ライフサイエンスコーパス: Ig receptor

1 mice expressing the autoreactive PC-specific Ig receptor.

2 etained the ability to bind to the polymeric Ig receptor.

3 ctivation of B cells expressing autoreactive Ig receptors.

4 Ags via fluid phase uptake or using membrane Ig receptors.

5 le B cell responding to Ag, with diversified Ig receptors.

6 e., B cells specifically activated via their Ig receptors.

7 xpressing mu/kappa or mu/lambda cell surface Ig receptors.

8 ing pattern recognition receptors (PRRs) and Ig receptors.

9 ansfected with the polymeric immunoglobulin (Ig) receptor.

10 nal transduction through the immunoglobulin (Ig) receptor.

11 Co-crosslinking of surface Ig receptors along with ligation of CD27 augments CD27-m

12 the DNA encoding the variable portion of the Ig receptor, although an additional role in deaminating

13 but they also have reduced levels of surface Ig receptor and express higher amounts of Fas Ag than VH

14 o two other IgM-binding receptors (polymeric Ig receptor and Fcalpha/muR) but exhibits an exclusive F

15 the gradient in expression of the polymeric Ig receptor and the transport of its ligand, oligomeric

16 t CD4+ T cells, immunomodulatory killer cell Ig receptors, and Ig-like transcript receptors may recog

17 CD79a and CD79b proteins associate with Ig receptors as integral signaling components of the B c

18 available for immature B cells to edit their Ig receptors, at least in response to certain soluble Ag

19 In vitro experiments show that Ig receptors bearing this mutation, while expressed norm

20 We measured serum SARS-CoV-2 spike-specific Ig, receptor-binding domain-specific (RBD-specific) IgG,

21 ristate acetate (PMA) was able to bypass the Ig receptor block and activate MAPK activity.

22 study, we identified the myeloid-associated Ig receptor CD300f as an IL-4-induced molecule in macrop

23 en cultured with Ag recognized by the B cell Ig receptor (cognate Ag) and not when cultured with a no

24 Biosynthesis of the immunoglobulin (Ig) receptor components and their assembly were examined

25 In the present study, we analyze the role of Ig receptor cross-linking in T cell-dependent stimulatio

26 These studies imply that Ig receptor cross-linking renders postswitch sIgA+ B cel

27 Upstream of p70(S6K), signaling through both Ig receptors depresses PI3K pathway phospholipids below

28 IgM and IgD receptor downmodulation, HS1 and ERK activation, che

29 meric (d) IgA that is bound by the polymeric Ig-receptor ectodomain, called secretory component (SC).

30 gen-driven immune response before undergoing Ig-receptor editing and after germinal-center leukemogen

31 The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is

32 d by the classical phagocytic receptors, the Ig receptors (FcRgammaI and FcgammaRIII) or complement r

33 plays a role in binding Ig to the polymeric Ig receptor for transport into secretions.

34 suggest that, in autoimmunity, B cells with Ig receptors for apoptotic cells and DNA are positively

35 We identify the Ig receptor G6f-like as a collagen receptor and demonstr

36 ets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor gamma-chain, which

37 CD23 is unique among Ig receptors in that it belongs to the C-type (calcium-d

38 mstances in which B cells take up Ag through Ig receptors in vivo.

39 Stimulation of B lymphocytes through the Ig receptor initiates a cascade of biochemical changes,

40 We found that the Ig receptor interactions identified using our methodolog

41 her ligation of CD40 Ag or cross-linking the Ig receptor is also insufficient to render B lymphocytes

42 The level of expression of polymeric Ig receptor is controlled to a large extent by transcrip

43 e, suggesting that antigenic stimulation via Ig receptors may occur prior to malignant transformation

44 Under these conditions, B cells activated by Ig receptor-mediated endocytosis of Ag induced both naiv

45 the J chain, which is required for polymeric Ig receptor-mediated IgA transport.

46 subtypic immunity, indicating that polymeric Ig receptor-mediated transport is not required.

