ライフサイエンスコーパス: IPP

1 IPP also induced the rapid and persistent phosphorylatio

2 IPP increases in some transformed or aminobisphosphonate

3 IPP is produced by the mevalonate pathway in archaea, fu

4 IPP isomerase activity could not be demonstrated for the

5 P7 synthesis by Asp1 kinase, without which 1-IPPs can accumulate to toxic levels that elicit precocio

6 he sll1556 gene, distantly related to type 2 IPP isomerase genes, was disrupted by insertion of a Kan

7 nth compared to nonpandemic periods in 5-24 (IPP rate per 10 million: 48 vs 9 (95% confidence interva

8 When (R)-[2-2H]IPP was a substrate for chain elongation, no deuterium w

9 In contrast, the deuterium in (S)-[2-2H]IPP was incorporated into all of the products.

10 er stopped-flow experiments using (R)-[2-2H]-IPP.

11 A 3kb IPP cDNA clone was isolated from a human placenta librar

12 insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhib

13 e have identified four unique congeners of 4-IPP that exhibit MIF inhibitory activity at concentratio

14 ons 10x to 20x lower than that of parental 4-IPP.

15 very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins,

16 this compound, 4-iodo-6-phenylpyrimidine (4-IPP), is approximately 5x to 10x times more potent in bl

17 the overall database, which includes 185 446 IPPs and approximately 1.5 billion NIPs from five primar

18 on the ability of rubber transferase to add IPP to the allylic diphosphate initiator were determined

19 The importance of influenza for adult IPP varies by serotype and host comorbidity.

20 ified in three steps, and its identity as an IPP isomerase was established biochemically.

21 Transcriptional profiling delineates an IPP-responsive regulon composed of genes overexpressed w

22 V lambda sequences within the confines of an IPP follicle.

23 Ablation of BB and IPP decreased RA DF from 10.9+/-1.2 to 9.0+/-1.5 Hz (P<0

24 BB and IPP were subsequently ablated.

25 n 81+/-5% and 80+/-10% of cases along BB and IPP, respectively.

26 -right decrease in DFs occurred along BB and IPP, resulting in an LA-right atrium (RA) frequency grad

27 d, influenza-associated hospitalizations and IPP cases (pneumococcus isolated from normally sterile s

28 nalogues for DMAPP (E-2-OPP and Z-2-OPP) and IPP (4-OPP) were synthesized and found to be potent acti

29 VPP and IPP largely prevailed in almost all cheeses.

30 treated neutrophils produced little, if any, IPP and expressed much lower levels of farnesyl pyrophos

31 entified in this study, including PPL, APPH, IPP and PPG with corresponding IC50 values of 2.86, 3.95

32 multaneous inactivation of the Asp1 and Aps1 IPP pyrophosphatases is lethal, but this lethality is su

33 gest that only pyrophosphomonoesters such as IPP are true Vgamma9Vdelta2 T-cell agonists, whereas alk

34 Failure to synthesize IP8 (via Asp1 IPP kinase mutation) results in pho1 hyper-repression.

35 Increasing IP8 (via Asp1 IPP pyrophosphatase mutation) de-represses the PHO regul

36 karyotes, archaebacteria, and some bacteria, IPP is synthesized from acetyl coenzyme A by the mevalon

37 o form geranyl diphosphate (GPP) and between IPP and GPP to give farnesyl diphosphate (FPP).

38 inhibited by statin treatment, which blocks IPP production.

39 nactive oxidized flavin-enzyme complex bound IPP in a Mg2+-dependent manner for which KD approximatel

40 knockdown of BTN3A1 abolished stimulation by IPP that could be restored by re-expression of BTN3A1 bu

41 the cyanobacterium, nor did it affect [(14)C]IPP incorporation stimulated by DHAP plus GA3P.

42 lity to catalyze the isomerization of [(14)C]IPP to [(14)C]DMAPP.

43 ctivity; K(m)(IPP) was 52 microM, and k(cat)(IPP) was 0.23 s(-1).

44 Vgamma2Vdelta2 cells and increased cellular IPP.

45 We compared IPP rates during peak pandemic months (April 2009-March

46 plasmid-encoded copy of the ORF complemented IPP isomerase activity in vivo in Salmonella enterica se

47 inhibitory potential at peak concentration (IPP), which integrates IC(50), slope, and peak concentra

48 velopment of the functional foods containing IPP.

