ライフサイエンスコーパス: IL-7 receptor

1 cytokine, IL-7, due to reduced expression of IL-7 receptor.

2 feration results from signals other than the IL-7 receptor.

3 found to have mutations in the gene for the IL-7 receptor.

4 al interleukin receptors, including IL-2 and IL-7 receptors.

5 y depends on signaling through both IL-2 and IL-7 receptors.

6 SCs express lowered levels of interleukin-7 (IL-7) receptor.

7 ated CD4(+) T cells expressed high levels of IL-7 receptor a chain but very low levels of TSLP recept

8 nterleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor sub

9 d impaired IL-7 sensitivity due to decreased IL-7 receptor a-chain (IL-7Ra) expression was found in p

10 It has not been determined whether the IL-7 receptor actually delivers a proliferative signal o

11 Consistently, deficiency in IL-7 receptor alone, a common gamma chain-containing rec

12 ceptor gamma chain (gammac) and interleukin (IL)-7 receptor alpha (IL-7Ralpha)-deficient mice.

13 s via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TS

14 sis infection, accompanied by a reduction in IL-7 receptor alpha (CD127) expression.

15 complex, a heterodimer composed of TSLPR and IL-7 receptor alpha (CD127).

16 cking IL-7 signaling with a mAb that targets IL-7 receptor alpha (IL-7Ralpha) alone or following T ce

17 cultures show differential expression of the IL-7 receptor alpha (IL-7Ralpha) chain (CD127).

18 IL-7 receptor alpha (IL-7Ralpha) expression is subject t

19 In IL-7 receptor alpha (IL-7Ralpha) knockout mice, B cell d

20 for thymopoiesis in mice and humans because IL-7 receptor alpha (IL-7Ralpha) mutations result in a s

21 e prevented by antibody-mediated blockade of IL-7 receptor alpha (IL-7Ralpha) signaling.

22 blastic leukemia cell line, using lentiviral IL-7 receptor alpha (IL-7Ralpha) to serve as a model sys

23 in T-cell development caused by mutations in IL-7 receptor alpha (IL7RA) and IL-2 receptor gamma (IL2

24 IL-7 led to transient down-regulation of the IL-7 receptor alpha chain (CD127) in both CD4(+) and CD8

25 Uniquely, however, expression of the IL-7 receptor alpha chain (CD127) on CD4 T cells was mor

26 is increased markedly in the presence of the IL-7 receptor alpha chain (IL-7R alpha).

27 enerating mice deficient in both Bax and the IL-7 receptor alpha chain (IL-7R).

28 e that IL-2 potently decreases expression of IL-7 receptor alpha chain (IL-7Ralpha) mRNA and protein.

29 immunodeficiency caused by mutations in the IL-7 receptor alpha chain (IL-7Ralpha) still generate pe

30 etal liver but not adult bone marrow (BM) of IL-7 receptor alpha chain (IL-7Ralpha)-deficient mice ca

31 T cells with decreased expression of CD127 (IL-7 receptor alpha chain) and (b) nonalloreactive T cel

32 ow that pDCs expressed the TSLP receptor and IL-7 receptor alpha complexes upon activation and became

33 f the patient, and showed that patients with IL-7 receptor alpha, ADA, and CD3 chain gene mutations c

34 dexamethasone upregulated ILC2 expression of IL-7 receptor alpha, which augmented and sustained signa

35 For loss-of-function studies, anti-IL-7 receptor alpha-chain (anti-IL-7Ralpha) antibody or

36 Foxp1 repressed expression of the IL-7 receptor alpha-chain (IL-7Ralpha) by antagonizing F

37 he survival of naive and memory T cells, and IL-7 receptor alpha-chain (IL-7Ralpha) expression is dyn

38 g many acute viral and bacterial infections, IL-7 receptor alpha-chain (IL-7Ralpha) is expressed on a

39 in the expression of the transcript for the IL-7 receptor alpha-chain (IL-7Ralpha), and these result

40 Circulating IL-7 and soluble IL-7 receptor alpha-chain (soluble CD127) concentrations

41 7 production or upregulate expression of the IL-7 receptor alpha-chain.