47 J chain also is required for poly-Ig receptor-mediated transport of these Ig classes acros

48 is study, we found that intestinal polymeric Ig receptor (pIgR) and IgA production was impaired in T

49 ) cells transfected with the human polymeric Ig receptor (pIgR) and the cells studied by flow cytomet

50 The polymeric Ig receptor (PIgR) constitutes an important part of the

51 Polymeric Ig receptor (pIgR) is a central player in mucosal immuni

52 The polymeric Ig receptor (pIgR) is conserved in mammals and has an av

53 is paper indicates that the receptor is poly-Ig receptor (pIgR) known in humans and domestic cattle t

54 The polymeric Ig receptor (pIgR) mediates transport of IgA across muco

55 th factor-B (TGF-B) down-regulates polymeric Ig receptor (pIgR) on mucosal epithelium, resulting in d

56 ric (d) IgA, which is bound by the polymeric Ig receptor (pIgR) on the basolateral surface of epithel

57 imeric immunoglobulin (Ig)A to the polymeric Ig receptor (pIgR) stimulates transcytosis of pIgR acros

58 The polymeric Ig receptor (pIgR) transcytoses its ligand, dimeric IgA

59 The polymeric Ig receptor (pIgR) transports polymeric Abs across epith

60 acking B cells, IgA, secreted IgM, polymeric Ig receptor (pIgR), or J chain.

61 The polymeric Ig receptor (pIgR), produced by renal epithelia, transpo

62 l cells transfected to express the polymeric Ig receptor (pIgR), were transfected with HIV proviral D

63 cross epithelia is mediated by the polymeric Ig receptor (pIgR), which is expressed on the basolatera

64 olateral to the apical surface via polymeric Ig receptor (pIgR)-mediated binding and the internalizat

65 Polymeric Ig receptor (pIgR)-mediated IgA transport into the intes

66 med to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could

67 gut secretions is mediated by the polymeric Ig receptor (pIgR).

68 receptors and in the transcytotic polymeric Ig receptor (pIgR).

69 port of polymeric Igs (pIg) by the polymeric Ig receptor (pIgR).

70 ls into external secretions by the polymeric Ig receptor (pIgR).

71 pt that antigen-driven selection of specific Ig receptors plays a role in the clinical course of B-CL

72 r both a bcl-xL death inhibitory gene and an Ig receptor recognizing hen egg lysozyme (HEL-Ig) effici

73 The polymeric Ig receptor regulates transport of dimeric IgA and penta

74 Although the nature of the IgD receptor remains elusive, cross-linking of IgD on ba

75 Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be

76 at Btk signaling occurs in the region of the Ig receptor signaling complex, suggesting a similar loca

77 the hypothesis that CD5 negatively regulates Ig receptor signaling in anergic B cells and functions t

78 that can only generate B lymphocytes with an Ig receptor specific for the synthetic polymer polyvinyl

79 n immature B cell is highly dependent on its Ig receptor specificity.

80 Here, a breeding scheme with polymeric Ig receptor-sufficient and -deficient mice was used to s

81 ance to dsDNA is achieved through editing of Ig receptors that react with dsDNA.

82 is a newly identified avian immunoglobulin (Ig) receptor that includes both activating and inhibitor

83 in ligands with reduced affinity for the HEL-Ig receptor, the editing response was shown to correlate

84 when PG was directly targeted to the B cell Ig receptor through a conjugate of 4-hydroxy-3-nitrophen

85 This generates high-affinity Ig receptors to pathogens but can also produce autoreact

86 nal B cells, naive Ag-specific B cells (from Ig receptor transgenic mice), or splenic adherent cells

87 enes encoding a phosphocholine (PC)-specific Ig receptor were introduced into recombinase-activating

88 pathogens but can also produce autoreactive Ig receptors, which are removed by selection mechanisms

89 Cross-linking of surface Ig receptors with anti IgM (anti-mu heavy chain, anti-mu