ライフサイエンスコーパス: IVH

1 IVH and intracerebral hemorrhage (ICH) volume were measu

2 IVH grades 1 to 4 (Papile classification).

3 IVH treatment by intraventricular fibrinolysis (IVF) was

4 IVH up to 24 HOL before and after 2007 was 44% (95% CI,

5 IVH varies in severity and can present as a bleed confin

6 IVH volume may be important in outcome prediction and ma

7 IVH was also graded using a simple classification system

8 IVH-induced hypersecretion of CSF is mediated by TLR4-de

9 , 26.0 [24.7-27.4] weeks; 152 male [56.1%]), IVH or death occurred in 38.7% (58 of 150) of infants in

10 Children with grade 2 IVH (n = 145), however, performed significantly worse th

11 icular hemorrhage (IVH), 2 (29%) had grade 2 IVH, and 2 had severe (grade 3) IVH (29%); none required

12 iation with NDI was accounted for by grade 2 IVH.

13 ce appeared limited to children with grade 2 IVH.

14 had grade 2 IVH, and 2 had severe (grade 3) IVH (29%); none required neurosurgical intervention.

15 rade (grades 1-2) or high-grade (grades 3-4) IVH, very preterm controls without IVH, and full-term co

16 onally, Sonic Hedgehog activation alleviated IVH-induced inflammation and several transcriptomic chan

17 mographic characteristics, stability ICH and IVH volumes, ICH location, and time to first dose of stu

18 and January 31, 2015, patients with ICH and IVH were randomized to receive either intraventricular a

19 and SBF in severe IVH (Grade III or IV) and IVH diagnosed within 72 h of life, while CBF variability

20 receptor inhibition alleviates OPC loss and IVH-induced inflammation and restores myelination and ne

21 r OS was consistently worse at local LVH and IVH.

22 (0.87-1.00), respectively, for ICH, PHE, and IVH segmentation.

23 Primary outcome was deltaIVH defined as IVH volume on end-of-treatment CT minus IVH volume on st

24 2, 2016, through February 21, 2023, assessed IVH and early death outcomes of extremely preterm infant

25 Improving long-term outcomes at IVH may provide opportunities for greater access to qual

26 ctions at LVH, but only for proctectomies at IVH.

27 ubgroup analyses were performed for baseline IVH volume, admission ICH volume, and ICH location.

28 ere 349 (27%) of 1310 patients with baseline IVH, and 107 (11%) of 961 initially IVH-free patients wh

29 nalysis demonstrated no associations between IVH reduction and functional outcomes (adjusted OR (aOR)

30 Compared to HVH, both IVH (hazard ratio 1.25, 95% CI 1.19-1.31) and LVH (hazar

31 resence of concomitant neonatal sepsis, BPD, IVH, PDA, and NEC further increases the risk of ROP.

32 lity for all resections compared to HVH, but IVH was associated with mortality only for proctectomies

33 ritical patients suffering from often deadly IVH.

34 proximately 12,000 premature infants develop IVH every year in the United States, and a large number

35 formed in the first week of life to diagnose IVH.

36 The proportion of very early IVH (up to 6 HOL) after 2007 was 9% (95% CI, 3%-23%), wh

37 IVHS enables clinicians to rapidly estimate IVH volume.

38 yielded the following formula for estimating IVH volume (mL): eIVHS/5 (R = .75, p < 0.001).

39 4 (3.19) DALYs for HE, 2.45 (4.16) DALYs for IVH, and 1.96 (2.66) DALYs for PHE (P < .001) among the

40 4 (6.62) DALYs for HE, 4.58 (4.75) DALYs for IVH, and 3.35 (3.28) DALYs for PHE among patients with I

41 ytopenia did not correlate with the risk for IVH, and platelet transfusions did not reduce this risk.

42 en severity of thrombocytopenia and risk for IVH.

43 Potential therapies for IVH are currently undergoing investigation in preclinica

44 GM-IVH usually begins in the GM, a highly vascularized regi

45 better sensitivity than SO2 in detecting GM-IVH-related effects on infant brain development.