42 ys an important role in the transcription of IL-7 receptor alpha-subunit (CD127), enabling responsive

43 c stromal lymphopoietin (TSLP), 2 ligands of IL-7 receptor alpha.

44 Soluble interleukin-7 (IL-7) receptor alpha (sCD127) is implicated in the patho

45 Genetic variation in the IL-7 receptor-alpha (IL-7R) gene is associated with susc

46 Here we show that blocking IL-7 receptor-alpha (IL-7Ralpha) with monoclonal antibod

47 1), recent thymic emigration (CD31), and the IL-7 receptor-alpha (IL-7Ralpha).

48 ished use of IL-7 but that IL-7 signaling on IL-7 receptor-alpha-positive (IL-7Ralpha(+)) dendritic c

49 Surface expression of interleukin-7 (IL-7) receptor-alpha (IL-7R alpha), a component of the h

50 This subset expressed IL-7 receptor and chemokine receptor 5 (CXCR5) and induc

51 ptors - such as c-kit, flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor - are known to prom

52 etermine whether eosinophils have functional IL-7 receptors and to assess the potential contribution

53 xpressed the transcription factor FOXO1, the IL-7 receptor, and BCL2.

54 -Kit levels have diminished and cell surface IL-7 receptors are detectable.

55 eceptor signals, such as those transduced by IL-7 receptors, are required for differentiation of sign

56 We found that a short course of anti-IL-7 receptor blocking antibody following T cell depleti

57 like other T cells, require signals from the IL-7 receptor, but unlike other T cells, do not require

58 s) with a constitutively active interleukin (IL)-7 receptor (C7R-GD2.CARTs).

59 proper expression of the alpha-chain of the IL-7 receptor (CD127) and Ebf1.

60 We found that the IL-7 receptor (CD127) is down-regulated on a subset of C

61 affects IL-7 serum levels, expression of the IL-7 receptor (CD127), and T-cell cycling.

62 by low levels of the interleukin (IL)-2 and IL-7 receptors (CD25(-)CD127(-)).

63 not only produce IL-7, but also express the IL-7 receptor chains IL-7Ralpha and CD132.

64 with the common gamma-chain (gammac) in the IL-7 receptor complex and the unique TSLP-R chain in the

65 rations is specific to signaling through the IL-7 receptor complex.

66 SPGs on B-lineage precursors may function as IL-7 receptor components similar to HSPGs known to be im

67 Interestingly, the IL-7 receptor contains a tyrosine (Tyr-429)-based sequen

68 Thus the IL-7 receptor controls at least two distinct pathways, i

69 Thus, IL-7 receptor controls early B lymphopoiesis through act

70 e signaling complex, the signalosome, on the IL-7 receptor cytoplasmic domains.

71 lymphopenia in conjunction with its induced IL-7 receptor defects.

72 In IL-7 receptor-deficient (IL-7R-/-) mice, lymphoid precur

73 etitively to RAG2(-/-) mice (with ILC2s) and IL-7 receptor-deficient mice (lack ILC2s), and total ILC

74 IL-2 receptor gamma chain/Janus kinase 3/IL-7 receptor-deficient SCID, myeloablative conditioning

75 IL-2 receptor gamma chain/Janus kinase 3/IL-7 receptor-deficient SCID, myeloablative conditioning

76 This has established a major role for IL-7-receptor-dependent signaling in T cell development

77 Activated IL-7 receptors embedded in membrane microdomains induce

78 We demonstrated impaired monocyte IL-7 receptor expression as well as IL-7 sensitivity in

79 d mycobacterial cell wall components induced IL-7 receptor expression in monocytes and IL-7 boosted m

80 cells and by permanently upregulating their IL-7 receptor expression, enabling IL-7 to sustain them

81 not inhibit lymphopoiesis by down-regulating IL-7 receptor expression, since this cytokine did not re

82 IL-7 and IL-7 receptor functions are believed to result in lympho

83 Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, a

84 le negative) thymocytes require interleukin (IL)-7 receptor (IL-7R) signals for survival and prolifer

85 ingly, gene disruption of either IL-7 or the IL-7 receptor (IL-7R) alpha subunit in mice leads to imm

86 IL-7 receptor (IL-7R) and T-cell receptor (TCR) signalin

87 own resistance by promoting upregulation of IL-7 receptor (IL-7R) expression.

