ライフサイエンスコーパス: IgA

1 IgA sequencing analysis indicated that human ILFs are si

2 IgA(+)CD138(+) plasma cells from Peyer's patches and lam

3 IgA, IgM, and IgG and neutralizing antibody responses we

4 IgA-mediated programmed neutrophil death was PI3K-, p38

5 IgAs are transported across the epithelium, as dimers an

6 VID, P<0.001), and anti-Beta2 Glycoprotein-1 IgA (sdCOVID and scCOVID, P<0.001).

7 ntibodies were 133.3/106 (IgG) and 16.7/106 (IgA) in peripheral blood mononuclear cells (PBMCs).

8 of immunoglobulins A specific to SARS-CoV-2 (IgA) in saliva and serum is needed to complement tests t

9 9 days postchallenge with an average of 3253 IgA and 1227 IgG antibody-secreting cells per million pe

10 t other antibody isotypes (IgG(1) , IgG(4) , IgA, and IgD) may have a protective function; yet, their

11 Some 103 (2.53%) IgA nephropathy patients had an earlier inflammatory bow

12 hedders showed seroconversion for IgG (80%), IgA (78%), and blockade antibodies (87%).

13 The specificities of the ELISAs were 83% (IgA), 98% (IgG), and 97% (IgM and total antibody).

14 BP230 (MBL International), immunoglobulin A (IgA) A and immunoglobulin G indirect immunofluorescence

15 motes systemic and mucosal immunoglobulin A (IgA) and T cell responses, and almost entirely prevents

16 accine serum antirotavirus immunoglobulin A (IgA) as an individual-level immune correlate of protecti

17 Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoim

18 Norovirus-specific immunoglobulin A (IgA) levels in baseline saliva samples were low and incr

19 A common renal disease, immunoglobulin A (IgA) nephropathy (IgAN), is associated with glomerular d

20 he induction of intestinal immunoglobulin A (IgA).

21 nd Huus et al. reveal that nutrition affects IgA responses to the microbiota and oral vaccines.

22 comparing mice able to produce high-affinity IgA antibodies with mice lacking AID-enabled Ig affinity

23 in 29 (46%), IgG were found in 27 (43%), and IgA were found in 27 (43%) CAP patients.

24 an half of patients had IgM (21/35, 60%) and IgA (20/35, 57%) vs (3/52, 5%) each in healthy controls.

25 Membranous nephropathy (MN, 24.96%) and IgA nephropathy (IgAN, 24.09%) were the most common prim

26 NF-alpha), and IgG anti-toxin A in blood and IgA/G anti-toxin B in stool were significantly higher in

27 propria were analyzed by flow cytometry and IgA repertoire was determined by next-generation sequenc

28 ifically hampering gut lymphocyte homing and IgA(+) plasma cell differentiation.

29 Higher total IgA and IgA-aPL were consistently associated with severe illness

30 by the detection of IL-1beta, total IgA, and IgA specific to Mycobacterium tuberculosis antigen in th

31 mine CD27(+) and CD27(-) IgG(+) , IgE(+) and IgA(+) memory B cells, Th1, Th2, Th17, and Treg-memory c

32 Serum IgG and IgA antibodies against SARS-CoV-2 spike protein were det

33 h levels of neutralizing GP-specific IgG and IgA antibodies.

34 s, with successful detection of IgM, IgG and IgA antibody-antigen interactions.

35 Vero-E6-TMPRSS2 cells; a commercial IgG and IgA ELISA to detect the spike (S) protein S1 domain (EUR

36 method for simultaneous analysis of IgG and IgA glycopeptides was developed and applied on a serum s

37 Measurements of IgG and IgA in human rectal secretions are used to evaluate the

38 fied bNAb lineages with neutralizing IgG and IgA members targeting distinct sites of HIV-1 Env vulner

39 age and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the

40 ar lavage levels of anti-P6-specific IgG and IgA that were protective, with immunized mice exhibiting

41 the magnitude of the anti-SARS-CoV-2 IgG and IgA titers.

