ライフサイエンスコーパス: IC

1 IC patients had human immunodefiency virus (HIV)/AIDS, c

2 IC performance metrics (sensitivity, specificity, positi

3 IC(50) variability (25/75 percentiles) differed for drug

4 IC(50) was determined to be 460 nM.

5 ICs showed differential sensitivity to positive and nega

6 At 0.1 IC(50), 15i, 17d, and 25b inhibited pERK1/2 and pAkt by

7 ad exquisite selectivity toward both IRAK-1 (IC(50) = 24 nm) and IRAK-4 (IC(50) = 20 nm), with only m

8 inst HOCl (IC(50) = 0.79 ug/mL) and O(2)(-) (IC(50) = 12.92 ug/mL) without toxicity on intestinal cel

9 obiological intent-to-treat population (~21% IC).

10 otent lead compound [compound 14 (ARN-21934) IC(50) = 2 muM for inhibition of DNA relaxation, as comp

11 SAR studies on the initial hit, compound 4 (IC(50) = 257 nM), resulted in several highly potent inhi

12 ard both IRAK-1 (IC(50) = 24 nm) and IRAK-4 (IC(50) = 20 nm), with only minimal TAK1-inhibiting activ

13 profile and an inhibitory concentration 50 (IC(50)) of <0.003 muM for both RET and VEGFR2.

14 he evaluation of Michaelis-Menten and EC(50)/IC(50) kinetic parameters, as well as the results of hig

15 affect calculated Michaelis-Menten or EC(50)/IC(50) kinetic parameters.

16 0) 0.43 mM), 5NFA (IC(50) 1.2 mM), and 5AMF (IC(50) ~3 mM) but no inhibition by M5NF.

17 ndent block of the AQP1 ion current by 5HMF (IC(50) 0.43 mM), 5NFA (IC(50) 1.2 mM), and 5AMF (IC(50)

18 ion current by 5HMF (IC(50) 0.43 mM), 5NFA (IC(50) 1.2 mM), and 5AMF (IC(50) ~3 mM) but no inhibitio

19 yl]-1H-pyrazol-1-yl}methyl)benzonitrile (73, IC(50) = 12 nM) and 4-({5-[4-chloro-1-(2H-indazol-6-yl)-

20 yl]-1H-pyrazol-1-yl}methyl)benzonitrile (74, IC(50) = 19 nM).

21 justed risk of developing HCC [sHR=0.27, 95% IC (0.08-0.90); p=0.034].

22 lized acid-secreting A-intercalated cells (A-ICs) in the kidney using both imaging and functional stu

23 Pase proton pumps at the apical surface of A-ICs in KO mice compared to controls.

24 pound 15 showed improved anti-HAdV activity (IC(50) = 0.27 muM), significantly decreased cytotoxicity

25 hich exhibit potent in vitro HDAC8 activity (IC(50) = 66, 23, and 66 nM, respectively) and up to 410-

26 with only minimal TAK1-inhibiting activity (IC(50) = 0.5 mum).

27 Thus, G4 landscapes reveal additional IC-related intratumor heterogeneity in PDTX biopsies, im

28 .9-fold higher than protein binding-adjusted IC(90) (PA-IC(90)) of LPV for HIV-1 (140 ng/mL) followin

29 of either type of interneuron did not affect IC sound-evoked activity.

30 been discovered with high binding affinity (IC(50) values of 67-84 nM) and good selectivity over oth

31 with clinical outcomes both during and after IC completion.

32 pment of newer preventive approaches against IC.

33 reduced for indeterminate uptake across all IC (mean PPV primary tumour 36%, nodes 48%).

34 reus accessory gene regulator (agr) alleles (IC(50) 2-70 muM).

35 e, we introduce a novel platform that allows IC-FPOP to occur in a sterile incubation system complete

36 Although IC(50) determinations showed that solenopsins are more t

37 Intensive care was more likely among IC patients 65-79 years (aOR, 1.25; 95% CI, 1.06-1.48) a

38 ntial morbidity and mortality occurred among IC adults hospitalized with influenza.

