ライフサイエンスコーパス: IL-4 receptor

1 or SHIP1, two adapter proteins that bind the IL-4 receptor.

2 sthma with both the human 5q31 locus and the IL-4 receptor.

3 ot occur in FAPs expressing knockdown of the IL-4 receptor.

4 include anti-IgE antibodies and the soluble IL-4 receptor.

5 t physically associated with and deactivated IL-4 receptor.

6 ells and dendritic cells need to express the IL-4 receptor.

7 coupling IRS proteins to activated IL-9 and IL-4 receptors.

8 d a cytokine receptor, typically the IL-2 or IL-4 receptors.

9 proliferation in human astroglia expressing IL-4 receptors.

10 human PBMC and tumor lines known to express IL-4 receptors.

11 h the cytoplasmic tail of the interleukin 4 (IL-4) receptor.

12 ated peptide derived from the interleukin 4 (IL-4) receptor.

13 IL-4 receptor a (IL-4Ra) is key in allergic asthma and r

14 ts were performed to test the requirement of IL-4 receptor a (IL-4Ra) signaling on MMC9s in experimen

15 d that IL-4 induces acute antinociception by IL-4 receptor a (IL-4Ra)-dependent release of opioid pep

16 M-dependent knockout (IIl4ra ( myel)) of the IL-4 receptor a-chain (IL-4Ra), the mandatory signaling

17 set of light zone GC B cells expressing high IL-4 receptor-a (IL4Ra) and CD23 and lacking a Myc-assoc

18 pathways involved in eotaxin-3 secretion by IL-4 receptor-a signaling.

19 cytokines that signal through interleukin-4 (IL-4) receptor-a have been shown to stimulate eotaxin-3

20 ROS, in turn, promoted IL-4 receptor activation by oxidatively inactivating PTP

21 ROS were not required for the initiation of IL-4 receptor activation.

22 ceptor (BCR) cross-linking or interleukin-4 (IL-4) receptor activation in B cells, and after lipopoly

23 n of interleukin 4 (IL-4), engagement of the IL-4 receptor, activation of signal transducer and activ

24 specially in the context of the proasthmatic IL-4 receptor allele Il4raR576.

25 IL 4 receptor alpha (IL-4Ralpha) expression by non-bone

26 We also asked the role of interleukin (IL)-4 receptor alpha (IL-4Ralpha)-signal transducer and

27 rphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conver

28 The interleukin (IL)-4 receptor alpha-chain (IL-4Ralpha) contains a seque

29 IL-4 receptor alpha (IL-4Ralpha) blockade is beneficial

30 The Q576->R576 polymorphism in the IL-4 receptor alpha (IL-4Ralpha) chain common to IL-4 an

31 IL-4 signaling through the IL-4 receptor alpha (IL-4Ralpha) chain on CD4(+) T cells

32 The IL-4 receptor alpha (IL-4Ralpha) gene is genetically abr

33 IL-4 receptor alpha (IL-4Ralpha) is key in allergic asth

34 (SCI) associated with impaired induction of IL-4 receptor alpha (IL-4Ralpha) on microglia.

35 a mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Ralpha) signaling on B cells in

36 ts were performed to test the requirement of IL-4 receptor alpha (IL-4Ralpha) signaling on MMC9s in e

37 ed a major role for the interleukin-4 (IL-4)/IL-4 receptor alpha (IL-4Ralpha) signaling pathway in sy

38 Ablation of IL-4 receptor alpha (IL-4Ralpha) signaling restored the

39 Dupilumab, an mAb targeting the IL-4 receptor alpha (IL-4Ralpha) subunit, inhibits IL-4

40 However, when IL-13Ralpha1 combines with IL-4 receptor alpha (IL-4Ralpha), a signaling high affin

41 Through the actions of the IL-4 receptor alpha (IL-4Ralpha), type 2 cytokines resul

42 abrogated by a neutralizing antibody to the IL-4 receptor alpha (IL-4Ralpha)-chain but not to the IL

43 via IL-13 receptor alpha1 (IL-13Ralpha1) and IL-4 receptor alpha (IL-4Ralpha).

