ライフサイエンスコーパス: IPAA

1 IPAA fail from 3% to 15% of the times, mainly due to tec

2 IPAA is a standard surgical treatment for conditions lik

3 IPAA is an excellent option for patients with MUC, IC, F

4 IPAA prioritizes the best models to derisk target-drug d

5 IPAA was performed for ulcerative colitis in 73% of the

6 long-term results in a single cohort of 409 IPAA patients are unique and are likely a more accurate

7 After IPAA, 50 (31%) patients attempted to conceive.

8 After IPAA, quality of life improved promptly in both groups.

9 thrombi appear to be relatively common after IPAA surgery and are most likely segmental, multiple, an

10 t, no patient had a new cancer develop after IPAA.

11 ant), 5 had Crohn's disease (diagnosed after IPAA), 1 had indeterminate colitis, and 8 had familial a

12 nd pouch survival rates are equivalent after IPAA for IndC and UC, there is an increase in some compl

13 Early function after IPAA is good for most patients.

14 here is no data on the quality of life after IPAA for IndC.

15 a delayed fashion at median 36 months after IPAA in 87(43%).

16 red for reconstruction (mean 68 months after IPAA).

17 time and ageing on long-term outcomes after IPAA.

18 nancy on long-term functional outcomes after IPAA.

19 significantly higher in older patients after IPAA for CUC compared with younger patients.

20 Fifteen patients attempted pregnancy after IPAA, of which 11 (73%) were able to conceive, resulting

21 as time to first spontaneous pregnancy after IPAA.

22 Eighty-five women who became pregnant after IPAA had pouch function, which was comparable with women

23 Short-term function and QoL after IPAA is good.

24 The mean follow-up after IPAA was 68 +/- 33 months (range 6-136).

25 atients followed annually for 15 years after IPAA.

26 matory or fistulizing Crohn's disease and an IPAA performed for diagnosis of ulcerative colitis were

27 ds of 7 patients with Crohn's disease and an IPAA treated with infliximab were reviewed.

28 t patients with Crohn's disease involving an IPAA who are refractory to conventional therapies.

29 ence (P = .02) rather than to creation of an IPAA at the first operation (P = .55).

30 to divert in patients with CUC undergoing an IPAA.

31 years; range, 12-66 years) who underwent an IPAA between 1987 and 2002 (mean follow-up, 33.6 months;

32 ced CT after a total proctocolectomy with an IPAA.

33 novel integrative pathway activity analysis (IPAA), we identified 83 dysregulated pathways common bet

34 colectomy with ileal pouch-anal anastamosis (IPAA) after diagnosis of severe ulcerative colitis (UC)

35 transabdominal ileal pouch-anal anastomoses (IPAA) redo surgery for a failed initial IPAA.

36 octectomy, and ileal pouch anal anastomoses (IPAA) with a protective ileostomy.

37 ry training in ileal pouch-anal anastomosis (IPAA) and identify possible differences in the learning

38 vely collected ileal pouch-anal anastomosis (IPAA) database was reviewed retrospectively to identify

39 ate results of ileal pouch-anal anastomosis (IPAA) done for patients with familial adenomatous polypo

40 colectomy with ileal-pouch anal anastomosis (IPAA) for an original diagnosis of ulcerative colitis.

41 colectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, familial colonic polyposis

42 colectomy with ileal pouch-anal anastomosis (IPAA) has substantially reduced the risk for ulcerative

43 the results of ileal pouch-anal anastomosis (IPAA) in patients in whom the anal mucosa is excised by

44 colectomy with ileal pouch anal anastomosis (IPAA) is associated with tubal factor infertility in fem

45 performance of ileal pouch-anal anastomosis (IPAA) is controversial in CD.

46 Ileal pouch anal anastomosis (IPAA) is the treatment of choice for chronic, medically

47 patients with ileal pouch-anal anastomosis (IPAA) may be due to inflammatory conditions, including p

48 double-stapled ileal pouch-anal anastomosis (IPAA) or a mucosectomy and hand-sewn anastomosis, and wh

49 esulting in an ileal pouch-anal anastomosis (IPAA) or permanent end ileostomy (EI).

50 ks for robotic ileal pouch-anal anastomosis (IPAA) proficiency, evaluating individual surgeon learnin

51 colectomy with ileal pouch-anal anastomosis (IPAA) represents the standard treatment for therapy-refr

52 colectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cance

53 ts who undergo ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC) or indetermina

54 s common after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC).

55 colectomy with ileal pouch-anal anastomosis (IPAA) will subsequently have pouchitis, and among those

56 PALGA) to identify all patients with IBD and IPAA in The Netherlands from January 1991 to May 2012.

57 We identified 1200 patients with IBD and IPAA; 25 (1.83%) developed pouch neoplasia, including 16

58 range, 5-170 months) had proctocolectomy and IPAA at Mayo Medical Center in Rochester, Minnesota.