42 Prior to trypsin digestion, IgG and IgA were enriched simultaneously, followed by a one-step

43 ities and functions differed between IgG and IgA, with antiviral functions (neutralization and phagoc

44 anscriptional signature shared by IgG(+) and IgA(+) swMBCs and distinct from NBCs, while unswMBCs dis

45 class-switched to immunoglobulin G (IgG) and IgA.

46 linked immunosorbent assay for IgM, IgG, and IgA anti-SARS-CoV-2 antibodies.

47 he levels of immunoglobulin G (IgG), IgM and IgA antibodies against four SARS-CoV-2 antigens.

48 D-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG ant

49 S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation perio

50 Although robust IgM and IgA responses evolved in both survivors and non-survivor

51 While IgM and IgA secretion by IghPax5/+ plasma cells was normal, IgG

52 ID-19 patients make high titer IgG, IgM, and IgA Ab responses to the Cys-like protease from SARS-CoV-

53 LIPS) assays, we characterized IgG, IgM, and IgA antibodies to the spike receptor binding domain (RBD

54 LISA to assess serum levels of IgG, IgM, and IgA autoantibodies against FceRIalpha and investigated w

55 eveloped competitive ELISA for IgG, IgM, and IgA autoantibodies to FceRIalpha.

56 Immunogenicity and IgA induction by the microbiota is determined by inter-b

57 ked to increased circulating IgA levels, and IgA nephropathy, the most common form of primary GN and

58 ing; infant gut microbiota, metabolites, and IgA; and childhood body mass index and atopy in 1667 inf

59 and determined that ZmpA, ZmpD proteins, and IgA protease, were uniquely found in ST615.

60 domain (RBD) was predictive of survival and IgA against the viral spike protein (S protein) associat

61 antigen induced specific IgG (systemic) and IgA (mucosal) responses against LTB, ST, and LptD epitop

62 Rheumatoid factors (RFs)-IgM and -IgA were measured by ELISA.

63 ed gliadin peptide, and endomysial antibody (IgA).

64 Postvaccination antirotavirus IgA is a valuable correlate of protection against rotavi

65 or had significantly greater serum antitoxin IgA and IgG against toxins A (P = .02 for both) and B (P

66 albumin, lactoferrin, lysozyme, antitrypsin, IgA, and osteopontin).

67 a strongly suggest that a vigorous antiviral IgA-response, possibly triggered in the bronchial mucosa

68 As IgA threshold increased, risk of rotavirus gastroenterit

69 Variants of these bNAbs reconstituted as IgA demonstrated broadly neutralizing activity, and the

70 G patients, total B-cell numbers, as well as IgA + and IgG + switched memory B cells, were reduced wh

71 a, and IgG anti-toxin A in blood, as well as IgA and IgG anti-toxin B in stool, separated CDI patient

72 rodentium-specific IgA production as well as IgA(+)CD38(+)CD138(-) memory B cells in Peyer's patches

73 sequencing of SIgA-coated/uncoated bacteria (IgA-Biome) was conducted on stool and saliva samples of

74 ethod, novel associations were found between IgA N- and O-glycosylation and age.

75 The functional links between IgA deposition, inflammation, and matrix remodelling are

76 os (HRs) describing the relationship between IgA thresholds and occurrence of rotavirus gastroenterit

77 ither four (LF2 and BGLF2 IgG, LF2 and BMRF1 IgA) or two (LF2 and BGLF2 IgG) antibodies on dichotomou

78 Among the 71 women who were positive by both IgA and IgM antibody tests, 61 (85.9%) were acutely infe

79 Moreover, both IgA(+) and IgG(+) double negative (IgD(-) CD27(-)) CD11c

80 rthritis, or sepsis were susceptible to both IgA- and IVIG-mediated death.