46 nd CMRO2i in ELGA neonates with low-grade GM-IVH compared to neonates without hemorrhages.

47 in, yet the long-term impact of low-grade GM-IVH on cerebral blood flow and neuronal health have not

48 age (ELGA) neonates (seven with low-grade GM-IVH) and monitored them weekly until they reached full-t

49 minal matrix-intraventricular hemorrhage (GM-IVH) is the most common complication in extremely premat

50 minal matrix-intraventricular hemorrhage (GM-IVH) is the most devastating neurological complication i

51 de insights into the role of pericytes in GM-IVH pathogenesis.

52 The occurrence of GM-IVH is highly associated with hemodynamic instability in

53 l benefit for monitoring the evolution of GM-IVH, evaluating treatment response, and potentially pred

54 pericytes as key factors contributing to GM-IVH pathogenesis.

55 minal matrix/intraventricular hemorrhage (GM/IVH).

56 In nineteen ELGA infants (with 9 cases of GM/IVH) monitored for 6-24 h between days 2-5 of life, we f

57 y identification of infants vulnerable to GM/IVH.

58 aging than with US for the detection of GMH, IVH, and cortical infarction or ischemia (P < .005).

59 th CT than with US for the detection of GMH, IVH, IPH, and cortical infarction or ischemia (P <.005).

60 Regional abnormalities after GMH-IVH were observed in T2-weighted images that showed sign

61 In addition, at 24 h after GMH-IVH, transcriptome analysis results showed that the high

62 h) and subacute (3d and 7d) phases after GMH-IVH.

63 /- 1) and thirty neonates with low-grade GMH-IVH (13 males, average GA 30 weeks +/- 1.5, corrected GA

64 ospective study, neonates with low-grade GMH-IVH and control neonates were recruited, and DKI were pe

65 Neonates with low-grade GMH-IVH exhibited lower MK and RK values in the PLIC and the

66 rived metrics in neonates with low-grade GMH-IVH, and to demonstrate their association with later neu

67 ntal outcomes in neonates with low-grade GMH-IVH.

68 aemorrhage-intraventricular haemorrhage (GMH-IVH) suffer from neurobehavioural deficits as they enter

69 inal matrix-intraventricular hemorrhage (GMH-IVH) rat model.

70 matrix and intraventricular hemorrhage (GMH-IVH).

71 how that compared to sham group, rats in GMH-IVH group caused abnormal motor function.

72 assessment of neurological alteration in GMH-IVH rat pups, and providing great value in evaluating lo

73 o observed changes in striatum region in GMH-IVH.

74 d a postnatal day 5 (PND 5) rat model of GMH-IVH.

75 The overall occurrence of any grade IVH and severe IVH among preterm infants was calculated

76 The primary outcome was any grade IVH on head ultrasonography or death before day 7.

77 NDI decreased significantly after high-grade IVH (a 74% reduction; aOR, 0.26; 95% CI, 0.22-0.31), and

78 mmon, especially among those with high-grade IVH (with prevalences of 44.55% [715 of 1605 infants] an

79 The mean (SD) incidence of high-grade IVH and low-grade IVH increased between 2013 and 2019, a

80 Children with high-grade IVH consistently showed poorer academic performance into

81 Children with high-grade IVH performed significantly worse than very preterm cont

82 tly weak domain for children with high-grade IVH throughout school age (eg, at age 8 to 9 years, AMD

83 : 557 with low-grade IVH, 85 with high-grade IVH, 2557 very preterm controls without IVH, and 404 990

84 de IVH, 31.5 [95% CI, 29.0-34.0]; high-grade IVH, 30.2 [95% CI, 24.1-36.4]).

85 Of the 2809 included infants with high-grade IVH, the median (IQR) gestational age was 25 (24-26) wee

86 each statistical significance for high-grade IVH.

87 .31), and to a lesser extent after low-grade IVH (a 12% reduction; aOR, 0.88; 95% CI, 0.79-0.98).

