Cys cysteine-rich domain (DHHC-CRD).

97 BsPdaC retains the conserved Asp-His-His metal-binding triad characteristic of CE4 enzyme

98 cylated at a site defined by a conserved Asp-His-His-Cys motif.

99 The residue H75 defines a cross-protomer Asp-His-Trp triad, which potentially serves as a pH-dependen

100 ate depolarizations in the atrioventricular (His)-bundle associated with lethal ventricular arrhythmi

101 ve recombinant histidine-tagged cathepsin B (His-CATB).

102 to hydroxyaspartate at alpha-His-50 and beta-His-2 is also significantly higher in oral cancer patien

103 dues at alpha-His-20, alpha-His-50, and beta-His-2 to aspartate were significantly decreased.

104 vealed that the extents of oxidation at beta-His-77 and beta-Asp-99 of globin were significantly elev

105 2% of that of GH-WT and that dimeric GH-C53S-His has no significant bioactivity in cell proliferation

106 ctivity requires direct binding between CAIV-His-88 and a charged amino acid in the extracellular dom

107 (HK) containing a phosphorylatable catalytic His with phosphotransfer and phosphatase activities over

108 A conserved His residue, His(114), is hydrogen-bonded to the Zn(II)-

109 hairpin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s)

110 binding is mediated by the highly conserved His-88 residue in CAIV, which is also the central residu

111 Furthermore, mutation of the conserved His(151) abolished the pH dependence of RIPK1 activation

112 of ASIC1 that includes the highly conserved 'His-Gly' (HG) motif.

113 At pH 7, in contrast, His residues are predominantly neutral, and the Q/H segm

114 lock), which was most amenable to corrective His bundle pacing by recruitment of latent Purkinje fibe

115 a highly active cysteine-lipase having a Cys-His-Asp catalytic triad and additional mutations W104V/A

116 s a part of the characteristic catalytic Cys-His-Asp triad of Cys proteases.

117 conserved residues from CTD and the His-Cys-His (HCH) motif from the N-terminal segment of the neigh

118 a naturally-occurring contracted Cys-Lys-Cys-His (CKCH) heme-binding motif, which is encoded in the h

119 model results with calculations on mutant D1-His-198-Ala and D2-His-197-Ala RCs, our simulated absorp

120 calculations on mutant D1-His-198-Ala and D2-His-197-Ala RCs, our simulated absorption-difference spe

121 icipation of AP in tachycardia by delivering His-synchronous premature ventricular contractions that

122 g the Cys-aldimine for Calpha deprotonation, His-123 acts to protonate the Ala-enamine intermediate,

123 and GLP-1 action at the GLP-1R, whereas des-His(1)-[Glu(9)]glucagon antagonized glucagon action at t

124 hen testing Ex(9-39) in combination with des-His(1)-[Glu(9)]glucagon in INS-1 832/13 cells, we valida

125 uorescently labeled chelator heads to detect His-tagged proteins in PAGE and blot membranes.

126 High-output pacing at the distal His location delivered PHCs.

127 selective responses of the system to diverse His-tag-labeled proteins further demonstrate the potenti

128 the ones with a protonable side chain, i.e., His, Asp, and Glu, were able to mediate electron transfe

129 We expressed His-tagged hGH variants in the cytoplasm of genetically

130 We provide tools to insert 3xHA, His(6)FLAG, His(6)-Biotin-TEV-RGSHis(6), mCherry, GFP, and the auxin

131 oil with two independent and highly flexible His tails.

132 re a general base substitution of an Asp for His preserves both the structure and activity as a gener

133 onstrate that post-run staining is ideal for His-tag detection by metal ion-loaded and fluorescently

134 protein is consistent with a three- or four-His geometry.

135 sdA, Heme 2 reduction triggers a switch from His/Lys ligation (E(m) , -129 mV) to His/Met (E(m) , +26

136 Furthermore, His(100) and Asp(171) were preferential affinity sites f

137 -1 2H phosphoesterase activity, we generated His-to-Ala variants and examined their ability to negati

138 hich combines the selectivity of the Gly-Gly-His (GGH) peptide probe with the sensitivity of the elec

139 e missense variant rs147647315 (R (Arg) > H (His)) as the sole causal variant.

140 In C. jejuni, TsdA Heme 2 has His/Met ligation and an E(m) of +172 mV.

141 The active site Heme 1 in both enzymes has His/Cys ligation in the ferric and ferrous states and th

142 TF2 and TF6 are tagged with a hexahistidine (His(6)) for ease of purification.

143 common reason for performing LBBP was a high His-Bundle pacing threshold (n=23) at implant.

144 , which permits identification of histidine (His), arginine (Arg), lysine (Lys), aspartate (Asp), glu

145 phase peptide synthesis (SPPS) of histidine (His)- and human influenza hemagglutinin (HA)-tags.

