ライフサイエンスコーパス: Ig

1 Ig gamma marker (GM) allotypes, encoded by highly polymo

2 s cognate receptor, VEGF receptor (VEGFR)-10-Ig, is also essential for the deployment of the skeletog

3 endothelial growth factor receptor (VEGFR) 3-Ig in the skin, scavenging VEGF-C and VEGF-D, the role o

4 f CTLA4-Ig (cytotoxic T-lymphocyte antigen 4-Ig), a fusion protein blocking costimulatory signaling b

5 of the patients has been treated with CTLA-4-Ig and achieved sustained remission.

6 he inhibition of alloimmunity in that CTLA-4-Ig blocks both CD28 costimulation and CTLA-4 coinhibitio

7 Abatacept is a CTLA-4-Ig fusion protein that binds to the costimulatory ligand

8 CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these dono

9 D28 domain antibody (dAb) compared to CTLA-4-Ig led to superior inhibition of Tfh cell, germinal cent

10 in oligodendrocyte glycoprotein (MOG)(35-55) Ig-like transcript 3 (ILT3) is an inhibitory cell surfac

11 r, trackable populations of B cells in B1-8i Ig transgenic mice that express the VH186.2 H chain and

12 advance our earlier QM/MM maturation of A17 Ig-paraoxonase (WTIgP) as a reactibody for organophospho

13 The most abundant Ig heavy chains detected in both control individuals and

14 ric-ACE2 configuration, we generated an ACE2-Ig variant that neutralizes SARS-CoV-2 at picomolar rang

15 then developed potently anticoronavirus ACE2-Ig proteins that are broadly effective against the four

16 hese data demonstrate that the improved ACE2-Ig variants developed in this study could potentially be

17 We also developed recombinant ACE2-Ig proteins that are able to potently block these viral

18 05-induced B cell activation and thereby all Ig production.

19 (light and heavy chains) based on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits i

20 ch as T4, and its C-terminal domain adopt an Ig-like fold of unknown function.

21 ividuals and KC patients were Ig alpha-1 and Ig alpha-2 likely correlating to the higher IgA levels r

22 2) contributes to proliferative activity and Ig isotype production in CD19(+) cells upon BCR stimulat

23 stimulated B cells to produce cytokines and Ig.

24 diverse range of variable gene families and Ig classes, including IgA, and several showed significan

25 quences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the human IgK germline variable

26 adaptive immune system based on the MHC and Ig superfamily-based AgR.

27 Mucosal plasma cells (PC) and Ig production are essential to fend pathogens and to mai

28 utrophin are more in line with the PEVK and Ig-like repeats of titin rather than those reported for

29 nd MS patients showed similar phenotypic and Ig repertoire characteristics.

30 genesis, and Lrig1 (leucine-rich repeats and Ig-like domains 1) marks a distinct population of progen

31 B-lymphocyte survival and Ig production were assayed in vitro.

32 on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits in non-KC tears (n = 7 control i

33 ither Th1 cells or with IFNgamma, IL-2, anti-Ig and TLR7/8 ligand and that IL-21 dependent ASC format

34 d a novel lineage in the TCRdelta-associated Ig-like V segments.

35 ured in serum; calprotectin and anti-toxin B Ig A/G were measured in stool.

36 B cell development, basal Ig levels, and T-independent responses were unaffected b

37 suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to

38 mulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/mac

39 the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is expressed by tum

40 Siglec-15 is a conserved sialic acid-binding Ig-like lectin, which is expressed on osteoclasts.

41 Sialic acid-binding Ig-type lectins (Siglecs) are cell surface receptors fou

42 receptor (BCR) comprising the membrane-bound Ig (mIg) molecule and the Igalpha/Igbeta heterodimer fun

43 CD4-Ig is a fusion of the HIV-1-binding domains of CD4 with

44 e >12,000-fold more potent than sCD4 and CD4-Ig and >100-fold more potent than the broadly neutralizi

45 s showed reduced sensitivity to sCD4 and CD4-Ig but remained sensitive to neutralization by CD4-VLPs

46 esigns, including soluble CD4 (sCD4) and CD4-Ig, were ineffective.

47 rkedly greater resistance to eCD4-Ig and CD4-Ig, with correspondingly dramatic losses in infectivity

48 compared with monomeric sCD4 and dimeric CD4-Ig, we generated virus-like nanoparticles that present c

49 eCD4-Ig is more difficult than that from CD4-Ig or the bNAb NIH45-46.

