ライフサイエンスコーパス: Horner

1 Horner syndrome refers to the constellation of signs res

2 A Horner-Wadsworth-Emmons olefination joins two chiral bui

3 and employed a B-alkyl Suzuki coupling and a Horner-Wadsworth-Emmons olefination to accomplish their

4 The XF skeleton was synthesized by a Horner reaction to assemble the distyrylbenzene unit fol

5 one 28 to angelic aldehyde 27, followed by a Horner-Wadsworth-Emmons (HWE) coupling of 32 with glutar

6 aleic anhydrides via oxidation followed by a Horner-Wadsworth-Emmons reaction pathway in very good yi

7 The synthesis of FLD (3) employs a Horner-Wadsworth-Emmons olefination reaction followed by

8 The synthesis of FLD (3) employs a Horner-Wadsworth-Emmons olefination reaction followed by

9 The resulting phosphonate was employed in a Horner-Wadsworth-Emmons condensation with an aldehyde re

10 The approach involves a Horner-Emmons olefination with a suitably protected glyc

11 te to this advanced intermediate involving a Horner-Wadsworth-Emmons coupling of fragments 22 and 25.

12 e we were exploring the substrate-scope of a Horner-Wadsworth-Emmons (HWE) reaction.

13 To approach the desired compounds through a Horner-Wadsworth-Emmons condensation, new indole derivat

14 the macrocyclization was carried out using a Horner-Emmons olefination at the C(2)-C(3) olefin.

15 They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step an

16 strategy for accessing these molecules via a Horner-Wadsworth-Emmons reaction and cysteine condensati

17 pared through a convergent synthesis, with a Horner-Wadsworth-Emmons condensation employed to form th

18 ation/methylation sequence to cast ring X, a Horner-Wadsworth-Emmons coupling of WXYZA' ketophosphona

19 in 37 (43.0%), opsoclonus in 20 (23.3%), and Horner syndrome in 24 (27.9%).

20 acetylation, deprotection of the acetal, and Horner-Emmons olefination-conjugate addition reaction to

21 e, followed by oxidation to the aldehyde and Horner-Wadsworth-Emmons olefination), (ii) conversion to

22 ine-catalyzed sequential alpha-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes a

23 t as amino acid transition state analogs and Horner-Wadsworth-Emmons reagents, respectively.

24 prepared, and alternating Heck coupling and Horner-Wadswoth-Emmons (HWE) reactions were used to coup

25 ergent protocols, such as oxidative Heck and Horner-Wadsworth-Emmons, to accommodate a complete range

26 ed as substrates in attempted Knovenagel and Horner-Wadsworth-Emmons condensations, but elimination w

27 k by a combination of phosphite-mediated and Horner-Wadsworth-Emmons reactions for introduction of th

28 ganotrifluoroborates by using the Wittig and Horner-Wadsworth-Emmons olefination is described.

29 stly, the localizing pitfalls of anisocoria--Horner and Raeder syndromes, physiologic anisocoria, pup

30 or of the pupil in common disorders, such as Horner's syndrome and tonic pupil.

31 hydroboration sequence, a Gais's asymmetric Horner-Wadsworth-Emmons reaction, and a mercury salt cat

32 It reacted as a borylated Horner P(=O)CH(2)B carbon nucleophile with carbon dioxid

33 lculations support the mechanism proposed by Horner in which a hydride is transferred from silicon to

34 Formation of the conjugated tetraene by Horner-Wadsworth-Emmons condensation of the functionaliz

35 resulting dienes were further transformed by Horner-type Wittig reactions and a Diels-Alder cycloaddi

36 prepared from 2-indanones in high yields by Horner-Wadsworth-Emmons reaction.

37 Mutually complementary Horner-Wadsworth-Emmons and Still-Gennari (SG) olefinati

38 ction of multi-element events based on cues (Horner et al., 2015).

39 talytic hydrogenation and diastereoselective Horner-Emmons-Michael cascade to obtain functionalized p

40 amination, an improved version of the Emmons-Horner reaction, and other common reactions.

41 , apraclonidine is used off-label to exclude Horner syndrome.

42 ylation, followed by a vinyl sulfone forming Horner-Wadsworth-Emmons olefination.

43 ractures, LeFort II or III facial fractures, Horner's syndrome, skull base fractures involving the fo

44 metrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed keta

45 toms in ICAD are cervical pain and headache, Horner's syndrome, paralysis of the cranial nerves and s

46 r phosphonate esters that can be employed in Horner-Wadsworth-Emmons olefination reactions.