146 M2 channel also contains a second histidine (His), H27, equidistant from the gating tryptophan, which

147 (lysine, Lys; arginine, Arg; and histidine, His), along with nonproteinaceous analogs of Lys harbori

148 6b contains two highly conserved histidines, His(232) and His(237) We found that different mutagenic

149 ucts of apoA-I His-165-apoA-I Lys-93, apoA-I His-154-apoA-I Lys-105, apoA-I His-154-apoA-IV Lys-149,

150 ys-93, apoA-I His-154-apoA-I Lys-105, apoA-I His-154-apoA-IV Lys-149, and apoA-II Lys-30-apoE His-227

151 mice, including cross-link adducts of apoA-I His-165-apoA-I Lys-93, apoA-I His-154-apoA-I Lys-105, ap

152 lpha-ketoglutarate-dependent enzymes (IbetaH(His)) hydroxylates histidyl residues with l-threo stereo

153 itical residue of the dimer-dimer interface, His-110, altered the tetramer dissociation profile by in

154 onditioned media differentially internalized His-CATB, dependent on the HIV replication levels.

155 Neurons internalized His-CATB, an effect that was partially decreased by pre-

156 ogonal magnetic orbitals on the cross-linked His residue.

157 The mean His lead fluoroscopy time was significantly lower in gro

158 Besides oxidation at certain sites of Met, His, and Tyr, conversion of histidine to aspartate and h

159 e(II) and the integrity of its binding motif His-X-Asp, which is conserved in Fe-dependent dioxygenas

160 l node region; Zone II-atrioventricular node/His region; and Zone III-bundle branch/Purkinje fiber re

161 During permanent nonselective His bundle (ns-HB) pacing, it is crucial to confirm HB c

162 ate between selective (S), nonselective (NS) His bundle pacing (HBP), and right ventricular septal ca

163 We have taken advantage of the ability of His to coordinate Zn(2+) to promote metal ion bridges, a

164 AP/PNPNL loop residue His-624 in HasR and of His-221 in its N-terminal plug domain required for heme

165 ransmethylate the N, S, and O side chains of His, Cys, Glu, Asp, and Lys residues.

166 recognitions between known concentrations of His-tag RGS11 and unknown concentrations of target RGS11

167 Traditionally, the detection of His-tagged proteins relies on immunoblotting with anti-H

168 an ideal metal tag for selective labeling of His-tag containing recombinant proteins to enable their

169 ularly effective at covalent modification of His-tags, which are common motifs to facilitate protein

170 veal that platinum(II) binds the Nepsilon of His in a manner that preserves the Pt-As bond.

171 nd that different mutagenic perturbations of His(232), just below the metal-binding site along the pr

172 rted membranes in the absence or presence of His-cytNL2.

173 tic analyses show that the turnover rates of His-257 mutants are significantly smaller than those of

174 In contrast, any replacement of His(237), lining the metal exit route, locked the transp

175 have seen further insights into the role of His bundle pacing on improving outcomes.

176 We have found that the rotamer of His is not influenced by the environmental pH, ruling ou

177 Substitutions of His-583 revealed that it is essential for glycine bindin

178 e cofactor core, are each coordinated by one His and two Cys.

179 of DICER in cancer cells impedes Ad.mda-7 or His-MDA-7/IL-24 inhibition of cell growth, colony format

180 g the proteinaceous amino acids Lys, Arg, or His adjacent to backbone ester bonds generally promote R

181 ither cardiac biventricular pacing (BiVP) or His bundle pacing (HisBP) may prevent adverse structural

182 ed Arg, Lys, Glu, and Asp residues by Gly or His.

183 In this study, we investigated an OR(His) variant of Arabidopsis OR, genetically mimicking th

184 ession or knockout of ARC3 in Arabidopsis OR(His) plants significantly alters total carotenoid levels

185 opsis OR, genetically mimicking the melon OR(His) allele, and found that it also constrains chromopla

186 hloroplast division, suggesting a role of OR(His) in competing with PARC6 for binding to ARC3 to rest

187 viously, a natural allele of Orange (OR), OR(His), was found to promote carotenoid accumulation by ac

188 We further showed that OR(His) interferes with the interaction between ARC3 and PA

189 and in vivo experiments demonstrate that OR(His) specifically interacts with the Membrane Occupation

190 BP followed by left ventricular (LV) pacing (His-Optimized CRT [HOT-CRT]) to maximize electrical resy

191 unsaturated metal centres-including a penta-His-coordinated non-haem Fe site-and well-defined bindin

192 Although permanent His bundle pacing was first reported almost 2 decades ag

193 Conventional permanent His Bundle pacing (PHBP) can be challenging and associat

194 ndent rotamer switch of the phosphorylatable His.

