ライフサイエンスコーパス: Ig-like domain

1 f implicated in proper folding of the KIR D0 Ig-like domain.

2 e of obscurin that is C-terminal to its last Ig-like domain.

3 and containing a single extracellular V-set Ig-like domain.

4 to competitive binding of the stalk with the Ig-like domain.

5 ntains the paracaspase domain and an ensuing Ig-like domain.

6 ion of DC-HIL to reside in its extracellular Ig-like domain.

7 sulfate proteoglycans via an immunoglobulin (Ig)-like domain.

8 pe I membrane glycoproteins that contain two Ig-like domains.

9 ependent of each other to the p50 N-terminal Ig-like domains.

10 sPvr is segmented into three well-defined Ig-like domains.

11 protein products with related extracellular Ig-like domains.

12 ogous to those of the three individual CD155 Ig-like domains.

13 ambda5/14.1, contain both unique regions and Ig-like domains.

14 e expression and purification of recombinant Ig-like domains.

15 hed genes that encode membrane proteins with Ig-like domains.

16 n kinase which similarly contains associated Ig-like domains.

17 eraction of only the first two extracellular Ig-like domains.

18 superfamily composed of three extracellular Ig-like domains.

19 for A24nef, which is contacted by all three Ig-like domains.

20 aB-crystallin on the N2B-Us and its flanking Ig-like domains.

21 8-WT)), four (CD48-CD2), or five (CD48-CD22) Ig-like domains.

22 d a large extracellular region composed of 3 Ig-like domains.

23 CD147, a transmembrane glycoprotein with two Ig-like domains.

24 ity is mainly caused by the unfolding of its Ig-like domains.

25 ds to the sequential unfolding of individual Ig-like domains.

26 regulated through unfolding/refolding of its Ig-like domains.

27 s comprising serially linked immunoglobulin (Ig)-like domains.

28 lycosylation, and 12 C2-type immunoglobulin (Ig)-like domains.

29 eals that PrgB contains four immunoglobulin (Ig)-like domains.

30 differing in their number of immunoglobulin (Ig)-like domains.

31 acellular regions similar to immunoglobulin (Ig)-like domains.

32 motifs, followed by two immunoglobulin like (Ig-like) domains.

33 r (alphaPDGFR) extracellular Immunoglobulin (Ig) like domains 1-3 contain major determinants for liga

34 Deletion of the Ig-like domain 1 (D1) of gp130, but not anti-gp130 mAbs

35 genesis, and Lrig1 (leucine-rich repeats and Ig-like domains 1) marks a distinct population of progen

36 by the absence of a complete immunoglobulin (Ig)-like domain 3 within MLCK2.

37 d IIIc ("c"), that encode the second half of Ig-like domain 3 (D3) of FGFRs.

38 c alternative splicing in the second half of Ig-like domain 3 (D3) of fibroblast growth factor recept

39 ed protein: 182 and 283 in the extracellular Ig-like domains, 320 in the transmembrane region, and 37

40 ernatively spliced isoform of VCAM-1 lacking Ig-like domain 4) binds alpha4beta1 with a higher relati

41 ding was evident on a L1 fragment containing Ig-like domains 4, 5, and 6.

42 Removal of Ig-like domains 4, 5, or 6, or simply substituting Asp32

43 It is concluded that KDR Ig-like domains 4-7 contain structural features that inh

44 ive versus mutant receptor proteins in which Ig-like domains 4-7, 4-6, or 7 had been deleted.

45 To clarify the functional role of KDR Ig-like domains 4-7, we compared VEGF-induced signaling

46 dicted extracellular portion of Mep bears an Ig-like domain, a cysteine-rich region, and sequences ho

47 The Hibris protein has eight Ig-like domains, a fibronectin domain and a 160 amino ac

48 tatory organs and encoded a protein with two Ig-like domains, a single putative transmembrane domain,

49 at shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasm

50 We hypothesize that the Ig-like domains act as a rigid stalk that presents the p

51 mutations in the same region of the tapasin Ig-like domain affect MHC class I surface expression and

52 that lamin A variants, which destabilize the Ig-like domain, affect protein-protein interactions more

53 d processing event eliminates the C-terminal Ig-like domain along with the ability of N-MADD-4B to bi

54 consists of the partial 11th and entire 12th Ig-like domain (amino acids 1014-1119).

55 The transcript consists of 11 exons with an Ig-like domain, an epidermal growth factor-like (EGF) do

56 n its extracellular part six immunoglobulin (Ig)-like domains and five fibronectin type III homologou

57 todomain consisting of three immunoglobulin (Ig)-like domains and nine fibronectin type III (FnIII) r

58 y its role in modulating the dynamics of the Ig-like domain and altering the accessibility of canonic

59 es four thrombospondin (TSP) domains and one Ig-like domain and binds NLG-1.