88 D) incidence of high-grade IVH and low-grade IVH increased between 2013 and 2019, although this did n

89 Children with low-grade IVH performed similarly to preterm controls at age 8 to

90 Although low-grade IVH was associated with functional impairments, most sur

91 e thalamus of preterm infants with low-grade IVH were associated with lower NBNA scores (r = 0.831, 0

92 Overall, 5519 included infants had low-grade IVH with a median [IQR] gestational age of 26 (25-27) we

93 s cohort study, the association of low-grade IVH with worse school performance appeared limited to ch

94 [95% CI, 31.2-33.5]; children with low-grade IVH, 31.5 [95% CI, 29.0-34.0]; high-grade IVH, 30.2 [95%

95 ncluded 408 189 children: 557 with low-grade IVH, 85 with high-grade IVH, 2557 very preterm controls

96 In preterm infants with low-grade IVH, the volume of brain parenchymal fraction (BPF) was

97 in volumes in preterm infants with low-grade IVH, which provides clinicians with a more comprehensive

98 assessment of preterm infants with low-grade IVH.

99 tional age in preterm infants with low-grade IVH.

100 499 patients in MISTIE-III, 310 (62.1%) had IVH on stability scans; mean age (SD) was 61.2+/-12.3 ye

101 after 24 h, absolute increase in haematoma+/-IVH volume was larger (5.2/5.0 mL) in those with compare

102 Intensive BP lowering reduced haematoma+/-IVH growth by 4.7/7.1 mL in patients on antithrombotics

103 Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity

104 defined as new intraventricular haemorrhage (IVH) on the latter scan.

105 ) with/without intraventricular haemorrhage (IVH) over 24 h were estimated in analyses of covariance.

106 death, severe intraventricular haemorrhage (IVH), and periventricular leucomalacia (PVL) in preterm

107 cular extension of intracerebral hemorrhage (IVH) is an independent predictor of poor outcome.

108 00]) and severe intraventricular hemorrhage (IVH) (median score, 90.0 [IQR, 80.0-100]) were rated as

109 ns following an intraventricular hemorrhage (IVH) and other chronic disease management.

110 bocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infan

111 Intraventricular hemorrhage (IVH) has been described to typically occur during the ea

112 Intraventricular hemorrhage (IVH) has proven to be a challenging and enduring complic

113 Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arres

114 Intraventricular hemorrhage (IVH) in preterm infants leads to cerebral inflammation,

115 Intraventricular hemorrhage (IVH) is a major cause of neonatal morbidity and mortalit

116 Intraventricular hemorrhage (IVH) is a major complication of prematurity and a large

117 Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral he

118 Intraventricular hemorrhage (IVH) is a significant complication of preterm birth, aff

119 dema (PHE), and intraventricular hemorrhage (IVH) on noncontrast CT scans of patients with spontaneou

120 pathogenesis of intraventricular hemorrhage (IVH) relates to the fragility of the immature capillarie

121 Intraventricular hemorrhage (IVH) remains a major cause of white matter injury in pre

122 Intraventricular hemorrhage (IVH) results in neural cell death and white matter injur

123 Intraventricular hemorrhage (IVH) results in periventricular inflammation, hypomyelin

124 bolysis reduces intraventricular hemorrhage (IVH) volume in patients with spontaneous intracerebral h

125 Intraventricular hemorrhage (IVH) was the most common type of hemorrhage (n = 16, 62%

126 asia (BPD), and intraventricular hemorrhage (IVH) were statistically higher in infants with ROP compa

127 d no or grade 1 intraventricular hemorrhage (IVH), 2 (29%) had grade 2 IVH, and 2 had severe (grade 3

128 insurance type, intraventricular hemorrhage (IVH), and age at assessment, public health insurance was

129 ation following intraventricular hemorrhage (IVH), is a common disease usually treated by suboptimal

130 EC), and severe intraventricular hemorrhage (IVH), were also analyzed.

131 ccurs following intraventricular hemorrhage (IVH).

132 with low-grade intraventricular hemorrhage (IVH).

