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1                                              IFITM proteins are components of the innate antiviral de
2                                              IFITM proteins are important effectors in interferon-med
3                                              IFITM proteins are located in the plasma membrane and en
4                                              IFITM proteins deter HIV-1 entry when expressed in targe
5                                              IFITM proteins impede viral entry, and ZMPSTE24 expressi
6                                              IFITM proteins were expressed and further induced by int
7                                              IFITM-2 and -3 restricted RVFV infection mostly by preve
8                                              IFITM-derived peptides and targeting antibodies inhibit
9  interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum
10 n-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antivir
11 nducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that med
12 ependent manner, in part to mitigate against IFITM-mediated restriction and promote replication and t
13 t low doses of alpha interferon (IFN-alpha), IFITM-2 and -3 mediated more than half of the antiviral
14 s, platelet reactivity, and thrombosis in an IFITM-dependent manner.
15                         Overexpression of an IFITM protein in MRC5 cells slightly enhanced HCMV produ
16           However, even in the context of an IFITM-susceptible virus, IFITM3 packaging is not suffici
17 er, indicate that, even in the context of an IFITM-susceptible virus, IFITM3 packaging is not suffici
18 We found that large fractions of IFITM-2 and IFITM-3 occupy vesicular compartments that are distinct
19 nsmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity a
20  TBEV might partially escape interferon- and IFITM-mediated suppression during high-density coculture
21 ad may be less prone to both interferon- and IFITM-mediated suppression, potentially facilitating esc
22 virus entry by a route that avoids antiviral IFITM proteins.
23  the viral envelope glycoproteins as well as IFITM subcellular localization within the target cell.
24  also mediate a physical association between IFITM proteins, and the loss of this interaction decreas
25 hat are distinct from the vesicles coated by IFITM-1.
26  was restricted by IFITM-2 and -3 but not by IFITM-1, whereas the remaining viruses were equally rest
27 ed that modulation of membrane properties by IFITM proteins is responsible for the IFITM-mediated blo
28         We found that RVFV was restricted by IFITM-2 and -3 but not by IFITM-1, whereas the remaining
29 g the range of viruses restricted in vivo by IFITM proteins and suggesting overall that IFITM1 is bro
30 ntry depends on lysines within the conserved IFITM intracellular loop.
31 e data suggest that higher prefrontal cortex IFITM mRNA levels in schizophrenia may be attributable t
32               We have characterized the duck IFITM locus and identified IFITM3 as an important restri
33                              We express each IFITM in chicken DF-1 cells and show duck IFITM1 localiz
34 ion film analysis revealed markedly elevated IFITM mRNA levels (+114% and +117%, respectively) in pre
35                          However, endogenous IFITM expression supports efficient infection of SARS-Co
36 at we show here to be required for endosomal IFITM activity.
37 els correlated with the potency of endosomal IFITM restriction and exogenous PIP3 enhanced inhibition
38 fy PIP3 as a critical regulator of endosomal IFITM restriction linking it to the Pi3K/Akt/mTORC pathw
39           Additionally, the ability to evade IFITM restriction contributes to the different interfero
40  mRNA levels were also markedly elevated for IFITM (+304%), multiple cytokines including IL-6 (+493%)
41 ry, and ZMPSTE24 expression is necessary for IFITM antiviral activity.
42 ession, potentially facilitating escape from IFITM-mediated immunity.
43 ouse models of neuroinflammation have higher IFITM levels and deficits in gamma-aminobutyric acid (GA
44 The authors sought to clarify whether higher IFITM mRNA levels and other immune-related disturbances
45 re unknown, and it is unclear whether higher IFITM mRNA levels are associated with lower GABA-related
46 ding that schizophrenia subjects with higher IFITM mRNA levels in cortical blood vessels have greater
47                         At least three human IFITM proteins-IFITM1, IFITM2, and IFITM3-have antiviral
48               Recent studies have identified IFITM proteins as the first ISG to inhibit viral entry p
49                             We also identify IFITM-2 as a BAG3 receptor and show that it signals thro
50                                       Immune IFITM genes are poorly conserved across species, suggest
51 wo antiviral activities of IFITM3.IMPORTANCE IFITM proteins have been associated with the sequestrati
52             Conclusion: Our results indicate IFITM proteins as drivers of viral immune escape and ant
53 9%) and interferon-beta (+29%), which induce IFITM expression; lower mRNA levels for Schnurri-2 (-10%
54                     HCMV infection inhibited IFITM protein accumulation in the later stages of infect
55                               Interestingly, IFITM expression promoted virus uptake and the acidifica
56        Unlike plasma membrane (PM)-localized IFITM restriction that targets infectious SARS-CoV2 and
57 0%), a transcriptional inhibitor that lowers IFITM expression; and higher mRNA levels for nuclear fac
58                        Caraphenol A-mediated IFITM downregulation did not alter the LV integration pa
59  natural host would result in the evasion of IFITM restriction.
