ライフサイエンスコーパス: IHC

1 IHC also revealed that while most of the gland underwent

2 IHC analysis from Finasteride treated patients showed PC

3 IHC captured all cases of MMRD subsequently determined b

4 IHC confirmed the down-regulation of E-cadherin (CDH1) a

5 IHC expression of PD-L1 correlated strongly with PD-L1 (

6 IHC for MMR assessment is a useful tool for patient sele

7 IHC for pS6 also revealed increased mTOR activation in i

8 IHC occurred in 1.7% (42/2416) of patients with ICH.

9 IHC of differentially-expressed glomerular and tubuloint

10 IHC on normal human tissues found that ALPPL2 is express

11 IHC outperformed MSI for tumour triage and reliably iden

12 IHC positivity for GIP, but not GLP-1, staining cells in

13 IHC showed that glomerular tuft staining for cathepsin B

14 IHC staining for programmed cell death ligand 1 (PD-L1)

15 IHC staining of two biomarkers, ASCL1 and S100, sufficie

16 IHCs are involved in conveying acoustic stimuli to the C

17 IHCs have been thought to be electrically and metabolica

18 IHCs of Myo7a-DeltaC mice undergo normal development, bu

19 sults, another dataset with more than 30 000 IHC stained nuclei in 88 images were prepared.

20 Additionally, the 2 IHC-defined subtypes were significantly associated with

21 nctional outcome (modified Rankin Scale=4-6: IHC: 29/37 (78.4%) vs non-IHC: 1213/2048 (59.2%); p=0.01

22 Additionally, IHC analysis revealed that ERbeta tumors had increased e

23 e size of the BK current decreased with age, IHCs retained a normal KCNQ4 current and resting membran

24 The degree of efferent rewiring onto aged IHCs, most likely coming from the lateral olivocochlea f

25 unctional axon-somatic connections with aged IHCs, but this was seen only sporadically in C3H/HeJ mic

26 tu hybridization for HER2/MET amplification, IHC with or without RNA sequencing for ALK/ROS1/NTRKs/RE

27 ned with confocal Ca(2+) imaging we analyzed IHCs in which Galphai signaling was blocked by Cre-induc

28 A expression levels determined using ARG and IHC.

29 as the 9 primary tumors selected for ARG and IHC.

30 cancer tissues confirmed by western blot and IHC.

31 blic databases of human breast carcinoma and IHC analysis of mice xenograft tumors demonstrated that

32 identified as ECM3 or non-ECM3 with H&E and IHC images, we were also able to observe an association

33 omated colorimetric analysis of both H&E and IHC WSIs stained with a triple-antibody cocktail against

34 Multimodal imaging, electrophysiology, and IHC were performed to determine the relationship between

35 Histology, ISH, and IHC revealed disrupted junctional epithelium, connective

36 ative surgical margins, K17 at both mRNA and IHC level is sufficient to identify the subgroup with th

37 n postmortem human AUD hippocampus, mRNA and IHC protein are increased for the entire death receptor

38 Once MS and IHC images were coregistered, the quantification of the

39 This accurate colocalization of MS and IHC signals showed limited penetration of the clinically

40 registered, the quantification of the MS and IHC signals was performed by an algorithm evaluating sig

41 he overlay of the mass spectrometry (MS) and IHC spheroid images, typically without any morphological

42 time the combination of correlative muCT and IHC to enable 3D mathematical modelling of human lung mi

43 al lesions that were validated by RT-PCR and IHC.

44 Proteomic profiling and IHC revealed that mechanisms underlying AVE 0991 effects

45 such that, by 8 months of age, both OHCs and IHCs of Baiap2l2 deficient mice have lost most of the se

46 ugh the age-related morphological changes at IHC ribbon synapses contribute to the different progress

47 In addition, the DNA hybridization-based IHC can be rapidly removed to regenerate the sample for

48 old effect: It abbreviated signaling between IHC and the auditory nerve and also balanced differences

49 eceptor potentials." Ribbon synapses between IHCs and auditory nerve neurons are responsible for conv

50 C; and 96.9% with combined results from both IHC and FISH analyses.

51 119 melanoma specimens had both IHC and gene expression information available.

52 AAV2.7m8 infects both IHCs and OHCs with high efficiency.

53 ements for PD-L1 were weakly correlated, but IHC did not distinguish protein abundance differences de

54 By IHC, 76 specimens in the training cohort (54%) had high

55 tudy included melanoma specimens analyzed by IHC on tumor tissue microarray (TMA) cores and by gene e

56 lows unequivocal detection of RanBP9 both by IHC and WB.