50 eCD4-Ig is more difficult than that from CD4-Ig or the CD4-binding site antibody NIH45-46.

51 es have demonstrated that the potency of CD4-Ig is markedly increased by appending a coreceptor-mimet

52 eCD4-Ig is markedly more potent than CD4-Ig due to its C-terminal coreceptor-mimetic peptide.

53 swarms that were completely resistant to CD4-Ig, suggesting that escape pathways that confer resistan

54 selected under the same conditions with CD4-Ig or NIH45-46 fully escaped from those inhibitors.

55 f aging on SHM targeting, we analyzed B cell Ig repertoire sequences from 27 healthy male and female

56 ncoded within the NK complex and killer cell Ig-like receptor genes encoded within the leukocyte rece

57 sity have focused on the MHC and killer cell Ig-like receptor.

58 The killer cell Ig-like receptors (KIR) modulate immune responses throug

59 The T cell Ig and mucin domain (TIM) proteins inhibit release of HI

60 s, including programmed death (PD)-1, T cell Ig and mucin domain-containing protein 3 (TIM-3), lympho

61 se of renal epithelial damage marker (T-cell Ig and mucin domain 1) in Npr2(-/-) mice.

62 all B lymphocytes express the H and L chain Ig molecules from the intra-islet-derived anti-peripheri

63 an algorithm designed to fully characterize Ig gene rearrangements and oncogenic translocations from

64 To characterize Ig genes and specificities of antral mucosal iNOS(+) and

65 Currently, a complete Ig characterization cannot be extracted from whole-genom

66 d with reduced germinal centers, compromised Ig switch and low avidity of lymphocytic choriomeningiti

67 r study identified expression of a conserved Ig superfamily protein, Basigin, at the glial membrane o

68 ic T-lymphocyte associated protein 4 (CTLA4)-Ig-treated wild-type (WT) recipients, they were rejected

69 CTLA4-Ig reduced CD4(+) central memory and effector memory T c

70 CTLA4-Ig was also significantly less effective in older recipi

71 ased expression of CD28 with aging and CTLA4-Ig treatment in old recipients resulted in reduced frequ

72 uppressive molecules such as PD-L1 and CTLA4-Ig.

73 e, we assessed age-specific effects of CTLA4-Ig (cytotoxic T-lymphocyte antigen 4-Ig), a fusion prote

74 rejected at ~30 days in MR1-treated or CTLA4-Ig-treated recipients selectively deficient in C5aR1 res

75 mulation blockade-based strategy using CTLA4-Ig and anti-CD154 antibodies to modulate T-cell activati

76 ained inhibition of PC generation with CTLA4-Ig or belatacept (B/B).

77 n young mice (2-3 months) treated with CTLA4-Ig survived indefinitely, whereas 80% of old recipients

78 data reveal high galactosylation like anti-D Ig (>60%) together with lower fucosylation (<60%) as saf

79 lastoid cell lines (B) was similar to anti-D Ig although fucosylation varied, affecting ADCC activity

80 ll lines) and one blood donor-derived anti-D Ig were obtained by HPLC and mass spectrometry using 3 m

81 Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus

82 mmunisation but less effectively than anti-D Ig.

83 ore efficient ADCC and clearance than anti-D Ig.

84 is challenged by the existence of different Ig isotypes and subclasses, their varying serum concentr

85 (D)J recombination assembles and diversifies Ig and T cell receptor genes in developing B and T lymph

86 V-domain Ig suppressor of T-cell activation (VISTA) is an immune

87 eCD4-Ig is markedly more potent than CD4-Ig due to its C-term

88 eCD4-Ig-resistant viruses acquired unique changes in the V2 a

89 d not directly affect neutralization by eCD4-Ig or neutralizing antibodies.

90 tions will be necessary to fully escape eCD4-Ig without loss of viral fitness.IMPORTANCE HIV-1 broadl

91 investigated whether viral escape from eCD4-Ig is more difficult than that from CD4-Ig or the CD4-bi

92 istant to but did not fully escape from eCD4-Ig.

93 The engineered HIV-1 entry inhibitor eCD4-Ig has greater breadth than bNAbs and similar potency.

94 and exceptionally broad entry inhibitor eCD4-Ig is more difficult than that from CD4-Ig or the bNAb N

95 ngineered antibody-like entry inhibitor eCD4-Ig neutralizes every human immunodeficiency virus type 1

96 The exceptional breadth of eCD4-Ig derives from its ability to closely and simultaneousl

97 rm selected with high concentrations of eCD4-Ig was increasingly resistant to but did not fully escap

98 iral fitness without affecting serum or eCD4-Ig sensitivity.

