ライフサイエンスコーパス: I region

1 eding a critical phenylalanine in the switch I region.

2 n the Cdc42 insert domain but not the Switch I region.

3 human major histocompatibility complex class I region.

4 esent as a cluster within the Fugu MHC class I region.

5 genes were discovered in the human MHC class I region.

6 posed, closely aligned and located in switch I region.

7 tical in the conformationlly sensitive amide I region.

8 GS-box that interacts with the Galpha switch I region.

9 by interactions involving RhoA's pre-switch I region.

10 fferent events in the evolution of the Class I region.

11 a conserved asparagine in the GTPase switch-I region.

12 and 238) in the NS5A low complexity sequence I region.

13 scopy was used to probe changes in the amide I region.

14 he corresponding bands assigned in the amide I region.

15 o seen across ethnic groups in the HLA class I region.

16 d adjacent regions, especially in the switch I region.

17 All associated SNPs mapped to the HLA class I region.

18 he corresponding bands assigned in the amide I region.

19 us to examine the role of N45 in the switch I region.

20 independent association within the MHC Class I region.

21 and 10), in CDCl 3 was measured in the amide-I region.

22 alterations in the region encoding the VacA i-region.

23 ncompasses the junction of the class III and I regions.

24 the NH, CH stretching and bending, and amide I regions.

25 hydrophobic, amide III, amide II, and amide I regions.

26 and denaturant are shifted out of the amide I' region.

27 own to possess unusual features in the amide I' region.

28 by a high density of Na+ channels in the AH-IS region.

29 ves of synthase monomer contains half of the ID regions.

30 rtonicity, resulting in stabilization of its ID regions.

31 The deconvolution of the amide I region (1580-1720 cm(-1)) and the analysis of the sub-

32 cting the underlying FTIR bands of the amide I region (1700-1600 cm(-1)) and the water region (3500-3

33 uble extracts and deconvolution of the Amide I region (1700-1600 cm(-1)) from Fourier Transform Infra

34 s a more detailed characterization of the LG(I)region (a broader region than the liquid disordered-li

35 ter (HOH-bending) overlapping with the amide I region, a highly stable temperature control unit with

36 Tyr(34) is located within the switch I region adjacent to the nucleotide-binding site.

37 Many of these RF-reactive class I regions also showed positive ELISA reactions with mono

38 A peptide encoding the Switch I region (amino acids 199-216) also stimulated AC2 and A

39 nates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the fra

40 PCR primers that flanked the deleted TbetaR-I region amplified a single band from JK cell genomic DN

41 al region of the 2D IR spectrum of the amide I region, analogous to those in 2D NMR spectroscopy.

42 a disordered loop and helices in the switch I region and a visible switch II loop, which is disorder

43 l conformational rearrangement of the switch I region and additional striking alterations of side cha

44 0.001) tagged by rs4711249 in the HLA class I region and rs9275582 in the HLA class II region.

45 uding a conserved Lys-45 close to the switch I region and the C-terminal membrane-binding domain of R

46 he overlap between the amide I and non-amide I regions and allow for different scattering efficiencie

47 tty acid synthesis separated by interdomain (ID) regions and predicts that two appropriate halves of

48 rom the observation that neurosteroid action is region and neuron selective.

49 lial-mediated control of intestinal motility is region and pathway specific.

50 the degree of coupling between the different ID regions, and 4) whether the stability of ID domains i

51 Genes in the human extended class I region are also well conserved in Xenopus, excluding t

52 dicated that large portions of the HLA class I region are conserved among mammals.

53 ermediate, infrared differences in the amide I region are dominated by much larger structural changes

54 We show here that the AG MADS domain and the I region are necessary and sufficient for DNA binding in

55 R) spectra of AFGP8 and AFGP1-5 in the amide I region are quite different.

56 ith experimental data showing that the s and i regions are the key determinants of vacuolating cytoto

57 Intrinsically disordered (ID) regions are disproportionately higher in cell signal

58 owed by reperfusion every 12 h) with the non-IS region as control.

59 e and urea both absorb strongly in the amide I region, as does H2O.

