ライフサイエンスコーパス: IL-13 receptor

1 gulate sPLA2 and MUC2 production through the IL-13 receptor.

2 e unresponsive to IL-13, and did not express IL-13 receptor.

3 nal in response to IL-13 and did not express IL-13 receptor.

4 its in several receptor types, including the IL-13 receptor.

5 both chains are essential components of the IL-13 receptor.

6 nal signaling component of both the IL-4 and IL-13 receptors.

7 d against the IL-4Ralpha subunit of IL-4 and IL-13 receptors.

8 bservation that human T cells do not express IL-13 receptors.

9 Here, we show that the IL-13 receptor alpha 2 (IL-13R alpha 2) is a critical me

10 We demonstrate that increased IL-13 receptor alpha 2 (IL-13Ralpha2) expression is resp

11 The role of IL-13 receptor alpha 2 (IL-13Ralpha2) in mediating these

12 (sixfold) reduction in decoy IL-13 receptor (IL-13 receptor alpha-2) expression when compared with in

13 tored in PsKO mice by treatment with soluble IL-13 receptor alpha-2-Fc, the exacerbated fibrotic resp

14 role in pathogenesis of bronchial asthma via IL-13 receptor alpha1 (IL-13Ralpha1) and IL-4 receptor a

15 ested to establish the expression pattern of IL-13 receptor alpha1 (IL-13Ralpha1) on islet-associated

16 as abolished in liver cells lacking Stat3 or IL-13 receptor alpha1 (Il-13ralpha1), which suggests tha

17 umanized mAb, inhibits IL-13 binding to both IL-13 receptor alpha1 and alpha2.

18 e lung was dependent upon recipient IL-5 and IL-13 receptor alpha1 and donor eosinophil C-C chemokine

19 tibodies to TSLPR and ST2, respectively, and IL-13 receptor alpha1 in both scenarios.

20 of recruited M-MDSCs, which highly expressed IL-13 receptor alpha1.

21 The interleukin (IL) 13 receptor alpha2 (IL13Ralpha2) is a glioma-restric

22 The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary

23 Interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is an essent

24 IL-13 receptor alpha2 (IL-13Ralpha2) binds IL-13 with hi

25 during infection and binds to its receptor, IL-13 receptor alpha2 (IL-13Ralpha2), to regulate the pa

26 epair and promotes tubular cell survival via IL-13 receptor alpha2 (IL13Ralpha2)-mediated signaling.

27 as, decreased collagen levels, and increased IL-13 receptor alpha2 gene expression compared to contro

28 Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity I

29 s for these peptides are EphA2, interleukin (IL)-13 receptor-alpha2, YKL-40, and gp100.

30 alpha (IL-4Ralpha) chain common to IL-4 and IL-13 receptors alters IL-4 signaling and is associated

31 s exhibit divergent expression of functional IL-13 receptor and this expression dictates the responsi

32 tive mAb for AD, dupilumab, targets the IL-4/IL-13 receptor and was approved in early 2017 in the Uni

33 but it also participates in the induction of IL-13 receptors and miR-126a expressed on/in the MDSCs.

34 tment to phosphotyrosine residues on IL-4 or IL-13 receptors and subsequent Tyr641 phosphorylation to

35 levels of expression of the interleukin-13 (IL-13) receptor and downstream effectors of IL-13 signal

36 ytokine receptors, including IL-4, IL-6, and IL-13 receptors as well as CCR3.

37 Our findings also reveal that the IL-13 receptor-associated tyrosine kinase Jak2 is requir

38 th anti-IL-4R mAb, an antagonist of IL-4 and IL-13 receptor binding, or with a control mAb.

39 same mechanism through which it improves AD: IL-13 receptor blockade, which leads to increased IL-13

40 Dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent sero

41 with 5-10-fold improved binding affinity to IL-13 receptors compared with wild-type IL-13 (wtIL-13).

42 ur studies have characterized the functional IL-13 receptor complex and the downstream signaling even

43 ma, IL-10, TGF-beta, TNF-alpha, and the IL-4/IL-13 receptor complex play important roles.

44 xhibit on their surfaces the interleukin 13 (IL-13) receptor designated IL13Ralpha2.

45 levels of IL-13 in the plasma and increased IL-13 receptor expression in marrow megakaryocytes.

46 ased surface expression of the high affinity IL-13 receptor IL-13Ralpha2, suggesting that IL-13Ralpha

47 g chain of the high affinity interleukin-13 (IL-13) receptor IL-13Ralpha1.

48 d a significant (sixfold) reduction in decoy IL-13 receptor (IL-13 receptor alpha-2) expression when

49 ) mice have demonstrated a critical role for IL-13 receptor (IL-13R) alpha1 in allergen-induced airwa

50 ave previously shown that the decoy receptor IL-13 receptor (IL-13R) alpha2 attenuates responses of f

51 fication of IL-13Ralpha1, a component of the IL-13 receptor (IL-13R), as a novel ligand of integrin M

52 Moreover, genes encoding IL-15, the IL-13 receptor (IL-13Ra1), and CD14 were suppressed duri

53 A third, high-affinity IL-13 receptor, IL-13Ralpha2, also exists.

54 GBMs express an IL-13 receptor (IL13Ralpha2) that differs from the physi

55 at leads us to postulate interactions at the IL-13/receptor interface.

56 Thus, reduced expression of the decoy IL-13 receptor mediated by the elevated type 1 cytokine

57 These results indicate that IL-4/IL-13 receptor-mediated Stat3 signaling may contribute t

58 monoclonal antibody in asthma and anti-IL-4/IL-13 receptor neutralizing monoclonal antibody in asthm

59 racellular/transmembrane domains of the IL-4/IL-13 receptor, not the cytoplasmic domains, control sig

60 exotoxin (IL13-PE), which targets and kills IL-13 receptor overexpressing cells.

61 essing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pat

62 ignificantly reduced the numbers of IL-4 and IL-13 receptor-positive mononuclear cells and macrophage

63 , nor did it solely block mucin synthesis or IL-13 receptor-proximal signaling.

64 gy to thrombospondin type 1 and interleukin (IL)-13 receptor (R) alpha2.

65 Here, we show that IL-13 receptor (R)alpha2 is a critical down-regulatory f

66 Activated IL-4 and IL-13 receptors recruit the tyrosine phosphatases SHP-1

67 that cells can dynamically alter their IL-4/IL-13 receptor signature to modulate downstream immune o

68 n a manner that is dependent on the IL-4 and IL-13 receptor subunit expression by these cells.

69 ing antibodies against IL-13 or the IL-4 and IL-13 receptor subunit IL-4Ralpha, as well as an antibod

70 3K, bound with 4-fold higher affinity to the IL-13 receptor than wild-type IL-13 but retained no dete

71 IL-13Ralpha2 does not participate in the IL-13 receptor that is up-regulated upon activation of q

72 For a functional IL-13 receptor, the IL-13Ralpha1 chain forms a productiv

73 Because murine lymphocytes do not have IL-13 receptors, we examined the ability of macrophage/n