ライフサイエンスコーパス: IL-10 receptor

1 sis of the interaction between IL-10 and the IL-10 receptor.

2 -10-mediated effects and is a subunit of the IL-10 receptor.

3 Ba/F3 cells that stably expressed the murine IL-10 receptor.

4 histochemistry that cortical neurons express IL-10 receptor.

5 odies specific for interleukin-10 (IL-10) or IL-10 receptor.

6 production from microglial cells through the IL-10 receptor.

7 n of KC, even though the cells expressed the IL-10 receptor.

8 sted using in vivo and in vitro IEC-specific IL-10 receptor 1 (IL-10R1) depletion under homeostatic c

9 ingle-nucleotide polymorphisms (SNPs) in the IL-10 receptor 1 (IL10R1) gene.

10 ithin the YXXQ-STAT3-docking site within the IL-10 receptor 1 and that no other signals appeared to b

11 STAT protein phosphorylation is identical to IL-10 receptor activation on normal cells and similar to

12 e-treatment peptide and was reversed by anti-IL-10 receptor administration.

13 ed more IL-10 and expressed higher levels of IL-10 receptor after CD40 engagement compared to other B

14 ated IL-10) is a first-in-class, long-acting IL-10 receptor agonist that induces oligoclonal T-cell e

15 okines IL-23 or IL-17 into immunosuppressive IL-10 receptor agonists.

16 pe, IL-10 reporter, and conditional IL-10 or IL-10 receptor alpha (IL-10Ralpha) knockout mice by mean

17 that Treg cells possess higher expression of IL-10 receptor alpha and that Treg cell IL-10 receptor a

18 analysis of the intracellular domain of the IL-10 receptor alpha chain showed that whereas two redun

19 n of IL-10 receptor alpha and that Treg cell IL-10 receptor alpha expression directly correlates with

20 IL-10 receptor alpha is highly enriched in mature adipoc

21 vealed that the epithelial anti-inflammatory IL-10 receptor alpha subunit (IL-10RA) is also important

22 protein 3 (FOXP3), CD40 ligand (CD40L), and IL-10 receptor alpha(IL10RA), as well as patients with t

23 ore rapidly in the presence of an anti-human IL-10 receptor-alpha antibody, and efferocytosis by IL-1

24 cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for bind

25 e IL-2 receptor gamma(IL2RG) gene as well as IL-10 receptor and CD40 ligand deficiencies had normal o

26 , designated cmvIL-10, binds to the cellular IL-10 receptor and effects potent immune suppression.

27 xtracellular domain of the recombinant human IL-10 receptor and IL-10 is consistent with two IL-10 ho

28 IL-10 provides neuroprotection by acting via IL-10 receptor and PI3K/AKT and STAT-3 signal transducti

29 That the duration of IL-10 receptor and STAT3 activation can direct distinct

30 The IL-10 receptor and the IL-2 receptor gammac chain were a

31 We set out to map the human IL-10 receptor and to identify the key elements involved

32 (+) T cells expressed elevated levels of the IL-10 receptor and were directly activated by IL-10, res

33 fects were specifically mediated through the IL-10 receptor and were not observed when DCs were treat

34 s the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor.

35 ssors of cytokine signaling proteins (SOCS), IL-10 receptor, and galectin-7.

36 ignificant upregulation of HLA-C, HLA-G, the IL-10 receptor, and other markers involved in innate imm

37 he overexpression of interleukin-10 (IL-10), IL-10 receptor, and suppressor of cytokine signaling (SO

38 ansiently during the chronic phase with anti-IL-10 receptor antibodies achieved sterile cure, suggest

39 vention with neutralizing anti-IL-10 or anti-IL-10 receptor antibodies.

40 nositide 3-kinase (PI3K) inhibitor, and anti-IL-10 receptor antibody revealed that the PI3K pathway i

41 Blockade of IL-10 signaling with anti-IL-10 receptor antibody reversed the age-related decay.

42 e anti-inflammatory effects of IL-37 because IL-10-receptor antibody blockade did not reverse IL-37-m

43 Moreover, we found IL-10 receptors are expressed by neurons and astroglia.

44 class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II

45 lymorphism (A/G) at cDNA position 238 of the IL-10 receptor beta gene (IL10RB/c238) was genotyped in

46 present study, we examined variation in the IL-10 receptor beta gene as a further test of the hypoth

47 increased 6.5-fold and minimal responses to IL-10 receptor blockade suggested downregulated IL-10.