49 partum long-acting reversible contraception (IPP-LARC) separately from global payment for all service

50 In contrast, IPP is synthesized by a mevalonate-independent pathway i

51 s, which are isomerized to the corresponding IPP derivatives.

52 rption and emission profiles of the coumarin-IPP derivatives can be fine-tuned: an electron-donating

53 PP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP.

54 PP labeled with 1 mol of deuterium at C-2 (d-IPP).

55 (d-DMAPP) is slower than its conversion to d-IPP.

56 The alpha D60N-IPP-Ser alpha 2 beta 2 complex does not undergo the foll

57 L-serine bound to the beta-site (alpha D60N-IPP-Ser), and this structure is compared with that of th

58 t been possible to unequivocally demonstrate IPP isomerase activity in this cyanobacterium.

59 9-fold and reduced isopentenyl diphosphate (IPP) accumulation by 4-fold.

60 n reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) to form geran

61 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic bu

62 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic fi

63 Archaea synthesize isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the essentia

64 ate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), where it int

65 trate analogues for isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), where the C3

66 d diphosphates from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

67 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

68 ay for synthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

69 ay branches to form isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

70 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

71 prenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

72 of all terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate, are derived from two

73 oprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate.

74 also forms between isopentenyl diphosphate (IPP) and GcpE.

75 ne building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), t

76 on building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), w

77 ase (IDI) activates isopentenyl diphosphate (IPP) for polymerization by converting it to its highly n

78 lyl diphosphate and isopentenyl diphosphate (IPP) in a reaction catalyzed by homodimeric or heterodim

79 talyzed reaction of isopentenyl diphosphate (IPP) in D(2)O gives a 66% yield of dimethylallyl diphosp

80 phate acceptor with isopentenyl diphosphate (IPP) in the cis (Z) configuration to generate linear pol

81 rbon double bond in isopentenyl diphosphate (IPP) in the primary building reactions in the isoprenoid

82 Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of

83 Type II isopentenyl diphosphate (IPP) isomerase catalyzes the interconversion of IPP and

84 a putative type II isopentenyl diphosphate (IPP) isomerase.

85 ion of thousands of isopentenyl diphosphate (IPP) molecules to an allylic diphosphate initiator, such

86 soprenoid precursor isopentenyl diphosphate (IPP) proceeds via two distinct pathways.

87 e (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to ge

88 ntial conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) in the mevalon

89 te pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and

90 sphate analogues of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosp

91 monoesters, such as isopentenyl diphosphate (IPP), nitrogen-containing bisphosphonates (N-BPs), and a

92 (MVAPP) to produce isopentenyl diphosphate (IPP), which is essential in both eukaryotes and prokaryo

93 ive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isopr

94 bolic intermediate, isopentenyl diphosphate (IPP).

95 of two molecules of isopentenyl diphosphate (IPP).

96 oid building block, isopentenyl diphosphate (IPP).

97 (MVAPP), producing isopentenyl diphosphate (IPP).

98 identified type II isopentenyl diphosphate (IPP):dimethylallyl diphosphate (DMAPP) isomerase (IDI-2)

99 Isopentenyl diphosphate (IPP):dimethylallyl diphosphate isomerase catalyzes the i

100 il condensations of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and

101 ux amplification to isopentenyl-diphosphate (IPP) and dimethylallyl-diphosphate (DMAPP) precursors of

102 to the homoallylic (isopentenyl diphosphate, IPP) site, not to the allosteric site, whereas zoledrona

103 e determining step in the forward direction (IPP to DMAPP) occurs prior to DMAPP formation.