99 These data suggest that eCD4-Ig will be more difficult to escape and that even partia

100 ulted in markedly greater resistance to eCD4-Ig and CD4-Ig, with correspondingly dramatic losses in i

101 iruses that were partially resistant to eCD4-Ig were markedly less infective and more sensitive to an

102 The observed elevated Ig-levels, distortion in IgM(+) B cells, increase in dou

103 ies among a growing number of taxa employing Ig-TCRdelta rearrangements that blend these distinct lin

104 IgA antibodies with mice lacking AID-enabled Ig affinity maturation, we found that IgA deposition and

105 For seven of 14 recombinantly expressed Ig, Ag specificity could be determined.

106 gene conversion to diversify their expressed Ig loci, whereas mice and humans rely solely on untempla

107 de-bridged dimerization of the extracellular Ig domains of Igalpha and Igbeta.

108 lation is mediated by a transcription factor Ig (TIG/IPT) domain, a fold found in the NF-kappaB famil

109 This structure reveals that of the five Ig-like polycystic kidney disease (PKD) domains in AAVR,

110 D40 ligand and secreted cytokines that guide Ig class switching.

111 A broad range of anti-HAV Ig plasma titers was observed among these centers, with

112 Importantly, elevated anti-HAV Ig titers were broadly observed across plasma units obta

113 of genes in this region drove elevated HER2 Ig levels.

114 rticularly important for sustaining the high Ig production in IgG(+) B cells.

115 nalyzing a large collection of 956,157 human Ig sequences while controlling for the confounding influ

116 of templated mutagenesis in murine and human Ig loci that are similar to or even higher than the orig

117 nesis readily occurs at the murine and human Ig loci.

118 onstrated the successful expression of human Ig genes and antibodies.

119 Strikingly, CP antagonism suppressed human Ig-induced activation of B cells derived from patients w

120 -target genes, its role at the hypermutating Ig locus in the germinal center is unexplored.

121 f an extracellular region with hypervariable Ig domains, a transmembrane domain, and a cytoplasmic ta

122 All women had CMV immunoglobin (Ig) G and IgM testing at 11-14 weeks of each pregnancy.

123 alizing antibodies, anti RSV-F immunoglobin (Ig) G, and ChAd155 neutralizing antibodies.

124 Immunoglobulin (Ig) domains on the phage surface interact with mucin mol

125 Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are

126 Immunoglobulin (Ig) glycosylation is recognized for its influence on Ig

127 ymphocyte antigen 4 (CTLA-4) immunoglobulin (Ig), Qa-1 mutant mice developed robust donor-specific an

128 on blockade using the CTLA-4-immunoglobulin (Ig) fusion protein (abatacept) in a mouse model of diabe

129 ics (QM/MM) maturation of an immunoglobulin (Ig) powered by supercomputation delivers novel functiona

130 of T cell receptor (TCR) and immunoglobulin (Ig) genes by V(D)J recombination generates the antigen r

131 kines and anti-toxin A and B immunoglobulin (Ig) were measured in serum; calprotectin and anti-toxin

132 responsiveness, we developed immunoglobulin (Ig)-knockin mice with elevated numbers of PfCSP-binding

133 V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune

134 nephritis by downregulating immunoglobulin (Ig)G, IgG1, and IgG2a production.

135 B cells will express either immunoglobulin (Ig) light chain kappa or lambda, we designed a second-ge

136 previously shown that fecal immunoglobulin (Ig) A levels are decreased in mice fed a diet free of ar

137 , we studied the anti-glycan immunoglobulin (Ig) G and IgM responses in vaccinated and challenged bab

138 comprising the entire human immunoglobulin (Ig) gene repertoire in the germline configuration was in

139 d protein with a single IgC2 immunoglobulin (Ig) domain and a high-quality signal peptide [9], and we

140 ne deaminase (AID) initiates immunoglobulin (Ig) class switch recombination (CSR), somatic hypermutat

141 a (MM) arises from malignant immunoglobulin (Ig)-secreting plasma cells and remains an incurable, oft

142 t the role of the monoclonal immunoglobulin (Ig) light chain (LC) is strongly suspected because of th

143 tein-specific T-cell but not immunoglobulin (Ig) M or IgG antibody responses.