59 Risk for neoplasia in patients with UC and IPAA is small and not eliminated by colectomy or mucosec

60 not appear to justify the decision to avoid IPAA creation at the first operation provided that it is

61 Half of them already had a child before IPAA.

62 CD diagnosis was before IPAA (intentional) in 20(10%), from postoperative histop

63 xperience independence when deciding between IPAA and EI, but struggle with inadequate educational in

64 OBE-compliant study analyzed 234 consecutive IPAA patients (117 robotic, 117 laparoscopic).

65 Transanal resection of an elongated IPAA spout was performed on 58 patients; abdominoperinea

66 going transabdominal redo surgery for failed IPAA between 1983 and 2014 were evaluated.

67 fe (QOL) outcomes of redo surgery for failed IPAA, especially in large series of patients.

68 In UC patients with failing IPAA, partial or complete pouch reconstruction can be do

69 ne sequencing data from paired biopsies from IPAA patients with UC and familial adenomatous polyposis

70 Female patients older than 18 years that had IPAA under the age of 41 were eligible for inclusion (n

71 Of those patients who had IPAA at our institution, pouch failure occurred in 197 p

72 o either endorectal mucosectomy and handsewn IPAA or to double-stapled IPAA, which spared the anal tr

73 s of fecal incontinence compared to handsewn IPAA, which excises the mucosa.

74 ith IndC should not be precluded from having IPAA surgery.

75 ision, and monitoring, the learning curve in IPAA surgery may be reduced even further.

76 ainee staff demonstrated a learning curve in IPAA surgery.

77 M) model was used for monitoring outcomes in IPAA surgery.

78 ses (IPAA) redo surgery for a failed initial IPAA.

79 The initial IPAA was constructed at our institution in 32 patients a

80 reduced blood loss (P=0.0003) compared to L-IPAA.

81 LAP-IPAA is equivalent to open IPAA in terms of safety and f

82 LAP-IPAA patients had shorter median time to regular diet (3

83 This report describes 100 LAP-IPAA patients case matched to 200 open IPAA patients.

84 (range, 16-34 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

85 In addition, LAP-IPAA provides significant improvements in short-term rec

86 Between 1998 and 2004, 100 consecutive LAP-IPAA patients (75 laparoscopic assisted, 25 hand assiste

87 s nil, and readmission rates were equal (LAP-IPAA = 21%, open IPAA = 22%).

88 .Postoperative morbidity was equivalent (LAP-IPAA = 33%, open IPAA = 37%), mortality was nil, and rea

89 Outcomes of laparoscopic IPAA (LAP-IPAA) have been incompletely characterized.

90 Reoperation was required in 3% of LAP-IPAA and 6.5% of open IPAA patients (P < 0.2) during the

91 Median operative time was longer for the LAP-IPAA group (333 minutes versus 230 minutes, P < 0.0001).

92 d a higher pregnancy rate after laparoscopic IPAA (log-rank, P = 0.023).

93 However, fertility after laparoscopic IPAA has never been assessed.

94 rate appears to be lower after laparoscopic IPAA than after open surgery.

95 are significantly higher after laparoscopic IPAA.

96 , pregnancy, pouch salvage, and laparoscopic IPAA.

97 Outcomes of laparoscopic IPAA (LAP-IPAA) have been incompletely characterized.

98 patients who underwent a total laparoscopic IPAA between 2000 and 2011 and were aged 45 years or les

99 open and 27 (54%) had undergone laparoscopic IPAA.

100 e identified from a prospectively maintained IPAA database.

101 trend towards fewer reoperations and 3-month IPAA-associated complications after diverting loop ileos

102 Reports on the outcome of IPAA for IndC have been inconclusive because of the smal

103 ing performance during the learning phase of IPAA surgery.

104 were identified and case matched to 200 open IPAA control patients by age, operation, gender, date of

105 0 LAP-IPAA patients case matched to 200 open IPAA patients.

106 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

107 ssion rates were equal (LAP-IPAA = 21%, open IPAA = 22%).

108 rbidity was equivalent (LAP-IPAA = 33%, open IPAA = 37%), mortality was nil, and readmission rates we

109 required in 3% of LAP-IPAA and 6.5% of open IPAA patients (P < 0.2) during the first 3 months.

110 LAP-IPAA is equivalent to open IPAA in terms of safety and feasibility.

111 es or enteric leaks occurred in 23 patients; IPAA function was excellent in 19 of these patients (2 h

112 and chart review of 3707 consecutive primary IPAA cases.

113 and median follow-up 7.4 years) with primary IPAA were included.

114 R-IPAA demonstrated a lower conversion rate to open surger

115 In a high-volume robotic surgery center, R-IPAA reduced the risk of conversion to open surgery whil

116 ame procedure again, and 98% would recommend IPAA to others with IndC.

117 edo surgery, 101 (n = 20%) patients had redo IPAA failure.

118 oning pouch, and 46 patients (1.2%) had redo IPAA.

119 Repeat IPAA can often salvage pelvic pouches in patients with M

120 ad a functioning pouch 6 months after repeat IPAA.

