ライフサイエンスコーパス: ICR

1 ICR cell array systems consisting of three or five cells

2 ICRs were found in 17 patients and were not associated w

3 assess the following conditions in male CD-1/ICR mice: group size (1, 2, or 3), age at grouping (5 or

4 istributed as follows: CR, 0 (n=386, 42.7%); ICR, >0 to 4 (n=184, 20.4%), >4 to 8 (n=167, 18.5%), >8

5 MARY BACKGROUND DATA:: Recurrence rate after ICR for CD can be up to 60%, but its predictive factors

6 rs of reduced postoperative recurrence after ICR for CD.

7 CR deletion in mice and patients, whereas an ICR-driven Percc1 transgene was sufficient to rescue the

8 Subjects who presented with an ICR at t(1) presented with a significantly reduced cogni

9 clinical outcomes were stratified by CR and ICR (tertiles of the residual SYNTAX Score: >0-4, >4-8,

10 rs also mean that comparisons between CR and ICR are subject to multiple confounders and are difficul

11 in all cells were simultaneously excited and ICR signals from each cell were independently amplified

12 Within the PCI and CABG arms, ICR (compared with CR) seemed to be a surrogate marker o

13 The findings associating ICR (compared with CR) with higher frequencies of 4-year

14 , respectively, without altering H4R3me2s at ICRs.

15 PSCs harboring abnormal hypermethylation at ICRs of the Dlk1-Gtl2-Dio3 imprinting cluster diminished

16 preserves DNA methylation through stage I at ICRs and meiotic gene promoters and is required for the

17 e 5-methylcytosine oxidation specifically at ICRs.

18 elective, and cell active inhibitor 13 (BAZ2-ICR) of the BAZ2A/B bromodomains through rapid optimizat

19 Our work reveals the link between ICR and CP, significantly extending the knowledge of how

20 decided to explore the relationship between ICR, subjective evaluation of cognitive performance and

21 Experiment 1: Intravenously cannulated ICR mice received chow, PN, or PN + BBS injections for 5

22 Compared to CCR, ICR decreased tumor incidence in genetically engineered

23 Chinese Clinical Trial Registry ChiCTR-ICR-15006053.

24 However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controve

25 concentrations in the pore, and consequently ICR.

26 Despite ICR following PCI, there was no incremental benefit in a

27 With the exception of detecting ICR in S. aureus, Vitek 2 performed reliably for antimic

28 rs SYNTAX trial, angiographically determined ICR has a detrimental impact on long-term clinical outco

29 We have used genetic mouse models to dissect ICR-mediated genetic and epigenetic regulation of imprin

30 Subjects were female ICR mice 8-10 weeks old.

31 -sequencing protocols to design IMPLICON for ICRs in adult tissues of inbred mice, validating it in h

32 FT ICR mass spectrometry continues to be the leader in the

33 in which an open, dynamically harmonized FT ICR cell is integrated into a vacuum system with the out

34 ntroduction of the dynamically harmonized FT ICR cell, it has become possible to achieve the resolvin

35 and the factor of insufficient vacuum in FT ICR mass spectrometers with an ultrahigh magnetic field

36 on cyclotron resonance mass spectrometry (FT ICR MS), can resolve thousands of molecular ions in comp

37 We offer a new design for the FT ICR cell and the whole mass spectrometer, in which an op

38 FT-ICR mass spectral data revealed an overall similarity in

39 yclotron resonance mass spectrometry (21T FT-ICR MS).

40 the present study, the capabilities of 2D FT-ICR MS are explored with a tryptic digest of cytochrome

41 2D FT-ICR MS has been optimized as a data-independent method f

42 olution FT-ICR MS/MS analysis, but the 2D FT-ICR MS method required only one experimental scan.

43 cyclotron resonance mass spectrometry (2D FT-ICR MS) allows the correlation between precursor and fra

44 ide and proteins within the ICR cell of a FT-ICR mass spectrometer are accomplished through appropria

45 ed with a nanoESI ion source coupled to a FT-ICR-MS (limit of detection for lysine: 0.5 pg).