144 upon serial measurements of immunoglobulin (Ig) M and IgG and on IgG avidity in sera collected at ea

145 we investigated the level of immunoglobulin (Ig)G targeting the different types of PfEMP1 CIDR during

146 5 days after disease onset, immunoglobulin (Ig) M, IgA, and total antibody ELISAs increased in sensi

147 Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be

148 B cells exhibited restricted immunoglobulin (Ig) light chain expression (either Igkappa or Iglambda),

149 Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds p

150 ion, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibo

151 for quantification of serum immunoglobulin (Ig) levels, specific antibodies against Streptococcus pn

152 ontrol), and peanut-specific immunoglobulin (Ig)E concentration of more than 4 kU/L.

153 ld increase in GI.1-specific immunoglobulin (Ig)G titers when compared with baseline.

154 sma pneumoniae (Mp)-specific immunoglobulin (Ig)M antibody-secreting cells (ASCs) improved diagnosis

155 e genetic variability of the immunoglobulin (Ig) and T cell receptor (TR) gene loci.

156 on process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protec

157 ntigen demonstrated that the immunoglobulin (Ig) G1 response is a potential indicator of a patient's

158 repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editin

159 and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene.

160 igen driven, we examined the immunoglobulin (Ig) repertoire of diseased tissue from each BA group.

161 The immunoglobulin (Ig) superfamily protein BTLA regulated HVEM-expressing B

162 that SAMHD1 localizes at the immunoglobulin (Ig) switch region, and serves as a novel DNA repair regu

163 A therapeutic immunoglobulin (Ig) G(1) monoclonal antibody lost more than half of its

164 cytidine deaminase (AID) to immunoglobulin (Ig) loci promotes antibody class switch recombination (C

165 In addition to immunoglobulin (Ig)G and IgM serology and traditional reverse-transcript

166 re antibody (anti-HBc) total immunoglobulin (Ig) or IgG, and antibody to hepatitis B surface antigen-

167 vices from 2008 to 2017 with immunoglobulin (Ig) M and IgG tested at diagnosis were classified accord

168 Microbiota (total and immunoglobulin [Ig]A-coated) in intestinal samples were analyzed by16S a

169 plantation than in controls (immunoglobulin [Ig]G1, P < .001; IgG3, P < .001).

170 d plasma antibody responses (immunoglobulin [Ig] M, IgA, and IgG) to these antigens by means of enzym

171 In Ig light-chain (LC) amyloidosis (AL), the unique antibod

172 upted resulting in a substantial decrease in Ig production, PI3Kdelta kinase-dead mutant donor bone m

173 ndividuals with no significant difference in Ig kappa/Ig lambda ratios or heavy chain levels.

174 asma cell subsets, somatic hypermutations in Ig genes, and in vitro proliferation and antibody produc

175 deaminase (AID) generates U:G mismatches in Ig genes that can be converted into untemplated mutation

176 o TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient-d

177 g RGYW/WRCY hotspot motifs in the individual Ig genes, indicating T cell-dependent maturation.

178 ation of human peripheral blood B cells into Ig-producing cells, we aimed to study the role of ROS ge

179 ood-brain barrier breakdown, and intrathecal Ig synthesis.

180 nt cleavage of pooled human IgG (intravenous Ig) in vitro upon endopeptidase treatment.

181 In mice passively immunized with intravenous Ig, IdeS administration decreased anti-AAV antibodies an

182 ins) based on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits in non-KC tears (n = 7

183 s with no significant difference in Ig kappa/Ig lambda ratios or heavy chain levels.

184 Variegated expression of killer Ig-like receptors (KIR) in human NK cells is a stochasti

185 ns at the single-cell level of the kinetics, Ig repertoire, and activation phenotype of established p

186 tic E. coli, the diffusive T4 mutant lacking Ig domains outperformed the subdiffusive T4 wild type.

187 heavy chains) based on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits in non-KC te

188 ey transplant patients, cells from leukocyte Ig-like receptor B1 (LILRB1) transgenic mice, humanized

189 variable regions and allow single cell level Ig and TCR repertoire analysis.

190 nalyses indicated that PD-1H has a very long Ig variable region (IgV)-like domain and extraordinarily

191 bone marrow transplantation exhibited lower Ig levels in vivo compared to controls despite normal pe

192 artly resembled that of MALT B cell lymphoma Ig genes, suggestive of a mechanism in which a progressi

193 ata, we generate a collection of 3.6 million Ig sequences, termed the atlas of immunoglobulin reperto

194 from infection through production of natural Ig, which is germline-like due to minimal insertion of N

195 mutation (SHM), whereas AID targeting of non-Ig loci can generate oncogenic DNA lesions.