121 or "poor." All said they would choose repeat IPAA surgery again.

122 Patients who had successful repeat IPAA surgery often report functional problems but would

123 Foundation patients who had undergone repeat IPAA surgery after septic complications from previous pe

124 Patients with retained IPAA at follow-up had near-perfect/perfect continence (7

125 spective analysis of 123 consecutive robotic IPAA procedures performed by 11 surgeons between June 20

126 The acquisition of skill in robotic IPAA is a highly individualized process, suggesting the

127 However, the robotic IPAA learning curve is not clearly defined.

128 The learning curve for hand-sewn IPAA surgery was quantified only for senior staff who at

129 the learning curve for stapled and hand-sewn IPAA surgery.

130 n failure rate between stapled and hand-sewn IPAA, but there is no literature that evaluates the diff

131 and long-term outcomes after 2- and 3-stage IPAA in patients with UC in our department.

132 Two-stage vs 3-stage IPAA procedures for active ulcerative colitis.

133 Stapled IPAA, which preserves the mucosa of the anal transition

134 Two hundred one patients underwent a stapled IPAA since May 1989, 192 as a one-stage procedure withou

135 the authors performed 126 additional stapled IPAA procedures for ulcerative colitis and familial aden

136 ctomy and handsewn IPAA or to double-stapled IPAA, which spared the anal transition zone.

137 The triple-stapled IPAA without temporary ileal diversion has a relatively

138 case mix, trainee staff undertaking stapled IPAA surgery showed an improvement in the pouch failure

139 Ta-IPAA for UC is a safe procedure, resulting in fewer pati

140 f transanal ileal pouch-anal anastomosis (ta-IPAA) with transabdominal minimal invasive approach in u

141 Overall, ta-IPAA led to lower CCI scores.

142 ve morbidity were 0.52 times lower in the ta-IPAA group (95% confidence interval [0.29; 0.92] P = 0.0

143 Ninety-seven patients (male: 52%) with ta-IPAA were compared to 119 (male: 53%) with transabdomina

144 These data support the conclusion that IPAA is a durable operation for patients requiring proct

145 The IPAA eradicates the risk of colorectal cancer in patient

146 at 3, 6, 9, 12, 18, and 24 months after the IPAA and yearly thereafter.

147 We conclude that the IPAA confers a good quality of life.

148 We use the IPAA model of IBD to associate mucosal host gene express

149 oing major reconstructive revisions of their IPAA at our institution between 1981 and 2005.

150 pared to 119 (male: 53%) with transabdominal IPAA.

151 s who had chronic pouchitis after undergoing IPAA for ulcerative colitis.

152 nic pouchitis had developed after undergoing IPAA for ulcerative colitis.

153 nine hundred and eleven patients undergoing IPAA for Ind and UC from 1983 to 1999 were evaluated.

154 vision in this series of patients undergoing IPAA is due to a policy of aggressive correction when pa

155 were collected from 1965 patients undergoing IPAA surgery by 12 surgeons in a single center between 1

156 r risk stratification of patients undergoing IPAA surgery.

157 outcomes for IBD and FAP patients undergoing IPAA.

158 We evaluated 87 patients who had undergone IPAA for inflammatory bowel disease.

159 Nine were male, 10 underwent IPAA, and 6 underwent EI.

160 dex of 23 kg/m (range, 16-34 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

161 Of the 1,454 patients who underwent IPAA for CUC between 1981 and 1994, 1,386 were part of t

162 In contrast, early colectomy with IPAA accrued a discounted lifetime cost of $147,763 per

163 iate clinical settings, early colectomy with IPAA after diagnosis of severe UC reduces health care ex

164 th IPAA was necessary for the colectomy with IPAA strategy to be cost-ineffective.

165 age or death, comparing early colectomy with IPAA strategy to the standard medical therapy strategy.

166 , while QALY-gained for early colectomy with IPAA was 20.72.

167 value of less than 0.7 after colectomy with IPAA was necessary for the colectomy with IPAA strategy

168 Quality-of-life after colectomy with IPAA was the most sensitive variable impacting cost-effe

169 Making the diagnosis of CD in patients with IPAA can be difficult, but it is important for prognosti

170 For CD patients with IPAA, when the diagnosis is established preoperatively o

171 this test in the management of patients with IPAA.

172 y diagnostic features of CD in patients with IPAA.

173 for evaluation of symptomatic patients with IPAA.

174 or 3-stage restorative proctocolectomy with IPAA at our institution from 2001 to 2021 was performed.

175 both the 2- and 3-stage proctocolectomy with IPAA demonstrate favourable and comparable postoperative

176 e underwent restorative proctocolectomy with IPAA from 1984 to 2009 at the Cleveland Clinic.

177 The restorative proctocolectomy with IPAA has become the procedure of choice for patients wit

178 Total proctocolectomy with IPAA is known to be associated with postoperative infert

179 nce in quality of life, or satisfaction with IPAA surgery.

180 Sixty consecutive subjects with IPAA for inflammatory bowel disease had measurements of