60             We found that large fractions of IFITM-2 and IFITM-3 occupy vesicular compartments that a
61 er, few reports have evaluated the impact of IFITM genes on viral pathogenesis in vivo In this study,
62 teomics and lipidomics in cellular models of IFITM restriction.
63           However, no studies on the role of IFITM proteins in TBEV infection have been published thu
64          Here, we show the important role of IFITM proteins in the inhibition of TBEV infection and v
65     However, the cell types that overexpress IFITM messenger RNA (mRNA) in schizophrenia are unknown,
66  interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic vi
67 he interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several d
68  interferon inducible transmembrane protein (IFITM) family transcripts in the prefrontal cortex.
69 he interferon-induced transmembrane protein (IFITM) family.
70 ng interferon-induced transmembrane protein (IFITM) have been reported to inhibit multiple families o
71 or interferon-induced transmembrane protein (IFITM) in the prefrontal cortex.
72 or interferon-induced transmembrane protein (IFITM), which inhibits viral entry and replication-have
73 e interferon-induced transmembrane proteins (IFITM) are implicated in several biological processes, i
74 film and grain counting analyses to quantify IFITM mRNA levels in prefrontal cortex area 9 of 57 schi
75 lators, including those reported to regulate IFITM expression, in the prefrontal cortex from 62 schiz
76 proteins of several different viruses resist IFITM inhibition, the detailed mechanisms are not fully
77 er, little is known about how viruses resist IFITM inhibition.
78 hizophrenia and comparison subjects revealed IFITM mRNA expression in pia mater and blood vessels.
79                           Conversely, stable IFITM knockdowns in BeWo trophoblasts increased their sp
80 chemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry,
81 to infect different host species, suggesting IFITM proteins may provide a crucial barrier for zoonoti
82                        Our results show that IFITM proteins are cofactors for efficient SARS-CoV-2 in
83                                 We show that IFITM sensitivity of HIV-1 strains is determined by the
84        We also present evidence showing that IFITM family members work as homo- and hetero-oligomers
85                                          The IFITM grain density over blood vessels was 71% higher in
86                                          The IFITM mRNA levels were negatively correlated with GABA-r
87                                          The IFITM proteins confer basal resistance to influenza A vi
88                                          The IFITM repertoire varies widely between species and consi
89                                 Although the IFITM locus, which includes IFITM1, -2, -3, and -5, is p
90                                  Because the IFITM gene family is primarily expressed in the endothel
91                          Here we discuss the IFITM proteins, recent work on their mode of action, and
92  that the structural motifs critical for the IFITM proteins' enhancement of HCoV-OC43 infection are d
93 ies by IFITM proteins is responsible for the IFITM-mediated blockade of viral entry and enhancement o
94 terferon-stimulated proteins, members of the IFITM (interferon-induced transmembrane) family are uniq
95 al gene expression, including members of the IFITM and APOBEC3 family.
96 tion and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific.
97        Both the magnitude and breadth of the IFITM proteins' in vitro effects suggest that they are c
98 ew the discovery and characterization of the IFITM proteins, describe the spectrum of their antiviral
99 ent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of
100                       Here, we show that the IFITM locus exists in chickens and is syntenic with the
101           In conclusion, we propose that the IFITM proteins act in a coordinated manner to restrict H
102   Further characterization revealed that the IFITM proteins inhibit the early replication of flavivir
103 ts into the possible mechanisms by which the IFITM family members restrict distinct viruses.
104                Perturbation studies with the IFITM antagonist amphotericin B revealed that modulation
105  exists in chickens and is syntenic with the IFITM locus in mammals.
106 D and genetic markers close to or within the IFITM cluster or RAB31, DUSP1, and ADM genes.
107 onstrated that S-palmitoylation of all three IFITM proteins is essential for anti-HCV activity, where
108  entry and Interferon-induced transmembrane (IFITM) antiviral transcripts.
109        The interferon-induced transmembrane (IFITM) family of proteins have recently been identified
110        The interferon-induced transmembrane (IFITM) gene family performs multiple functions in immuni
111 specifically, the IFN-induced transmembrane (IFITM) protein family that inhibit entry of diverse enve
112 coding for interferon-induced transmembrane (IFITM) proteins 1, 2, and 3 suggests AmB enhances SARS-C
113        The interferon-induced transmembrane (IFITM) proteins are a family of small membrane proteins
114        The interferon-induced transmembrane (IFITM) proteins broadly inhibit the entry of diverse pat
115  levels of interferon-induced transmembrane (IFITM) proteins IFITM2 and IFITM3 and their association
116 s have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, r
117        The interferon-induced transmembrane (IFITM) proteins, known for inhibiting fusion between vir
118 restricted interferon-induced transmembrane (IFITM)-like protein (BRIL) and pigment epithelium-derive
119 that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the repl
120          Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cell
121      The interferon-inducible transmembrane (IFITM) proteins are one class of ISGs that restrict the
122      The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and
123 he induction of IFN-inducible transmembrane (IFITM) proteins.

 
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