ライフサイエンスコーパス: Ig heavy chain

1 omplementarity-determining region III of the Ig heavy chain.

2 express the membrane-bound form of the micro Ig heavy chain.

3 cells that express more than one functional Ig heavy chain.

4 ce used the transgene rather than endogenous Ig heavy chains.

5 membrane-bound forms of the immunoglobulin (Ig) heavy chain.

6 s and mutations, and in some cases, the same Ig-heavy chains.

7 O mice carried fewer hypermutations in their Ig heavy chain alleles than those of WT mice, indicating

8 mples each had rearrangements involving both Ig heavy chain alleles.

9 In plants expressing both the membrane Ig heavy chain and its partner light chain, functional a

10 deficient B cells that harbored preassembled Ig heavy chain and kappa-light chain "knock-in" (HL) all

11 erated via complementation of DP-T mice with Ig heavy chain and light chain knock-in transgenes (DP-T

12 inately assembled into half-molecules of one Ig heavy chain and one Ig light chain.

13 n receptor assembly, D and J segments of the Ig heavy chain and T cell receptor beta loci are recombi

14 he ends of the active DJ domains of both the Ig heavy chain and T cell receptor beta loci.

15 pERp1 promoted correct oxidative folding of Ig heavy chains and prevented off-pathway assembly inter

16 are assembled into complete molecules of two Ig heavy chains and two Ig light chains, whereas the fou

17 reaction (PCR) analyses for immunoglobulin (Ig) heavy chain and T-cell receptor (TCR)-gamma gene rea

18 g a disulfide bond to the C termini of their Ig heavy chains, and it controls IgM/IgA transport acros

19 oprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V,

20 Unassembled Ig heavy chains are retained in the ER via the binding o

21 to 10-fold increase in mutation frequency in Ig heavy chain, BCL-6, p53, and beta-catenin genes of in

22 s a component of unassembled immunoglobulin (Ig) heavy chain:BiP complexes.

23 Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before

24 in or 5' to the switch regions of nearly all Ig heavy chain C region genes and also is known to incre

25 ged mouse Myc gene, Myc(His), into the mouse Ig heavy-chain Calpha locus.

26 The Ig heavy chain class switch in B lymphocytes involves a

27 Ig heavy chain class switch recombination (CSR) determin

28 Ig heavy chain class switch recombination (CSR) involves

29 homologous DNA end-joining (NHEJ) protein in Ig heavy chain class switch recombination (CSR), we assa

30 ional enhancers speculated to play a role in Ig heavy chain class switch recombination (CSR).

31 ibodies are modulated through the process of Ig heavy chain class switch recombination (CSR).

32 tion and immunodeficient because of impaired Ig heavy chain class switch recombination.

33 The switch in immunoglobulin (Ig) heavy chain class is preceded by germline transcript

34 Immunoglobulin (Ig) heavy chain class switch recombination (CSR) mediate

35 IG heavy chain clonal evolution was most pronounced amon

36 ated by germline encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HC

37 able B cell clonal populations detectable by Ig heavy chain complementary-determining region 3 mRNA s

38 ctivated mature B cells can change expressed Ig heavy chain constant region exons by class switch rec

39 (S) regions that lie upstream of the various Ig heavy chain constant region exons.

40 between switch (S) regions that precede each Ig heavy chain constant region gene.

41 demonstrate that a transgene containing the Ig heavy chain constant region locus, inserted into five

42 results indicated that the accessibility of Ig heavy chain constant regions targeted for CSR was est

43 on downstream of the most 3' immunoglobulin (Ig) heavy chain constant region gene (Calpha) contains a

44 demonstrate that DIR2 is used to form human Ig heavy chains, contributing to 7% of the human heavy c

45 ace BCR expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these ce

46 The most abundant Ig heavy chains detected in both control individuals and

47 for the basic recombination reaction and for Ig heavy chain DH to JH joining, is essential for effici

48 The Ig heavy chain enhancer of the channel catfish (Ictaluru

49 on of a c-myc transgene under control of the Ig heavy-chain enhancer (Emu) results in an increase in

50 The lymphoma-inducing potential of Ig heavy-chain enhancer- and promoter-regulated Epstein-

51 -regulation of CD43 can occur independent of Ig heavy chain expression.

52 client protein interactions, immunoglobulin (Ig) heavy chain folding intermediates containing bound G

53 en-binding fragment (Fab) shows a binding of Ig heavy chain framework residues to the Ibp Domain D an

54 sequences, and a group of randomly selected Ig heavy chains from Genbank.

