ライフサイエンスコーパス: IL-2R beta

1 32D cells expressing the wild-type human (hu)IL-2R beta.

2 ptosis in response to IL-2 as well as the wt IL-2R beta.

3 pha to the cytoplasmic domain of a truncated IL-2R beta.

4 active Akt mutants in BAF/3 cells expressing IL-2R beta[A0]delta S promotes the expression of Bcl-2 a

5 chromatography, followed by IL-2R alpha and IL-2R beta affinity chromatography and hydrophobic inter

6 FRET data from donor- and acceptor-labeled IL-2R beta-alpha, gamma-alpha, and gamma-beta pairs demo

7 Signals transduced via the S region of the IL-2R beta (amino acids 267-322) in BAF/3 cells activate

8 do the dominant negative forms of the common IL-2R beta and gamma chains.

9 regulation, illustrating the specificity of IL-2R beta and gamma subunit signaling on the regulation

10 p12I stabilizes the immature forms of the IL-2R beta and gamma(c) chains and decreases their cell

11 this effect depends on the presence of both IL-2R beta and gamma(c) chains and Jak3.

12 The IL-2R beta and gamma(c) chains associated with p12I are

13 The interactions of p12I with IL-2R beta and gamma(c) may have important implications

14 , which nearly span the entire length of the IL-2R beta and gamma(c) subunits.

15 Helix A of IL-2 wedges tightly between IL-2R beta and gamma(c) to form a three-way junction tha

16 -15 creates a less stable bridge between the IL-2R beta and IL-2R gamma c chains than does IL-2 on YT

17 precipitated through IL-2R beta showed that IL-2R beta and IL-2R gamma c co-precipitate in a 1:1 rat

18 While IL-2R alpha did co-precipitate with IL-2R beta and IL-2R gamma c in the presence of IL-2, IL

19 and immunoprecipitates that were probed for IL-2R beta and IL-2R gamma c on Western blots.

20 the interactions of IL-2 and IL-15 with the IL-2R beta and IL-2R gamma c subunits, as differences in

21 Inasmuch as IL-2R beta and IL-2R gamma subunits also serve as a comp

22 quired for high-affinity IL-2 binding, while IL-2R beta and IL-2R gamma(c) are required for the trans

23 eletion of JH7-6 impaired the association of IL-2R beta and IL-4R alpha chains with Jak1 but did not

24 e signals transduced via the S region of the IL-2R beta and is linked to the translocation of Akt to

25 (IL-2R alpha), a protein that together with IL-2R beta and the common cytokine receptor gamma chain

26 that were directed against the IL-2R alpha, IL-2R beta, and gamma(c) subunits of IL-2R.

27 zation of the receptor subunits IL-2R alpha, IL-2R beta, and gamma(c).

28 eration of cells co-expressing IL-15R alpha, IL-2R beta, and IL-2R gamma chains.

29 a R beta L, IFN-gamma R alpha, IL-10R alpha, IL-2R beta, and IL-4R alpha.

30 Other cytokines sharing the IL-2R beta- and/or common gamma-chains (i.e., IL-15, IL-

31 s analyzed, including phosphorylation of the IL-2R beta-associated kinase Jak1, expression of c-myc a

32 main binds a phosphopeptide derived from the IL-2R beta chain (corresponding to residues surrounding

33 ed T cell proliferation was dependent on the IL-2R beta chain but not the IL-2R alpha chain.

34 As increasing the IL-2 affinity for the IL-2R beta chain leads to better antitumor effect, we ge

35 ith a naive phenotype expressed little or no IL-2R beta chain, a shared component of the IL-2 and IL-

36 ed by IL-15 requires expression of an intact IL-2R beta chain, indicating that IL-15 operates in this

37 A monoclonal antibody to the IL-2R beta chain, Mik beta 1, reduced CD69 expression an

38 , interacts with the tyrosine-phosphorylated IL-2R beta chain.

39 from different cytoplasmic tyrosines on the IL-2R beta-chain (IL-2Rbeta).

40 sisted of the extracytoplasmic domain of the IL-2R beta-chain and the cytoplasmic domain of IL-7R alp

41 essing different chemokine receptors and the IL-2R beta-chain but not the IL-2R alpha-chain.

42 7R alpha-chain and the cytoplasmic domain of IL-2R beta-chain in IL-2Rbeta(-/-) mice did not prevent

43 how that transgenic thymic expression of the IL-2R beta-chain in IL-2Rbeta-deficient mice prevents le

44 This suggests that the acidic domain of the IL-2R beta-chain plays an essential role in regulating I

45 is inhibited in mice treated with Ab to the IL-2R beta-chain that blocks signaling by either IL-2 or

46 BAF-B03 cells transfected with the wild-type IL-2R beta-chain undergo apoptosis when stimulated with

47 Neither IL-2R alpha nor IL-2R beta chains are required for IL-15 binding.

48 (ii) In vivo, mutant IL-2R beta chains lacking the acidic region of IL-2Rbeta

49 ast the p55IL-2R (IL-2R alpha) and p70IL-2R (IL-2R beta) components of the multimeric high affinity I

50 Fusion of the A region of the IL-2R beta cytoplasmic tail to IL-7R alpha enables IL-7

51 IL-15R alpha did not co-precipitate with the IL-2R beta/gamma c complex.

52 high enough to titrate intermediate-affinity IL-2R beta/gamma(c) receptors.

53 2/IL-2R alpha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).

54 s on CIA using transgenic mice expressing an IL-2R beta/IL-4R alpha chimeric cytokine receptor transg

55 -mediated protection, CIA was exacerbated in IL-2R beta/IL-4R alpha chimeric receptor transgenic mice

56 Neutralizing IL-2, IL-2R alpha, or IL-2R beta inhibited AICD.

57 n CLPs are delivered via IL-2 receptor beta (IL-2R beta) intracellular domains.

58 Although IL-2-induced phosphorylation of IL-2R beta, JAK1, and STAT5 all required the presence of

59 risingly, IL-2R alpha makes no contacts with IL-2R beta or gamma(c), and only minor changes are obser

60 te oligonucleotides specific for IL-2, IL-4, IL-2R beta, or IL-2R gamma chains, added in culture, cou

61 endent of either the cytoplasmic tail of the IL-2R beta- or gamma c-subunits and their associated sig

62 uMik beta 1) Abs directed at IL-2R alpha and IL-2R beta, respectively, inhibit IL-2 binding and biolo

63 ated with IL-2 and then precipitated through IL-2R beta showed that IL-2R beta and IL-2R gamma c co-p

64 ation as well as cytolytic activity involves IL-2R beta signals that also up-regulate expression of t

65 IgG exhibited both anti-IL-2R alpha and anti-IL-2R beta specificities in binding assays.

66 en linked to a compromised expression of the IL-2R beta subunit (CD122) by old CD8+ T cells.

67 due to cross-linking of the IL-2R alpha and IL-2R beta, thus blocking IL-2 binding and possibly impe

68 ly from IL-2/IL-2R alpha to IL-2/IL-2R alpha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).

69 c co-precipitate in a 1:1 ratio, while only IL-2R beta was found in the immunoprecipitates of YT cel

70 Heterodimerization of IL-2R beta with either gamma c or the truncated erythrop

71 ing and possibly impeding the association of IL-2R beta with IL-15R.