ライフサイエンスコーパス: IDV

1 IDV caused minor clinical signs in the infected cattle,

2 IDV IC(50) correlated with HIV-1 RNA response after the

3 IDV-NP-BMM treatment led to robust IDV levels and reduce

4 IDV-NP-BMM was administered i.v. to mice resulting in co

5 in the same order-buyer cattle facility, 32 IDV isolates were recovered from both healthy and sick a

6 f IDVs in cattle and recovered a total of 32 IDV isolates from both healthy and sick animals, includi

7 vir (IDV)/zidovudine (ZDV)/lamivudine (3TC), IDV, or ZDV/3TC.

8 tanding of the immune response induced after IDV infection.

9 als, including those with antibodies against IDV.

10 luding those with evident antibodies against IDV.

11 In addition, we developed an IDV minigenome replication assay and identified the E697

12 We also developed and validated an IDV minireplicon reporter system that specifically measu

13 nd 50% inhibitory concentrations for SQV and IDV at baseline.

14 Here, we have developed a plasmid-based IDV reverse-genetics system that can generate infectious

15 ed into murine bone marrow macrophages (BMM, IDV-NP-BMM) after ex vivo cultivation.

16 t and PM1 T cell lines were not inhibited by IDV.

17 istered i.v. to mice resulting in continuous IDV release for 14 days.

18 a new genus of influenza, influenzavirus D (IDV).

19 genus of influenza virus, influenzavirus D (IDV).

20 prescribed PrEP in the Integrated Dataverse (IDV) from Symphony Health for the period of September 20

21 By using a recently developed IDV reverse-genetics system derived from low-titer OK/11

22 Using a recently developed IDV reverse-genetics system, we identified viral nucleop

23 h form of 9-O-acetylated sialic acids drives IDV entry, we took advantage of a CASD1 knockout (KO) MD

24 wn about the functional receptor that drives IDV entry and promotes its cross-species spillover poten

25 ustrates an NP-based mechanism for efficient IDV infection and production in vitro.

26 y flow (MRI) (mL/min)= 0.85 x coronary flow (IDV) (mL/min)+17 (mL/min), r=.89, and coronary flow rese

27 , but to date, no RGS had been described for IDV.

28 e I interferon response was not necessary in IDV clearance.

29 ize the role of Neu5,9Ac(2) and Neu5Gc9Ac in IDV infection and determine which form of 9-O-acetylated

30 that active genetic reassortment occurred in IDV and that five reassortants were identified in the Mi

31 on 5 of the 3' conserved noncoding region in IDV and influenza C virus (ICV) resulted in the ineffici

32 Indinavir (IDV) (also called CRIXIVAN, MK-639, or L-735,524) is a p

33 Indinavir (IDV) is a potent and selective human immunodeficiency vi

34 dine (ZDV), lamivudine (3TC), and indinavir (IDV), and found a significant increase in the expression

35 jects who received 36-52 weeks of indinavir (IDV)/zidovudine (ZDV)/lamivudine (3TC), IDV, or ZDV/3TC.

36 rmulations of saquinavir (SQV) to indinavir (IDV) in patients with extensive hard-gel SQV experience.

37 ir (SQV) hard capsules (SQVhc) to indinavir (IDV) or saquinavir soft-gel capsules (SQVsgc) after >48

38 ART was prepared using indinavir (IDV) nanoparticles (NP, nanoART) loaded into murine bone

39 our findings provide important insight into IDV replication fitness mediated by the NP protein, whic

40 Rhodamine-labeled IDV-NP was readily observed in areas of HIVE and specifi

41 Although the disease observed was mild, IDV induced neutrophil tracking and epithelial attenuati

42 Moreover, IDV did not inhibit activation of caspases-1, -3, -4, -5

43 NP-IDV-BMMs administered to HIV-1-challenged humanized mice

44 In the former, NP-IDV formulation contained within BMMs was adoptively tra

45 these problems, a nanoparticle indinavir (NP-IDV) formulation packaged into carrier bone marrow-deriv

46 We conclude that a single dose of NP-IDV, using BMMs as a carrier, is effective and warrants

47 ased on these results, and on the ability of IDV to infect and transmit in multiple mammalian species

48 Adaptation of IDV by serial passages in mice was not sufficient to ind

49 estigated the effects of ex vivo addition of IDV on lymphocyte activation and apoptosis in cells from

50 To investigate the circulation of IDV among pigs in Italy, in the period between June 2015

51 initiated therapy with suboptimal dosages of IDV, we monitored the emergence of viral resistance to t

52 her our understanding of the epidemiology of IDV, real-time reverse transcription-PCR was performed o

53 ong with serological and genetic evidence of IDV infection in humans have raised concerns regarding t

54 ll surface is responsible for the failure of IDV replication; (ii) feeding CASD1 KO cells with Neu5,9

55 s are resistant to IDV infection and lack of IDV binding to the cell surface is responsible for the f

56 acid substitutions and the observed level of IDV resistance.

57 e for two distinct cocirculating lineages of IDV which freely reassort.

58 tious virus particle production mechanism of IDV.

59 dy replication, tropism, and pathogenesis of IDV.IMPORTANCE Influenza D virus (IDV) is a new type of

60 ies to determine the pathogenic potential of IDV are warranted.