39 toheptaoside (<50% inhibition) than amylose (IC(50): epigallocatechin gallate = 20.41 +/- 0.25 uM, qu

40 An IC(50) value of 0.50 muM +/- 0.05 was obtained for U937

41 d considerably improved potency, reaching an IC(50) value up to 100-fold lower than an inhibitor that

42 le (compound 187) and FhTIM, which showed an IC(50) of 5 uM and a K(d) of 66 nM.

43 PTX-MB@PLGA NPs showed an IC(50) of 78 mug mL(-1) and 44.7+/-4.8 % decrease of tum

44 ibition of DNA relaxation, as compared to an IC(50) = 120 muM for the anticancer drug etoposide] with

45 st potent azaindole 45 inhibits SHP2 with an IC(50) = 0.031 muM in an enzymatic assay and with an IC(

46 0.031 muM in an enzymatic assay and with an IC(50) = 2.6 muM in human pancreas cells (HPAF-II).

47 nyl-mediated block of hERG channels, with an IC(50) at pH 8.4 being 7-fold lower than that at pH 7.4.

48 remaining activity was still strong with an IC(50) of 16.8 +/- 2.03 ug/mL.

49 inhibit monoamine oxidase B (MAO-B) with an IC(50) of 18 +/- 7.1 muM in preliminary assays.

50 iester bonds by TDP1 in a FRET assay with an IC(50) of 190 nM.

51 led the juvenile form of F. hepatica with an IC(50) of 3 uM, better than the reference drug triclaben

52 over, tatM2NX is a potent antagonist with an IC(50) of 396 nM.

53 id (LCA) inhibits NAPE-PLD activity (with an IC(50) of 68 mum), but LCA is also a highly potent ligan

54 tracellular vestibule of the channel with an IC(50) of 72 nM and greater than 200-fold selectivity ov

55 BSA 9 inhibited CaMKII activity with an IC(50) value of 0.79 muM and displayed EC(50) values of

56 alogue (CPPB) inhibits DPAGT1 enzyme with an IC(50) value of 200 nM.

57 09, neutralized authentic SARS-CoV-2 with an IC(50) value of 3.1 ng/mL.

58 cer cells in a dose-dependent manner with an IC(50) value of 6.98 uM after 48 h treatment.

59 nase activity of mutant c-KIT(D816V) with an IC(50) value that is 9-fold more potent than the sunitin

60 lpB-DnaK bichaperone system in vitro with an IC(50)~5 muM and suppressed the growth of cultured Esche

61 t the basal, ATPase activity of ClpB with an IC(50)~5 muM.

62 inhibition of ~50%, Hill coefficient ~1, and IC(50) ranging from 10 to 20 uM.

63 depth, ACD (SRC = 0.64, SPCC(2) = 0.19) and IC (SRC = -0.26, SPCC(2) = 0.041) were the strongest det

64 fixime, and amoxycillin), drug efficacy, and IC(50).

65 the complexes, NMR titration experiments and IC(50) measurements reveal the molecular basis underlyin

66 with the percent inhibition being lower and IC(50) being higher for the edited GluA2(R) relative to

67 ng connectivity patterns, while the anterior IC connectivity was distinct, suggesting two major funct

68 tibody fused with alkaline phosphatase (anti-IC-HT2 scFv-ALP) which is able to produce an electroacti

69 s-associated protein with nanomolar apparent IC(50) values, and reduce TEAD target gene expression.

70 nt and balanced activities against BRD4 BD1 (IC(50) =11 nm) and HDAC1 (IC(50) =21 nm).

71 ification of 20, a molecule with biochemical IC(50) BACE2/BACE1 ratio of 47.

72 maintaining HIV latency and whether blocking IC molecules with Abs reverses HIV latency.

73 al administration could be increased in both IC and non-IC adults.

74 The extracts are analyzed by IC-DRC-ICP-MS for Cr(VI).

75 rall cure (resolution of signs of candidemia/IC + mycological eradication) at day 14 (primary endpoin

76 Invasive candidiasis (IC) is the most common nosocomial infection and a leadin

77 The prevalence rate of invasive candidiasis (IC) was 11.4% (95% CI 9.2-13.6%), and the rate of non-Ca

78 performed the highest antioxidant capacity (IC(50) = 176.8 ug/mL) under blue light.