195 how that substitution of the N-terminal plug His-221 disrupts both signaling and transport, leading t

196 They contain poly-histidine chains (poly-His), whose imidazole groups generate (14) N-quadrupolar

197 On this basis, the poly-His moieties were conjugated to biocompatible polymers,

198 The poly-His quadrupolar peaks are detectable only when the polym

199 We hypothesized that a premature His complex (PHC) will always perturb AVRT because the H

200 de practical recommendations for programming His bundle pacing, to deliver optimal therapy and ensure

201 in sorting 25) and the Bro1 proteins HD-PTP (His domain-containing protein tyrosine phosphatase) and

202 to the desuccinylation reaction of purified His-SIRT5.

203 idine-tagged recombinant ADAMTS13 (rADAMTS13-His(6)) was immobilized on nitrilotriacetic acid (NTA)-c

204 studies were performed to optimize rADAMTS13-His(6) immobilization and to confirm the specificity of

205 c in vitro Sequence analysis revealed a rare His -> Asn variation adjacent to the CysRS catalytic poc

206 he heme irons in each subunit exhibit a rare His/Cys ligation, which, as we show by substitution, cau

207 nteracted directly with purified recombinant His-MLC2.

208 WT ApbE and mutants of the conserved residue His-257, to understand its role in substrate binding and

209 of the extracellular FRAP/PNPNL loop residue His-624 in HasR and of His-221 in its N-terminal plug do

210 A conserved His residue, His(114), is hydrogen-bonded to the Zn(II)-bound water/h

211 erestingly, in OTUB2, the catalytic residues His(224) and Asn(226) formed a stable hydrogen bond.

212 nteractions between the active-site residues His(265) and Asp(267) In OTUB2, however, the arrangement

213 for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1

214 0 ms ahead of the His) due to the retrograde His conduction time.

215 displacement bi-bi mechanism involving a Ser-His-Asp catalytic triad and unconventionally uses an Arg

216 GEs contain a Ser-His-Asp/Glu catalytic triad, but the location of the cat

217 d demonstrated that substitutions in its Ser-His-Asp triad, proposed to serve a general acid-base rol

218 se B (CALB) as the model enzyme with the Ser-His-Asp catalytic triad, a highly active cysteine-lipase

219 ieth anniversary of the discovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variat

220 nd to contain a conserved and functional Ser/His/Asp catalytic triad.

221 simulations indicated that in WT MGL(short), His(259) mediates H bonds directly or engages the Tn-gly

222 ed pathology localized within the left-sided His fibers (left intrahisian block), which was most amen

223 was localized to the level of the left-sided His fibers (left intrahisian) or left bundle branch.

224 oligomerization interface based on specific His/Trp ring orientations while stabilizing the pK(a) of

225 dl's name was listed as "and Ulrich Steidl." His name has been updated to "Ulrich Steidl." The error

226 R-C1 peritrophin A-type domain fused to SUMO/His-tag confirmed that SfPER binds to chitin.

227 ith selectivity toward a hexa-histidine tag (His-tag).

228 The polyhistidine tag (His-tag) is one of the most popular protein tags used in

229 23, and DipA, were expressed with C-terminal His-tags.

230 AA9 LPMO family display a natural N-terminal His to Arg substitution (Arg-AA9).

231 scherichia coli, giving superior purity than His-tag/nickel-nitrilotriacetic acid.

232 roxyl substrate glycerol, demonstrating that His-1084 increases the hydroxyl reactivity of A2ML1's th

233 Surprisingly, we found that His-152 and Lys-187 alanine-substituted variants maintai

234 Given that His(6) possesses specific affinity toward alumina throug

235 Alignment of ACMSD sequences revealed that His-110 is highly conserved in a few bacteria that utili

236 nd 1.92 angstrom resolutions, revealing that His-257 is located in the catalytic site and that the su

237 t the rates of interconversion are such that His/Lys ligation would be retained during turnover.

238 ramp's conformational state, suggesting that His(232) serves as a pivot point for conformational chan

239 The His-tag can also be directly detected by metal ion-loade

240 At pH 7, the His residues do not bind RNA or Ca(2+), but do bind Zn(2

241 distance between the aortic annulus and the His bundle.

242 lated by conserved residues from CTD and the His-Cys-His (HCH) motif from the N-terminal segment of t

243 x (PHC) will always perturb AVRT because the His bundle is obligatory to the circuit.

244 rbohydrate recognition domain containing the His(259) residue.

245 yer activated by glutaraldehyde, and ii) the His-tagged recombinant protein G.

246 ue (pK (ES1)) increases by 2 pH units in the His-257 mutants, suggesting that this residue plays a ro

247 el of complete conduction block (CCB) in the His-Purkinje system.