57 ened patients had an MMR-deficient cancer by IHC.

58 ere analyzed relative to enumerated cells by IHC using Spearman rank test to calculate r-values.

59 This finding was confirmed by IHC.

60 among these IGJ and SLMAP were confirmed by IHC.

61 total 132/500 tumours were MMR deficient by IHC of which 83/132 (63%) had MLH1-hypermethylation, and

62 with unresolved HER2 statuses (equivocal by IHC and in situ hybridization) was significantly higher

63 (IHC); plaque vulnerability was examined by IHC against macrophages, collagen, vascular smooth muscl

64 ks together with HIF1A protein expression by IHC appeared significant.

65 Conclusion COX-2 expression by IHC failed to select patients who could benefit from sel

66 MSI to be performed and directly followed by IHC analysis on exactly the same spheroid section.

67 -5) and the PTCL-GATA3 subtype identified by IHC were independent adverse predictors of OS (P = .0015

68 and tissues were stained for CD31 and KDR by IHC.

69 issue samples that were negative for PCV2 by IHC analysis identified 45 of 48 that were PCV3 positive

70 that previously tested negative for PCV2 by IHC analysis.

71 f a subset also testing positive for PCV3 by IHC analysis.

72 higher CD4/CD8 ratios in metastases shown by IHC.

73 nerated to detect its presence in tissues by IHC.

74 ndefatigable release of synaptic vesicles by IHCs is controlled by otoferlin, a six-C2-domain (C2-ABC

75 hresholds, however GFP overexpression caused IHC loss.

76 CD8-IHC confirmed the PET imaging results.

77 d and Damaraland mole rats, inner hair cell (IHC) afferent ribbon density was reduced, whereas outer

78 smitter release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergi

79 associated with the loss of inner hair cell (IHC) ribbon synapses, lower hearing sensitivity and decr

80 active zone (AZ) of a given inner hair cell (IHC).

81 reocilia in both inner and outer hair cells (IHCs and OHCs).

82 f mechanotransducer cells, inner hair cells (IHCs) and outer hair cells (OHCs).

83 ormation from the cochlear inner hair cells (IHCs) and transmit that information to the cochlear nucl

84 mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that conv

85 Mammalian cochlear inner hair cells (IHCs) are specialized sensory receptors able to provide

86 Inner hair cells (IHCs) are the primary receptors for hearing.

87 Inner hair cells (IHCs) are the primary sensory receptors of the mammalian

88 red age-related changes in inner hair cells (IHCs) between four mouse strains with different levels o

89 rominent, and in mammalian inner hair cells (IHCs) displays unusual properties.

90 Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors,

91 onset of hearing, cochlear inner hair cells (IHCs) present spontaneous Ca(2+) action potentials that

92 the onset of hearing, the inner hair cells (IHCs) receive inhibitory efferent input from cholinergic

93 In contrast, inner hair cells (IHCs) survive normally but they fail to acquire adult ba

94 ibbon synapses of cochlear inner hair cells (IHCs) undergo molecular assembly and extensive functiona

95 e GFP reporter showed that inner hair cells (IHCs) were transfected throughout the cochlea, and outer

96 t conventional AAVs infect inner hair cells (IHCs) with various efficiencies, they infect outer hair

97 r cells, preferentially in inner hair cells (IHCs), and was lacking from the postsynaptic spiral gang

98 hair cells (OHCs), but not inner hair cells (IHCs), began to lose their third row of stereocilia and

99 neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses, a process termed s

100 mary sensory receptor, the inner hair cells (IHCs), the mature functional characteristics of OHCs are

101 before the primary sensory inner hair cells (IHCs), which become competent at about the onset of hear

102 tivity in immature sensory inner hair cells (IHCs), which is crucial for the refinement of the develo

103 is severely diminished in inner hair cells (IHCs), while expression in outer hair cells is affected

104 Intrahepatic cholestasis (IHC) was observed in 4.9% of InO recipients and in 5.5%

105 elease from MOC terminals in voltage-clamped IHCs in the whole-cell configuration.

106 The surface area of apical coil IHCs (9-12 kHz cochlear region) decreases by about 30-40

107 hemistry (IHC); gal-3), and fibrosis (col1a1 IHC) was performed on terminal liver biopsies and compar

108 similar to the one obtained by conventional IHC.