46 d FT-ICR) or continuous IRMPD activation (FT-ICR).

47 at pressures as low as 10(-6) mbar in an FT-ICR mass spectrometer source, and the expected mass reso

48 ution and/or throughput of DESI-MSI on an FT-ICR MS by developing and implementing a sophisticated da

49 performance data acquisition system to an FT-ICR MS instrument to record the time-domain signals (tra

50 ificantly reduced by tandem-MS (Q-ToF and FT-ICR) followed by mild collisional or continuous IRMPD ac

51 ucoside-micelle by collisional (Q-ToF and FT-ICR) or continuous IRMPD activation (FT-ICR).

52 clotron resonance mass spectrometry (APPI FT-ICR MS) to identify molecular transformations in oil-res

53 oils samples were analyzed using APPI(+)-FT-ICR MS considering six replicates.

54 tly after the fire using state-of-the-art FT-ICR (Fourier transform ion cyclotron resonance) and GC x

55 to replace the entrance lens of a Bruker FT-ICR collision cell, the dynamic range enhancement (DRE)

56 e overall loss of HMW species observed by FT-ICR MS has not previously been documented and is counter

57 lving power and mass accuracy provided by FT-ICR MS.

58 The mass spectra acquired by ESI FT-ICR MS of untreated, borohydride-reduced, and borodeuter

59 1% of the DOM molecules identified by ESI FT-ICR MS, may suggest a microbial provenance and high bioa

60 er Transform Ion Cyclotron Resonance (ESI FT-ICR) mass spectrometry and liquid state (1)H NMR spectro

61 mples was then performed through ESI(+/-)-FT-ICR MS analysis.

62 ron resonance mass spectrometry (ESI(+/-)-FT-ICR MS).

63 lotron resonance mass spectrometry (ESI(-)FT-ICR MS) and physicochemical characterisation analysis (t

64 The ESI(-)-FT-ICR data also showed a clear and evident change in the c

65 ESI(-)-FT-ICR MS is a powerful tool to predict the physicochemical

66 racterization methods have shown that ESI-FT-ICR hyphenated with liquid chromatography (LC) is a prom

67 The ESI-FT-ICR MS readings were acquired and the data were correlat

68 The online nano solid phase extraction-FT-ICR-MS method provides novel insight into the processes

69 gh H/C values of identified formulas from FT-ICR MS data.

70 Metabolic fingerprints from FT-ICR-MS data could discriminate wines according to the ad

71 FAC)) and the exact mass information from FT-ICR-MS, and thus revealing the extent of sulfur-containi

72 ltrahigh resolution mass analyzers (e.g., FT-ICR MS).

73 ed and successfully installed in a hybrid FT-ICR instrument in place of the standard gas collision ce

74 Hitherto, the use of absorption mode in FT-ICR mass spectrometry has required either specially adap

75 ncy multiples for increased throughput in FT-ICR MS, essential for numerous applications with time co

76 detection limit should become routine in FT-ICR-MS data processing.

77 he ultrahigh mass resolution available in FT-ICR.

78 of z' ions in protein top-down MALDI-ISD FT-ICR mass spectra and show why these distributions can de

79 ident assignments of z' ions in MALDI-ISD FT-ICR mass spectra.

80 positive and negative ion mode MALDI-ISD FT-ICR MS in the m/z range 46-13 500 showed an increased se

81 on of a postcolumn counter gradient in LC-FT-ICR-MS analyses of NOM offers novel insight into the mos

82 composition during gradient elution in LC-FT-ICR-MS, ionization conditions also change throughout the

83 served in infected kidney tissue by MALDI FT-ICR IMS through accurate mass matching.