248 ogeneous expression of TRPM4 channels in the His/Purkinje system is required for type II heart block,

249 actor T-box 18 (TBX18) was injected into the His bundle region in either of 2 experimental protocols:

250 , at which point TBX18 was injected into the His bundle region.

251 binding sites (four per dimer) involving the His-rich motifs and having similar metal affinity (K(D)

252 this Review, we summarize the anatomy of the His bundle and early clinical observations, implantation

253 del and confirming that the chemistry of the His is responsible for the decrease in the phosphatase a

254 to allow for the specific adsorption of the His(6)-tagged intracellular domain of Neuroligin-2 (His-

255 erturbed by a late PHC (<=20 ms ahead of the His) due to the retrograde His conduction time.

256 a structural explanation for the role of the His-Gly dipeptide in the structure and function of ASICs

257 site correlated with its EAM position on the His cloud ( P=0.045).

258 tween HBP threshold and lead location on the His cloud.

259 ration (QRSd) were recorded while pacing the His lead with simultaneous 12-lead ECG rhythm strips.

260 By stimulating the His-Purkinje network directly, HBP results in synchroniz

261 on at Cys codons in vivo We surmise that the His -> Asn variation can be introduced into any CysRS to

262 ues for both substrates, indicating that the His-257 residue plays important roles in catalysis and i

263 s of the CAIV-binding site revealed that the His-88 in CAIV can either act as H donor or H acceptor f

264 R finds that Cd(2+) binds exclusively to the His imidazole side chains of the repeat segment, with a

265 reveals a His/Asp active center in which the His acts as a Bronsted acid and Asp as a Bronsted base i

266 Ru(III) to be selectively placed within the His-tag segment.

267 A2ML1s conjugated and inhibited thermolysin, His-1084 was required for the conjugation and inhibition

268 roscopy of purified wild-type Apd1 and three His to Cys variants demonstrated that Cys207 and Cys216

269 ses specific affinity toward alumina through His(6)-Al chelation, TF2- and TF6-immobilized alumina-co

270 protonating bound substrate, and assigned to His-120 based on studies of protein variants.

271 as followed by LV pacing at a delay equal to His-ventricular interval.

272 ch from His/Lys ligation (E(m) , -129 mV) to His/Met (E(m) , +266 mV), but the rates of interconversi

273 Response to His bundle pacing was assessed in patients with and with

274 The P4 Arg-to-His substitution partially rescues this defect.

275 Here we report that a charge-altering Asp-to-His mutant (D46H) expands native cholesterylation activi

276 tRNA(His) guanylyltransferase (Thg1) adds a single guanine to

277 pression levels of tRF-5 fragments from tRNA(His) in CLL samples and healthy controls, and determined

278 needed for their essential function in tRNA(His) maturation.

279 a single guanine to the -1 position of tRNA(His) as part of its maturation.

280 are derived from distinct genes of pre-tRNA(His), and are down-regulated in CLL 3- to 5-fold vs. nor

281 tilizes the GUG anticodon for selective tRNA(His) recognition, and Thg1-tRNA complex structures have

282 ly modest addition of one nucleotide to tRNA(His) ensures translational fidelity by providing a criti

283 prevalent plant ICA genes encoding two tRNA(His) guanylyl transferase 1 units evolved ~120 million y

284 (Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp), and tRNA(SeC) to produce tRNA halves an

285 Our findings indicate that the twin-His motif is the core structure responsible for substrat

286 His/Lys (heme 1), His/Cys (heme 2), and two His/His ligations (hemes 3 and 4).

287 biogenesis) leading to the key covalent Tyr-His cross-link in CcO.

288 proposed to be a key intermediate in the Tyr-His cofactor biogenesis.

289 cells by sequestering Fe(II) at its unusual His(6) site.

290 Antigen binding via His-tag insertion into the CoPoP bilayer results in a se

291 The most frequent mutation was His to Tyr at amino acid 44; additional escape mutants h

292 At pH 4, where His residues are protonated, the PLD is disordered and f

293 R is required to initiate signaling, whereas His-624 is required for simultaneously closing off the h

294 We propose a reaction mechanism in which His-257 acts as a general base that deprotonates the acc

295 han surface ECG criteria for correction with His bundle pacing.

296 at the lead deployment site correlates with His cloud location.

297 a distorted trigonal bipyramid geometry with His(117), His(257), Asp(116), Asn(216), and a water/hydr

298 rs four low-spin hexa-coordinated hemes with His/Lys (heme 1), His/Cys (heme 2), and two His/His liga

299 mpetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critica

300 Phe(59) and Tyr(101) substitutions with His and Phe, respectively, reduced LsdA activity (k (cat