ライフサイエンスコーパス: IL-15 receptor

1 ng that this effect is specific to the human IL-15 receptor.

2 ated upregulation of interleukin (IL)-15 and IL-15 receptor.

3 122, the beta-subunit shared by the IL-2 and IL-15 receptors.

4 on of IL-12, IL-15, and IL-18 or the IL-2 or IL-15 receptors.

5 is shared by the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors.

6 mma chain of the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors.

7 is distinct from known components of T-cell IL-15 receptors.

8 ell-derived IL-15, which is complexed to the IL-15 receptor a chain (IL-15/Ra).

9 ceptor II and a human interleukin-15 (IL-15)/IL-15 receptor a complex.

10 ht NK cells from MM patients primed with the IL-15 receptor agonist ALT-803 in vivo displayed enhance

11 Additionally, our data suggest that IL-15 receptor agonists may be useful tools in treating

12 Interleukin 15 (IL-15) and the IL-15 receptor alpha (IL-15Ralpha) chain are both requir

13 We show that endogenous soluble IL-15 receptor alpha (IL-15Ralpha) derived from epiderma

14 expression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Ralpha) in the same cell allo

15 co-expression of interleukin 15 (IL-15) and IL-15 receptor alpha (IL-15Ralpha) in the same cell allo

16 IL-15 receptor alpha (IL-15Ralpha) is a component of the

17 ion proteins have been engineered to provide IL-15 receptor alpha (IL-15Ralpha) mediated trans-presen

18 n 3 (MCP-3), IL-2 receptor beta (IL-2Rbeta), IL-15 receptor alpha (IL-15Ralpha), interferon receptor

19 s, and determined that these cells expressed IL-15 receptor alpha (IL-15Ralpha).

20 e treated T. gondii immune mice with soluble IL-15 receptor alpha (sIL-15Ralpha) to block the host en

21 ent as a heterodimer associated with soluble IL-15 receptor alpha (sIL-15Ralpha).

22 lls, possibly by affecting the expression of IL-15 receptor alpha and IL-15.

23 These are all tissues that express IL-15 receptor alpha but not IL-2 receptor alpha.

24 ing molecule (Bim), interleukin (IL)-15, and IL-15 receptor alpha chain (IL-15R alpha ) were associat

25 Significantly, mRNA for the IL-15 receptor alpha chain was not expressed in NK cells

26 ed that these tolerant T cells expressed the IL-15 receptor alpha chain, and could be induced to prol

27 using mice deficient in either IL-15 or the IL-15 receptor alpha chain.

28 GF-beta) receptor II and interleukin (IL)-15/IL-15 receptor alpha domains, enhances metabolic and cyt

29 Expression of the IL-15 receptor alpha on cancer cells was needed to effic

30 The IL-15 receptor alpha subunit (IL-15Ralpha) mediates high

31 ferred is through trans-presentation via the IL-15 receptor alpha subunit.

32 timulatory cytokine trans-presented with the IL-15 receptor alpha-chain to the shared IL-2/IL-15Rbeta

33 , whereas intratubular CD8 T cells expressed IL-15 receptor alpha.

34 We now report that IL-15 and the IL-15 receptor (alpha, beta, gamma chains) are constitut

35 ation of CD40 led to increased expression of IL-15 receptor-alpha by dendritic cells, an action that

36 IL-15 precomplexed to IL-15 receptor-alpha was used in immunotherapy experimen

37 anscription factors for development, but not IL-15 receptor-alpha, indicating that intraepithelial IL

38 by treating mice with IL-15 precomplexed to IL-15 receptor-alpha, which induced the development of e

39 in (IL)-15 superagonist mutant and a dimeric IL-15 receptor alphaSu/Fc fusion protein, was found to e

40 unts of the antiapoptotic protein Bcl-2, the IL-15 receptor and the receptor CD27, and little homeost

41 These expressed the common IL-2/IL-15 receptors and another subset of APOBEC3G anti-vira

42 noclonal antibodies targeting either IL-2 or IL-15 receptors and safer than inhibitors of downstream

43 increase in CD4(+) T cells was recorded with IL-15 receptors, APOBEC3G and CC chemokines, the latter

44 flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor - are known to promote the expansion and

45 Here, we report that IL-2/IL-15 receptor B chain and inducible costimulatory (ICOS

46 characterized by high expression of the IL-2/IL-15 receptor beta (CD122).

47 receptor alpha chain (IL-15Ralpha) and IL-2/IL-15 receptor beta chain (IL-2Rbeta) knockout mice.

48 of the transcription factors T-bet, the IL-2/IL-15 receptor beta chain CD122, and suppression of eome

49 ress high levels of NKG2A/C and the IL-2 and IL-15 receptor beta chain, CD122.