79 the posterior limb of the internal capsule (IC), comprised primarily of corticofugal fibers, showed

80 curs either spontaneous in inactive carrier (IC) patients or therapy-induced by nucleos(t)ide analogu

81 omogenates obtained from human Caco-2 cells (IC(50) = 64.75 ug/mL).

82 Both intact cells (IC) and intracellular cell-free extracts (CFE) from most

83 extended to protein labeling in live cells (IC-FPOP), allowing the study of protein conformations in

84 eater potency in drug-resistant NSCLC cells (IC(50) = 17 nM) and in mice with H1975 xenograft tumor.

85 KI)-sensitive and TKI-resistant NSCLC cells (IC(50) = 77 nM) and in xenograft mice.

86 Twelve strains of immortalised cells (ICs) were generated and characterised using molecular, i

87 IRI) model, we show that intercalated cells (ICs) rapidly adopted a proinflammatory phenotype after I

88 cells expressing multiple immune checkpoint (IC) molecules, including programmed death (PD)-1, T cell

89 ute myeloid leukemia induction chemotherapy (IC) among clinical and microbiome covariates.

90 l recovery following induction chemotherapy (IC) in 97 AML patients.

91 No difference in ischemic cholangiopathy (IC), vascular thrombosis/stenosis or graft, and patient

92 n rice is reported using ion chromatography (IC) and dynamic reaction cell inductively coupled plasma

93 tion density of silicon integrated circuits (ICs) have progressed at an unprecedented pace in the pas

94 tions them to ideally respond to circulating ICs.

95 ed in the midbrain, the inferior colliculus (IC) integrates information from numerous auditory nuclei

96 and sound level in the inferior colliculus (IC) of unanesthetized rabbits of both sexes.

97 n auditory nucleus, the inferior colliculus (IC), but have not examined the cellular patterns of expr

98 In the inferior colliculus (IC), the hub of the central auditory pathway, molecular

99 les in the awake rabbit inferior colliculus (IC).

100 s significantly higher following combination IC blockade compared with other latency-reversing agents

101 In the initiation complex (IC), the template in the expanded 7-mer bubble positions

102 e presence of high-density immune complexes (IC).

103 DC) reservoir of HIV-bound immune complexes (ICs) is unknown.

104 at 30 muM and discovery of potent compounds (IC(50) < 10 nM) for every target.

105 ency (half-maximal inhibitory concentration (IC(50)) <1 muM) and selectivity (>=12-fold) for skeletal

106 ifted-half-maximal inhibitory concentration (IC(50)) for CYP4Z1 compared to ABT, efficient mechanism-

107 howed half-maximal inhibitory concentration (IC(50)) values 1 order of magnitude better than diflunis

108 cells with median inhibitory concentration (IC(50)) values between 24 picomolar and 35 nanomolar.

109 I-04 (half maximal inhibitory concentration [IC(50)] = 32 nM), the glycoconjugate, FGlc-FAPI (IC(50)

110 erlin-Frankfurt-Munster (BFM) consolidation (IC).

111 a to lower IgG antibodies and IgG containing ICs may also reduce the risk of venous thromboembolism.

112 IgG-containing ICs that bind to FcgammaR and FcRn induced FXa activity,

113 induced FXa activity, whereas IgG-containing ICs with an Fc engineered to be unable to engage FcRn di

114 ates in cellular responses to IgG-containing ICs.

115 demonstrated that, instead of a conventional IC pathway, an unexpected intramolecular singlet fission

116 Internal conversion (IC) has been considered as one of the major competitive

117 epth (ACD), lens vault (LV), iris curvature (IC), anterior chamber width, lens thickness, vitreous ca

118 Apart from its remarkably high cytotoxicity (IC(50) = 0.07-0.7 muM in different cancerous cell lines)

119 ucted include, Ag-Phen induced cytotoxicity (IC(50) 4.5 muM at 72 h) and 2-fold ROS generation, and a

120 grelor, and uridine triacetate had different IC(50) values for ENT1 and ENT2.

121 ter prediction of in vivo efficacy than drug IC(50) or combination index.