84 N-Glycans are detected with a MALDI FT-ICR mass spectrometer in a concentration-dependent manne

85 rticular, TOF-SIMS and confirmatory MALDI FT-ICR MS (/MS) analysis permitted the mapping of several l

86 nation of negative and positive ion MALDI FT-ICR MS is a useful tool to improve the characterization

87 In addition, MALDI FT-ICR MS of IdeS-digested mAbs allowed isotopic-level prof

88 and dynamic range combined in a 21T MALDI FT-ICR MSI experiment enable researchers to visualize molec

89 lotron resonance mass spectrometry (MALDI-FT-ICR MS) and single cell imaging flow cytometry to detect

90 The ultrahigh resolving power of FT-ICR MS combined with sSEC fractionation enabled targeted

91 late with DOM composition, the ability of FT-ICR MS to characterize DOM subpopulations provides uniqu

92 ing from the ultrahigh resolving power of FT-ICR, we isotopically resolved 31 distinct proteoforms (3

93 The combination of FT-ICR-MS and chemometrics allowed the distinction of whisk

94 Robust correlations of FT-ICR-MS peak intensities with chlorophyll a and solar irr

95 proves all performance characteristics of FT-ICR; mass resolving power improves linearly, while mass

96 esults are compared to alternative TIMS-q-FT-ICR MS/MS experiments with quadrupole isolation at nomin

97 position data obtained by high resolution FT-ICR mass spectrometry to correctly identify the source o

98 power of 90-220) to ultrahigh resolution FT-ICR MS (resolving power over 400k) permitted the identif

99 lity and precision as the high resolution FT-ICR MS.

100 matched data provided by high-resolution FT-ICR MS/MS analysis, but the 2D FT-ICR MS method required

101 ourier-transform ion cyclotron resonance (FT-ICR) and linear quadrupole ion trap (LQIT) mass spectrom

102 ourier transform ion cyclotron resonance (FT-ICR) mass analyzer allows for tandem mass spectrometry w

103 ourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer to perform MAIV from both interme

104 ourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer.

105 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometry data allows the spectra to be pre

106 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometry to identify compositional changes

107 ourier transform ion cyclotron resonance (FT-ICR) MS affords ultrahigh resolving power and provides h

108 ourier transform ion cyclotron resonance (FT-ICR) MS partially overcomes this limitation, but to furt

109 ourier transform ion cyclotron resonance (FT-ICR) MS, and ion mobility spectrometry (IMS).

110 ourier-transform ion cyclotron resonance (FT-ICR) MS.

111 ourier transform ion cyclotron resonance (FT-ICR) MS.

112 ourier transform ion cyclotron resonance (FT-ICR) tandem mass spectrometry.

113 ourier transform ion cyclotron resonance (FT-ICR) to analyze product ions derived from the applicatio

114 ourier-transform ion cyclotron resonance (FT-ICR), MALDI mass spectrometry imaging (MSI) to image the

115 ourier transform ion cyclotron resonance (FT-ICR)-MS approach was used for initial screening of wild-

116 The SID-FT-ICR platform has been tested with several protein comple

117 orm Ion Cyclotron Resonance mass spectra (FT-ICR-MS) of natural organic matter are complex and consis

118 Fourier transform ICR mass spectrometer (FT-ICR MS).

119 on cyclotron resonance mass spectrometry (FT-ICR MS) and quantify DOM photochemical activity using pr

120 on cyclotron resonance mass spectrometry (FT-ICR MS) and two-dimensional gas chromatography (GC x GC)

121 d ultrahigh resolution mass spectrometry (FT-ICR MS) enables an improved characterization of complex

122 on cyclotron resonance mass spectrometry (FT-ICR MS) enables extensive compositional characterization

123 on cyclotron resonance mass spectrometry (FT-ICR MS) for direct separation and characterization of ta

124 on cyclotron resonance mass spectrometry (FT-ICR MS) has been increasingly employed to characterize d

125 on cyclotron resonance mass spectrometry (FT-ICR MS) identified 3897 m/z ions and their exact molecul