50 etal thymus were activated and expressed the IL-15 receptor beta chain, skin-homing receptors, and th

51 to the relatively high expression levels of IL-15 receptor beta, IL-7 receptor, IL-18 receptor, and

52 er signaling via CD122 (interleukin-2 [IL-2]/IL-15 receptor beta-chain) plays a role in regulating th

53 alpha production by IL-15 required the (IL-2/IL-15) receptor beta chain, as demonstrated by receptor

54 Neutralisation of the high-affinity IL-15 receptor binding subunit, IL-15ralpha in elderly m

55 Peritransplant IL-15 receptor blockade does not prolong allograft survi

56 IL-15 receptor blockade in mouse cardiac and islet allot

57 This study investigated the efficacy of IL-15 receptor blockade using Mut-IL-15/Fc in an outbred

58 KG2A(+)KLRG1(+) CD8 T cells express IL-7 and IL-15 receptors, can survive long-term without cognate A

59 d Nfil3) as well as one of the components of IL-15 receptor, CD122.

60 ation and molecular association of IL-2 (and IL-15) receptor chains in the ER/Golgi, which became mor

61 ntified a gene-gene interaction between IL-2/IL-15 receptor common beta chain and IL-2/IL-7/IL-15 rec

62 -15 receptor common beta chain and IL-2/IL-7/IL-15 receptor common gamma chain.

63 estigated for defects in the interleukin-15 (IL-15) receptor complex because functional IL-15 signali

64 CH1 and RBPJ, as well as the interleukin-15 (IL-15) receptor complex, the latter enhancing IL-15 auto

65 he interleukin (IL) 2, IL-4, IL-7, IL-9, and IL-15 receptor complexes remains undefined.

66 The IL-15 receptor consists of IL-15Ralpha, IL-2Rbeta, and t

67 he interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors, contributes to both cytokine binding an

68 igh affinity alpha-chain of the interleukin (IL)-15 receptor exists not only in membrane-anchored but

69 -cell survival but rather repressed IL-7 and IL-15 receptor expression, STAT5 phosphorylation, and BC

70 Interleukin-2 (IL-2) and IL-15 receptors have been detected on some murine neopla

71 To inhibit IL-15 function and to target IL-15 receptor (IL-15R) bearing cells, we have generated

72 ion are regulated by IL-15, the influence of IL-15 receptor (IL-15R)-mediated signaling at the cellul

73 IL-15 and the IL-15 receptor (IL-15R)alpha chain are essential for nor

74 previously described unique features of the IL-15 receptor (IL-15R)alpha.

75 essing IL-15 bound to the alpha chain of the IL-15 receptor (IL-15Ralpha).

76 The high affinity interleukin (IL)-15 receptor, IL-15Ralpha, is essential for supportin

77 mice lacking the high affinity interleukin (IL)-15 receptor, IL-15Ralpha, surprisingly results in th

78 Interleukin (IL)-15 and its high affinity IL-15 receptor, IL-15Ralpha, support NK cell homeostasis

79 ibody recognizing a signaling subunit of the IL-15 receptor, IL-2/15Rbeta, had a significant ( approx

80 n in cells that expressed the heterotrimeric IL-15 receptor in cis.

81 counter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of

82 interfering with the signal of the IL-2 and IL-15 receptors in a primate model of experimental autoi

83 In T and NK cells the IL-15 receptor includes IL-2/15R beta and gamma c subuni

84 homeostatic pathway defined by IL-15/IL-15R (IL-15 receptor) interaction and the inflammasome pathway

85 alpha was not co-precipitated from the [125I]IL-15 receptor-ligand complex, demonstrating that IL-15

86 New forms of therapy directed at IL-2 and IL-15 receptors may be effective against certain neoplas

87 mbinant cytokines (rIL-15, rTNFalpha) and an IL-15 receptor neutralising antibody.

88 ility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of hum

89 Mast cell IL-15 receptors recruit JAK-2 and STAT-5, instead of JAK

90 anscripts for the CD122 interleukin 2 (IL-2)/IL-15 receptor required by NK-lineage precursors.

91 ta chain, a shared component of the IL-2 and IL-15 receptors required for receptor function.

92 Death of NK cells resulted from diminished IL-15 receptor signaling within miR-142-deficient mice,

93 However, IL-15Ralpha is not merely an IL-15 receptor subunit, as mice lacking either IL-15 or

94 zed that differential expression of IL-2 and IL-15 receptor subunits on cycling T cells in vivo may d

95 T-cell divisions and expression of IL-2 and IL-15 receptor subunits, we demonstrate that IL-15 is a

96 on with anti-PD1 antibody (alphaPD1) and the IL-15 receptor superagonist N-803 to increase cytolytic

97 lated cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical s

98 vascular endothelial cells (VECs) expressed IL-15 receptors, the present study was undertaken to inv

99 modulate expression of the beta-chain of the IL-15 receptor, thus establishing a central axis between

100 and expressed reduced levels of the IL-7 and IL-15 receptors, thus providing a possible mechanism for

101 s of IL-12 and IL-15 mRNAs and the IL-12 and IL-15 receptors were also increased.