ライフサイエンスコーパス: IS element

1 in the stable genomic sites which flank the IS element.

2 quences in a manner unlike that of any other IS element.

3 kov models constructed from manually curated IS elements.

4 high-throughput tool for a global search of IS elements.

5 permine-responsive promoter contained within IS elements.

6 ed based on the previously identified ~1,500 IS elements.

7 consistent with the NCBI annotations of the IS elements.

8 karyotic genomes with curated annotations of IS elements.

9 lso detected 48 long deletions not involving IS elements.

10 een described with such a high proportion of IS elements.

11 ted ISPg5, has features of the IS3 family of IS elements.

12 rect repeats had not been observed for other IS elements.

13 0 kb region separated by insertion sequence (IS) elements.

14 on of direct repeats and insertion sequence (IS) elements.

15 genetic elements such as insertion sequence (IS) elements.

16 replicon, and two intact insertion sequence (IS) elements.

17 al chromosomal genes (88 to 98%) or in other IS elements (95 to 97% for IS605, IS606, and IS607) from

18 IS elements account for ~35% of the mutations that reach

19 e, the genome harbors 73 insertion sequence (IS) elements, almost all of which are closely related to

20 study, a 7.5-kb region positioned within the IS elements and downstream of abiA was sequenced to reve

21 Taken together, similarities in IS elements and H. pylori population genetic structures

22 mology to transposases of the IS30 family of IS elements and is most closely related (27% identical a

23 sing a novel strategy that uses the ratio of IS elements and LA-ICP-TOFMS analysis.

24 ufficient to activate transcription of these IS elements and of nearby genes in broth culture and in

25 we report novel insertions and excisions of IS elements and recombination between homologous IS elem

26 These genetic maps of recently active IS elements and the several interesting observations wou

27 Here, we investigate the dynamics of IS elements and their contribution to genomic evolution

28 The long-term dynamics of IS elements and their effects on bacteria are poorly und

29 Mobile genetic elements in the form of IS elements and transposons are prominent in the genome

30 for mutations involving insertion sequence (IS) elements and identified two genes where multiple lin

31 transposons, integrons, insertion sequence (IS) elements and the 'new' ISCR (IS common region) eleme

32 y to tRNA genes, (ii) a previously described IS element, and (iii) a novel IS-like element.

33 in sequences interrupted by the insertion of IS elements, and (iv) pre-dictions that 92 genes are par

34 Here, we present a new IS elements annotation pipeline to address these issues.

35 IS elements appear to have remodeled genome architecture

36 Several vestigial IS elements appeared different from the IS distribution

37 This rickettsial IS element appears to be active in that complete termina

38 The features of these two chimaeric IS elements are discussed in terms of possible transposi

39 h B and K, 16 in common, and likely founding IS elements are identified.

40 Three IS elements are located near the first gene of the 2,4,5

41 the flanking regions of the recently active IS elements are significantly enriched with genes encodi

42 While IS elements are well known to contribute to evolution th

43 Insertion sequence (IS) elements are mobile genetic elements in bacterial ge

44 Insertion sequence (IS) elements are the simplest autonomous transposable el

45 The insertion sequence (IS) elements are the smallest but most abundant autonomo

46 We found that insertion sequence (IS) elements are unusually abundant in the relatively re

47 transposase protein, the insertion elements (IS elements) are similar to IST2 of Thiobacillus ferroox

48 Prokaryotic insertion sequence (IS) elements behave like parasites in terms of their abi

49 son defined by inverted repeats of a 1347 bp IS element belonging to a recently discovered family whi

50 the correct answer ("inlying" elements; that is, elements closer to the reference value).

51 Both IS elements contain a single open reading frame (ORF) en

52 We developed a database of IS elements coupled to a computational pipeline that ide

53 complete copy of the previously unidentified IS element, designated PGIS2, had inserted into IS4351R

54 Our work shows that IS elements drive bacterial genome diversification withi

55 terms of possible transposition mechanisms, IS element evolution, and effects of IS elements on geno

56 we targeted the intronic silencing sequence (ISS) elements flanking the alternatively spliced alpha-e

57 (IS) element, IS1629, with homology to other IS elements from prokaryotic animal pathogens.

58 s of two other H. pylori insertion sequence (IS) element genes, orfA, which encodes a putative serine

59 The numerous IS elements, genomic rearrangements, and pseudogenes of

60 Simultaneous targeting of the ISS elements had no additive effect, suggesting that spl

61 lutionary event in which transposition of an IS element has a direct impact on virulence gene regulat

62 The pCoo DNA between these IS elements has a wide range of G+C content (35 to 57%),

63 ination between abundant insertion sequence (IS) elements has resulted in genome plasticity manifeste

64 orn out of gas with few or no 'metals' (that is, elements heavier than helium).

65 Atmospheric metal enrichment (that is, elements heavier than helium, also called 'metallici

66 ditions, we found that (a) the activities of IS elements heavily depend on the environments where the

67 gment of aqpZ and additional full or partial IS elements (i.e., IS629, IS91, and IS911) downstream of

68 Further sequencing identified partial IS elements (i.e., IS91 and IS630) and wzz upstream of t

69 lements and recombination between homologous IS elements identified in a large collection of Escheric

70 of the lanthanide signal to the ratio of the IS elements improved the calibration correlation coeffic

71 isms live; (b) the number of recently active IS elements in a genome tends to increase with the genom

72 More than 50 sites are occupied by IS elements in both B and K, 16 in common, and likely fo

73 rtion Sequences and IScan currently identify IS elements in completely assembled and annotated genome

74 1485, FB8, MM294, and RB791) did not contain IS elements in the flhD regulatory region and were poorl

75 cps loci, consisting of insertion sequence (IS) elements in unique positions that did not disrupt th

76 ides targeting either upstream or downstream ISS elements increased alpha-exon inclusion from 10% up

77 We discovered that diverse IS elements insert into the genomes of intestinal bacter

78 f commonly used lab strains was screened for IS element insertion and motility.