126 on cyclotron resonance mass spectrometry (FT-ICR MS) is applied to the analysis of the low energy wat

127 on cyclotron resonance mass spectrometry (FT-ICR MS) offers superior mass accuracy and mass resolving

128 on cyclotron resonance mass spectrometry (FT-ICR MS) offers the highest mass spectral performance for

129 on cyclotron resonance mass spectrometry (FT-ICR MS) provides ultrahigh resolution and ultrahigh mass

130 on cyclotron resonance mass spectrometry (FT-ICR MS) technique to characterise in situ chemical compo

131 on cyclotron resonance mass spectrometry (FT-ICR MS) to determine the elemental compositions of DOM m

132 on cyclotron resonance mass spectrometry (FT-ICR MS) typically utilizes an m/z-independent excitation

133 on cyclotron resonance mass spectrometry (FT-ICR MS).

134 on cyclotron resonance mass spectrometry (FT-ICR MS).

135 on cyclotron resonance mass spectrometry (FT-ICR-MS) "top-down" analysis of PA1006 purified from Pae

136 on cyclotron resonance mass spectrometry (FT-ICR-MS) and data from two independent studies to disenta

137 y ultrahigh resolution mass spectrometry (FT-ICR-MS) and excitation emission matrix fluorescence (EEM

138 on cyclotron resonance mass spectrometry (FT-ICR-MS) as a nontargeted technique to assign unambiguous

139 on cyclotron resonance mass spectrometry (FT-ICR-MS) for the analysis of a pyrolysis liquid from brow

140 on cyclotron resonance mass spectrometry (FT-ICR-MS) identified both the photolabile and the photopro

141 on cyclotron resonance mass spectrometry (FT-ICR-MS) is one of the state-of-the-art methods to analyz

142 ) ultrahigh resolution mass spectrometry (FT-ICR-MS) revealed a strong interaction between DOM and re

143 on cyclotron resonance mass spectrometry (FT-ICR-MS) to determine the biodegradability and molecular

144 on cyclotron resonance mass spectrometry (FT-ICR-MS) was developed to extract and analyze organic mat

145 on cyclotron resonance mass spectrometry (FT-ICR-MS), (13)C-nuclear magnetic resonance spectrometry (

146 on Cyclotron Resonance Mass Spectrometry (FT-ICR-MS), as a proxy for labile SOM.

147 on cyclotron resonance mass spectrometry (FT-ICR-MS), combined with chromatographic prefractionation,

148 on Cyclotron Resonance-Mass Spectrometry (FT-ICR-MS), which delivered the molecular formulae and ion

149 on cyclotron resonance mass spectrometry (FT-ICR-MS).

150 on cyclotron resonance mass spectrometry (FT-ICR-MS).

151 on cyclotron resonance mass spectrometry (FT-ICR-MS).

152 sSEC/FT-ICR ECD facilitated the identification and sequence char

153 matography (sSEC) fractionation with 12 T FT-ICR MS for targeted top-down characterization of protein

154 times higher than those provided by 10 T FT-ICR MS with a standard ICR cell.

155 ple from the deep North Pacific on a 15 T FT-ICR-MS; each of these replicate runs consisted of 500 cu

156 extensive residue cleavages with 21 telsa FT-ICR MS/MS.

157 The FT-ICR experiments led to the identification of approximate

158 examples where the high resolution of the FT-ICR is advantageous for deconvoluting overlapping SID fr

159 mited by the slow acquisition rate of the FT-ICR MS (<1 Hz), a database driven retention time compari

160 intact, demonstrating the ability of the FT-ICR to maintain the noncovalent interactions and efficie

161 timal bacteriorhodopsin liberation on the FT-ICR, in comparison to the Q-ToF and Orbitrap instruments

162 re compared, the Q-ToF, Orbitrap, and the FT-ICR, to analyze, under native instrument and buffer cond

163 The TIMS-FT-ICR MS analysis provided, in addition to the heteroatom

164 y, we further push the boundaries of TIMS-FT-ICR MS by performing chemical formula-based ion mobility