60 through an N-terminal amphipathic helix, the Ig-like domain and HAD phosphatase catalytic core, and a

61 The C-terminal PSK domain is adjacent to an Ig-like domain and is most similar to calcium/calmodulin

62 The first Ig-like domain and second fibronectin type III-like doma

63 Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4; C

64 ated form of ICAM-1 containing the first two Ig-like domains and a peptide with amino acid sequence c

65 It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF

66 eins with six highly conserved extracellular Ig-like domains and distinctive membrane proximal, trans

67 t-associated receptor (OSCAR), which has two Ig-like domains and functions as a bone-specific regulat

68 ine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity.

69 Both mSiglecs have extracellular Ig-like domains and intracellular tyrosine-based motifs.

70 It contains five Ig-like domains and is a sialic binding protein.

71 The ectodomain of MAG is comprised of five Ig-like domains and uses neuronal cell-type-specific mec

72 hat contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain.

73 extracellular region of ALCAM includes five Ig-like domains, and its N-terminal V-like domain specif

74 presence but not specific properties of the Ig-like domain are needed.

75 Ig-like domains are among the most widely represented pr

76 The structures reveal that PirB's six Ig-like domains are arranged at acute angles, similar to

77 of the second and third immunoglobulin-like (Ig-like) domains are deleted.

78 Conversely, the FnIII domains, but not the Ig-like domains, are required during oogenesis, suggesti

79 These data identify the Ig-like domain as the primary determinant for N-MADD-4B

80 In particular, phage Ig-like domains bind variable glycan residues that coat

81 nd without the IG-like domain, we found that IG-like domain binding to endogenous HSPGs produces a 4-

82 interactions involving its first N-terminal Ig-like domain, but it is still unclear which sequences

83 Analyses of TPV-15L revealed no Ig-like domain, but it retains the ability to bind hepar

84 The Ig-like domains, but not the FnIII domains, are essentia

85 ure and interactions of the cardiac-specific Ig-like domain C0, a part of cardiac MyBP-C of which lit

86 ceptor distinct from that of the other CD147 Ig-like domains, CD147 Ig1-Ig2.

87 mains (CD8(f)) or their respective component Ig-like domains (CD8) were expressed in Chinese hamster

88 only the N-terminal death domain and the two Ig-like domains completely blocked CD3/CD28 costimulatio

89 All of the Ig-like domains contain the two conserved cysteine resid

90 t for paracellular water permeation and that Ig-like domain containing receptor 1 (ILDR1) regulates i

91 Tricellulin and immunoglobulin-like (Ig-like) domain containing receptor 1 (ILDR1, also refer

92 Here it is shown that elimination of the Ig-like domain-containing neuregulins by homologous reco

93 ly demonstrated that leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting prot

94 Leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting prot

95 rial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulf

96 , CD, DE, and FG loops of the amino-terminal Ig-like domain (D1) at the end distal to the cellular me

97 ll seven mAbs are directed against the first Ig-like domain (D1) of hLAG3, despite their different or

98 The pIgR's five Ig-like domains (D1-D5) undergo a conformational change

99 ra-cellular portion of pIgR consists of five Ig-like domains (D1-D5), each of which contains 104-114

100 teral interactions between membrane proximal Ig-like domains D4 and D5 of two KIT molecules.

101 led a sequence motif in a loop in the fourth Ig-like domain (D4) that is responsible for forming homo

102 oncogenic mutation located in the C-terminal Ig-like domain (D5) of the ectodomain, rendering KIT tyr

103 tified in the most membrane-proximal seventh Ig-like domain (D7) of vascular endothelial growth facto

104 of an FcgammaRI with all three extracellular Ig-like domains (designated as D1, D2, and D3).

105 tructural motifs located in the two adjacent Ig-like domains dictate the processing of CTDs by the T9

106 rtion of CAR consists of two immunoglobulin (Ig)-like domains, each with a consensus sequence for N-g

107 n alpha-helical capsid-binding domain and an Ig-like domain exposed to the solvent.

108 nique protein architecture consisting of two Ig-like domains followed by an elongated beta-stranded d

109 rotein consists of four immunoglobulin-like (Ig-like) domains followed by six fibronectin type III do

110 of a single C2-type Ig domain resembling the Ig-like domains found in mammalian Fc receptors such as

111 which its Ig-like domain was replaced by the Ig-like domain from mouse IZUMO1.