122 argeting of antibiotic administration during IC could decrease subsequent infectious complications in

123 than MG (log P = - 0.14) in donating H/e(-) (IC(50) = 36.4 vs. 39.9 muM and FRAP value = 598 vs. 514

124 processing (HHP) on the inhibitory effects (IC(50)) of kiwiberries (cv. 'Weiki'), on the formation o

125 so evaluated the anti-proliferative effects (IC(50)) of these samples on triple-negative breast cance

126 ENT1 IC(50)-based models were generated from ChEMBL; subvalid

127 percent uptake and 63% when using estimated-IC(50) values.

128 ght exposure, the photosensitizers exhibited IC(50) values around 11.1-23.8 muM.

129 0)] = 32 nM), the glycoconjugate, FGlc-FAPI (IC(50) = 167 nM), showed slightly lower affinity for FAP

130 contrast to our previous study in the ferret IC, task engagement had little effect on sound-evoked ac

131 ropy (FA) in callosal and projection fibers (IC and corona radiata) relative to controls, but lower F

132 a holding potential of -90 mV, the following IC(50) values were found (in micromolars): >1000 (Ca(V)2

133 lease in SC, and volatility and polarity for IC.

134 Short-term effectiveness of SET for IC is not determined by the location of stenosis.

135 s advocate SET before invasive treatment for IC, but early revascularization remains widespread, espe

136 increasing aroma intensity in SC while, for IC, all loads of microparticles improved aroma intensity

137 We find that for ICs from various species, there is a correlation between

138 All four IC have similar diagnostic performance characteristics a

139 CE incorporated interoceptive feedback from IC to improve discrimination of CS valence.

140 NUC-treated patients differed markedly from IC patients, especially in DC, monocytes and CD8+ T cell

141 xpression of purified leukocyte subsets from IC versus NUC-treated patients, and evaluated the putati

142 nd glycerol ester hydrolase or lipase (gehB, IC(50) 1.5-25 muM).

143 tstanding breadth (97%) and potency (GeoMean IC(50) = 0.048 mug/mL).

144 omycin as the inhibitor of cyst germination (IC(50) = 19.8 mug/L); beta-rubromycin did not inhibit gr

145 = 23 +/- 2 ug/mL) and oxidative haemolysis (IC(50) at 60 min = 46.0 +/- 0.8 ug/mL).

146 mistry optimization, the most potent hit has IC(50) 280 nM, corresponding to K (i) of 173 nM.

147 tivity; beyond this, 10 of 23 compounds have IC(50) better than 50 muM.

148 against BRD4 BD1 (IC(50) =11 nm) and HDAC1 (IC(50) =21 nm).

149 h grade dysplasia or invasive carcinoma (HGD/IC)] was determined.

150 noted in 59 (23%), of which 36 (61%) had HGD/IC (P < 0.003).

151 ars and 49% were females): 122 (47%) had HGD/IC.

152 ted UDD to be a significant predictor of HGD/IC in those remote lesions (odds ratio: 4.41, P = 0.039)

153 ll-free HIV or concentrated, immobilized HIV-ICs in cell-free experiments.

154 elling scavenging efficiencies against HOCl (IC(50) = 0.79 ug/mL) and O(2)(-) (IC(50) = 12.92 ug/mL)

155 At the individual level, however, IC is strongly recommended for assessing energy requirem

156 e of recent antifungal prophylaxis; however, IC and non-Candida breakthrough IFIs were observed, most

157 We propose that IgE-ICs are noninflammatory through reduced engagement by Fc

158 ilonRI on allergic effector cells, while IgE-ICs were noninflammatory because of reduced FcepsilonRI

159 netic depletion of HIF1alpha, attenuated IgG IC-induced activation of macrophages in vitro, including

160 Thus, CD32a and FcRn coregulate IgG IC-mediated immunity in a manner favoring the CD32aH var

161 viding support for FcRn's direct role in IgG IC-associated inflammation.

162 Conversely, FcRn induced responses to IgG IC independently of classical FcgammaR, but optimal resp

163 go a switch to glycolysis in response to IgG IC stimulation, mirroring macrophage metabolic changes i

164 ant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc rec

165 Hospitalized immunocompromised (IC) adults with influenza may have worse outcomes than h

166 In IC, learning integrated unconditioned stimulus (US)-evok

167 tivity and decreased stimulus selectivity in IC, whereas suppression had no effect.