165 ciple for further application of OSA-TIMS-FT-ICR MS for the unsupervised analysis of complex mixtures

166 TIMS-FT-ICR MS is an important alternative to study the isomeric

167 ions (<1%) can be measured using OSA-TIMS-FT-ICR MS with high mobility resolving powers (RIMS up to 2

168 In the case of OSA-TIMS-FT-ICR MS, the TIMS operation sequence, trapping conditions

169 3 KRGRGRPRK [M + 2H](+2) during OSA-TIMS-FT-ICR MS.

170 or off-line electrochemical oxidation to FT-ICR-MS detection.

171 that allows spectra recorded on unadapted FT-ICR mass spectrometers to be phase corrected, their base

172 Insights generated using FT-ICR-MS analysis can be confirmed and further explored us

173 13)C labelled peaks were identified using FT-ICR-MS spectra.

174 he rate coefficients were determined with FT-ICR mass spectrometry under single-collision conditions

175 ing organic formulas were identified with FT-ICR-MS in the stormwater runoff and pond outflow water,

176 eproducibly determine isotope ratios with FT-ICR-MS.

177 the level of identification possible with FT-ICR-MS.

178 e and constitution of this structure with FT-ICR-MS/MS, NMR, and UV-vis-NIR experiments and isolated

179 In contrast to most of the genome, ICRs must maintain their DNA methylation and parental id

180 ted differentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF

181 A closer look at H19 ICR revealed complete erasure in SSCiPSC in contrast to

182 rentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) w

183 out mice however lacked demethylation of H19 ICR.

184 2 and the H19 imprinting control region (H19 ICR) compared with term infants over the first year of l

185 during gametogenesis at primary regions (H19 ICR).

186 both DMR2 (beta=-2.84, p=0.013) and the H19 ICR (beta=-2.31, p=0.048) compared with term infants at

187 nts with a history of chronic angina who had ICR post-PCI were randomized 1:1 to oral ranolazine vers

188 upgrade with a novel dynamically harmonized ICR cell, i.e., ParaCell, for mapping isotopically resol

189 (mIC1) is replaced by the orthologous human ICR (hIC1) sequence, designated H19(hIC1) We show that h

190 Microdeletions at the human H19/IGF2 ICR (IC1) are proposed to be responsible for IC1 epimuta

191 ck-in mouse in which the endogenous H19/Igf2 ICR (mIC1) is replaced by the orthologous human ICR (hIC

192 mice carry a 1.3 kb deletion at the H19/Igf2 ICR [Delta2,3] removing two of four CCCTC-binding factor

193 gest that insulator activity of the H19/Igf2 ICR varies by cell type and may depend on cell-specific

194 The H19/insulin-like growth factor 2 (Igf2) ICR has a multifunctional role including insulation, act

195 In ICR biosensing, a nanopore coated with an analyte specif

196 t that estrogen alters the gut microbiota in ICR (CrljOri:CD1) mice, particularly AOM/DSS-treated mal

197 f angiographic complete (CR) and incomplete (ICR) revascularization and its association with the pres

198 A/H-F/V was transplanted subcutaneously into ICR mice for up to 4 weeks to assess its in vivo effect

199 of the nanopore aperture, thus altering its ICR response in a time dependent manner.

200 A characteristic of the known ICRs is that they acquire different epigenetic states, e

201 The maternally methylated KvDMR1 ICR regulates imprinted expression of a cluster of mater

202 Two days after venous cannulation, male ICR (Institute of Cancer Research) mice were randomized

203 xidative stress and hepatic fibrosis in male ICR mice.

204 genomic imprinting is conserved in mammals, ICRs are genetically divergent across species.

205 Neonatal (P0) male and female mice (ICR) were exposed to systemic LPS (5 mg/kg, IP) and inna

206 ponsible for maintaining methylation at most ICRs.