60 These antisera identified I-region associated (Ia) antigens.

61 ce express no detectable classical MHC class I-region associated (Ia) heavy chains, although beta2-mi

62 each had major absorption bands in the amide I region at 1626 and 1636 cm-1 both prior to and after d

63 d the strongest association in the HLA class I region at rs7750641 (p = 1.2 x 10(-92) ; odds ratio [O

64 irst in the axon hillock/initial segment (AH-IS) region because of a locally high density of Na+ chan

65 romosome (BAC) clones spanning the HLA class I region between HLA-C and HLA-E and of YACs extending t

66 Beyond the formation of intermolecular helix I region between U6atac and U12 snRNAs, several other re

67 this complex revealed that the EF-Tu switch I region binds to the non-catalytic surface of AbDsbA.

68 nown, peptides derived from the EF-Tu switch I region bound to AbDsbA with submicromolar affinity.

69 ximal major histocompatibility complex class I region, but approximately a dozen genes in the candida

70 le three-component band fitting of the amide I region can assist in the conformational characterizati

71 Because ID regions commonly fold as part of their intracellular

72 SFG spectra taken from the amide-I region contain features near 1630 and 1670 cm(-1) rela

73 undertaken domestically, in which case the M&I region could benefit, or by major palm oil importers,

74 everal woody feedstocks, and its composition is region-dependent.

75 lear spectral red shift in the protein amide I region due to incorporation of (13)C atoms originating

76 Analysis of the amide I region, emanating from the carbonyl stretch vibration,

77 ing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 inte

78 unctionally distinct regions, 2) whether any ID regions fold upon activation, 3) the degree of coupli

79 sional infrared (2D IR) spectra in the amide I region for aggregates of AcWL(5) peptides with single

80 UAA, TAP, and LMP genes, the so-called class I region found in most nonmammalian vertebrates.

81 genes located outside the class II and class I region genes.

82 ed with the presence of the vacA s-, m-, and i-region genotypes in Western countries.

83 over 2.4 Mb pairs including the entire class I region has been isolated as a series of overlapping YA

84 xplain the increased propensity for turns in ID regions (IDRs) utilized biologically for phase separa

85 An in vitro assay showed that the region I, region II, and region I+II (D51/E52/E55/D166A) mutant

86 k genes may also be present in the HLA class I region in a subset of DRB1*0404 haplotypes.

87 However, the 32 amino acid Hinge I region in ABP-280 that contains a calpain cleavage sit

88 ditional locus located in the extended class I region in proximity to TRIM27 tagged by a haplotype co

89 racteristic "Z"-shaped pattern for the amide I region in the 2D IR spectrum.

90 ition-state model conformation of the switch I region in this complex where the reoriented switch I r

91 on a conserved Y32 residue within the switch I region in vitro and that in vivo, Ras-Y32 phosphorylat

92 Comparisons of isotope effects on the amide I regions in P(M) minus O spectra demonstrate that amide

93 of the role of the VacA intermediate region (i-region) in toxin activity.

94 The MHC class I region, in contrast, contains 13 MHC-B genes, four MHC

95 These faces overlap with IFN-I regions independently essential for engaging the IFNAR

96 Intense bands in the amide I region indicate that a protein conformational change o

97 in this complex where the reoriented switch I region interacts with a conserved rRNA region of the 4

98 ermore, the solution structure of the switch I region is analyzed by pulsed electron-electron double

99 The second half of the Box I region is crucial for the interaction with the basal t

100 In Sec4-GDP, the switch I region is highly disordered and displaced relative to

101 These results indicate that the VacA i-region is an important determinant of VacA effects on

102 s, the genomic organization of the MHC class I region leads to biased expression of a single classica

103 he class III region rather than in the class I region, likely reflecting the ancestral condition.