168 serves as a primary pacemaker conductance in ICs of the GI tract.

169 T) are also frequently contacted by incoming IC axons, but the strength of this connection is weak.

170 ic compounds content, and anti-inflammatory (IC(50) = 72 ug/mL) and cytotoxic (GI(50) of 30-79 ug/mL)

171 gr) alleles in absence of growth inhibition (IC(50) values: 1-64 mug/mL).

172 ections onto either excitatory or inhibitory IC neurons, and adeno-associated viral tracings to label

173 characterization of positive hits (that is, IC(50) and K(i) ), as well as inhibition-reactivation as

174 ncy against human class I HDACs (e.g., JT86, IC(50) 0.7 nM, HDAC1), 25-fold increased cytotoxicity ag

175 re potently inhibited by intracellular K(+) (IC(50) = 2.8 mm).

176 c-Kit(+) ICs are a minor population of ICs in murine renal pelvis

177 Ca(2+) transients were observed in c-Kit(+) ICs, smMHC(+) PDGFRalpha cells and smMHC(-) PDGFRalpha c

178 sound-evoked activity in central (lemniscal) IC of the marmoset.

179 All extracts inhibited pancreatic lipase (IC(50) between 1.15 and 0.59 mg/mL), although the hydrol

180 ability to inhibit the function of P-gp (log IC(50) of 4.20 nM for quinidine and 4.61 nM for the mPEG

181 -regulated reporters for leucocidin A (lukA, IC(50) 0.4-25 muM) and glycerol ester hydrolase or lipas

182 elial barrier dysfunction using Caco-2 and m-IC(C12) cell monolayers in vitro and mice in vivo.

183 In Caco-2 and m-IC(C12) cell monolayers, LPA attenuated radiation-induce

184 The posterior and medial IC exhibited resembling connectivity patterns, while the

185 of alpha-glucosidase, showing low-micromolar IC(50) values, far lower than that of the antidiabetic d

186 ed from the longitudinal prospective MONITOR-IC cohort study.

187 whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent.

188 ver, the brain-wide connections of the mouse IC have not been comprehensively mapped.

189 Myosin-IC (Myo1c) has been proposed to function in delivery of

190 icacy but evoked more potent UDB of I (NaP) (IC(50) = 0.07 and 0.6 uM, respectively) than ranolazine

191 c and clinical characteristics of IC and non-IC adults using descriptive statistics.

192 ration could be increased in both IC and non-IC adults.

193 ay have worse outcomes than hospitalized non-IC adults.

194 , 1.35; 95% CI, 1.06-1.73) compared with non-IC patients in those age groups.

195 ly restored the mutant appressorium, but not IC, formation.

196 These novel ICs offer a unique resource to study human alveolar epit

197 sae two-component system, was also observed (IC(50) 0.4-12.5 muM).

198 The aim was to compare accuracy of IC (NI-RADS, Porceddu, Hopkins, Deauville) for predictin

199 The addition of IC to treatment for patients with SR-average disease did

200 demographic and clinical characteristics of IC and non-IC adults using descriptive statistics.

201 followed up patients from index diagnosis of IC for 5 years, or until patients discontinued insurance

202 or patient gender, age at index diagnosis of IC, and diagnosis with diabetes mellitus) followed up pa

203 First episodes of IC occurred a median of 31 days (interquartile range [IQ

204 ity can be strongly upregulated on firing of IC neurons.

205 ght on the previously described functions of IC and CeA through direct projections to the LH.

206 st that it is the level of disorder in H2 of IC along with its charge, rather than sequence specifici

207 lity, while accounting for the influences of IC and antifungal therapy.

208 lity post abdominal surgery, irrespective of IC.

209 alysis of TLR stimulation in the presence of IC predicted the downstream activation of AKT and the in

210 At the start of IC, higher stool Shannon diversity (hazard ratio [HR], 0

211 c-Kit(+) ICs are a minor population of ICs in murine renal pelvis.

212 f cortico-collicular feedback projections on IC sound responses in mice.