196 analyzed using productive and nonproductive Ig sequences, respectively.

197 dependent or -independent Ag elicited normal Ig isotype secretion in the Duox1 mutant mice.

198 bodies consist of a configuration of normal Ig scaffolds that undergo natural diversification in B c

199 ely regulates proliferative activity but not Ig isotype production in primary splenic CD19(+) B cells

200 The analysis of Ig repertoire in control trout suggests different struct

201 The diversity of Ig and TCR repertoires is a focal point of immunological

202 Moreover, the flow of Ig clonotypes and inter-tissue repertoire similarities a

203 It can also assist in the investigation of Ig- and TR-related genetic predispositions to diseases.

204 is of the Ig repertoire provided measures of Ig clonality and the Ig phenotype.

205 However, the large-scale profiling of Ig glycosylation in a biomedical setting is challenged b

206 nce of this kinase led to increased rates of Ig production and elevated serum Ab concentrations elici

207 ostasis and longevity but restrains rates of Ig production.

208 nd serves as a novel DNA repair regulator of Ig class switch recombination (CSR).

209 ) CD19(+) B cells showed normal responses of Ig production but a higher rate of proliferation than WT

210 gradation machinery, as well as secretion of Ig light chains and of cytokines and chemokines known to

211 During somatic hypermutation (SHM) of Ig genes in germinal center B cells, lesions introduced

212 However, the diagnostic value of Ig LC sequencing, especially in the case of incomplete f

213 oglobulins (light and heavy chains) based on Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain

214 osylation is recognized for its influence on Ig turnover and effector functions.

215 s, class switch recombination, and oncogenic Ig translocations.

216 es four thrombospondin (TSP) domains and one Ig-like domain and binds NLG-1.

217 roduced by copying short segments from other Ig genes.

218 sitivity was a positive result with both pan-Ig assays.

219 ssays (including two pan-immunoglobulin [pan-Ig] assays), and we determined that the appropriate meas

220 antiviral antibody titers assayed by two pan-Ig assays increased during 2 months after diagnosis by q

221 presence of multiple glycosylation sites per Ig.

222 Polymeric Ig receptor (pIgR)-mediated IgA transport into the intes

223 The polymeric Ig receptor (PIgR) constitutes an important part of the

224 meric (d) IgA that is bound by the polymeric Ig-receptor ectodomain, called secretory component (SC).

225 eviously shown to be also used in rearranged Ig loci of MALT B cell lymphomas.

226 avy- and light-chain sequences of rearranged Ig genes from multiple descendants of the same naive B c

227 H. pylori infection, we sequenced rearranged Ig genes from single cell-sorted PC from biopsy specimen

228 ike protein can bind to a BCMA-like receptor Ig fusion protein and to both BCMAL1- and BCMAL2-transfe

229 is known to bind inhibitory Sia-recognizing Ig superfamily lectins (Siglecs) to block neutrophil and

230 tissue types that often do not have reported Ig repertoires information.

231 se, a non-domain region of 647-742 residues, Ig domain, Fn3 domain and a second kinase domain.

232 hase II SHM activities impacts the resulting Ig phenotypes.

233 nable future studies to fully capture rhesus Ig and TCR repertoire diversity and is applicable for im

234 all known isotypes and chain types of rhesus Ig and TCR repertoires.

235 across the entire variable regions of rhesus Ig and TCR transcripts.

236 icant fraction (27-53% and 42-49%) of rhesus Ig/TCR diversity.

237 mplification strategies for profiling rhesus Ig and TCR repertoires are largely unknown.

238 The binding specificity of individual PC's Ig was determined following recombinant expression.

239 the same at different positions in the same Ig sequence.

240 Analysis of the nurse shark Ig-TCRdelta repertoire found that these rearrangements p

241 plasmablast/plasma cells with highly similar Ig heavy-chain sequences across MS subjects, similaritie

242 The structures reveal that PirB's six Ig-like domains are arranged at acute angles, similar to

243 IgG(+) memory B cells and allergen-specific Ig levels.

244 CR, next-generation sequencing, and specific Ig-ELISA were used to characterize the cells functionall

245 osal iNOS(+) PC producing H. pylori-specific Ig accumulate in infection and appear to be a product of

246 H. pylori-specific Ig are encoded by V and J family genes previously shown

247 e ability of nasal vaccines to induce spleen Ig responses.