55 The juxtaposition of the Ig heavy chain gene and Myc in Burkitt's lymphoma and in

56 the joining (J) gene segment of the chicken Ig heavy chain gene by homologous recombination in primo

57 Analysis of Ig heavy chain gene sequences showed identical variants

58 Transgenic mice were developed bearing an Ig heavy chain gene specific for the D protein component

59 determined cell division dynamics, germ-line Ig heavy chain gene transcription and surface IgG1 (sIgG

60 s as class switching and increased levels of Ig heavy chain gene transcription in plasma cells.

61 r the presence of ongoing mutations in their Ig heavy chain gene.

62 first evidence for a role of IRF proteins in Ig heavy-chain gene expression.

63 Clonal Ig heavy-chain gene rearrangements (lgHGR) have infreque

64 action (PCR) amplification of the rearranged Ig heavy-chain gene showed the same sized dominant produ

65 cells that had not undergone immunoglobulin (Ig) heavy chain gene class switching or somatic hypermut

66 these sequences on the regulation of IgM and IgD heavy chain gene expression in transfectants as well

67 -1/IgH translocation and clonally rearranged Ig heavy chain genes (IgH) provided molecular markers fo

68 ate production of germ-line transcripts from Ig heavy chain genes and subsequent switch recombination

69 hancer (3'alphaE) regulate expression of the Ig heavy chain genes during B cell development.

70 tion of a relatively small proportion of the Ig heavy chain genes expressed by normal adult B cells.

71 We therefore analyzed the expressed Ig heavy chain genes in 23 cases (11 families) of famili

72 Similar to the Ig heavy chain genes, the corresponding Ig light chain g

73 quenced 209 nonproductive and 926 productive Ig heavy chain genes.

74 evel of somatic hypermutations in rearranged IG heavy-chain genes could define two CLL subtypes assoc

75 ncing analysis of rearranged immunoglobulin (Ig) heavy chain genes from biological replicates, coveri

76 -2L(d) and the Fc portion of immunoglobulin (Ig) heavy chain genes mu or gamma1.

77 noglobulin (Ig) proteins derived from single Ig heavy chain (H) and light chain (L) alleles.

78 flexibility on the other, exemplified by the Ig heavy chain (H) isotypes IgM and IgD/W, respectively.

79 development, rearrangement and expression of Ig heavy chain (HC) genes promote development and expans

80 , we generated a knock-in mouse in which the Ig heavy chain (HC) variable region rearrangement (V(H)D

81 Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is

82 talurus punctatus), a novel complex chimeric Ig heavy chain, homologous, in part, to the heavy chain

83 ed Ig genes, and one case expressed switched Ig heavy chain (IgA), suggesting that they originated fr

84 The murine Ig heavy chain (IgH) 3' regulatory region contains four

85 We applied the algorithm to a large set of IG heavy chain (IGH) AIRR-seq data from 450 donors of an

86 was evaluated for translocations between the Ig heavy chain (IgH) and chromosomes 4, 11, and 16, tran

87 A-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) an

88 plays a dominant role in joining DSBs during Ig heavy chain (IgH) class switch recombination (CSR) in

89 (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

90 Ig heavy chain (IgH) class-switch recombination (CSR) re

91 n of switch regions, located upstream of the Ig heavy chain (IgH) constant genes.

92 The Ig heavy chain (IgH) constant region (CH) genes are orga

93 The intronic Ig heavy chain (IgH) enhancer, which consists of the cor

94 oteins that bind the HE2 region of the human Ig heavy chain (IgH) enhancer.

95 As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3' regulatory r

96 her B-lineage neoplasm, exhibits oligoclonal Ig heavy chain (IgH) gene rearrangement in 15% to 43% of

97 on (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows the same variable

98 e consensus primers for amplification of all Ig heavy chain (IGH) genes in a mixture of peripheral bl

99 of chimeric mice demonstrated that the core Ig heavy chain (IgH) intronic enhancer (iEmu) functions

100 -restricted regulatory regions including the Ig heavy chain (IgH) intronic enhancer, the IgH 3' enhan

101 Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE)

102 ing of long primary RNA transcripts from the Ig heavy chain (Igh) locus and serve as the receptors fo

103 Clonal rearrangements of the Ig heavy chain (IGH) locus consisting of either intrachr

104 Clonal rearrangements of the Ig heavy chain (IGH) locus occur in nearly all cases of

105 YAC) containing a 220 kb region of the human Ig heavy chain (IgH) locus.

106 uperanchor was positioned down-stream of the Ig heavy chain (Igh) locus.