109 Compared to the conventional IHC process using dye-labeled secondary antibodies (whic

110 rent increase with the number of dye-coupled IHCs.

111 ased computational method on pan-cytokeratin IHC stainings to quantify tumor fragmentation (TF), a me

112 ssed using necropsy, histologic examination, IHC analysis, flow cytometry, and advanced imaging.

113 PTXa-expressing IHCs exhibited larger Ca(V)1.3 Ca(2+)-channel clusters a

114 14) were significantly associated with fewer IHC.

115 on of a potentially novel AR-V7 antibody for IHC, AR-V7 protein expression was determined for 358 pri

116 0.0001, n = 319) with combined results from IHC and Fluorescence in situ hybridization (FISH) analys

117 hanoelectrical transducer (MET) current from IHCs decreased significantly with age in mice harbouring

118 channels that mediate glutamate release from IHCs.

119 isease which correlated with histopathology, IHC, MRI, Micro-Raman spectroscopy etc.

120 ) cohort, as defined by immunohistochemical (IHC) loss of expression of one or more mismatch repair (

121 could be obtained from immunohistochemical (IHC) staining.

122 Here, we used immunohistochemical (IHC) staining and 7-color multiplex staining to evaluate

123 on a dataset with 52 immunohistochemically (IHC) stained images.

124 Immunohistochemistry (IHC) analysis of sow tissue samples identified PCV3 anti

125 Immunohistochemistry (IHC) and MS measurements for PD-L1 were weakly correlate

126 Immunohistochemistry (IHC) can provide detailed information about protein expr

127 Immunohistochemistry (IHC) for CTNNB1 (beta-Catenin; clone beta-Catenin-1) was

128 Immunohistochemistry (IHC) for GIP and GLP-1 was also done on intestinal biops

129 flammation (galectin-3 immunohistochemistry (IHC); gal-3), and fibrosis (col1a1 IHC) was performed on

130 proliferation by Ki-67 immunohistochemistry (IHC).

131 study, we generated an immunohistochemistry (IHC) algorithm to identify the 2 subtypes in paraffin ti

132 , we have generated an immunohistochemistry (IHC) dataset for five major cell-types from brain tissue

133 LC-MS/MS) (n = 27) and immunohistochemistry (IHC) (n = 64), on four main diagnostic groups-SAGN, prim

134 lation microarray, and immunohistochemistry (IHC) on 8 pairs of non-small cell lung cancer (NSCLC) pr

135 icroarray analysis and immunohistochemistry (IHC) to examine messenger RNA and protein changes in gla

136 C), Mass Spectrum, and immunohistochemistry (IHC).

137 oradiography (ARG) and immunohistochemistry (IHC).

138 confirmed by qPCR and immunohistochemistry (IHC).

139 tion method (FISH) and immunohistochemistry (IHC).

140 reaction (qRT-PCR) and immunohistochemistry (IHC).

141 fluorescence (IF), and immunohistochemistry (IHC). Stimulated WT HSCs displayed increased levels of N

142 ecific (D240 antibody) immunohistochemistry (IHC), optimised high-resolution X-ray microfocus compute

143 n profiling as well as immunohistochemistry (IHC) to understand its underlying biology.

144 rches, by qPCR, and by immunohistochemistry (IHC) analysis of a panel of human tissue samples, includ

145 control lymph nodes by immunohistochemistry (IHC) for pS6, p4EBP1, and p70S6K, known effectors and re

146 protein expression by immunohistochemistry (IHC) in 763 tissue biopsies.

147 e genes were tested by immunohistochemistry (IHC) in an independent cohort (30 PSC, 31 LUAD, 31 LUSC)

148 SHH was detected by immunohistochemistry (IHC) on paraffin-embedded liver sections in subjects (N

149 e further validated by immunohistochemistry (IHC) staining in endometrial tissues from endometriosis

150 enes were validated by Immunohistochemistry (IHC) using tissue microarray sections containing both no

151 )-kappaB expression by immunohistochemistry (IHC), degree of apoptosis by the terminal deoxynucleotid

152 2 MMR gene products by immunohistochemistry (IHC).

153 fection post-mortem by immunohistochemistry (IHC).

154 ne cells identified by immunohistochemistry (IHC).