213 ORR-IC was higher in the tucatinib arm (47.3%; 95% CI, 33.7%

214 to trastuzumab and capecitabine doubled ORR-IC, reduced risk of intracranial progression or death by

215 e aimed to determine whether these and other IC molecules have a functional role in maintaining HIV l

216 her than protein binding-adjusted IC(90) (PA-IC(90)) of LPV for HIV-1 (140 ng/mL) following oral admi

217 We found PDGFRalpha(+) ICs in the adventitial layers of the pelvis, the muscle

218 ed an excellent degree of photocytotoxicity (IC(50) = 4.6-8.8 muM).

219 novel series of compounds reaching picomolar IC(50) inhibition in WNT/beta-catenin signaling cellular

220 reased in response to TNFalpha, but not poly-IC.

221 Stimulation by TNFalpha or poly-IC did not affect the total ST2 expression by epithelial

222 microbiome and infection susceptibility post-IC.

223 e inhibitor of CLC-2 with nanomolar potency (IC(50) = 17 +/- 1 nM).

224 uctural replacements to improve the potency (IC(50)), pharmacokinetic properties including the free f

225 of these dual inhibitors were highly potent (IC(50) < 10 nM) and selective against PI3Kgamma, delta a

226 ectrum Collection, with the two most potent (IC(50) = ~2 mum) being symmetrically substituted dichlor

227 amination point to the need for prioritizing IC interventions to control the spread of C. auris and C

228 ding modes, are 56- and 64-residue proteins (IC(50) ~ 0.16 nanograms per milliliter).

229 falciparum in vitro in the nanomolar range (IC(50) = 74 nM) with high selectivity index (SI > 1350).

230 t EBV lytic DNA replication, with respective IC(50) values of 0.30 muM and 84 nM.

231 meric 5-HT type 3AB receptors (5-HT(3AB)Rs) (IC(50) = 840 and 526 muM, respectively).

232 nzothiazoline-6-sulfonic) acid assays showed IC(50) values of 7.07 and 65.67 ug/mL, and 17.96 and 201

233 i.e., for sensing and actuating, and silicon ICs for computation and communication purposes.

234 electronics are not as efficient as silicon ICs for computation and signal communication.

235 rinted sensors and circuits, thinned silicon ICs, printed antennas, printed energy harvesting and sto

236 ple adrenergic receptor subtypes in a single IC cell, we measured co-expression of alpha(1) , alpha(2

237 Some IC neurons showed facilitation in response to HCT relati

238 Gynecology and Obstetrics (FIGO; 1988) stage IC-IIA high-grade serous, clear cell, or any poorly diff

239 ederation of Gynecology and Obstetrics stage IC-IV ovarian cancer and an Eastern Cooperative Oncology

240 of L. interrogans serovar Copenhageni strain IC:20:001 in semi-solid media at 29 degrees C.

241 V activities with nanomolar to submicromolar IC(50) values and high selectivity indexes (SI > 100), i

242 against thiobarbituric reactive substances (IC(50) = 23 +/- 2 ug/mL) and oxidative haemolysis (IC(50

243 for the alpha3beta2 neuronal nAChR subtype (IC(50) 1.3 nM).

244 the DPPH (SC(50)10.30-15.87 mug/mL), TBARS (IC(50) 18.46-20.84 mug/mL), and FRAP (RC(50) 0.203-0.309

245 The IC and PmIC states coexist in solution, revealing a dyna

246 The IC rate-place code was most prevalent for F0 > 800 Hz, w

247 The IC(50) value of 5FU-SLN(4) (7.4 +/- 0.02 uM) was 2.3 fol

248 s grown in monolayer, which increases as the IC(50) is approached.

249 ot reduce E-cadherin expression level at the IC(50) (DPAGT1) concentration.

250 While the connectivity between the IC and other cortical regions was highly bidirectional,

251 We uncover a strong connection between the IC and the lateral hypothalamus (LH) with a monosynaptic

252 fied a direct line of connection between the IC and the lateral hypothalamus (LH), which engages nume

253 rtical regions was highly bidirectional, the IC connectivity with subcortical structures was often un

254 Results: Regional metabolism of both the IC and the PAC was significantly reduced contralateral t

255 he novel compounds were characterized by the IC(50) values in a submicromolar range.

256 they are disproportionally controlled by the IC.

257 nd NPY signaling to regulate activity in the IC and auditory thalamus.