107 R) analysis for the presence of an identical Ig heavy chain (IgH) or T-cell receptor (TCR) gene rearr

108 on lymphopoiesis, we initially sequenced the Ig heavy chain (IgH) rearrangements within the late pro-

109 ection of antisense transcripts in assembled Ig heavy chain (IgH) variable region exons and their imm

110 Ig heavy chain (IgH) variable region exons are assembled

111 We used chromosomal translocations and Ig heavy chain (IGH)/T cell antigen receptor (TCR) rearr

112 ic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-

113 the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the hu

114 allows splenic B cells activated to undergo Ig heavy-chain (IgH) class-switch recombination (CSR) to

115 hemistry, EBV in situ hybridization, and for Ig heavy-chain (IgH) gene rearrangements, Clinically, we

116 kiss) EST gene index, we identified a unique Ig heavy-chain (IgH) isotype.

117 In mice, the Ig heavy-chain (IgH) locus contains, from 5' to 3', seve

118 SR may facilitate T(12;15): transposition of Ig heavy-chain (IgH) sequences to Myc.

119 (motif-1) or DPSFYSSSWTLFDY (motif-2) in the Ig heavy-chain (IgH) third complementarity-determining r

120 rimary antibodies as diverse immunoglobulin (Ig) heavy chain (IgH) and light chain (IgL) of their B c

121 oping lymphocytes and during immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) i

122 and the region spanning the immunoglobulin (Ig) heavy chain (IgH) variable (V), diversity (D), and j

123 ne deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) a

124 and beta-catenin was different from that of Ig heavy chain in HCV-infected cells, suggesting two dif

125 good evidence for a signaling role played by Ig heavy chain in the developmental transition through t

126 s, GRP94 remained in stable association with Ig heavy chains in the presence of ATP or ADP.

127 Gene rearrangement of the Ig heavy chain indicated monoclonality or oligoclonality

128 ffects of adenosine nucleotides on chaperone-Ig heavy chain interactions were examined.

129 elease of BiP from both wild-type and mutant Ig heavy chain intermediates, GRP94 remained in stable a

130 ed to the B cell compartment using the mouse Ig heavy chain intron enhancer.

131 narily conserved, as mammalian Ig lambda and Ig heavy chain intron enhancers efficiently stimulate hy

132 the core E alpha element (E alpha C), or the Ig heavy chain intronic enhancer (iE mu), all of which p

133 th 5' and 3' in a fashion reminiscent of the Ig heavy chain intronic enhancer-associated MARs.

134 These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivi

135 Ig heavy chain isotype switching in B lymphocytes is kno

136 because they have a targeted deletion in the Ig heavy chain (J) locus, were more resistant to infecti

137 ow crossed the TCRMOG mice with MOG-specific Ig heavy-chain knock-in mice (IgHMOG mice; also referred

138 inding of the transcription factor Bright to Ig heavy chain loci after B cell activation is associate

139 Translocations involving both Ig heavy chain loci and clonal-like, dynamic IgA switchi

140 Germ-line transcripts from Ig heavy chain loci precede the occurrence of isotype sw

141 V(D)J is tightly controlled at the Ig heavy chain locus (IgH) at several different levels,

142 ween 9p13 and the switch micro region of the Ig heavy chain locus (IgH) on 14q32.

143 The 3' Ig heavy chain locus (Igh) regulatory region is the most

144 At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells

145 by separate constant region genes within the Ig heavy chain locus (IGH).

146 rocess is independent of location within the Ig heavy chain locus and potentially AID-promoted.

147 The t(14;18) translocation involving the Ig heavy chain locus and the BCL-2 gene is the single mo

148 The Ig heavy chain locus contains a number of binding sites

149 Quantitative deep sequencing of the Ig heavy chain locus from B220(+)CD43(+) populations ide

150 important role in driving expression of the Ig heavy chain locus in a teleost fish.

151 appears to be greater than that found in the Ig heavy chain locus in the opossum, and light chains ar

152 The transcription of the murine Ig heavy chain locus is regulated not only by the intron

153 antisense germ-line transcription within the Ig heavy chain locus precedes V(D)J recombination and ha

154 gresses, RNA processing changes occur at the Ig heavy chain locus resulting in a switch from the memb

155 BLIN-2 has a clonal rearrangement of the Ig heavy chain locus, a dic(9;20) chromosomal abnormalit

156 train (H2dIgh-1b), which differs only in the Ig heavy chain locus, is resistant to HSK.

157 and can bind to regulatory sites within the Ig heavy chain locus.

158 rranged V(D)J segment at the immunoglobulin (Ig) heavy chain locus, the other allele being nonfunctio

159 and Rag1/2, which are critical for the IgH (Ig heavy-chain) locus contractions and rearrangement.

160 To further characterize the role of Ig heavy chain-mediated signaling in vivo, as well as in

161 IR gene segments by cross-breeding the human Ig heavy chain minilocus pHC1 transgenic mice and TdT-de

162 lls resulted in a decrease in the endogenous Ig heavy-chain mRNA secretory form-to-membrane ratio.