44 This was IL-5-dependent but IL-4 receptor alpha (Il4ra) independent, associated with

45 ES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha).

46 e show that in BALB/c mice deficient for the IL-4 receptor alpha chain (IL-4Ralpha(-/-)), which are u

47 rement of IL-4 and vascular endothelial (VE) IL-4 receptor alpha chain (IL-4Ralpha) signaling in hist

48 ed IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Ralpha), common to both I

49 nt paradox is explained by observations that IL-4 receptor alpha chain (IL-4Ralpha)-deficient mice an

50 IL-4 receptor alpha chain (IL-4Ralpha)-deficient mice we

51 transduction mechanisms are conferred by the IL-4 receptor alpha chain (IL-4Ralpha).

52 cells, depending on their expression of the IL-4 receptor alpha chain (IL-4Ralpha/CD124).

53 mice with a gain-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) and wild-type (WT)

54 mice with a gain-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) were orally sensit

55 Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil gran

56 n (IL-2Rbeta) and physically adjacent to the IL-4 receptor alpha chain gene on chromosome 16.

57 tic factors, such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms, are linked to i

58 Both the IL-4 receptor alpha chain R576 (IL-4RalphaR576) variant

59 hil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobil

60 Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated m

61 to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway.

62 tment with monoclonal antibodies to IL-4 and IL-4 receptor alpha chain.

63 ine-phosphorylated peptides derived from the IL-4 receptor alpha chain.

64 Subsequent experiments with IL-13 and IL-4 receptor alpha deficient mice demonstrated that gob

65 ctivating gene (RAG)2 knockout (KO) and RAG2/IL-4 receptor alpha double KO mice showed that inhibitio

66 w cytometry and Western blotting showed that IL-4 receptor alpha expression was elevated in TSK/+ fib

67 that amino acid changes in the 3' end of the IL-4 receptor alpha gene (IL4RA) or closely proximal var

68 in cells expressing a mutation of the human IL-4 receptor alpha in the immunoreceptor tyrosine-based

69 ant pharmacogenetic interaction between anti-IL-4 receptor alpha therapy and IL4RA gene variation, id

70 he AD molecular signature with targeted anti-IL-4 receptor alpha therapy.

71 BALB/cJ and IL-4 receptor alpha(-/-) mice were sensitized with ovalb

72 Methods: Neutrophil activation of IL4Ra (IL-4 receptor alpha) signaling pathways was explored ex

73 ials, dupilumab, a fully human mAb targeting IL-4 receptor alpha, markedly improved disease activity,

74 nerated mice with a specific deletion of the IL-4 receptor alpha-chain (IL-4Ralpha) in macrophages an

75 Signaling by the IL-4 receptor alpha-chain (IL-4Ralpha) is a key determin

76 the low neutrophil surface expression of the IL-4 receptor alpha-chain (IL-4Ralpha), essential for IL

77 g of STAT5 to the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha), was essential fo

78 tat6 reside in the cytoplasmic domain of the IL-4 receptor alpha-chain (IL-4Ralpha).

79 Mice deficient for the IL-4 receptor alpha-chain (IL-4Ralpha-/-) retain the cap

80 e BALB/c mice deficient in IL-4 (IL-4-/-) or IL-4 receptor alpha-chain (IL-4Ralpha-/-), we have obser

81 L-2 receptor components, but did not inhibit IL-4 receptor alpha-chain and CD69 expression or the ind

82 n patients with AD is available for the anti-IL-4 receptor alpha-chain antibody dupilumab, but a numb

83 naive B cells expressed significantly higher IL-4 receptor alpha-chain on their cell surface than the

84 d with acute rejection episodes, nor was the IL-4 receptor alpha-chain variant Q576R.

85 These patients were also typed for the IL-4 receptor alpha-chain variant Q576R.

86 ediated by increased expression of Stat6 and IL-4 receptor alpha-chain.

87 d expression of Il4ra, the gene encoding the IL-4 receptor alpha-chain.

88 , caused by Schistosoma mansoni infection in IL-4 receptor alpha-deficient mice (IL-4Ralpha(-/-)), re

89 We now demonstrate that (i) an IL-4 receptor alpha-subunit (IL-4Ralpha)/Stat6-dependent

90 ation, presumably due to upregulation of the IL-4 receptor alpha.