258 We found greater proportions of cells in the IC that expressed no adrenergic receptor-encoding mRNA,

259 Dysfunctional interactions in the IC<->CE/NBM network may underlie intolerance to uncertai

260 e one-third of the inhibitory neurons in the IC.

261 mately one-third of GABAergic neurons in the IC.

262 ctional roles of defined neuron types in the IC.

263 that NPY signaling regulates activity in the IC.

264 selectivity filter drastically increased the IC(50) value, suggesting that MDIMP binds to the extrace

265 Moreover, the IC(50) of phenytoin in RyR2 is at least threefold lower

266 notopically organized central nucleus of the IC cross isofrequency laminae.

267 sis of the structure and interactions of the IC from Chaetomium thermophilum demonstrates that the H2

268 anisms both dependent and independent of the IC MR receptor.

269 r-encoding mRNA across the subregions of the IC, alpha(2A) and beta(2) receptor-encoding mRNA was exp

270 Owing to these unique advantages of the IC-WiS electrolyte, the NaTiOPO(4) anode and Prussian bl

271 ed throughout the rostrocaudal extent of the IC.

272 or-encoding mRNA throughout all areas of the IC.

273 rastically, i.e. up to 245-fold, reduced the IC(50) for the cyclase inhibition.

274 he alpha (2) or beta (3) subunit reduces the IC(50) of TETS by ~700-fold in whole-cell patch-clamp ex

275 Thus, the ICs mimic the cellular heterogeneity in the human alveol

276 novel inhibitors of p300/CBP HAT with their IC(50) values as low as 620 nM were discovered.

277 trates that the H2 region of C. thermophilum IC has a low helical propensity and establishes that H2

278 These ICs can be passaged, replicate rapidly and remain conflu

279 underlie its importance in initiating tight IC-p150(Glued) complex formation.

280 Traditionally, IC-FPOP has been executed using a single cell flow syste

281 p53 sequence-specific DNA binding in vitro (IC(50) = 180 nM) and in vivo.

282 Among 35 348 adults, 3633 (10%) were IC; cancer (44%), nonsteroid immunosuppressive therapy (

283 new class of the inert-cation-assisted WiS (IC-WiS) electrolytes containing the tetraethylammonium (

284 tently neutralized authentic SARS-CoV-2 with IC(100) as low as 0.04 mug/mL, showing a broad spectrum

285 fectively inhibited the Sulf-1 activity with IC(50) = 0.53 muM, K(i) = 0.36 muM, and K(D) = 12 nM.

286 ed enhanced radical scavenging activity with IC(50) value equivalent to 39.57 and 6.23 uL/mL for DPPH

287 moiety displayed the highest activity, with IC(50) and EC(50) values in the lower micromolar range i

288 showed potent growth inhibitory effects with IC(50) values lower than 500 nM.

289 a virus glycoprotein-driven cell entry (with IC(50) values down to 95 pM), but only partially block D

290 excellent PARP-1 and PARP-2 inhibition with IC(50) of 1.3 and 0.9 nM, respectively.

291 ted in several highly potent inhibitors with IC(50) values lower than 20 nM for mPTPB.

292 active as inhibitors of PDE1 isoforms, with IC(50) values in the high nanomolar/low micromolar conce

293 ptides, VRP, LKY, VRY, KYKA, and LKYKA, with IC(50) values of 0.034-5.77 mug/mL, respectively, and fo

294 ) transport in a non-competitive manner with IC(50) ~ 2.5 muM, a value 400-fold lower than the K(M) f

295 providing unexpectedly active molecules with IC(50)'s from 2340 to 0.89 nM.

296 on diagnoses of maculopathy in patients with IC were exudative AMD (1.5%), drusen (0.8%), nonexudativ

297 ignificant cytotoxicities of porphyrins with IC(50) values between 23.3 and 44.2 muM in the dark, whe

298 found to inhibit Fyn A and BTK proteins with IC(50) values in the low micromolar range, with the most

299 MAO-A) and AChE inhibitor in the series with IC(50) values of 4.27 +/- 0.07 and 0.79 +/- 0.03 muM, re

300 tive to sacituzumab govitecan in vitro, with IC(50) values in the range of 0.18 to 0.26 nM (p = 0.02,