47 Imaging in Horner syndrome is commonly performed, however, imaging

48 Our initial Horner-Wadsworth-Emmons/oxa-Michael approach to the berk

49 nd 23% by physical examination (neck injury, Horner's syndrome).

50 nate aldol, Evans alkylation, intermolecular Horner-Wadsworth-Emmons olefination, Yamaguchi macrolact

51 lactone 24 to enone 27 by an intramolecular Horner-Emmons Wittig reaction and epimerization complete

52 assemble the polyene, and an intramolecular Horner-Wadsworth-Emmons olefination to forge the macrocy

53 ehyde allylation reaction, an intramolecular Horner-Wadsworth-Emmons olefination, and a dihydroxylati

54 y a tandem oxidative cleavage/intramolecular Horner-Wadsworth-Emmons reaction.

55 dole key intermediate via the intramolecular Horner-Wadsworth-Emmons reaction required a development

56 de macrolactonization through intramolecular Horner-Wadsworth-Emmons olefination, Yamaguchi-Hirao alk

57 in a one-pot benzoyl transfer-intramolecular Horner-Wadsworth-Emmons reaction.

58 of aryloxy-terminated omega chains involving Horner-Emmons elongation of an aldehyde to a methyl enon

59 in multistep synthetic procedures involving Horner-Wadsworth-Emmons olefination reactions and/or Hec

60 cal pain in neck or face with an ipsilateral Horner's syndrome preceding transient or persistent reti

61 erformed, however, imaging yield in isolated Horner syndrome has not been extensively studied.

62 possible to hold-off on imaging of isolated Horner syndrome especially if evidence exists establishi

63 or evaluation in pediatric cases of isolated Horner syndrome is physical examination, urinary catecho

64 rey-Chaykovsky-type reaction, and a modified Horner-Wadsworth-Emmons Z-selective olefination.

65 hesis of trisubstituted alkenes via modified Horner-Wadsworth-Emmons carbonyl olefination is presente

66 A novel Horner-Emmons olefination conjugate addition reaction of

67 ing quinuclidines are shown to undergo novel Horner-Wadsworth-Emmons-type (HWE-type) reactions to giv

68 reaction sequence complements the arsenal of Horner-Wadsworth-Emmons-type coupling reactions.

69 ew the yield of imaging in isolated cases of Horner syndrome in order to better understand if and whe

70 An appropriate evaluation of Horner syndrome and a timely elucidation of the etiology

71 erhidrosis elsewhere in the body, 8% risk of Horner syndrome (mostly self-limiting), 5% risk of pneum

72 ttempts of intramolecular Still's variant of Horner-Emmons olefination between the C(19)-phosphonocet

73 A high yielding synthetic scheme based on Horner-Wadsworth-Emmons or Pictet-Spengler reactions was

74 yclization with a concomitant imide opening, Horner-Wadsworth-Emmons olefination, and desilylation.

75 of in-office evaluation of blepharoptosis or Horner syndrome, and their therapeutic role remains unce

76 zene derivatives were prepared using Heck or Horner methodologies.

77 a combination of Heck coupling and Wittig or Horner reactions of suitable precursor modules.

78 1,2-addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed aldol reactions

79 rate the hydroxy group at the C-13 position, Horner-Wadsworth-Emmons olefination to form the C9-C10 b

80 The targets were prepared by a NaH-promoted Horner reaction of tetraethyl(2,5-diiodo-1,4-phenylene)b

81 d sequential 1,5 O --> O silyl rearrangement/Horner-Wadsworth-Emmons reaction used to construct 18, (

82 n chemistry was carried out using repetitive Horner-Wadsworth-Emmons (HWE) reactions of precisely sub

83 isubstituted vinyl fluorides via a selective Horner-Wadsworth-Emmons olefination/hydrolysis, which pr

84 orms, XF) have been prepared by a sequential Horner reaction of the bisphosphonate of 2,5-diiodo-1,4-

85 ecursor bicyclic lactam, followed by in situ Horner-Wadsworth-Emmons (HWE) olefination as the key syn

86 ol reactions, the discovery of a spontaneous Horner-Wadsworth-Emmons macrocyclization strategy, and t

87 al and Fmoc-L-valinal, and a resin supported Horner-Wadsworth-Emmons reaction, were treated with cinn

88 BS reduction, Hantzsch's thiazole synthesis, Horner-Wadsworth-Emmons reaction, and Shiina's macrolact

89 glion block, although patients had temporary Horner's syndrome indicating the effectiveness of the bl

90 The Horner method was used to synthesize random copolymers o

91 The Horner-Wadsworth-Emmons condensation of some alpha-phosp

92 The Horner-Wadsworth-Emmons reaction also gave the E-isomer

93 rectly to an amino aldehyde, which after the Horner-Wadsworth-Emmons reaction was elaborated to pinna

94 (+)-asteltoxin (1) has been achieved by the Horner-Emmons olefination of bis(tetrahydrofuran) aldehy

95 ,beta-unsaturated beta-boryl nitriles by the Horner-Wadsworth-Emmons reaction starting from potassium

96 s-based pyrroles is also demonstrated in the Horner reaction.