104 Here we demonstrate that the ratio of DMAPP:IPP produced by hydroxymethylbutenyl diphosphate reducta

105 olatile isoprenoids, but the plastidic DMAPP:IPP ratio is generally believed to be similar across dif

106 The DMAPP:IPP ratio could affect the balance between volatile and

107 the combination of lytB and a cDNA encoding IPP isomerase (ipi) was no more effective in enhancing c

108 Two cDNAs encoding IPP isomerase in Haematococcus, ipiHp1 and ipiHp2, were

109 actions with DMAPP in the presence of excess IPP and by comparing the steady-state kinetic constants

110 Somatic hypermutation was very low in fetal IPP and the IPP of germ-free piglets but increased 3- to

111 rink, 6.9 mg L(-1) for VPP, 6.1 mg L(-1) for IPP, 0.8 mg L(-1) for LPP and 3.2 mg L(-1) for FP were d

112 es were synthesized by joining fragments for IPP and the allylic diphosphates with a C-C bond between

113 The gene for IPP isomerase, idi, is not clustered with other known ge

114 at eukaryotes have inherited their genes for IPP biosynthesis from prokaryotes.

115 mploy exclusively the mevalonate pathway for IPP biosynthesis.

116 ce of the non-mevalonate DXP/MEP pathway for IPP synthesis in latex was noted by up-regulation of the

117 lDMAPP) (with IPP) were similar to those for IPP and DMAPP; however, values of k(cat) for both analog

118 Our results establish a novel role for IPPs in cell physiology.

119 lex, but the quaternary complex, UPPS.TA.FPP.IPP, cannot be formed.

120 distinct biosynthetic pathways can generate IPP; the cytosolic mevalonate pathway and the plastid-as

121 Higher IPP rates occurred during the peak pandemic month compar

122 hromosomal knockouts in the genes for type I IPP isomerase (idi) and 1-deoxy-D-xylulose 5-phosphate (

123 Type I IPP isomerase (IDI-1) utilizes a divalent metal in a pro

124 Type I IPP isomerase (IDI-1) utilizes a divalent metal in a pro

125 e type II enzyme and the well-studied type I IPP isomerase are identical, the type II protein require

126 e kinetic constants for the archaeal type II IPP isomerase from M. thermautotrophicus are as follows:

127 Recombinant type II IPP isomerase from Thermus thermophilus HB27 was purifie

128 His6-tagged M. thermautotrophicus type II IPP isomerase was produced in Escherichia coli and purif

129 flavin, has not been established for type II IPP isomerase.

130 hermautotrophicus encodes a putative type II IPP isomerase.

131 If allosteric activation of type II IPPs by PI(4)P and PS is a widespread feature of the gro

132 Novel coumarin-iminophosphorane (IPP) fluorophores that have stable resonance contributio

133 tonation of the carbon-carbon double bond in IPP or DMAPP to form a tertiary carbocation, followed by

134 a C-C bond between the methyl group at C3 in IPP and the Z-methyl group at C3 in DMAPP (3-OPP) and GP

135 The effect of ascites-induced changes in IPP on OvCa progression is largely unknown.

136 spitalization was associated with changes in IPP-LARC use and short-interval births between 2010 and

137 both conventional and novel PKC isoforms in IPP-induced proliferation, CD25 expression, and cytokine

138 can be partially suppressed by a mutation in IPP-5, an inositol polyphosphate 5-phosphatase, indicati

139 J signal joint circles were not recovered in IPP, and V-DJ signal joint circles were 5-fold lower tha

140 cause 20.1 treatment of APC did not increase IPP levels.

141 tabolite, appears to enter cells to increase IPP levels, whereas the alcohol of HMBPP and alkenyl pho

142 n the mevalonate pathway, thereby increasing IPP/triphosphoric acid 1-adenosin-5'-yl ester 3-(3-methy

143 igate follicular diversification, individual IPP follicles were isolated by microdissection; VA diver

144 also able to identify peptides' informative IPP.

145 In installing IPP, tourniquets were positioned around both thighs, and

146 itor that increases endogenous intracellular IPP.

147 hodnius prolixus IPPRp exists as an isolated IPP domain which is secreted into the saliva of this blo

148 ro in the presence isopentenylpyrophosphate (IPP), induce NK cell-mediated killing of tumors that are

149 netics and mechanism of p-isopropenylphenol (IPP) synthesis via bisphenol A (BPA) cleavage in HTW.

150 3 micromol min(-1) mg(-1) at pH 8.0 with a K(IPP)(m) value of 22.8 microm IPP.

151 the presence of the same ligands (beta K87T-IPP-Ser).