155 yme immunoassay (EIA), immunohistochemistry (IHC), and in vitro real-time quaking-induced conversion

156 y haematoxilin & eosin immunohistochemistry (IHC); plaque vulnerability was examined by IHC against m

157 st, while fluorescence immunohistochemistry (IHC) followed by LSCM was used to localize the cells fea

158 ncluded the following: immunohistochemistry (IHC) and in situ hybridization for HER2/MET amplificatio

159 d by pathologists from immunohistochemistry (IHC) staining of biopsied tissue for the targeted recept

160 e assays spanning from immunohistochemistry (IHC), to microarrays (protein, DNA), to high-throughput

161 u hybridization (ISH), immunohistochemistry (IHC), and transmission electron microscopy (TEM) were us

162 ion and scoring of K17 immunohistochemistry (IHC) was performed in a third independent cohort (n = 74

163 Tumours underwent MMR immunohistochemistry (IHC), microsatellite instability (MSI), and targeted MLH

164 erformed multispectral immunohistochemistry (IHC) on a cohort of colorectal tumors.

165 Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in

166 y quantitative RT-PCR, immunohistochemistry (IHC) and indirect immunofluorescence.

167 y PET/CT and standard, immunohistochemistry (IHC)-based, histopathologic classification of human epid

168 ntibody (DFA) testing, immunohistochemistry (IHC), and nucleic acid amplification tests (NAATs).

169 in agreement with the immunohistochemistry (IHC) data but with some exceptions.

170 ed and localized using immunohistochemistry (IHC) and confocal microscopy, and assessed for gene expr

171 ociated proteins using immunohistochemistry (IHC).

172 Herein, we utilized immunohistochemistry (IHC) staining and public microarray data analysis showin

173 Whereas immunohistochemistry (IHC) and immunoassays are routinely used for clinical an

174 ferent synapses but it leads to a failure in IHC maturation comparable to that observed in gata3(+/-)

175 ciency is poorly understood, particularly in IHC and in-gel immunoassays, where immobilized targets a

176 discordance in results due to variability in IHC preparation and pathologist subjectivity.

177 Functional changes in IHCs are a potential cause of age-related hearing loss.

178 alters the activation of Ca(2+) channels in IHCs primarily by increasing their voltage sensitivity.

179 OHCs and I(K,n) and I(K,f) (BK channels) in IHCs.

180 recombinase (gata3(fl/fl) otof-cre(+/-) ) in IHCs does not affect OHCs or the number of IHC afferent

181 ximately 25%) of the total Ca(2+) current in IHCs displaying fast inactivation and resistance to 20 m

182 regulation of the synaptic vesicle cycle in IHCs are still incompletely understood.

183 syndrome arises from functional deficits in IHCs as well as loss of function from OHCs and both affe

184 a dynamin-dependent ultrafast endocytosis in IHCs.SIGNIFICANCE STATEMENT Otoferlin, a large six-C2-do

185 kinetics of Ca(2+) -dependent exocytosis in IHCs was unaffected, indicating the presence of a previo

186 Consistent with a selective role of NO-GC in IHCs, NO-GC beta1 mRNA was found in isolated IHCs but no

187 activation was shifted more than +200 mV in IHCs from Lrrc52 KO mice.

188 ting the position-dependent AZ properties in IHCs and suggest that this signaling pathway contributes

189 tive role in presynaptic Ca(2+) signaling in IHCs.SIGNIFICANCE STATEMENT Physiologically distinct cla

190 evation of cGMP was detected in real-time in IHCs but not in OHCs.

191 s and channel localization were unaltered in IHCs from Lrrc26 knockout (KO) mice, BK current activati

192 s the replenishment of synaptic vesicles, in IHCs was not affected.

193 ear (MOC) system that transiently innervates IHCs during this period.

194 IHCs, NO-GC beta1 mRNA was found in isolated IHCs but not in OHCs.

195 mor-infiltrating lymphocytes (TIL) and PD-L1 IHC expression.

196 Nonetheless, PD-L1 IHC was positive in 93% of LELC cases.

197 We found that OHCs, like IHCs, fire spontaneous Ca(2+) -induced action potentials

198 lay a direct role in re-establishing the LOC-IHC synapses.

199 Mature IHCs of Myo7a-DeltaC mice degenerate over time, giving r

200 be required for hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive

201 668 (17.2%) fewer cases requiring tumor MMR IHC.

202 1053 (27.1%) fewer cases requiring tumor MMR IHC.