133 expansion [HE], intraventricular hemorrhage [IVH], and perihemorrhagic edema [PHE]).

134 (5.8-27.3), and 7.8 (3.1-15.5) miles to HVH, IVH, and LVH, respectively.

135 des ago, a number of in vitro hydroxylation (IVH) assays for PHD activity have been developed to meas

136 light disruption in cortical interneurons in IVH and identify a novel therapeutic strategy to restore

137 e Focal model showed improved performance in IVH segmentation compared with the Tversky, two-dimensio

138 hlights the role of AMPA-kainate receptor in IVH-induced white matter injury and identifies a novel s

139 en that TH promotes neurological recovery in IVH, TH treatment might improve the neurodevelopmental o

140 eplase group had a greater mean reduction in IVH volume compared with the SMC group (deltaIVH: -2.35

141 IVH was associated with a small reduction in IVH volume.

142 aperitoneal glycerol at 2 h of age to induce IVH; and the pups with IVH exhibit hypomyelination and g

143 the preterm rabbit model of glycerol-induced IVH and analyzed autopsy samples from premature infants.

144 theses in a rabbit model of glycerol-induced IVH and evaluated the expression of AMPA receptors in au

145 day death or major disability versus initial IVH (adjusted ORs 2.84 (95% CI 1.52 to 5.28) and 1.87 (1

146 baseline IVH, and 107 (11%) of 961 initially IVH-free patients who developed dIVH.

147 volume standards versus local intermediate (IVH) and low-volume (LVH) hospitals were identified.

148 cular alteplase use in patients with a large IVH was associated with a small reduction in parenchymal

149 fined to the germinal matrix, small-to-large IVH or periventricular haemorrhagic infarction.

150 Even mild BI, like IVH II degrees , significantly contributes to adverse ou

151 surgery at far HVH, 11,739 (23.7%) at local IVH, and 20,171 (40.8%) at local LVH.

152 p<0.001) and intraventricular blood (median IVH sum score 2 vs 1, p<0.001), and more often with intr

153 as performed in 25 preterm infants with mild IVH (Papile grading I/II) and 40 control subjects withou

154 Mimicking IVH with intraventricular blood led to increased CSF [K(

155 d as IVH volume on end-of-treatment CT minus IVH volume on stability CT scan.

156 Moreover, IVH decreased the population of parvalbumin+ and somatos

157 llowing correlations with mRS were obtained: IVH volume R = .305; ICH volume R = .468; total volume [

158 The addition of IVH to ICH volume increases its predictive power for poo

159 The development of IVH leads to inflammation of the periventricular white m

160 ion in England, 8461 received a diagnosis of IVH (5570 low-grade and 2891 high-grade, and 8328 were i

161 DI included lower birth weight, diagnosis of IVH, male sex, and older age at time of Bayley assessmen

162 Despite its prevalence, the effect of IVH beyond the impact of prematurity alone has been scar

163 s than 29 weeks' gestation with any grade of IVH between January 2013 and December 2019 in England we

164 re NDI was observed with increasing grade of IVH, decreasing gestation, bilateral compared to unilate

165 part of the study, the highest incidence of IVH (> 60%), occurred when glycerol was administered at

166 ave a significant effect on the incidence of IVH (hazard ratio, 0.92; 95% CI, 0.49-1.73; P = .80).

167 e second part of the study, the incidence of IVH and mortality rate following rhIGF-1/rhIGFBP-3 admin

168 er of platelet transfusions and incidence of IVH.

169 optimal time-point for glycerol-induction of IVH in relation to time-point of recombinant human (rh)

170 ses were tested in a preterm rabbit model of IVH and autopsy samples from human preterm infants.

171 To test the hypotheses, a rabbit model of IVH was used in which premature rabbit pups (E29) are tr

172 ological recovery in preterm rabbit model of IVH.

173 human preterm infants and a rabbit model of IVH.