91 (IL-6) polymorphisms and the interleukin-4 (IL-4) receptor alpha-chain variant on posttransplant ren

92 dition, naturally occurring mutations of the IL-4-receptor alpha chain have been identified and impli

93 studies employed artificial mutations of the IL-4-receptor alpha chain using site-directed mutagenesi

94 increases in IL-4 secretion, plasma soluble IL-4 receptor-alpha (IL-4Ralpha) concentration, and T-ce

95 RNA aptamer that blocks the murine or human IL-4 receptor-alpha (IL4Ralpha or CD124) that is critica

96 tosomiasis by injecting the bladder walls of IL-4 receptor-alpha knockout (Il4ra(-/-) ) and wild-type

97 s IL-4 and IL-13 through its activity on the IL-4 receptor-alpha; and tezepelumab prevents activation

98 -4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, includi

99 on factor, STAT6, which is downstream of the IL-4 receptor and binds virus gene 50 N4/N5 promoter in

100 was independent of signals mediated via the IL-4 receptor and hence occurred upstream of potential a

101 s, despite comparable levels of cell surface IL-4 receptor and phosphorylated Jak2 and STAT6.

102 We found that SGs and sebocytes expressed IL-4 receptor and produced high levels of T helper 2-ass

103 s linked to the ligand binding domain of the IL-4 receptor and shown to support the IL-4 induced grow

104 alpha chain is an essential component of the IL-4 receptor and signals via STAT6.

105 Expression of cell surface IL-4 receptors and IL-4Ralpha in lysates was constitutiv

106 Our data from infections of IL-4 receptor(-/-) and Stat6(-/-) mice further indicate

107 ene modifiers, anti-IL-5/IL-5 receptor, anti-IL-4 receptor, and anti-IgE) and invites exploration of

108 Human neutrophils expressed both types of IL-4 receptors, and their stimulation through IL-4 or IL

109 AIDS-KS cells express surface interleukin-4 (IL-4) receptors, and that IL-4 toxin (IL-4(38-37)-PE38KD

110 ding to the upregulation of CXCR3 through an IL-4-receptor- and eomesodermin-dependent pathway.

111 dicating that this molecule acts as a strong IL-4 receptor antagonist.

112 n development, including anti-IL-13 mAbs and IL-4 receptor antagonists.

113 expression of both MHC class II antigens and IL-4 receptor are completely abrogated, and lymphocytes

114 ed gamma-c restored function to the IL-2 and IL-4 receptors as shown by signal transduction mediated

115 itionally, we show that the requirements for IL-4 receptor binding and Stat6 activation extend to acc

116 T(H)2-MPP persisted despite in vivo IL-4 receptor blockade, while thymic stromal lymphopoiet

117 such immunosuppressive drugs, including the IL-4 receptor-blocking antibody dupilumab, on IgG4 skewi

118 yrosine phosphorylation or expression of the IL-4 receptor chains.

119 Thus, helminth activation of tuft cell-IL-4-receptor circuits in the gut exacerbates infection

120 onal down-regulation of both subunits of the IL-4 receptor complex (CD124, CD132) and are mediated vi

121 f phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p7

122 e and signals exclusively through the type I IL-4 receptor complex, providing previously inaccessible

123 SOCS-3/IL-4 receptor complexes, however, were increased in db/d

124 on of IL-4 and IL-13 and whether the type II IL-4 receptor (comprised of the IL-4Ralpha chain in asso

125 The human IL-4 receptor contains a sequence (the 14R motif) center

126 acrophages stimulated with IL-31, but not in IL-4 receptor-deficient macrophages.

127 -infected wild-type and IL-4-deficient mice, IL-4 receptor-deficient mice showed minimal RELMbeta ind

128 ntly, mice deficient in either mast cells or IL-4 receptor displayed greater susceptibility to the in

129 ntibody to the alpha-subunit of interleukin (IL)-4 receptor, dupilumab, was recently approved to trea

130 shown that BCR signaling is reprogrammed by IL-4 receptor engagement and that this reprogramming inv

131 Thus, type I and II IL-4 receptors exert distinct effects on immune response

132 aviors impacted by T cells were mediated via IL-4 receptors expressed on neurons.