88 Signaling through the IL-7 receptor (IL-7R) is necessary for the development o

89 Here we show that IL-7 receptor (IL-7R) is not strictly required for the d

90 Signaling through the IL-7 receptor (IL-7R) is required for development and ma

91 trols, we report that key transcripts of the IL-7 receptor (IL-7R) pathway are accumulated in inflame

92 The IL-7 receptor (IL-7R) stimulated glucose uptake and cell

93 active B cells, required the function of the IL-7 receptor (IL-7R), and contributed to maintenance of

94 mutations of upstream activators such as the IL-7 receptor (IL-7R), Janus kinase, and Fms-like tyrosi

95 8(+) T cells normally express high levels of IL-7 receptor (IL-7R, CD127), activated and memory allor

96 gh expression levels of IL-15 receptor beta, IL-7 receptor, IL-18 receptor, and 41BB relative to the

97 The high-affinity chain of the IL-7 receptor, IL-7Ralpha (CD127), is expressed by effec

98 like receptor (TLR)-related lnc interleukin (IL) 7 receptor (IL7R) were significantly reduced in peri

99 Sin1 deficiency results in increased IL-7 receptor (il7r) and RAG recombinase (rag1 and rag2)

100 murine T-cell line, different regions of the IL-7 receptor initiate the signal transduction pathways

101 (+) subpopulations demonstrates that surface IL-7 receptor is expressed on most CD34(high)CD5(+)CD1a(

102 antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation of three members

103 nt requires interleukin (IL)-7; IL-7(-/)- or IL-7 receptor(-/)- mice lack TCR-gammadelta cells.

104 D4 effectors generated from wild-type versus IL-7 receptor-/- mice were transferred to adoptive hosts

105 aused a downregulation of the interleukin-7 (IL-7) receptor, needed for survival of conventional T ce

106 ogeneic bone marrow transplant studies using IL-7 receptor null (IL-7R alpha(-/-)) mice as recipients

107 th increased surface expression of c-Kit and IL-7 receptors on the IL-18-treated cells.

108 ive is enhanced with increased expression of IL-7 receptor or B-cell lymphoma 2 (Bcl-2).

109 ith heterodimeric cytokine receptors such as IL-7 receptor or IL-9 receptor, in which JAK1 is appende

110 rs contribute to a dysregulation of the IL-7/IL-7 receptor pathway in T1D and identify a novel hyperg

111 To address whether IL-7 receptor (R) activity is essential for early B line

112 Interleukin (IL)-7 receptor(R)alpha-mediated signals were obligatory

113 l-mediated inflammation in an interleukin-7 (IL-7) receptor-, S1P receptor 1-, and CCR6-dependent man

114 Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor gamma

115 rly pro-B-like stage that is unresponsive to IL-7 receptor signaling and unable to efficiently comple

116 We investigated IL-7 receptor signaling by measuring signal transducer a

117 cted persons, it was not directly related to IL-7 receptor signaling function.

118 Thus, IL-7 receptor signaling is a participant in the formatio

119 the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8

120 nterleukin-7(+) (IL-7) cells and for optimal IL-7 receptor signaling.

121 Interleukin-7 (IL-7) receptor signaling begins with activation of the J

122 velopmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B cells induced ex

123 ines whose receptors share components of the IL-7 receptor: thymic stromal lymphopoietin (TSLP) and I

124 ly, sIL7Ralpha competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and

125 Although CLPs express IL-7 receptors, which share the common gamma chain with