203 Mismatch repair (MMR), IHC, and promoter hypermethylation status of MLH1 (MLH1p

204 MMR-IHC with targeted MLH1-methylation testing was more disc

205 nd synaptic plasticity properties at the MOC-IHC synapse upon MOC fiber activation at different frequ

206 The MOC-IHC synapse, functional from postnatal day 0 (P0) to hea

207 : 1213/2048 (59.2%); p=0.019) and mortality (IHC: 14/37 (37.8%) vs non-IHC: 485/2048 (23.7%); p=0.045

208 K channel function and localization in mouse IHCs.

209 ast exocytotic component in Otof (-/-) mouse IHCs.

210 MSI/IHC and PREMM(5) effectively identify patients with CRC

211 MSI/IHC and PREMM(5) had comparable sensitivity for identify

212 rance PVs, and any PVs) who had abnormal MSI/IHC testing and/or PREMM(5) score >= 2.5%.

213 nts (96.6% v 96.6%; P = 1.000), although MSI/IHC had significantly superior specificity for LS (81.3%

214 nts with CRC and/or EC with LS, although MSI/IHC has better specificity for LS.

215 The aim of this study was to compare MSI/IHC and the PREMM(5) prediction model to identify carrie

216 ility and/or mismatch repair-deficiency (MSI/IHC) and clinical prediction models effectively screen f

217 Among patients with normal MSI/IHC, PREMM(5) identified 84.2% and 83.3% of high-risk pa

218 ore >= 2.5%, including those with normal MSI/IHC, should be offered multigene panel testing.

219 ts, PREMM(5) had superior sensitivity to MSI/IHC at identifying patients with any high-penetrance PVs

220 Rankin Scale=4-6: IHC: 29/37 (78.4%) vs non-IHC: 1213/2048 (59.2%); p=0.019) and mortality (IHC: 14/

221 19) and mortality (IHC: 14/37 (37.8%) vs non-IHC: 485/2048 (23.7%); p=0.045) in disfavour of patients

222 ain of POLE; and (2) MMRP cohort with normal IHC expression of all MMR proteins.

223 Since the amplitude of IHC receptor potentials is invariant during this period,

224 ze or morphology, change the distribution of IHC synaptic locations, or affect the creation of synaps

225 e retrieval methods to enable flexibility of IHC methods.

226 Here, we characterized the nanostructure of IHC synapses from late prenatal mouse embryo stages (emb

227 disadvantages, namely, the nonspecificity of IHC and immunoassays, and potentially long analysis time

228 n IHCs does not affect OHCs or the number of IHC afferent synapses but it leads to a failure in IHC m

229 biophysical and morphological properties of IHC ribbon synapses in the ageing cochlea (9-12 kHz regi

230 Outcomes were defined as rates of IHC during hospital stay among patients with non-OAC-ICH

231 evealed no differences in incidence rates of IHC per 1000 patient-days (LDSH: 1.43 (1.04-1.93) vs non

232 Manual scoring of IHC images represents a logistical challenge, as the pro

233 vestigated the functional characteristics of IHCs from early-onset hearing loss mice harbouring the a

234 There was no significant loss of IHCs in the 9-12 kHz cochlear region up to at least 15 m

235 a synaptic location on the modiolar side of IHCs.

236 On IHC, ARG, and (68)Ga-PSMA-11 PET, the pancreatic tissue

237 of PSMA limited to the intercalated ducts on IHC (IRS = 10-15) and a minimal signal on ARG (1.3% +/-

238 included in the analysis, KDR expression on IHC matched well with imaging signal on USMI in 93% of b

239 I signal matches well with KDR expression on IHC.

240 d a wide range of PSMA staining intensity on IHC (IRS = 70-300) as well as in ARG (1.3%-22% of standa

241 vivo also showed high staining intensity on IHC.

242 Consequently, depolarization of one IHC triggers presynaptic Ca(2+)-influx at active zones i

243 totic component in the transduced Otof (-/-) IHCs was also associated with a recovery of Ca(2+) curre

244 -type IHCs but poorly expressed in Otof(-/-) IHCs, the latter having Ca(2+) currents with considerabl

245 alidated quadruple immunofluorescent OXPHOS (IHC) assay to detect CI deficiency in the diagnostic set

246 Phosphoprotein IHC have been impractical for diagnostics due to inconsi

247 ntestinal tumors (n = 28) for phosphoprotein IHC markers pAKT, pERK, pSRC, pSTAT3, and pSMAD2 and com

248 alin fixation protocol using phosphoproteins IHC.