152 ary lymphoid tissues between piglets lacking IPP and colonized controls, whereas both groups displaye

153 ononucleotide, and Mg(2+) for activity; K(m)(IPP) was 52 microM, and k(cat)(IPP) was 0.23 s(-1).

154 demic months (April 2009-March 2010) to mean IPP rates in nonpandemic years (April 2004-March 2009) a

155 pH 8.0 with a K(IPP)(m) value of 22.8 microm IPP.

156 logenetically distant GGPPS and can modulate IPP flux distribution between GPP and GGPP synthesis in

157 Natively, IPP and DMAPP are generated by the mevalonate (MVA) and

158 seasonal influenza rates included, observed IPP rates during the pandemic peak were within the predi

159 in the closed conformation in the absence of IPP.

160 mmon mechanism involving the accumulation of IPP.

161 thway) and the intracellular accumulation of IPP.

162 culture medium with the alcohol analogues of IPP and DMAPP (3-methyl-3-buten-1-ol and 3-methyl-2-bute

163 pectral changes indicate that the binding of IPP, DMAPP, and a saturated analogue isopentyl diphospha

164 er, these data suggest that the C2-H bond of IPP is cleaved in the rate determining step and that gen

165 Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are fo

166 the cloning and initial characterization of IPP, a novel human gene that predicts a kelch family pro

167 ectroscopy demonstrated the compatibility of IPP with the vesicles.

168 ying a critical role in the deprotonation of IPP en route to DMAPP formation.

169 d specifically by the kelch repeat domain of IPP.

170 ibiting the mevalonate pathway downstream of IPP synthesis.

171 Expression of IPP isomerase, and of two enzymes specific to the carote

172 The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP(3

173 data for BPA disappearance and formation of IPP and phenol and accurately predicted the yield of the

174 catalyzing the final step, the formation of IPP.

175 Incubation of IPP with 3-ClDMAPP gave 11-ClFPP as the sole product.

176 ) isomerase catalyzes the interconversion of IPP and dimethylallyl diphosphate (DMAPP).

177 any Bacteria, catalyzes the isomerization of IPP and DMAPP by a protonation-deprotonation mechanism.

178 sm for the enzyme-catalyzed isomerization of IPP and DMAPP.

179 The subsequent isomerization of IPP to DMAPP activates the five-carbon isoprene unit for

180 till likely to catalyze the isomerization of IPP to DMAPP.

181 refore rate determining for isomerization of IPP with a rate constant k(dis) approximately k(cat) = 0

182 Redox potentials of IPP-bound enzyme indicate that the neutral semiquinone s

183 and reoxidation processes in the presence of IPP and related analogues.

184 emiquinone, but evidence for the presence of IPP-based radicals could not be obtained by EPR spectros

185 n analogues were observed in the presence of IPP.

186 ATP to MVAPP, followed by the production of IPP.

187 Next, we expressed a fusion protein of IPP isomerase and the phosphatase (Idi1~NudB) along with

188 However, high rates of IPP incorporation were obtained with addition of dihydro

189 than ipi alone, indicating that the ratio of IPP and DMAPP produced via the DOXP pathway is influence

190 The steady-state equilibrium ratio of IPP/DMAPP in the enzymatic reactions was approximately 1

191 Two distinct routes of IPP biosynthesis occur in nature: the mevalonate pathway

192 Cp[b]Pyr ligand produced the first sample of IPP with all the steric pentad intensities fitting the e

193 Synthesis of IPP, an isoprenoid precursor molecule that is a critical

194 ibitors bind in a fashion similar to that of IPP.

195 The trafficking of IPP occurs unidirectionally from the plastids to cytosol

196 ctivate the enzyme for multiple turnovers of IPP to DMAPP.

197 The use of IPP showed great potential for the development of a full

198 E)-methyl group (d-DMAPP) and a 34% yield of IPP labeled with 1 mol of deuterium at C-2 (d-IPP).

199 idities, influenza had the largest impact on IPP incidence among low-invasiveness serotypes (influenz

200 Only one substrate, FPP or IPP, is able to bind to the UPPS.TA complex, but the qua

201 T cells in medium containing zoledronate or IPP strongly increased SF-derived fibroblasts' apoptosis

202 lutamate active-site residues found in other IPP isomerases.