174 ses were tested in a preterm rabbit model of IVH; autopsy brain samples from premature infants with a

175 fore, we hypothesized that the occurrence of IVH would reduce interneuron neurogenesis in the medial

176 The onset of IVH induces inflammation of the periventricular white ma

177 The temporal distribution of the onset of IVH was analyzed by pooling the time windows 0 to 6, 0 t

178 e intervention in optimizing the outcomes of IVH survivors.

179 The presence of IVH was evaluated using high-frequency ultrasound and po

180 GF-1/rhIGFBP-3 in reducing the prevalence of IVH and improving survival in the preterm rabbit pup.

181 nalysis found that the overall prevalence of IVH in preterm infants has not changed significantly sin

182 t dose of rhIGF-1/rhIGFBP-3 on prevention of IVH and survival in the preterm rabbit pup.

183 The overall rate of IVH did not decrease significantly before vs after 2007

184 heless, very preterm children, regardless of IVH grade, demonstrated academic progress over time, und

185 with neurodevelopment across the spectrum of IVH severity, independent of prematurity, and in the con

186 is, and motor impairment in the survivors of IVH.

187 ith increasing CA, children with early-onset IVH and subsequent significant central nervous system in

188 Only children with early-onset IVH followed by significant central nervous system injur

189 Using a porcine IVH model, the self-clearing catheters showed a greater

190 No optimal therapy exists to prevent IVH or to treat its consequences.

191 Participants with primary IVH were excluded.

192 lamping in extremely preterm infants reduces IVH or early death.

193 death (47/449 [11%] vs 58/449 [13%]), severe IVH (46/429 [11%] vs 55/411 [13%]), and PVL (34/367 [9%]

194 [24%] vs 27/179 [15%], p=0.0338) and severe IVH (19/219 [9%] vs 6/189 [3%], p=0.0209) were higher in

195 erall occurrence of any grade IVH and severe IVH among preterm infants was calculated along with a 95

196 ued the main outcomes, with death and severe IVH being rated as the 2 most important undesirable outc

197 < 60ml, Glasgow Coma Scale of <9, and severe IVH with tamponade of the third and fourth ventricles re

198 t dependency in patients with ICH and severe IVH.

199 s a risk factor for sepsis or NEC and severe IVH.

200 morphine were more likely to develop severe IVH (36/190 [19%] vs 19/219 [9%], p=0.0024).

201 42% vs 31%; 95% CI, 25%-36%), nor did severe IVH (10%; 95% CI, 7%-13% vs 11%; 95% CI, 8%-14%).

202 ed sepsis or NEC, and 353 (12.8%) had severe IVH.

203 ng correlation between CBF and SBF in severe IVH (Grade III or IV) and IVH diagnosed within 72 h of l

204 sions did not reduce the frequency of severe IVH, PVL, or death in ventilated preterm neonates, but i

205 aged 8 or less days with moderate to severe IVH identified by cerebral ultrasonography from 8 Swiss

206 ] vs 64 [IQR, 35-86]), and those with severe IVH vs those without (69 [IQR, 44-90] vs 64 [IQR, 36-86]

207 ovide evidence that, in patients with severe IVH, as compared to IVF alone, a combined approach of IV

208 In this cohort study, IVH was highlighted as a persistent issue with substanti

209 using a simple classification system termed IVH score (IVHS).

210 treatment outcomes in ICH research, and that IVH and PHE may represent potential treatment targets.

211 In a rat model of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-

212 We discovered that IVH reduced the number of Nkx2.1+ and Dlx2+ progenitors

213 We found that IVH augmented PPAR-y expression in microglia of both pre

214 We found that IVH resulted in apoptosis and reduced proliferation of o

215 Here, we hypothesized that IVH damages white matter via AMPA receptor activation, a

216 Therefore, we hypothesized that IVH in premature newborns initiates degeneration and mat

217 Therefore, we hypothesized that IVH would decrease TH signaling via changes in the expre

218 Therefore, we hypothesized that IVH would result in accumulation of HA, and that either

219 The study findings further suggest that IVH and PHE may be relevant for the overall outcome of p

220 The IVH estimation formula was then verified in the validati

221 No therapeutic strategy exists against the IVH-induced white matter injury.

222 Taken together, IVH reduced intraneuronal production and cortical intern

223 ematoma+intraventricular haemorrhage volume (IVH) with/without intraventricular haemorrhage (IVH) ove

224 Compared with those who were IVH-free, dIVH had greater odds of 90-day death or major

225 While IVH volume decreased significantly in both treatment gro

226 BF variability alone was not associated with IVH.

227 ces (AMDs) in z scores between children with IVH and very preterm controls.