133 our original hypotheses, IL-4 production and IL-4 receptor expression by T cells are both dispensable

134 "IL-4-dependent pulmonary priming" relies on IL-4 receptor expression on hematopoietic cells and stru

135 We found that IL-4 receptor expression on macrophages was required for

136 IL-4 receptor expression was detected in a variety of gl

137 terleukin (IL)-4 and IL-13 share the type II IL-4 receptor for cell signaling.

138 er ligand-dependent activation, interleukin (IL)-4 receptor generated reactive oxygen species (ROS) v

139 xpressing memory CD4(+) T cells that induced IL-4 receptor(hi) (IL-4R(hi)) CD206(+) alternatively act

140 The insulin/interleukin-4 (IL-4) receptor (I4R) motif mediates the association of i

141 out mice, we found that only deletion of the IL-4 receptor IL-4Ralpha in early myeloid progenitors in

142 kin 4 (IL-4) and IL-13 and the heterodimeric IL-4 receptor (IL-4R) complexes that they interact with

143 igated whether a relationship exists between IL-4 receptor (IL-4R) expression and MO persistence in t

144 The IL-4 receptor (IL-4R) in B cells is composed of two chai

145 toplasmic domain of the alpha-subunit of the IL-4 receptor (IL-4R) might be relatively resistant to t

146 hosen as a ligand based on the expression of IL-4 receptor (IL-4R) on most acute myeloid leukemia cas

147 ammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL

148 h2) differentiation is driven by a source of IL-4 receptor (IL-4R) that mobilizes IL-4R signaling pat

149 ypes responsive to IL-4, T cells express one IL-4 receptor (IL-4R) type, IL-4Ralpha/IL-2Rgamma (class

150 that gammadelta17 cells expressed the type I IL-4 receptor (IL-4R), and IL-4 increased STAT6 phosphor

151 DA express moderate- to high-density surface IL-4 receptor (IL-4R), whereas normal pancreatic samples

152 IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Ralpha1 a

153 IL-4 receptor (IL-4R)-deficient CD8+ T cells specific fo

154 tailored therapeutics targeting their common IL-4 receptor (IL-4R).

155 Soluble recombinant human IL-4 receptor (IL-4R; Nuvance; altrakincept) inactivates

156 neck cancer cell lines also express surface IL-4 receptors (IL-4R) and IL-4 binds to IL-4R on one ce

157 IL-4 receptors (IL-4Rs) are also expressed by nonhematop

158 Although IL-4 receptors (IL-4Rs) but not IL-12Rs are expressed on

159 notype with T(H)1/IFN-gamma, OASL, and T(H)2/IL-4 receptor/IL-5 skewing, although less than seen in p

160 ion of a4B7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch and

161 In line with this, gene expression of the IL-4 receptor (Il4ra) and its ligand IL-13 are elevated

162 lar domain was replaced by that of the human IL-4 receptor (IL4Ralpha/GPIbalpha-tg mice).

163 articipation of interleukin-4 (IL-4) and the IL-4 receptor in asthma.

164 the distinct functions of type I and type II IL-4 receptors in vivo.

165 monoclonal antibody against the interleukin (IL) 4 receptor, inhibits IL4 and IL13 signaling.

166 Because the IL-4 receptor is known to signal through the JAK1 and JA

167 apeutic mAb that blocks the shared IL-13 and IL-4 receptor, is the first drug to advance through clin

168 gG1 involves tyrosine phosphorylation of the IL-4 receptor, JAK1, JAK3, and STAT6 proteins induced by

169 IL-4 receptor knockout (Il4ra(-/-)) mice, which have red

170 or substrates, or to a failure to upregulate IL-4 receptor levels.

171 atterns are also evident at the cytokine and IL-4 receptor loci.

172 cific responses, we transplanted the insulin IL-4 receptor motif (I4R motif) of the huIL-4R alpha to

173 otif (488PLVIAGNPAYRSFSD) termed the insulin IL-4 receptor motif (I4R motif).

174 n 32D-IRS-1 cells transfected with the human IL-4 receptor mutated in the insulin-lL-4 receptor motif

175 ent understanding of the organization of the IL-4 receptor, of the signaling pathways that are induce

176 te that the concerted activation of TLR2 and IL-4 receptor on dendritic cells is sufficient for this

177 IL-4 also enhanced expression of the IL-4 receptor on microglia, facilitating a "feedforward"

178 vered by cytokines and also suggest that the IL-4 receptor on resting T cells may use a novel signali

179 ls produce IL-4, which attenuates damage via IL-4 receptors on neurons.