203 -use data sets of interacting protein pairs (IPPs), non-interacting protein pairs (NIPs) and associat

204 A new multiplex immune profiling panel (IPP) prototype was assessed for its ability to semiquant

205 e integrin-linked kinase (ILK)-PINCH-parvin (IPP) complex interacts with the cytoplasmic domain of be

206 ttle was studied in the ileal Peyer's patch (IPP) follicles of young calves and in the spleens of lat

207 The continuous ileal Peyer's patches (IPP) of sheep are regarded as a type of mammalian bursal

208 ma transcripts in the ileal Peyer's patches (IPPs) and mesenteric lymph nodes but on average only app

209 bundle (BB) and the inferoposterior pathway (IPP) during AF.

210 The well-known antihypertensive peptide IPP and several novel peptides that have structural simi

211 converting enzyme (ACE) inhibitory peptides, IPP (0.42-0.49 mg/kg), LPP (0.30-0.33 mg/kg), and VPP (0

212 pe II inositol polyphosphate 5-phosphatases (IPPs) act on both soluble inositol phosphate and phospho

213 olyzable analogue indole propanol phosphate (IPP).

214 e evaluated invasive pneumococcal pneumonia (IPP) rates during the 2009 influenza A(H1N1) pandemic.

215 ly rates of invasive pneumococcal pneumonia (IPP) were obtained from the Danish National Laboratory S

216 iospecificites, and isotactic polypropylene (IPP) Mw.

217 We conclude that the porcine IPP are not a site of B cell lymphogenesis, do not under

218 Pre-IPP/post-IPP median percentage of necrosis on magnetic resonance

219 Pre-IPP/post-IPP median percentage of necrosis on magnetic r

220 sible for producing the isoprenoid precursor IPP in many gram-positive bacteria and eukaryotes, we co

221 opologues from the respective C5-precursors, IPP and DMAPP, whereas one isoprene unit in the ring E o

222 lting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg

223 ted peptides Val-Pro-Pro (VPP), Ile-Pro-Pro (IPP), Leu-Pro-Pro (LPP) and Phe-Pro (FP) were separated

224 on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP.

225 ate (IP), which is phosphorylated to produce IPP.

226 vesicles loading Isoleucine-Proline-Proline (IPP) as suitable ingredients of functional beverages wer

227 and informative physicochemical properties (IPPs) identification simultaneously.

228 lized in the plastids, is thought to provide IPP and dimethylallyl diphosphate for hemiterpene, monot

229 The MEP pathway provides IPP precursors for both plastidial monoterpene and cytos

230 n reading frame (ORF696) encoding a putative IPP isomerase was identified in the E. coli chromosome a

231 Asp1, a bifunctional inositol pyrophosphate (IPP) kinase/pyrophosphatase that interconverts 5-IP7 and

232 on was not due to isopentenyl pyrophosphate (IPP) accumulation because 20.1 treatment of APC did not

233 s isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are

234 rbon diphosphates isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP).

235 Isopentenyl pyrophosphate (IPP) is a common precursor for the synthesis of all isop

236 phate (DMAPP) and isopentenyl pyrophosphate (IPP) to all of the known terpenes.

237 aIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMAPP) and vice ve

238 isomerization of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP), a reaction

239 l condensation of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP), with volati

240 When [14C]isopentenyl pyrophosphate (IPP) was used as the substrate for phytoene synthase a r

241 ight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to generate the C

242 stimulation with isopentenyl pyrophosphate (IPP), a metabolite in the mevalonate pathway, which is a

243 sults showed that isopentenyl pyrophosphate (IPP), a soluble phospholigand released by mycobacteria,

244 by microbes, and isopentenyl pyrophosphate (IPP), an intermediate in the mevalonate pathway used by

245 e biosynthesis of isopentenyl pyrophosphate (IPP), the precursor of all isoprenoids, including carote

246 rbon starter unit isopentenyl pyrophosphate (IPP).

247 e phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-methyl-but-2-enylpyrophosphate

248 s pyrophosphates (isopentenyl pyrophosphate [IPP]).