81 to one face, asymmetrically contacting both IgAs and JC.

82 A labelled anti-human IgA reveals the bound IgA fraction.

83 highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential

84 ly correlated with elevated anti-Cardiolipin IgA (sdCOVID and scCOVID, p-value<0.001), anti-Cardiolip

85 tal IgA(+) B cells as well as CD38(+)CD138(-)IgA(+) memory B cells were significantly increased in in

86 The associations of higher Treg and CD27(+) IgA(+) B-cell numbers in children with food-allergic sen

87 sensitization had higher total B and CD27(+) IgA(+) memory B-cell numbers (15.2% [95% CI 3.2; 28.7],

88 d higher Th2, Treg, Treg-memory, and CD27(+) IgA(+) memory B-cell numbers compared to children withou

89 thermore, IL-21 significantly induced B cell IgA production in vitro, with the increased expression o

90 inst microbes (anti-Saccharomyces cerevisiae IgA or IgG, anti-Escherichiacoli outer membrane porin C,

91 ne condition linked to increased circulating IgA levels, and IgA nephropathy, the most common form of

92 ease also was more common before a confirmed IgA nephropathy diagnosis.

93 stasis, the mouse and human meninges contain IgA-secreting plasma cells.

94 h, flaxseed, and micronutrients augmented CT-IgA production.

95 ed bacterial invaders conferred augmented CT-IgA responses in mice fed the supplemented diet and colo

96 h one joining-chain (JC) to form dimeric (d) IgA that is bound by the polymeric Ig-receptor ectodomai

97 ng signs of affinity maturation, gut-derived IgA monoclonal antibodies are cross-reactive in the sens

98 We report that plasma-derived IgA efficiently triggers death of neutrophils primed by

99 Our findings suggest that plasma-derived IgA might provide a therapeutic option for the treatment

100 pecific intestinal IgA yet failed to develop IgA in the FRT, indicating that IgA response in the FRT

101 A1, IgA2, and the joining chain from dimeric IgA.

102 ymphocytes and gastric microbes that enhance IgA production.

103 uantitate the levels of epitope-specific (es)IgA, esIgE, esIgD, esIgG(1) , and esIgG(4) antibodies di

104 the spike (S) protein S1 domain (EUROIMMUN); IgA, IgG, and IgM indirect ELISAs to detect the full-len

105 Fecal IgA production depends on colonization by a gut microbio

106 Most importantly, younger age fecal IgA -abundance and -nAg reactivity of lupus-prone mice s

107 Overall, these observations show that fecal IgA features, nuclear antigen reactivity particularly, a

108 reactivity to Rv0134 and an AUC of 0.98 for IgA reactivity to both Rv0629c and Rv2188c.

109 ral flow immunoassay (LFIA) immunosensor for IgA in serum and saliva.

110 nder the curve (AUC) of 1.0 was observed for IgA reactivity to Rv0134 and an AUC of 0.98 for IgA reac

111 ELISA sensitivity for IgA or IgG detection was 67.9% (95% CI, 59.4%-75.6%), in

112 tients, all the individual tests, apart from IgA IIF, and all test combinations were significantly di

113 s framework will inform the design of future IgA-based therapeutics.

114 A given IgA threshold provided better protection in low compared

115 ng a significantly lower level of anti-gp350 IgA at peak response.

116 owever, the bacterial strains that drive gut IgA production remain largely unknown.

117 ovatus as the species that best induced gut IgA production.

118 In the gut, IgA contributes to the establishment of a mutualistic ho

119 y transplanting a multiplex cocktail of high IgA-inducing B. ovatus strains but not individual ones.