163 We have analyzed 543 Ig heavy chain nonproductive rearrangements, involving a

164 demonstrated surface expression of membrane Ig heavy chain on up to 40% of the cells from a transgen

165 on of polyadenylation of the immunoglobulin (Ig) heavy-chain pre-mRNA argued for trans-acting modifie

166 In homozygous knockouts, Ig heavy chain production is eliminated, and no antibody

167 with LMP1 expressed under the control of the Ig heavy chain promoter and enhancer.

168 ession was driven by the Emicro-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to t

169 pment depends upon the surface expression of Ig heavy chain protein (mu) in a signaling complex known

170 uctures at the Igh locus that compact during Ig heavy chain rearrangement.

171 effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunize

172 CHD4-NuRD is also required for the Ig heavy-chain repertoire by promoting utilization of di

173 cells contributes to the suppression of the Ig heavy-chain secretory poly(A) site.

174 plasmablast/plasma cells with highly similar Ig heavy-chain sequences across MS subjects, similaritie

175 hypervariable, but not framework, regions of Ig heavy chain specifically stimulated CD4(+) and CD8(+)

176 on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits in non-KC tears (n = 7 control i

177 LR1 also binds Ig heavy chain switch region sequences and may function

178 e carrying c-myc illegitimately joined to an Ig heavy chain switch region, ie, the t(12;15) chromosom

179 differ strikingly at the molecular level in Ig heavy chain third complementarity determining region

180 The isotype of the Ig heavy chain thus contributes to surface expression an

181 ocytes in association with Vpre-B and the mu Ig heavy chain to form the pre-B receptor.

182 Despite having more than one Ig heavy chain transcript, each sample was found to expr

183 ed a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and el

184 The B cell regulator of Ig heavy chain transcription (Bright) is a DNA-binding p

185 'RR-deficient mice, whereas the simultaneous Ig heavy chain transcription rate is only partially redu

186 Thus, a recombined Ig heavy chain transgene prominently undergoes somatic d

187 TdT and an Ig heavy chain transgene were detected within a hormone-

188 a fide camelid IgG in which modifications of Ig heavy chain V (VH) sequences prevent dimer formation

189 The usage of >100 functional murine Ig heavy chain V(H) genes, when rearranged to D(H)J(H) g

190 s and GC B cells from infected mice revealed Ig heavy-chain V genes with significantly increased C-to

191 Unmutated CLLs, carrying Ig heavy chain variable (IGHV) genes in germline configu

192 Although Ig heavy chain variable region (V(H)) genes encode a sub

193 The Ig heavy chain variable region (V(H)) genes encode the a

194 To determine human Ig heavy chain variable region (VH) gene segment organiz

195 frozen tissue sections and their rearranged Ig heavy chain variable region (VH) genes of the V186.2/

196 phocytic leukemia (CLL) express a restricted Ig heavy chain variable region gene (VH gene) repertoire

197 Ig heavy-chain variable region exons are assembled devel

198 exclusively with rearrangements of a single Ig heavy-chain variable-region gene (V(H)3-30), despite

199 tribution of autoreactive antibodies between Ig heavy-chain variable-unmutated (IgV-unmutated) CLL (U

200 (BCLL) patients expresses an immunoglobulin (Ig) heavy chain variable (V(H)) region gene with some le

201 with sporadic B-CLL the same immunoglobulin (Ig) heavy chain variable region (VH) gene usage and occu

202 We examined the immunoglobulin (Ig) heavy chain variable region genes (V(H) genes) used

203 une repertoire sequencing of immunoglobulin (Ig) heavy chain variable regions (VH) from CSF and subso

204 and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene.

205 expressed immunoglobulin (Ig) encoded by the Ig heavy-chain-variable-region gene (IGHV), IGHV3-21.

206 Using a simplified two-domain Ig heavy chain (VH-CH1), we have determined why BiP rema

207 A nearly identical CLL69C Ig heavy chain was identified from an MAA-enriched umbil

208 The binding of BiP to Ig heavy chains was ATP-sensitive.

209 Because 38B9 cells lack Ig heavy chains, we stably expressed mu heavy chain prot

210 dies using the germ line VH3.33 gene-derived Ig heavy chain, were induced in five of 10 rhesus macaqu

211 coding for the membrane-bound form of the mu Ig heavy chain, which suggests a predominance of B lymph

212 by the association of incompletely assembled Ig heavy chains with the endoplasmic reticulum (ER) chap

213 n the negative selection of cells expressing Ig heavy chains with the potential to generate autoantib