112 Here, we show that the IG-like domain functions to keep the EGF-like domain at

113 The second Ig-like domain has been validated for self- (so-called h

114 ll-surface receptor, which contains a single Ig-like domain, has been shown to bind to SHP-1 and SHP-

115 ately 60 kD, which contains an extracellular Ig-like domain homologous to two other IgM-binding recep

116 We generated a mouse model in which 9 Ig-like domains (Ig3-Ig11) were deleted from the proxima

117 Addition of the N-terminal (D1) Ig-like domain (IGD) of gp130 to the CHR results in a tr

118 terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous t

119 ies of CD147 to its transmembrane domain and Ig-like domain II.

120 253R) in the highly conserved region linking Ig-like domains II and III of FGFR2.

121 We show that Ig-like domains II-XVI are involved in strong calcium-in

122 ain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3.

123 onds, one involving all five immunoglobulin (Ig)-like domains in an antiparallel alignment and the ot

124 te in the fourth of the five immunoglobulin (Ig)-like domains in Kit.

125 oth Flt-1 and KDR have seven immunoglobulin (Ig)-like domains in the extracellular domain.

126 Full length CD80 has two immunoglobulin (Ig)-like domains in the extracellular portion, IgC and I

127 -1-Delta2) to examine the role of the second Ig-like domain in HSV entry.

128 complex requires the membrane-proximal third Ig-like domain in IL-18Ralpha for the formation of IL-18

129 Further, we demonstrate that the first Ig-like domain in MuSK, which shares homology with the N

130 sults reveal a critical role for the tapasin Ig-like domain in tapasin function.

131 globulin (Ig) superfamily and contains three Ig-like domains in its extracellular portion.

132 ing either two or four alternatively spliced Ig-like domains in mice have been found in a number of e

133 ns reveal the presence of different types of Ig-like domains in the same phylogenetic groups, as well

134 ve agreement with force-induced unfolding of Ig-like domains in titin.

135 tro We further demonstrate in vivo that this Ig-like domain is essential, albeit not sufficient per s

136 heterodimers, the presence of the N-terminal Ig-like domain is required for efficient signal attenuat

137 These results demonstrate that a single Ig-like domain is the major determinant for VEGF-PlGF in

138 d predominant expression of the larger, four Ig-like domain isoform of B7-H3.

139 his suggests that these regions of the first Ig-like domain may contain or be close to binding sites

140 ty binding of heparin/heparan sulfate to the Ig-like domain may proceed from surface charge complemen

141 hese results provide the first example of an Ig-like domain mediating an interaction with an SRCR dom

142 h a separate interaction, leptin engages the Ig-like domain of a second liganded LEP-R, resulting in

143 sALCAM contains the single amino-terminal Ig-like domain of ALCAM and lacks a transmembrane domain

144 diate the interaction with the extracellular Ig-like domain of beta1, confirming the proposed functio

145 highly polymorphic in contrast to the single Ig-like domain of CD47.

146 ithout altering the overall structure of the Ig-like domain of CD8alpha or causing the MHCI to employ

147 his study, we report that the amino-terminal Ig-like domain of human ALCAM specifically binds to the

148 These data argue that the fourth Ig-like domain of Kit is not required for SCF-induced re

149 tion of an RGD sequence present in the sixth Ig-like domain of L1 abrogated M21 cell adhesion.

150 w that CDT interacts with the extracellular, Ig-like domain of LSR with an affinity in the nanomolar

151 tructural motifs that bind to the N-terminal Ig-like domain of mCEACAM1a.

152 presence of a nine-amino acid region in the Ig-like domain of mouse or human tapasin is required for

153 SK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and

154 functionally important regions of the first Ig-like domain of PECAM-1 that are required for the part

155 KP(621) downward arrowLI site in the seventh Ig-like domain of PTK7.

156 57BL/6 mice immunized with the extracellular Ig-like domain of rat myelin oligodendrocyte glycoprotei

157 we showed that the cysteine residues in the Ig-like domain of tapasin influence tapasin's stability,

158 otypic interactions in the membrane proximal Ig-like domain of the extracellular region differ from t

159 ated in Arg-385 or Glu-390 in D4 (the fourth Ig-like domain of the extracellular region) was compromi

160 21) downward arrowLI sequence of the seventh Ig-like domain of the full-length membrane PTK7 and gene

161 tein-geranyl-geranyl interaction face of the Ig-like domain of the Rho guanine nucleotide dissociatio

162 A mutation in the tenth Ig-like domain of titin's spring region is associated wi

163 complex with the two most membrane-proximal Ig-like domains of CD22 (CD22(d6-d7)).

164 lass II interact with the two amino-terminal Ig-like domains of CD4.