104 y the major histocompatibility complex class I region (MHC class I) present peptide antigens to cytot

105 n the major histocompatibility complex class I region (MHC I), with effect sizes ranging between 0.14

106 Two mutations in the switch I region (MinD box) and one mutation in the switch II re

107 K-Ras Switch-II region motions drive Switch-I region motions, while alpha-helix-3L7 motions control

108 s is located at the N-terminus of the switch I region near the nucleotide binding site whereas the ot

109 infrared spectra in the phosphate and amide I regions nearly equivalent to those found in naturally

110 have identified a binding site in the helix I region of 14-3-3zeta (residues 202-231) required for b

111 occur (206-220) is equivalent to the Switch I region of a large group of purine nucleotide-binding p

112 Application to the amide I region of a small globular protein reveals regions ass

113 ions of oncogenic human KRAS and in the Loop I region of bacterial colicin-immunity protein Im7, amon

114 Specific point mutations in the switch I region of Cdc42 abolish binding to and, therefore, act

115 x reveals a novel conformation of the switch I region of Cdc42.

116 A and MICB) are located within the HLA class I region of chromosome 6.

117 stantial conformational change in the Switch I region of EF-G, suggesting that a conformational signa

118 ric clashes with both aa-tRNA and the switch I region of EF-Tu.

119 nce (Arg-Arg-Pro-Thr(203)) within the switch I region of Galpha(13).

120 s were introduced at sites within the switch I region of Galphai to explore the structure and dynamic

121 3 and C5 regions of gp120 and in the cluster I region of gp41 are well exposed on the surface of inta

122 mplete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility compl

123 ctures quantified by deconvoluting the amide I region of infrared spectra strongly and negatively cor

124 rine residues in the low complexity sequence I region of NS5A responsible for NS5A phosphorylation; h

125 ng analogies can be drawn between the Switch I region of NtrC and that of p21(ras).

126 2D IR correlation spectra of the amide I region of poly-l-lysine, concanavalin A, ribonuclease

127 Furthermore, we demonstrate that the switch I region of Rab11a, which has been shown to be important

128 of the PB2 polymerase subunit and the switch I region of Rab11a.

129 rent and that a single residue in the switch I region of Rap proteins (residue 39) contributes consid

130 RasIn1 recognizes residues in the Switch I region of Ras, similar to Raf-RBD, and competes with R

131 ordered and displaced relative to the switch I region of Ras-GDP.

132 o a conserved tyrosine residue in the switch I region of Rho GTPases.

133 ows that conserved amino acids in the switch I region of RhoA are major PLD interaction sites and tha

134 sidues Tyr34, Thr37, and Phe39 in the switch I region of RhoA which are required for p190GD interacti

135 The switch I region of RhoA, which is the common effector domain of

136 d a mutation (S217A) in the conserved switch I region of the active site to examine how myosin couple

137 to form contacts with helix H and the switch I region of the cognate ARF, suggesting that loop>J may

138 Strong variations in the amide I region of the FTIR difference spectrum, however, refle

139 nding through an interaction with the switch I region of the G protein.

140 cally with the enzymatically critical Switch I region of the head.

141 The interaction of the Switch I region of the kinesin-1 head with the tail is striking

142 approximately 8 Mb of DNA between the class I region of the major histocompatibility complex on huma

143 The amide I region of the protein infrared spectrum is the widely

144 ain at position 12 by stabilizing the Switch I region of the protein.

145 ar optical (NLO) chiral effects in the amide I region of type I collagen was investigated using sum-f

146 at epitopes in the V3, C5, and gp41 cluster I regions of the envelope glycoproteins, since these reg

147 The cbb(I) region of Rhodopseudomonas palustris (Rp. palustris)

148 ponent system has been identified in the cbb(I) region of the nonsulfur purple photosynthetic bacteri

149 of the oldest subfamily is identical to the ID region of the rat BC1 RNA gene, suggesting that the B

150 rs, 10058-F4 and 10074-G5, bound to distinct ID regions of the monomeric c-Myc bHLHZip domain.

151 Intrinsically disordered (ID) regions of the transcription factor proteins have mu

152 ght the importance of fuzzy interfaces, that is, regions of nanometre-scale structure and property gr

153 in silico identification of hot spots, that is, regions of protein binding sites that are major cont

154 We surveyed the "dark" proteome-that is, regions of proteins never observed by experimental s

155 major histocompatibility complex (MHC) class I region on mouse chromosome 17 of strain 129/SvJ (H2bc)

156 Here, we report identification of (i) regions on Yotiao critical to its binding to KCNQ1 an

157 ster that is part of the 'extended MHC class I region' on human chromosome 6.