248 hile CD19 belongs to the extensively studied Ig superfamily, CD81 belongs to a poorly understood fami

249 IgG3 levels, suggesting that TCZ suppresses Ig production in B cells nonspecifically, likely through

250 Mxra8 ectodomain contains two strand-swapped Ig-like domains oriented in a unique disulfide-linked he

251 d processing event eliminates the C-terminal Ig-like domain along with the ability of N-MADD-4B to bi

252 , the results of this study demonstrate that Ig GM 17/17 genotype contributes to the risk of later AD

253 The Ig repertoires of iBA and BASM disease groups were oligo

254 argeted regardless of its position along the Ig sequence.

255 re provided measures of Ig clonality and the Ig phenotype.

256 the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the hu

257 sence/absence of autoantigen by crossing the Ig KI mice to Tgm2-/- mice.

258 ficient B cells were mostly specific for the Ig V region, suggesting a local or time-dependent need f

259 l rather than developmental function for the Ig-domain protein.

260 Furthermore, the Ig-TCRdelta rearrangements are expressed with TCRgamma,

261 These data identify the Ig-like domain as the primary determinant for N-MADD-4B

262 Uracils in the Ig gene loci can be recognized by uracil DNA glycosylase

263 In this proposed process, mutations in the Ig locus are introduced by copying short segments from o

264 Moreover, the Ig's molecular features partly resembled that of MALT B

265 Deep sequencing of the Ig chain DNA was performed on iBA and BASM biliary remna

266 interactions between the beta-sheets of the Ig domains.

267 n of switch regions, located upstream of the Ig heavy chain (IgH) constant genes.

268 ) data due to the inherent complexity of the Ig loci.

269 H for studying the genetic properties of the Ig loci.

270 Statistical analysis of the Ig repertoire provided measures of Ig clonality and the

271 thod for rapid and accurate profiling of the Ig repertoire, including the complementary-determining r

272 or broader functionalities of members of the Ig superfamily, including cell surface-exposed receptors

273 SLAMF6 is a homotypic receptor of the Ig-superfamily whose exact role in immune modulation has

274 A to FCRL4 following heat aggregation of the Ig.

275 eceptors (TLRs) are critical for shaping the Ig repertoire of B-1a cells as well as regulating their

276 exhibit intrinsic biases when targeting the Ig sequences.

277 ranscriptomic approaches, we report that the Ig superfamily protein GPA33 is expressed on a subset of

278 ha, which, similar to ICAM-1, belongs to the Ig superfamily and has previously been implicated in cel

279 ty binding of heparin/heparan sulfate to the Ig-like domain may proceed from surface charge complemen

280 n via somatic hypermutation (SHM) within the Ig variable H (VH) and variable L (VL) chains and Fab-N-

281 urate annotation and quantification of their Ig and TCR repertoires.

282 , as shown by somatic hypermutation of their Ig genes in adaptive immune receptor repertoire sequenci

283 butor to somatic hypermutation and therefore Ig diversification in mice and humans.

284 n-induced cytidine deaminase and, therefore, Ig class switch DNA recombination, as central to the mat

285 tro We further demonstrate in vivo that this Ig-like domain is essential, albeit not sufficient per s

286 widely distributed family of two- and three-Ig domain molecules with neuronal wiring functions, whic

287 Using a sensitive high-throughput Ig repertoire sequencing on RNA (rapid amplification of

288 e found that the Ortho anti-SARS-CoV-2 total Ig and IgG high-throughput serological assays (HTSAs) an

289 rovides quantitative information about total Ig, as well as IgG- and IgM-specific responses.

290 MNs is mediated by interacting transmembrane Ig superfamily proteins DIP-alpha and Dpr10, present in

291 The transmembrane Ig domain protein Basigin/CD147/EMMPRIN is highly expres

292 , full-length sequences for over 6000 unique Ig and TCR transcripts, without the need for sequence as

293 Using K14-VEGFR3-Ig mice that constitutively express soluble vascular end

294 pose tissue from melanoma-bearing K14-VEGFR3-Ig mice, which were further enriched with alternatively

295 us fish, with adaptive immunity provided via Ig and TCR lineages, and is one species among a growing

296 oth control individuals and KC patients were Ig alpha-1 and Ig alpha-2 likely correlating to the high

297 ecule (CD96), and T-cell immunoreceptor with Ig and ITIM domains (TIGIT) play a crucial role in regul

298 eath-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a function

299 dies against PD1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), or CD8 before the cancer ce

300 ne 3 (LAG-3), and T cell immunoreceptor with Ig and ITIM domains (TIGIT).