249 P] or endogenous (isopentenyl pyrophosphate, IPP) and PAg sensing depends on the expression of B7-lik

250 tabolite control by inositol pyrophosphates (IPPs), exerted through the 3'-processing/termination mac

251 m, measured by incorporation of radiolabeled IPP, was not stimulated by pyruvate, an initial substrat

252 pandemic likely resulted in an out-of-season IPP peak among persons >/=5 years.

253 Anatomically and developmentally similar IPP occur in swine.

254 lta T cell activation because they stimulate IPP production in monocytes by inhibiting the mevalonate

255 change in redox state between the substrate (IPP) and product (DMAPP), indicating that the FMN cofact

256 ly less reactive toward proton addition than IPP and DMAPP but have similar reactivities toward hydro

257 -fmDMAPP are approximately 50-fold less than IPP and DMAPP, respectively.

258 We conclude that IPP is not the sole site of VA diversification in cattle

259 The findings that IPP-responsive proinflammatory synovial Vgamma9(+) T cel

260 We infer that IPP-5 negatively regulates IP(3) signaling to ensure pro

261 mapping and Southern blot analysis show that IPP comprises eight exons spanning more than 47kb of gen

262 The IPP analogue (3-ClIPP) was a cosubstrate when incubated

263 The IPP cDNA clone contains a 1752bp open reading frame that

264 The IPP peak's magnitude was similar to that seen during sea

265 The IPP prototype consists of 16 biomarkers that target the

266 The IPP set can be set to specific model organisms, interact

267 The IPP tool may be used in the future to stratify criticall

268 ermutation was very low in fetal IPP and the IPP of germ-free piglets but increased 3- to 5-fold afte

269 ivity and the need to exclude DMAPP from the IPP binding site.

270 Results from the IPP pouch were comparable to standard quantitative polym

271 s a single electron transfer to and from the IPP substrate during catalysis.

272 r studies in cattle and sheep implicated the IPP as a likely site of Ab diversification, a close inve

273 us binding of inorganic pyrophosphate in the IPP subpocket leads to conformational closing of the act

274 iple features can be provided for all of the IPP and NIP pairs.

275 ined the role of ILK, a key component of the IPP complex, in diet-induced muscle insulin resistance.

276 ol and accurately predicted the yield of the IPP hydrolysis product acetone.

277 Resection of approximately 90% of the IPP in piglets at birth did not alter Ig levels in serum

278 The clinical assessment of the IPP markers demonstrated various gene modulations that c

279 ere used for the technical assessment of the IPP tool.

280 alleled the developmental persistence of the IPP, and its near disappearance corresponds to the diver

281 noids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiin

282 s occur as multidomain proteins in which the IPP domain is linked to lipid-binding or additional cata

283 Except for IgG3 in the IPPs and mesenteric lymph nodes, no stochastic pattern o

284 allow the user to control the make-up of the IPPs and NIPs as well as the quality of the resultant da

285 wing for the conversion of mevalonic acid to IPP by the mevalonate pathway.

286 intermediate in the pathway, is converted to IPP and DMAPP by the consecutive action of the IspD-H pr

287 ounds by controlling the ratio of IP/DMAP to IPP/DMAPP.

288 protein responsible for converting HMBPP to IPP and DMAPP in the ultimate step in the nonmevalonate

289 reaction similar to the conversion of IP to IPP.

290 equired to convert phosphomevalonate (PM) to IPP in eukaryotes.

291 amma9(+) T cell proliferation in response to IPP was significantly lower in SF than PBMC cultures, it

292 enous cellular substrate in Synechocystis to IPP and DMAPP, overcoming flux limitations of the native

293 ), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and

294 unt of ACE-I peptides changed, and only VPP, IPP, HLPLP and LHLPLP were detected in the intestinal di

295 rting enzyme-inhibitor (ACE-I) peptides VPP, IPP, RYLGY, RYLG, AYFYPEL, AYFYPE, LHLPLP and HLPLP were

296 lIPP) (with DMAPP) and K(M)(3-ClDMAPP) (with IPP) were similar to those for IPP and DMAPP; however, v

297 , the structure of the mutant complexed with IPP and serine exhibits ligand-induced conformational ch

298 e similar to those for chain elongation with IPP and DMAPP.

299 e when the reduced enzyme was incubated with IPP or DMAPP.

300 P and GPP gave FSPP, whereas incubation with IPP and GSPP gave FPP.