165 ated knockin mice in which the extracellular Ig-like domains of CD79A and CD79B were replaced with hu

166 These results suggest that the Ig-like domains of CD8 molecules are themselves sufficie

167 rce measurements to reveal how the first two Ig-like domains of cMyPB-C (C0 and C1) interact with the

168 ors where the first three or just the second Ig-like domains of Flt-1 replaced the corresponding doma

169 that B27(2) bound to the two membrane distal Ig-like domains of LILRB2.

170 We show that the first three Ig-like domains of MAG bind with high affinity and in a

171 The Ig-like domains of mouse CD8alphabeta and CD8alphaalpha

172 The four N-terminal Ig-like domains of neurofascin form a horseshoe shape, a

173 ntly, we show that antibodies raised against Ig-like domains of polycystin-1 disrupt cell-cell intera

174 ction region between the fifth and the sixth Ig-like domains of PTK7.

175 They bind to the extracellular Ig-like domains of soluble or native MuSK.

176 Movements of the membrane proximal Ig-like domains of tapasin, HLA-B*44:05, and beta(2)-mic

177 KIR2DL5 has two extracellular Ig-like domains of the D0 and D2 type, a structural conf

178 structure reveals that MuSK Ig1 and Ig2 are Ig-like domains of the I-set subfamily, which are config

179 d that in the physiological SL range (a) the Ig-like domains of the tandem Ig segments remain folded

180 The Ig-like domains of Trk receptors and the cysteine-rich r

181 receptor (KDR) contains seven extracellular Ig-like domains, of which the three most amino-terminal

182 II complexes utilize an unusual top-mounted Ig-like domain on IL-13R alpha1 for a novel mode of cyto

183 ike domain located C-terminally to either an Ig-like domain or a cysteine-rich domain specific to the

184 hesive domains of polycystin-1, including 16 Ig-like domains (or PKD domains) suggests that it may pl

185 s much higher in the surfaceome where Ig and Ig-like domains orchestrate cell-cell recognition, adhes

186 Mxra8 ectodomain contains two strand-swapped Ig-like domains oriented in a unique disulfide-linked he

187 In contrast, glycosylation of the Ig-like domain proximal to the membrane is key to the co

188 We found that Ig-like domains refold after mechanical unfolding.

189 pe I transmembrane protein with two pairs of Ig-like domains separated by a heptad peptide sequence.

190 e single-pass transmembrane proteins with an Ig-like domain, share the same subcellular distribution

191 ative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and

192 composed of four structural domains, namely, Ig-like domain, stalk region, transmembrane region, and

193 e (TM) protein with a single immunoglobulin (Ig)-like domain that is absolutely required for gamete f

194 phorylation, many spliced forms also have an IG-like domain that binds HSPGs and maintains a high con

195 Human and macaque MAdCAM-1 have two Ig-like domains that are similar to the two amino-termin

196 B7-H3 (named as B7-H3b hereafter) with four Ig-like domains that results from gene duplication and d

197 identified key residues in the D0 and other Ig-like domains that were shared and distinct from KIR3D

198 ts of force extension on the globular (FNIII/Ig-like) domains that comprise each protein.

199 nected to a carboxy-terminal immunoglobulin (Ig)-like domain through a beta-hairpin stabilized by dis

200 tate each of its first three immunoglobulin (Ig)-like domains to interact with SCF.

201 PD-1 use only the front beta-sheet of their Ig-like domain to bind ligands, NKp30 uses both front an

202 consist of variable numbers of extracellular Ig-like domains together with either a long cytoplasmic

203 stence length (0.43 +/- 0.04 nm), individual Ig-like domain unfolding forces (118 +/- 3 pN), or Ig ex

204 gD binding site is located within the first Ig-like domain (V domain) of HveC.

205 ructures beyond currently identified Ig- and Ig-like domain variants.

206 ressing chimeric SPE-45 protein in which its Ig-like domain was replaced by the Ig-like domain from m

207 at contains an extracellular immunoglobulin (Ig)-like domain, we postulated that it plays a role in T

208 the effects of substitutions in the tapasin Ig-like domain, we demonstrated that H-2L(d)/tapasin ass

209 recombinant neuregulins with and without the IG-like domain, we found that IG-like domain binding to

210 red protein of 181 amino acids with a single Ig-like domain weakly homologous to killer inhibitory re

211 dies (mAb) directed against individual PDGFR Ig-like domains were used to extend these observations.

212 mbinant mutants mapped the difference to the Ig-like domains, where site-directed mutagenesis showed

213 interaction is mediated mostly by the second Ig-like domain, which features an intermolecular beta-sh

214 st of tandem repeats of between two and five Ig-like domains whose amino-terminal domains (D1) intera

215 egulation was maintained after replacing the Ig-like domain with a thioredoxin protein of comparable