48 ice, migration assays, and antibody-mediated IL-10 receptor blockade to study plasmacytosis-associate

49 ion in the airways, which was reversed after IL-10 receptor blockade.

50 reduced in vaccinia virus-treated mice with IL-10 receptor blockade.

51 cytokine-inhibited mice were treated with an IL-10 receptor blocking antibody and a TLR-9 agonist, an

52 lygyrus-induced T1D protection, nor did anti-IL-10 receptor blocking antibody.

53 t not IL-10(-/-) BMDCs, a process blocked by IL-10 receptor blocking antibody.

54 sponses are enhanced in the presence of anti-IL-10 receptor-blocking Abs or on the removal of CD14+ c

55 esistance because its neutralization with an IL-10 receptor-blocking monoclonal antibody allowed accu

56 s directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant rece

57 Neutralizing IL-10 or blocking IL-10 receptors by antibodies reduced GC colonization by

58 The IL-10 receptor chains, IL-10R1 and IL-10R2, are expresse

59 an accessory chain essential for the active IL-10 receptor complex and to initiate IL-10-induced sig

60 re, we explored whether the stability of the IL-10 receptor complex contributes to the immunomodulato

61 Our study provides insights into how IL-10 receptor complex stability fine-tunes IL-10 biolog

62 cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction eve

63 on the JAK2 pathway and found that the IL-10/IL-10 receptor complex up-regulated JAK2 signaling.

64 CRF2-9 and IL-10R2, the second chain of the IL-10 receptor complex.

65 discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects

66 IL-10 receptor-deficient (Il10rb(-/-)) T(reg) cells also

67 lysaccharide (LPS)-challenged mice harboring IL-10 receptor-deficient microglia displayed neuronal im

68 r mice (VertX), cell-type-specific IL-10 and IL-10 receptor deletion mice, and bone marrow chimeric m

69 , we demonstrated that transient blockade of IL-10 receptor during the T cell priming phase early in

70 Ligand binding and activation of the IL-10 receptor expressed on B-CLL cells results in the p

71 s during remission from pain and signaled to IL-10 receptor-expressing sensory neurons.

72 Human IgG suppressed IL-10 receptor expression and altered IL-10 signaling in

73 f inhibition involved decreased cell surface IL-10 receptor expression and Jak1 activation and was de

74 We propose that CD8(+) T cells increase DRG IL-10 receptor expression and that IL-10 suppresses the

75 Paclitaxel increased DRG IL-10 receptor expression and this effect requires CD8(+

76 est that to optimize TR1 cell-based therapy, IL-10 receptor expression has to be taken into considera

77 In contrast, loss of IL-10 receptor expression impaired the critical conditio

78 tudy, we undertook a biochemical analysis of IL-10 receptor expression on freshly isolated B-CLL cell

79 es compared with control monocytes, although IL-10 receptor expression was similar in SLE and control

80 Genetic deletion of the IL-10 receptor from Advillin+ neurons prevented resoluti

81 Blocking the IL-10 receptor globally or specifically on microglia in

82 Using the examples of the IL-6 and IL-10 receptors, I will discuss how diverse outcomes in

83 infection in normal mice, anti-interleukin (IL)-10 receptor (IL-10R) monoclonal antibody (MAb) treat

84 oblot analysis was preformed to identify the IL-10 receptor (IL-10R) and phosphorylated or nonphospho

85 eiotropy by determining the structure of the IL-10 receptor (IL-10R) complex by cryo-electron microsc

86 Monogenic interleukin-10 (IL-10) and IL-10 receptor (IL-10R) deficiencies cause very early on

87 We also observed internalization of the IL-10 receptor (IL-10R) in mucosal lymphocytes, which co

88 Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation wit

89 IL-10 blockade in vitro with anti-IL-10 receptor (IL-10R) monoclonal antibody restored LPM

90 ulated with Helicobacter hepaticus plus anti-IL-10 receptor (IL-10R) monoclonal antibody was exacerba

91 0 within tumors, and therapeutic blockade of IL-10 receptor (IL-10R) was equivalent to CSF-1 neutrali

92 In vivo blockade of the IL-10 receptor (IL-10R) with a neutralizing antibody res

93 Blockade of IL-10 receptor (IL-10R) with an antagonist antibody dram

94 ection upregulated IL-10R1, a subunit of the IL-10 receptor (IL-10R), and also SOCS3, a negative regu

95 ated mice with a DC-specific deletion of the IL-10 receptor (IL-10R).

96 a negative feedback mechanism involving the IL-10 receptor (IL-10R).

