ライフサイエンスコーパス: IL-8 receptor

1 at is a constitutively active homolog of the IL-8 receptor.

2 ibody 1D4 to monitor the localization of the IL-8 receptor.

3 ypes modulate the rate of internalization of IL-8 receptors.

4 icity for binding of these chemokines to the IL-8 receptors.

5 CR), a homologue of the human interleukin-8 (IL-8) receptor.

6 upled receptors, particularly interleukin-8 (IL-8) receptors.

7 Truncation of the last 27 amino acids of the IL-8 receptor A severely impaired the IL-8-induced inter

8 The IL-8 receptor A was tagged with an epitope corresponding

9 Jurkat T cells were transfected with alpha (IL-8 receptor A) or beta (MIP-1alpha/CC-CKR-1) chemokine

10 Interleukin-8 (IL-8) receptor A (CXCR1) couples to a pertussis toxin-se

11 NOD and B10, and Cmkar2 (CXCR2, interleukin [IL]-8 receptor alpha).

12 zed LDL (lectin-like) receptor 1 (OLR1), and IL-8 receptor-alpha (IL8RA)] decreased after the HPC int

13 tractant receptor function, as the number of IL-8 receptors and chemoattractant-induced calcium influ

14 data identify the rat orthologs of the human IL-8 receptors, and describe cellular and tissue targets

15 nfirmed by demonstrating that the HMGB-1 and IL-8 receptors are expressed in ALK(+)ALCL biopsies.

16 we found that the rate of internalization of IL-8 receptor B triggered by IL-8 was faster than the on

17 n could be blocked with IL-8 neutralizing or IL-8 receptor blocking antibodies.

18 s also demonstrate upregulation of CXCR2, an IL-8 receptor, but not CXCR1.

19 d antiapoptotic enzyme cyclooxygenase-2, the IL-8 receptor C-X-C chemokine receptor (CXCR) 1, and the

20 taxis of HMECs to IL-8, indicating that both IL-8 receptors contributed to the migratory response of

21 Furthermore, the il-8 receptor cxcr-1/2 was expressed in myeloid cells, a

22 Chemokines that bind the IL-8 receptor CXCR-2 are essential for the development o

23 The selective IL-8 receptor CXCR1 and the promiscuous chemokine recept

24 ic IL-8 chemokine activity by binding to the IL-8 receptor CXCR1.

25 er stem cells (CSCs) through blockade of the IL-8 receptor CXCR1.

26 ECs) did not express detectable mRNA for the IL-8 receptors CXCR1 and CXCR2.

27 asiveness of ALK(+) cells, which express the IL-8 receptors CXCR1 and CXCR2.

28 cross-regulation of the human interleukin-8 (IL-8) receptors CXCR1 and CXCR2 by chemoattractants.

29 Here, we demonstrate that IL-8 receptor, CXCR1 or CXCR2, modified CARs markedly en

30 8 gene expression, whereas expression of the IL-8 receptor CXCR2 was reciprocally up-regulated as det

31 IL-8 activation of CXCR1, but not the IL-8 receptor CXCR2, cross-phosphorylated CCR5 and CXCR4

32 ncreased NETosis and activation of CXCR2, an IL-8 receptor; CXCR2 inhibition decreased NET production

33 investigated a novel selective inhibitor of IL-8 receptors, DF2726A, and showed its effects in count

34 significantly inhibited by an antagonist of IL-8 receptors during NTHI stimulation.

35 microvascular endothelial cells (HIMEC) and IL-8 receptor expression in human intestinal microvessel

36 ct role of IL-8 in angiogenesis by examining IL-8 receptor expression on endothelial cells and their

37 ressive increase in TNF-alpha (p60, p80) and IL-8 receptors following H/R.

38 genome; 2) most closely related to the human IL-8 receptor genes; and 3) orthologous to two previousl

39 encoding two functional human interleukin-8 (IL-8) receptors have been identified by molecular clonin

40 rved in mice lacking the murine interleukin (IL) 8 receptor homolog [mIL-8Rh(-/-)], and human (hu) IL

41 evaluate involvement and relevance of murine IL-8 receptor homolog (mIL-8Rh) in negative regulation o

42 mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-).

43 In contrast, the absence of the IL-8 receptor homologue did not reduce rolling or sticki

44 ng in vivo demonstrated that deletion of the IL-8 receptor homologue had minimal effect on rolling or

45 era, and CXCR2(-/-) mice that lack the human IL-8 receptor homologue, are much less susceptible to gr

46 n the same cellular context, we expressed an IL-8 receptor (IL-8RA) and FMLP receptor (FPR) in the ly

47 pendent manner, and blockade of the IL-6 and IL-8 receptors (IL-6R and IL-8R) with a novel bispecific

48 Functional interleuin-8 (IL-8) receptors (IL-8RA and IL-8RB: CXCR1 and CXCR2, res

49 hemotactic receptor subtypes for IL-8, named IL-8 receptors (IL8R) A and B, have been cloned.

50 involvement of basic residues of interleukin(IL)-8 receptors in coupling to the Gi and G16 proteins w

51 We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pul

52 es TuBECs in an autocrine manner as shown by IL-8 receptor inhibition.

53 Both IL-8 receptors interact with VEGFR2 after IL-8/CXCL8 tre

54 The IL-8 receptor is a seven-transmembrane spanning receptor

55 sic residues in the second inner loop of the IL-8 receptor is sufficient for Galpha16 coupling.

56 , an epithelial neutrophil attractant 78 and IL-8 receptor, is expressed at the apical domain of cyst

57 Activation of CXCR2 IL-8 receptor leads to activation of extracellular signa

58 logy to the CX3CR1-fractalkine and the CXCR1-IL-8 receptor-ligand systems demonstrated that the level

59 However, an IL-8 receptor mutant with double mutations at residues L

60 Surprisingly, the IL-8 receptor mutants with substitution of Ala for eithe

61 oteins was investigated by using a series of IL-8 receptor mutants.

62 zed the role of the C terminus domain of the IL-8 receptor on the signal transduction and receptor in

63 , and this was correlated with the levels of IL-8 receptors on the ECs.

64 The IL-8 receptors, particularly CXCR2, were induced on IL-5

65 cket and/or adjacent residues participate in IL-8 receptor recognition for both IL8R1 and IL8R2 and t

66 Thus this region contains a second site for IL-8 receptor recognition that, in combination with the

67 lipopolysaccharide, which down-regulates the IL-8 receptor, show that this inducing activity is becau

68 educed up to 77-fold the binding affinity to IL-8 receptor subtypes A (CXCR1) and B (CXCR2) and to th

69 Two IL-8 receptor subtypes, A and B, are expressed in neutro

70 The activation of PLC beta2 by an IL-8 receptor that is sensitive to pertussis toxin has b

71 receptor (vGPCR) is a homologue of the human IL-8 receptor that signals constitutively, activates mit

72 y angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic

73 specific antibodies that target the IL-6 and IL-8 receptors to concurrently block the signaling activ

74 fferent antibody constructs and the IL-6 and IL-8 receptors to establish how antibody properties and

75 deleting 31 C-terminal amino acids from the IL-8 receptor type B quantitatively impaired chemotaxis

76 g proteins (betaARK-ct and alphat) prevented IL-8 receptor type B-mediated chemotaxis but did not aff