180 were dependent on IL-4 acting through type 2 IL-4 receptors on neutrophils.

181 ion resulted in an increase of IFN-gamma and IL-4 receptors on PMCs.

182 escence was used to document the presence of IL-4 receptors on the gastric SOM-secreting cell (D cell

183 Moreover, genetic ablation of IL-4, the IL-4 receptor, or its downstream signaling molecule sign

184 Cotransfection of IL-4 receptor p140 (termed IL-4Rbeta) with gammac or IL-

185 rotein and the protein when complexed to the IL-4 receptor phosphopeptide.

186 pecifically induced by IL-4 and revealed the IL-4-receptor/PI3K/Akt-signaling pathway as a target.

187 sIg) engagement, physiological engagement of IL-4 receptors produced similar levels of Fas resistance

188 IL-4 receptor (R) alpha, the common receptor chain for I

189 aling through both B cell receptor (BCR) and IL-4 receptor (R) converge on the extinction of B7h mRNA

190 stage by anti-interleukin (IL)-4 blockade of IL-4 receptor (R) signaling.

191 At least two distinct receptor components, IL-4 receptor (R)alpha and IL-13Ralpha1, mediate the div

192 IL-4 receptor signaling in human neutrophils affects sev

193 interleukin (IL)-4 mirrors coinfection, and IL-4 receptor signaling in intestinal epithelial cells m

194 )::Cx3cr1-CreER mice, which are deficient in IL-4 receptor signaling in microglia.

195 We demonstrated this concept by showing that IL-4 receptor signaling in mouse and human neutrophils i

196 Furthermore, the absence of Type II IL-4 receptor signaling is sufficient to attenuate the e

197 IL-4 receptor signaling is supposed to play a major role

198 Loss of IL-4 receptor signaling partially restored anti-M pneumo

199 tor (TCR) stimulation and was independent of IL-4 receptor signaling through the transcription factor

200 The roles of IL-10 and IL-4 receptor signaling were evaluated in a murine model

201 Downstream from IL-4 receptor signaling, STAT6 activation is transient,

202 pSTAT6 levels and reducing the threshold of IL-4 receptor signaling.

203 te selection in CD4(+) T cells by regulating IL-4 receptor signaling.

204 on was highly dependent on IL-13 and type II-IL-4 receptor signaling.

205 g that GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions wit

206 f the adaptive immune system, eosinophils or IL-4 receptor signalling.

207 gnificant increase in the inhibitory soluble IL-4 receptor (sIL4R).

208 or with IL-4 or IL-13 for (1) expression of IL-4 receptor subunits, (2) neutrophil extracellular tra

209 ts studying signaling molecules activated by IL-4 receptor suggest that IL-4 signaling can be subdivi

210 do not express the gamma common chain of the IL-4 receptor, support PV-mediated but not IL-4-dependen

211 Thus, IL-4 receptor-targeted cytotoxin represents a potent age

212 stead of mouse FcepsilonRIalpha and a mutant IL-4 receptor that lacks inhibitory function.

213 to require signaling contributions from both IL-4 receptor, via STAT6, and CD28, but it cannot be eff

214 Expression of the IL-4 receptor was determined by flow cytometry and Weste

215 monstrated that the gammaC subunit of type I IL-4 receptor was required for robust tyrosine phosphory

216 ellular IL-4Ralpha-chain and in cell surface IL-4 receptors was associated with an inhibition of bios

217 CLL B-cell expression of IL-4 receptors was increased compared to normal B cells.

218 ng mice harboring a disinhibited form of the IL-4 receptor, we developed an adjuvant-free model of pe

219 ac]) and the type II (IL-4Ralpha/-13Ralpha1) IL-4 receptors, whereas IL-13 utilizes only the type II

220 depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs the developm

221 of injured neurons by activation of neuronal IL-4 receptors, which potentiated neurotrophin signaling

222 In macrophages, IL-4/-13 bind IL-4 receptors, which signal through insulin receptor su