158 these cancers were associated with HLA class I region only and HLA class II region only, implying the

159 mework improves the classic model, shows how ID regions poise the SHR/NR family for optimal allosteri

160 d transporter genes, defining the true class I region, present in all nonmammalian jawed vertebrates

161 on variable region (V(H)) and switch region (I) region promoters to initiate germ line (non-coding) t

162 n to a major contribution from the HLA class I region, PS susceptibility loci have been mapped to a n

163 The switch I region (residues 40-62) is well ordered in this struct

164 Raman spectral signatures in the amide I region revealed that there is no significant change in

165 Within the class I region, rs9263871 (C6orf15-HCG22) had the strongest ev

166 and was mapped to the nonclassical MHC class I region (RT1-C/E/M) using intra-MHC recombinant strains

167 HLA-DR region appears more complex than the I region since a second DC-like hybridizing sequence is

168 Interestingly, the synaptic difference is region specific as no differences were found in excit

169 ain of female rats, and that this regulation is region specific.

170 e specific nor completely random but instead is region specific.

171 es indicate that this non-canonical feedback is region specific: it is most prominent in lobules that

172 between slow-wave occurrence and performance is region-specific and the consequences of these local s

173 Re-methylation is region-specific but random with respect to individual

174 lated by flow-dependent DNA methylation that is region-specific in the arterial endothelium in vivo.

175 These data reveal that ER expression is region-specific within the neonatal amygdala.

176 in series and the beta-adrenergic modulation is region-specific, this modulation seems to be involved

177 a knockout mouse lines, that this regulation is region-specific, with the 5-HT4 receptor upregulated

178 in the switch II region and Glu-37 in switch I region stabilizes the intermediate conformation of alp

179 e in vitro Pit-1 binding sites within the HS-I region suggested a model in which Pit-1 binding at HS-

180 l passage in the NS3 protease or NS5A domain-I regions targeted by the drugs.

181 lass II subregions and also within the class I region than previously estimated.

182 tes in the highly conserved Myc homology box I region that controls c-Myc protein stability by oncoge

183 h FKBP38 through a section within its switch I region that is equivalent to the effector domain of ot

184 of association was observed in the HLA class I region that was fully explained by independent effects

185 the case of Ras, or a mutation in the switch I region that was identified as a contact site between R

186 Four categories of effect were observed: (i) regions that were recruited by patients and controls

187 eral can have multiple functionally distinct ID regions that interact and modulate the stability of i

188 identify energetically favorable sites, that is, regions that tend to bind a variety of molecules.

189 Neither the region (I region) that lies between the MADS and K domains nor t

190 In the HLA class I region, the putative causal locus might map outside th

191 In the switch I region, the side chain of Tyr-32, which undergoes a la

192 Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qua

193 ands isolated from a broad band in the amide I region using phase-sensitive detection were attributed

194 Homology modeling of the RbgA switch I region using the K-loop GTPase MnmE as a template sugg

195 ed tyrosine at position 32 within the switch I region via Src kinase.

196 nce imaging in the visible and near-infrared-I regions (VIS/NIR-I, 400-900 nm) might be interfered by

197 with a unique sequence at the missing Hinge I region was also identified (ABP-278).

198 In this model, wall thickening in the IS region was chronically depressed by approximately 37%

199 major histocompatibility complex (MHC) class I region were used to haplotype hh and normal chromosome

200 om infrared absorption of water in the amide I region, which is a serious limitation for measurements

201 Recently, the vacA intermediate (i) region, which is located between the signal (s) and m

202 ts are consistent with the proposal that the ID region, which has no known catalytic activity, associ

203 support the principle of a primordial class I region with few class I genes.

204 a second independent effect in the HLA class I region with SNP, rs9266722 (P = 2.84 x 10(-6)).

205 differ markedly only in part of their amide I regions with the in situ protein having additional pH-

206 tebrates examined to date have a true "class I region" with tight linkage of genes encoding the class

207 This report shows that (i) regions within gp41 distinct from those associated wi