120 The high IgA-inducing B. ovatus strains preferentially elicited m

121 atients with severe COVID-19, with very high IgA titers seen in patients with severe acute respirator

122 ustly and consistently converted into a high-IgA phenotype by transplanting a multiplex cocktail of h

123 Ig alpha-2 likely correlating to the higher IgA levels reported in human tears.

124 However, IgA was found only in the vaginal washes and fecal extra

125 A labelled anti-human IgA reveals the bound IgA fraction.

126 the reaction of the HRP-labelled anti-human IgA with a H(2)O(2)/luminol/enhancers substrate.

127 nal provided by nanogold-labelled anti-human IgA.

128 over and characterize a cross-reactive human IgA monoclonal antibody, MAb362.

129 ed with a vigorous total IgA response and if IgA antibodies are associated with complications of seve

130 In IgA nephropathy (IgAN), IgA immune complexes are deposited in the mesangium and

131 um concentrations of immunoglobulin G (IgG), IgA, and usually IgM, together with loss of protective a

132 vely capture anti-dsDNA autoantibodies (IgG, IgA and IgM AAbs) present in the sera of patients with r

133 om the pre-COVID-19 era were tested for IgG, IgA, and IgM to the antigen panel.

134 deposition of at least 1 of either IgM, IgG, IgA, or C3 at the basement membrane of the specimen; non

135 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens.

136 on of the device did not interfere with IgG, IgA, or hemoglobin ELISA.

137 fferential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity ma

138 (HPT) processing on the immunoglobulin (IgM, IgA and IgG), and cytokine content (IL-6, IL-8, IL-10, a

139 secondary antibodies (HRP-anti-human IgG/IgM/IgA mixture).

140 In IgA nephropathy (IgAN), IgA immune complexes are deposit

141 Differences in IgA-Biome alpha diversity were apparent for both stool a

142 Rs) for future inflammatory bowel disease in IgA nephropathy and conditional logistic regression to a

143 isk of earlier inflammatory bowel disease in IgA nephropathy.

144 bowel disease affects development of ESKD in IgA nephropathy.

145 ro-inflammatory cytokines and an increase in IgA levels and short chain fatty acids (SCFAs) in both t

146 tly modify a gut immune phenotype, including IgA production.

147 t increases in SCFA production and increased IgA levels.

148 In healthy individuals, IgA is the dominating isotype, whereas patients with inf

149 mals developed Chlamydia-specific intestinal IgA yet failed to develop IgA in the FRT, indicating tha

150 In contrast to IVIG, IgA did not promote cell death of quiescent neutrophils.

151 dies, where neutralizing antibody (and local IgA) may be a correlate of susceptibility/severity; (2)

152 mmune deficiency (hypogammaglobulinemia [low IgA], splenomegaly, and diminished immunization response

153 Remarkably, a low-IgA phenotype in mice could be robustly and consistently

154 ates in increased lamina propria and luminal IgA.

155 after disease onset, immunoglobulin (Ig) M, IgA, and total antibody ELISAs increased in sensitivity

156 e show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody res

157 Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2

158 The median IgA yield of samples using the OriCol method (75,253 ng)

159 memory IgA(+) B cell development and memory IgA responses in the intestines is still not completely

160 dicating a potential role of IL-21 in memory IgA(+) B cell responses in the intestines.

161 trated that IL-21 promotes intestinal memory IgA B cell development, possibly through upregulating di

162 However, how IL-21 regulates memory IgA(+) B cell development and memory IgA responses in th

163 /-) mice showed decreased Ag-specific memory IgA production in the intestines upon infection with Cit

164 ntravenous challenge, showing that meningeal IgA is essential for defending the central nervous syste

165 receptor sequencing confirmed that meningeal IgA(+) cells originated in the intestine.

166 eactivity profile of native human monoclonal IgA antibodies.

167 sma cells in mesenteric lymph nodes and more IgA-coated commensal bacteria in feces of DeltaDC mice.

168 ovatus strains preferentially elicited more IgA production in the large intestine through the T cell

169 esponses to A/H3N2 and B, but only a mucosal IgA response to A/H1N1.