97 widely useful, notably as substrates in the Horner-Wadsworth-Emmons-type olefinations.

98 Other key steps include the Horner-Wadsworth-Emmons reaction and the diastereoselect

99 ploys reliable transformations including the Horner-Wadsworth-Emmons and addition of Grignard reagent

100 as prepared in six steps, and the use of the Horner-Emmons olefination to yield the alpha,beta-unsatu

101 gent-growth methodology that made use of the Horner-Wadsworth-Emmons (HWE) reaction.

102 oselective Still-Gennari modification of the Horner-Wadsworth-Emmons olefination to afford (E)-benzyl

103 oyed as starting materials for preparing the Horner-Wadsworth-Emmons reagent 4-(diethoxyphosphoryl)-2

104 ne (exTTF-dpq) dyad is described through the Horner-Wardsworth-Emmons olefination methodology from th

105 nd the Davis oxaziridine, in addition to the Horner-Wadsworth-Emmons olefination of N-sulfinyl imines

106 aza-variant analogue is described using the Horner-Wadsworth-Emmons reaction as the key step in comb

107 The AVMB ligands were synthesized using the Horner-Wadsworth-Emmons reaction.

108 inevinylene)s 2D-PPQV1 and 2D-PPQV2, via the Horner-Wadsworth-Emmons (HWE) reaction of C(2) -symmetri

109 sphonate 6, which underwent a phase-transfer Horner-Emmons Wittig reaction with heptadecanal to provi

110 extremity neurapraxia (n = 1) and transient Horner syndrome (n = 3).

111 he naphthylidene indenes was developed using Horner-Wittig chemistry that afforded the Z isomer in th

112 unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroetho

113 duction of a double unsatured side chain via Horner-Wadsworth-Emmons reaction and assembly of the nap

114 onconjugated 1,4-dienes (skipped dienes) via Horner-Wadsworth-Emmons (HWE) olefination of novel Rauhu

115 (compounds 16-23) have been synthesized via Horner-Wadsworth-Emmons reaction involving a monophospho

116 he unsaturated phosphonate 1 as a vinylogous Horner-Wadsworth-Emmons reagent was explored in reaction

117 corporated using an intramolecular Wadsworth-Horner-Emmons olefination of phenylselenylated alpha-hyd

118 ted, again using an intramolecular Wadsworth-Horner-Emmons olefination reaction to give phyllanthine

119 .5%) with orbital involvement, 7 (1.3%) with Horner syndrome, and 1 (0.2%) with orbital involvement a

120 gonist, reverses anisocoria in patients with Horner syndrome, a disruption of the sympathetic chain t

121 Wittig-Horner reaction of a chiral phosphonate derived from (S)

122 -(E)-decenal, which is subjected to a Wittig-Horner reaction after chlorination in alpha-position.

123 ers (11a-c) has been carried out by a Wittig-Horner reaction of the respective phosphonate esters (10

124 ich, Sonogashira, Suzuki, Wittig, and Wittig-Horner reactions.

125 nother double bond employing a common Wittig-Horner prolongation sequence.

126 Key steps include Wittig-Horner olefination of a d-xylofuranose precursor, [I(+)]

127 An alternative synthetic strategy (Wittig-Horner approach instead of our previously used Pd-cataly

128 The analogues were synthesized by the Wittig-Horner approach starting from Inhoffen-Lythgoe diol.

129 e synthetic strategy was based on the Wittig-Horner coupling of the known A-ring phosphine oxide with

130 red in convergent syntheses using the Wittig-Horner reaction as a key step.

131 y a convergent synthesis applying the Wittig-Horner reaction as a key step.

132 y convergent syntheses, employing the Wittig-Horner reaction.

133 which were subjected to Lythgoe type Wittig-Horner coupling with C,D-fragments 35a and 35b.

134 ,19-dinorvitamin D3 were prepared via Wittig-Horner coupling of 25-hydroxy-18-nor Grundmann type keto

135 The synthetic pathway was via Wittig-Horner coupling of the corresponding A-ring phosphine ox