97 e cells, we previously demonstrated that the IL-10 receptor (IL-10R1) is expressed in dorsal root gan

98 ically, we generated mice harboring IL-10 or IL-10 receptor (IL-10Ralpha) mutations in intestinal lam

99 Upon IL-10 receptor (IL10R) blockade a pronounced effect is a

100 Blockade of IL-10 receptor in Bhlhe40(-/-) mice renders them suscept

101 Genetic ablation of Axl and Mertk in M s or IL-10 receptor in DCs or Timp1 substantially reduced MPE

102 Ablation of the IL-10 receptor in Treg cells resulted in selective dysre

103 4(+) T cells differentially express IL-6 and IL-10 receptors in an activation state-dependent manner,

104 4 and IL-10, promoted clustering of IL-4 and IL-10 receptors in sensory neurons, leading to unique si

105 In contrast, an antagonistic antibody to the IL-10 receptor increased LPS-induced hepatomegaly by as

106 duction requires two distinct regions of the IL-10 receptor intracellular domain and thereby establis

107 Stat3, Jak1, and two distinct regions of the IL-10 receptor intracellular domain.

108 an integral membrane protein or is bound to IL-10 receptors is not yet known.

109 The interleukin-10 (IL-10) receptor is another member of the IFN receptor fa

110 , IL-10R1, the ligand-binding subunit of the IL-10 receptor, is predominantly expressed by TNF-produc

111 Conversely, LHb neuronal IL-10 receptor knockdown in naive mice increased Fos exp

112 These results suggest complex regulation of IL-10 receptor-ligand interactions and subsequent biolog

113 Last, mice with muscle-specific ablation of IL-10 receptor (M-IL10R(-/-)) were generated to determin

114 it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.

115 is associated with the induction of cellular IL-10 receptor-mediated signaling pathways.

116 vIL-10His6, with recombinant mouse and human IL-10 receptors (mIL-10R, hIL-10R).

117 We found that the cells expressed IL-10 receptor mRNA, suggesting that autocrine effects a

118 presence on the intracellular domain of the IL-10 receptor of a carboxyl-terminal sequence containin

119 interleukin-10 (IL-10), which activated the IL-10 receptor on HSCs to dampen their profibrotic activ

120 reases macrophage-derived IL-10 signaling to IL-10 receptors on Advillin+ sensory neurons to resolve

121 ding functional evidence for the presence of IL-10 receptors on CD4(+) T cells.

122 , WT MSC do not reverse CIPN in mice lacking IL-10 receptors on peripheral sensory neurons.

123 Treatment with anti-IL-10-receptor or anti-CD25 antibody enhanced early para

124 oduction in lesions, and blocking the murine IL-10 receptor prevented antibody-mediated disease exace

125 -339) peptide antigen, together with an anti-IL-10 receptor (R) mAb led to the enhancement of a Th1 r

126 t with a functional blocking antibody to the IL-10 receptor reduced both Stat-3 and AKT phosphorylati

127 dministration of an antibody that blocks the IL-10 receptor restored T-cell function and eliminated v

128 onstrate that the CRFB4 chain is part of the IL-10 receptor signaling complex.

129 TR1 cells with impaired IL-10 receptor signaling lost their regulatory activity

130 ese events were prevented by either blocking IL-10 receptor signaling or inhibiting proteasome degrad

131 TR1 cells required IL-10 receptor signaling to activate p38 MAPK, thereby s

132 mice and transgenic mice with impairment in IL-10 receptor signaling were used to test the activity

133 TR1 cell regulatory activity is dependent on IL-10 receptor signaling.

134 Blockade of IL-10 receptor signalling attenuated the PA-related redu

135 t specificity and express between 47 and 127 IL-10 receptor sites per cell, with a dissociation const

136 ansgenic mice expressing a dominant-negative IL-10 receptor specifically in T cells (CD4dnIL-10Ralpha

137 domization analysis ahowed that the APOE and IL-10 receptor subunit B genes were causally linked to i

138 hat muscle cells in mdx muscle expressed the IL-10 receptor, suggesting that IL-10 could have direct

139 od dendritic cells were found to express the IL-10 receptor, suggesting that IL-10 may directly act o

140 in binding of one or more components of the IL-10 receptor system, and thus the structural differenc

141 different molecular mechanisms to engage the IL-10 receptors that ultimately enhance the respective a

142 ) protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-10 in

143 ertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory respons

144 The IL-10 receptor was localized on VTA dopamine and non-dop

145 7) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for

146 human IL-6, vIL-6, human IL-10, and soluble IL-10 receptor were used.