61 ollected in 2015 showed a high prevalence of IDV antibody titers (11.7%), while archive sera from 200

62 Gc9Ac resulted in a dose-dependent rescue of IDV infectivity; and (iii) diverse IDVs replicated robus

63 t with the near-ubiquitous seroprevalence of IDV previously found.

64 xperimental model to facilitate the study of IDV pathogenesis and the immune response.

65 that our mouse model allows for the study of IDV replication and fitness (before selected viruses may

66 re a relevant in vivo model for the study of IDV replication.

67 ghlight a need for continued surveillance of IDV in humans, as well as for further investigation of i

68 fection have raised concerns about potential IDV adaptation in humans.

69 This model will allow for rapid IDV fitness and replication evaluation and will enable p

70 Eighty-nine subjects received IDV or SQVsgc or continued to receive SQVhc and continue

71 Recent IDV outbreaks in swine along with serological and geneti

72 rve (MRI) =0.79 x coronary velocity reserve (IDV) + 0.34, r=.89.

73 IDV-NP-BMM treatment led to robust IDV levels and reduced HIV-1 replication in HIVE brain r

74 nation with the single-round and multi-round IDV infection assays.

75 Tissue and sera IDV levels were greater than or equal to 50 microM for 2

76 To better study IDV at the molecular level, a reverse-genetics system (R

77 supporting the utility of this RGS to study IDV infection biology.

78 s, calves, and guinea pigs in order to study IDV pathogenesis.

79 It is concluded that IDV may prolong cell survival indirectly by inhibiting t

80 These data demonstrate that IDV can utilize Neu5,9Ac(2)- or non-human Neu5Gc9Ac-cont

81 We have previously demonstrated that IDV binds both 9-O-acetylated N-acetylneuraminic acid (N

82 Here, we demonstrated that IDV binds exclusively to 9-O-acetylated N-acetylneuramin

83 erase and Ifnar1(-/-) mice demonstrated that IDV induced mild inflammation and that a type I interfer

84 Transcriptomic analyses demonstrated that IDV induced the activation of proinflammatory genes, suc

85 n 2011, subsequent studies demonstrated that IDV is widespread in global cattle populations, supporti

86 In summary, this study demonstrates that IDV causes a mild respiratory disease upon experimental

87 Our findings provide evidence that IDV has acquired the ability to infect and transmit amon

88 We also extended our previous finding that IDV-resistant viral variants exhibit various patterns of

89 The findings indicate that IDV interferes with cell-cycle progression in primary ce

90 n together, these observations indicate that IDV NP protein performs a critical role in infectious vi

91 This finding also indicates that IDV has the potential to emerge in humans because Neu5,9

92 Here, we show that IDV is common in clinical samples of bovine respiratory

93 These results suggest that IDV is common in bovines with respiratory disease and th

94 cattle populations, supporting a theory that IDV utilizes bovines as a primary reservoir.

95 2 that directly affected the activity of the IDV ribonucleoprotein (RNP) complex, resulting in either

96 ection provides an evolutionary advantage to IDV for expanding its host range.

97 e sequencing were done; 12 codons related to IDV and SQV resistance were analyzed.

98 , 63, 71, and 90 with in vitro resistance to IDV and SQV.

99 gave rise to measurable viral resistance to IDV.

100 how that (i) CASD1 KO cells are resistant to IDV infection and lack of IDV binding to the cell surfac

101 with HIV-1 RNA response after the switch to IDV but added little predictive power once the genotype

102 s receiving SQVhc then switched treatment to IDV.

103 thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac cath

104 e its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hos

105 nly Neu5,9Ac(2).IMPORTANCEInfluenza D virus (IDV) has emerged as a multiple-species-infecting pathoge

106 genesis of IDV.IMPORTANCE Influenza D virus (IDV) is a new type of influenza virus that uses cattle a

107 The newly identified influenza D virus (IDV) of the Orthomyxoviridae family has a wide host rang

108 Influenza D virus (IDV) of the Orthomyxoviridae family has a wide host rang

109 Influenza D virus (IDV) utilizes bovines as a primary reservoir with period

110 mmune response.IMPORTANCE Influenza D virus (IDV), a new genus of Orthomyxoviridae family, presents a

111 Influenza D virus (IDV), a new member of the Orthomyxoviridae family, was f

112 tentatively classified as influenza D virus (IDV), was identified in swine, cattle, sheep, and goats.

113 nism for newly discovered influenza D virus (IDV), which utilizes bovines as a primary reservoir, wit

114 e United States and named influenza D virus (IDV).

115 tentatively classified as influenza D virus (IDV).

116 ted from sick animals, it is unclear whether IDV causes any clinical disease in cattle.

117 blood mononuclear cell (PBMC) cultures with IDV resulted in a dose-dependent inhibition of lymphopro

118 from baseline was significantly greater with IDV and was inversely correlated with the number of prot

119 how that cattle experimentally infected with IDV can shed virus and transmit it to other cattle throu

120 idual pens were inoculated intranasally with IDV strain D/bovine/Mississippi/C00046N/2014.

121 ct cattle from experimental reinfection with IDV.

122 ct cattle from experimental reinfection with IDV.