207 lelically expressed genes, may represent new ICRs.

208 O was the strongest independent predictor of ICR after PCI (hazard ratio: 2.70, 95% confidence interv

209 Multivariate predictors of ICR were determined.

210 praise the evidence linking various types of ICR to adverse outcomes in patients with multivessel dis

211 ed here significantly expands the utility of ICR biosensing measurements for detecting low-abundance

212 tudy introduces an operational definition of ICRs and suggests to their role as a factor for cognitiv

213 ells, as well as the sustained expression of ICRs.

214 re has been much focus on gametic marking of ICRs as the point of imprint specification, recent mecha

215 ZFP57 act together, maintaining all but one ICR in vivo, whereas earlier embryonic expression of ZNF

216 genous expression of prostasin could protect ICR suckling mice from life-threatening DENV-2 infection

217 quadrupole mass filter of a commercial QhFT-ICR mass spectrometer to perform selected ion ejection p

218 led on a commercial dual source, hybrid QhFT-ICR mass spectrometer for use during imaging mass spectr

219 nges during IMS experiments on a hybrid QhFT-ICR MS.

220 Rather, ICRs are part of more widespread methylation events that

221 ntion as a novel immune checkpoint receptor (ICR) on chronically stimulated, often dysfunctional, T c

222 ific set of inhibitory checkpoint receptors (ICRs), such as programmed cell death protein 1 (PD-1) an

223 Of late, ion current rectification (ICR) biosensing measurements have received a great deal

224 The behavior of ionic current rectification (ICR) in a conical nanopore with its surface modified by

225 ying mechanism of ion current rectification (ICR), a continuum model based on a set of Poisson-Nernst

226 ms and 58 fetuses; imprinting control region ICR strain) and 17.5 (21 dams and 158 fetuses) under res

227 lation at the H19 imprinting control region (ICR) induced by 5-AzaCdR, reduced IGF2, increased H19 ex

228 ethylation at the imprinting control region (ICR), but the underlying mechanism remains largely uncle

229 encompassing the imprinting control region (ICR), concomitant with increased DNA methylation and red

230 that we term the intestine-critical region (ICR) cause intractable congenital diarrhoea in infants(1

231 f CpG islands at imprinting control regions (ICR) determines the monoparental expression of a subset

232 ines that act at imprinting control regions (ICRs) and meiotic genes (stage II).

233 identifies known imprinting control regions (ICRs) as well as some novel differentially methylated re

234 nt demethylation of imprint control regions (ICRs) associated with increased mRNA expression of the c

235 mprinting, binds imprinting control regions (ICRs) in mice and humans.

236 NA methylation at imprinted control regions (ICRs) is established in gametes and, although largely pr

237 y, all the known imprinting control regions (ICRs) were classified into germ-line or somatic ICRs.

238 mono-allelic at imprinting control regions (ICRs), at which it marks the same parental allele as H3K

239 are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-speci

240 g in mammals are imprinting control regions (ICRs), which are the discrete genetic elements that conf

241 A methylation at imprinting control regions (ICRs).

242 lements known as imprinting control regions (ICRs).

243 y DNA methylated imprinting control regions (ICRs).

244 he relevance of isolated cognitive relapses (ICRs ie, those occurring in absence of new sensorimotor

245 isk factors following ileocolonic resection (ICR) for Crohn disease (CD) in a nationwide cohort study

246 ureus with inducible clindamycin resistance (ICR) (n = 30), trimethoprim-sulfamethoxazole-resistant M

247 n (UVPD) within the ion cyclotron resonance (ICR) cell of a Fourier transform-ion cyclotron resonance

248 A multielectrode ion cyclotron resonance (ICR) cell, herein referred to as the "4X cell", for sign

249 f Fourier transform ion cyclotron resonance (ICR) cells as detectors that constitute the first MS arr

250 (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects.

251 CR) than after incomplete revascularization (ICR) in patients with multivessel disease.

252 life (QOL) in incomplete revascularization (ICR) post-PCI patients.