249 gradient between the modiolar and the pillar IHC side.

250 Photopic ERG, visual evoked potentials, IHC and cell counting indicated relatively long survivin

251 sue specimens were analyzed by means of PSMA-IHC (using an anti-PSMA-antibody and an immunoreactivity

252 level of gene expression and its quantified IHC cell marker for CD45(+), CD3(+), CD8(+), CD4(+), and

253 Using quantitative IHC, we identified a transient proliferative response th

254 tients with ICH appears to be safe regarding IHC among non-OAC-ICH, VKA-ICH and NOAC-ICH in this obse

255 egative feedback loop positioned to regulate IHC activity and maturation of the ascending auditory sy

256 SGNs innervating the same IHC differ in their relative vulnerability to noise.

257 ingle gene may be used to represent a single IHC immune cell marker in melanoma.

258 stics were observed for T. pallidum-specific IHC (49-92%).

259 documented by immuno-histochemical staining (IHC).

260 We propose that IHC functional differentiation into mature sensory recep

261 n our findings and modeling, we propose that IHC-mini-syncytia enhance sensitivity and reliability of

262 D electron microscopy indicates instead that IHCs are coupled by membrane fusion sites.

263 nt of the efferent contacts, suggesting that IHCs may play a direct role in re-establishing the LOC-I

264 The IHC algorithm classification showed high interobserver r

265 The IHC algorithm will aid in identifying the 2 subtypes in

266 The IHC assay has clear diagnostic potential to identify pat

267 The IHC Ca(2+) action potential frequency pattern, which is

268 The IHC examination of human CCA specimen for VDR revealed t

269 The IHC results were evaluated by 2 pathologists and the nuc

270 The IHC ribbon synapse structure, synaptic Ca(2+) currents,

271 pothesis pointed to vesicle depletion at the IHC as responsible for auditory adaptation.

272 ence position-dependent AZ properties at the IHC base.

273 ound that increased expression of K17 at the IHC level is also associated with decreased survival of

274 pse contribute to synaptic depression at the IHC ribbon synapse and spike rate adaptation in the audi

275 both pre- and postsynaptic mechanisms at the IHC ribbon synapse contribute to synaptic depression at

276 ich tether a large number of vesicles at the IHC's presynaptic active zones, allowing high rates of s

277 g GEP data, the 2 subtypes identified by the IHC algorithm matched the GEP results with high sensitiv

278 that additional factors may help define the IHC BK gating range.

279 h age, both modiolar and pillar sides of the IHC exhibited a loss of ribbons, but there was an increa

280 ond to stereotyped synaptic positions on the IHC.

281 With the IHC data as the benchmark, this resource enables quantit

282 rties according to their position within the IHC, to some extent forming a gradient between the modio

283 lts suggest that glutamate released from the IHCs activates group I mGluRs (mGluR1s), probably presen

284 nels progressively decreases with age in the IHCs from most mouse strains, but the basolateral membra

285 C52 disrupted BK channel localization in the IHCs.

286 C) efferent fibers transiently innervate the IHCs.

287 developmental maturation, in mice 30% of the IHCs are electrochemically coupled in 'mini-syncytia'.

288 lease of acetylcholine and inhibition of the IHCs.

289 tial as an orthogonal analytical approach to IHC for clinical applications.

290 lso found that connexin expression is key to IHC functional maturation.

291 cording conditions we found that, similar to IHCs, immature OHCs elicited spontaneous Ca(2+) action p

292 , which carry approximately 75% of the total IHC Ca(2+) current with slow inactivation and confer hig

293 RK fusion diagnosis exist, including pan-Trk IHC, FISH, reverse transcription PCR, DNA-based next-gen

294 gnal amplification immunohistochemistry (TSA-IHC).

295 their mRNA is highly expressed in wild-type IHCs but poorly expressed in Otof(-/-) IHCs, the latter

296 viral cDNA transfer approach in vivo, where IHCs of mouse lacking otoferlin (Otof (-/-) mice of both

297 0.9998 +/- 0.0002 (p < 0.0001, n = 224) with IHC analysis, and 0.9942 +/- 0.0031 (p < 0.0001, n = 319

298 analyses, we achieved 99.5% concordance with IHC; and 96.9% with combined results from both IHC and F

299 ) increasing the LB subtype consistency with IHC by 25-49%.

300 .7%); p=0.045) in disfavour of patients with IHC.

301 s between patients with ICH with and without IHC.