228 in patients with moderate to large ICH with IVH, especially in a thalamic location.

229 -dose erythropoietin in preterm infants with IVH affects brain injury scores on conventional magnetic

230 hite matter injury in premature infants with IVH and highlights the importance of early detection of

231 rabbit pups and human premature infants with IVH compared with controls.

232 Thus, in infants with IVH the combined elevation in deiodinase-3 and reduction

233 could transform the outcome of infants with IVH.

234 urological outcome of premature infants with IVH.

235 urons and cognitive function in infants with IVH.

236 rological outcome for premature infants with IVH.

237 rological recovery in premature infants with IVH.

238 neurologic outcome in premature infants with IVH.

239 ytes and myelination in preterm infants with IVH.

240 ion was also increased in human infants with IVH.

241 evelopmental outcome of preterm infants with IVH.

242 rological recovery in premature infants with IVH.

243 ation and neurological function in kits with IVH.

244 n and neurobehavioural function in kits with IVH.

245 s and cognitive function in rabbit kits with IVH.

246 buting to neurological recovery in kits with IVH.

247 hx6 and Sox6, were also reduced in kits with IVH.

248 rogenitor cell (OPC) maturation in kits with IVH.

249 avioural function in premature newborns with IVH.

250 omote neurological recovery in newborns with IVH.

251 neurologic recovery in preterm newborns with IVH.

252 ulated gene-6 were elevated in newborns with IVH; and depletion of HC-HA levels by HA oligosaccharide

253 ss class imbalance (30% of participants with IVH in dataset).

254 hase III (MISTIE-III) trial in patients with IVH on the stability CT scan.

255 2 h of age to induce IVH; and the pups with IVH exhibit hypomyelination and gliosis at 2 weeks of po

256 he density of Iba1(+) microglia in pups with IVH.

257 restored neurological function in pups with IVH.

258 y, and motor function in premature pups with IVH.

259 rain samples of both humans and rabbits with IVH compared with controls without IVH.

260 Hyaluronidase treatment of rabbits with IVH reduced CD44 and TLR4 expression, proinflammatory cy

261 function and MAPK signalling in rabbits with IVH.

262 neurologic recovery in preterm rabbits with IVH.

263 on and neurological recovery in rabbits with IVH.

264 on and neurological function in rabbits with IVH.

265 tion and neurologic recovery in rabbits with IVH.

266 as clinical recovery in preterm rabbits with IVH.

267 on and neurological recovery in rabbits with IVH.

268 he forebrain of both humans and rabbits with IVH.

269 red into the ICH in MISTIE-III subjects with IVH was associated with a small reduction in IVH volume.

270 aturity and a large number of survivors with IVH develop cerebral palsy and cognitive deficits.

271 States, and a large number of survivors with IVH develop cerebral palsy and cognitive deficits.

272 neurodevelopmental outcome of survivors with IVH.

273 and neurological function in survivors with IVH.

274 compared premature newborns with and without IVH for intraneuronal progenitors, cortical interneurons

275 ples from premature infants with and without IVH were analyzed.

276 bbit pups and human infants with and without IVH, but HA receptors--CD44, TLR2, TLR4--were elevated i

277 e neocortex in both infants with and without IVH.

278 preterm humans and rabbits with and without IVH.

279 rade IVH, 2557 very preterm controls without IVH, and 404 990 full-term controls.

280 ades 3-4) IVH, very preterm controls without IVH, and full-term controls.

281 bits with IVH compared with controls without IVH.

282 e than their peers born very preterm without IVH.

283 rading I/II) and 40 control subjects without IVH.