253 AX Score >0 as incomplete revascularization (ICR).

254 reatment Rule's information collection rule (ICR) and to a literature review of norovirus (NoV) densi

255 finger protein (KZFP) ZFP57 protects select ICRs from demethylation and preserves parental identity.

256 of 5-hydroxymethylcytosine (5hmC) at several ICRs.

257 ions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) were analyzed in DNA from

258 s) were classified into germ-line or somatic ICRs.

259 e provided by 10 T FT-ICR MS with a standard ICR cell.

260 arable to the ones obtained for the standard ICR cell on the same mass spectrometer.

261 Here, we subjected ICR mice to mTBI and examined the bone response in the s

262 rmation Collection Rule Supplemental Survey (ICR SS) required analysis of Cryptosporidium and Giardia

263 It appears that ICR decreases IGF-1 and leptin and increases adiponectin

264 Thus, the evidence suggests that ICR exerts greater anticancer effect in genetically engi

265 We showed that ICRs were not associated with changes in mood, fatigue l

266 The ICR (Imprinting Control Region) of the Peg3 (Paternally

267 The ICR behavior depends highly on the charged conditions of

268 e ability of the target analyte to alter the ICR response of the nanopore upon it binding to the aper

269 cupancy of the insulator protein CTCF at the ICR.

270 tion does not perturb DNA methylation at the ICR; however, it does disrupt imprinted expression.

271 The high mass accuracy, obtained by the ICR mass analyzer, for both the precursor and product io

272 isolated by quadrupol and fragmented in the ICR cell by the ECD method.

273 In the ICR cell, the precursor ion radii are modulated before f

274 ecular ion signals (Deltam/z = 0.036) in the ICR cell, using single-shot ejections after broadband ej

275 the phenotypes found in mice that lacked the ICR.

276 n the developing gut of mice that lacked the ICR.

277 dence time of 30 days most closely match the ICR dataset.

278 While repressive functions of the ICR are compromised by the deletion regardless of tissue

279 Targeted deletion of the ICR in mice caused symptoms that recapitulated the human

280 Thus, the imprinted maternal allele of the ICR may be a suppressor antagonistic to the active pater

281 onistic to the active paternal allele of the ICR, suggesting a potential intralocus allelic conflict.

282 tervening sequence, approximately 75% of the ICR.

283 e Centrally Conserved Domain upstream of the ICR.

284 the maternal-specific DNA methylation on the ICR was properly established and maintained, causing no

285 rter assays in transgenic mice show that the ICR contains a regulatory sequence that activates transc

286 of human Naa10p disrupts its binding to the ICR of H19 and Dnmt1 recruitment.

287 ises the fundamental question of whether the ICR plays a species-specific role in regulating imprinti

288 of the IGF2 promoters to associate with the ICR.

289 D of a model peptide and proteins within the ICR cell of a FT-ICR mass spectrometer are accomplished

290 components, a competitive effect within the ICR cell takes place that hampers the detection of a pot

291 e 1 (Dnmt1) to DNA substrates, including the ICRs of the imprinted allele during S phase.

292 tion of skin Trm cells in situ through their ICRs should open new perspectives for the treatment of A

293 the mechanism of gene dysregulation through ICR epimutations, such as loss or gain of DNA methylatio

294 (51)MnCl2 was intravenously administered to ICR mice which were scanned by dynamic and static PET, f

295 rized on a commercial 10 T Fourier transform ICR mass spectrometer (FT-ICR MS).

296 to 2015, 346 consecutive patients undergoing ICR for CD and a postoperative ileocoloscopy within 6 to

297 ed phenotypes similar to those observed upon ICR deletion in mice and patients, whereas an ICR-driven

298 ng-term prognostic implications of CR versus ICR is unsettled.

299 ation was constrained because treatment with ICR antagonists dramatically enhanced the magnitude and

300 p evaluations compared with patients without ICR.