79 ormatic analysis raises the possibility that IS element insertion in this region represents an adapti

80 We suggest that IS element insertion may activate transcription of the f

81 due to loss of bacteriophage sequences after IS element insertions and rearrangements.

82 to a computational pipeline that identifies IS element insertions in the microbiota.

83 enes are generated by nonsense mutations and IS element insertions, events that seldom produce the ps

84 onal start site of flhD was unaltered by the IS element insertions.

85 An IS element is inserted into the rrs gene of one of only

86 However, our knowledge of this IS element is relatively limited; even its two basic cha

87 These events are mostly contributed by the IS elements IS1, IS2, IS5 and IS186 Spatial analysis of

88 ersed among three intact insertion sequence (IS) elements (IS100 and two new IS elements, IS1616 and

89 bp upstream of the P. gingivalis endogenous IS element IS1126.

90 n5506 contained a single insertion sequence (IS) element, IS1216V2, whereas the right end was compose

91 on sequence (IS) elements (IS100 and two new IS elements, IS1616 and IS1617) and numerous defective o

92 s 84.34 identified a new insertion sequence (IS) element, IS1629, with homology to other IS elements

93 putative transposases of two other unrelated IS elements (IS200 and IS1341), was found in nearly one-

94 re linked by a series of insertion sequence (IS) elements (IS256, IS257, and IS1216) of staphylococca

95 It contains 12 and 14 copies of two novel IS elements, ISAba25 and ISAba26, respectively.

96 re due to a 312-bp fragment derived from the IS element ISFtu1.

97 o classes of Francisella insertion sequence (IS) elements, ISFtu1 and ISFtu2, and the genes adjacent

98 i, we identified a novel insertion sequence (IS) element, ISRpe1, disrupting the coding sequence of r

99 One intact IS element, ISYen1, was a new IS belonging to the IS256

100 cus, however, correlated with differences in IS element location.

101 This suggests that ISPg5 and other IS elements may contribute to strain diversity and can b

102 hat this system represents a rare example of IS element-mediated evolution in which the IS elements p

103 found, suggesting that pNRC100 evolved from IS element-mediated fusions of several smaller plasmids.

104 A multi-step IS element-mediated process is proposed to account for t

105 een acquired by bacteriophage integration or IS element-mediated transposition.

106 undergoes high-frequency insertion sequence (IS) element-mediated insertions and deletions, as well a

107 ed to known and putative insertion sequence (IS) elements; no known bacterial plasmid has previously

108 was demonstrated by similar targeting of the ISS elements of the human hnRNPA1 gene.

109 anisms, IS element evolution, and effects of IS elements on genome organization and evolution in the

110 The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of

111 Our results confirm the hypothesis that IS elements play a central role in transcription of 2,4,

112 uld help to improve our understanding of how IS elements proliferate and how they are involved in the

113 gene nor evidence for classically organized IS elements, prophages, or plasmids.

114 f IS element-mediated evolution in which the IS elements provide homologous sequences for amplificati

115 The unique spatial location of specific IS elements provided the basis for the development of a

116 ,346-bp circle, has shown the presence of 27 IS elements representing eight families.

117 These IS-element-rich regions of the genome may serve to excha

118 wer GC composition and overrepresentation of IS elements, similar to the minichromosomes.

119 ates the first on-line detection system that is element-specific, nondestructive, and directly applic

120 ctures and evidence of adaptive evolution in IS elements suggest that there is coevolution between th

121 rgest genome with the fewest pseudogenes and IS elements suggests that this isolate's lineage is at a

122 All the IS elements that have been identified in this strain are

123 Porphyromonas gingivalis insertion element (IS element) that is capable of transposition within P. g

124 16-kb region, flanked by insertion sequence (IS) elements, that encodes the restriction/modification

125 Despite its numerous repeated sequences and IS elements, the serotype 2 genome has remained remarkab

126 maps of recently active Insertion Sequence (IS) elements, the simplest form of MGEs, for all sequenc

127 Extreme environmental perturbations force IS elements to fall out of the microbiota, and many fail

128 By linking the predicted IS elements to various characteristics of the organisms

129 Only one IS element was found in T. litoralis.

130 A total of 23 homologous IS elements was found in the genome sequence of P. furio

131 Eight other ORFs not associated with IS elements were identified and deserve future investiga

132 uence of P. furiosus, whereas no full-length IS elements were identified in the genomes of Pyrococcus

133 Four new IS elements were identified.

134 and require extensive laboratory resources, IS elements were investigated as a means to subtype this

135 rived from a Roseiflexus insertion sequence (IS) element where the resulting transcriptional slippage

136 This is the first genome-scale maps of IS elements with detailed structural information on the

137 . furiosus is flanked by insertion sequence (IS) elements with inverted and direct repeats.

138 restimates reactive Cu, Cr, As, and Mo, that is, elements with a particularly high affinity for organ

139 mutations that introduced stop codons and/or IS elements within the gene or the promoter region in fi