170 al infection induced a serum IgM and mucosal IgA response against the toxin, but a low serum IgG resp

171 This Review discusses how mucosal IgA responses occur in an increasingly complex humoral d

172 microbiota-dependent differences in mucosal IgA responses to oral vaccination with cholera toxin (CT

173 cantly higher titers of RSV-specific mucosal IgA antibodies.

174 was no significant difference in the mucosal IgA repertoire of I-Ab(DeltaIEC) vs control mice, but op

175 icipants, there were inverse associations of IgA and lactoferrin concentrations with motor skills (P

176 bacterial clearance by decreasing binding of IgA to commensal and pathogenic bacteria.

177 tion of FCRL4 was demonstrated by binding of IgA to FCRL4 following heat aggregation of the Ig.

178 rowing evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA o

179 antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form di

180 fordable and ultrasensitive determination of IgA to SARS-CoV-2.

181 of the IgA response revealed an expansion of IgA(+) germinal center B cells and plasma cells in mesen

182 xplain these apparently opposing features of IgA, being at the same time cross-reactive and selective

183 from integrating the protective functions of IgA, these hitherto neglected mucosal antibodies may str

184 In humans, several grams of IgA are secreted every day in the intestinal lumen.

185 ducing pathways and the functional impact of IgA on mucosal commensal bacteria.

186 els of IgE, IgG1, IgG2a and higher levels of IgA antibodies than control mice.

187 cted at 9-12 months underwent measurement of IgA, IgG, and IgM against TCD toxins A and B and neutral

188 etaGeo) mice contained diminished numbers of IgA-secreting cells, while elevated germinal center B ce

189 ith Citrobacter rodentium, the percentage of IgA(+)CD38(+)CD138(-) memory B cells in Peyer's patches

190 ice resulted in the diminished production of IgA in the intestine and the nAg reactivity of these ant

191 -Ab(DeltaIEC) mice had a lower proportion of IgA-coated bacteria compared with control mice, and a re

192 ucible enough for the semi-quantification of IgA in subjects with a strong serological response and i

193 Notably, lung mucosal quantities of IgA cross-reactive with beta-glucan or chitosan/chitin a

194 ined the abundance and the nAg reactivity of IgA antibody produced in the intestine under lupus susce

195 However, the antigen specificity of IgA and IgG for the microbiota and underlying mechanisms

196 IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scorin

197 ne complexes, with no anticipated effects on IgA, IgM, IgE, complement, plasma cells, B cells, or oth

198 ucosal surfaces have historically focused on IgA.

199 While only one IgA isotype exists in mice, humans secrete IgA1 and IgA2

200 cific depletion of meningeal plasma cells or IgA deficiency resulted in reduced fungal entrapment in

201 ls of IgM-anti-FceRIalpha, but not of IgG or IgA against FceRIalpha, were linked to low blood basophi

202 Elevated IgM, but not IgG or IgA, autoantibodies were significantly more frequent in

203 , IgD(+) unswitched (unsw)MBCs and IgG(+) or IgA(+) class-switched (sw)MBCs from humans of different

204 wn whether such patients also exhibit IgM or IgA autoantibodies against FceRIalpha.

205 IgG titers were greater than either IgM or IgA titers for S1, full-length S, and S-RBD in the overa

206 tures of dimeric, tetrameric, and pentameric IgA-Fc linked by the joining chain (JC) and in complex w

207 ial in Bangladesh, rotavirus-specific plasma IgA antibody seroconversion rates were higher among infa

208 ared the binding patterns of both polyclonal IgA subclasses to commensals and glycan arrays and deter

209 To date, there is little data on possible IgA-mediated autoimmune responses.

210 ARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 sym

211 Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominan

212 ciated glomerulonephritis (SAGN) and primary IgA nephropathy (IgAN) are separate disease entities req

213 es of nAg (dsDNA and nucleohistone) reactive IgA producing B cells compared to B6 females.

214 y-matured, microbiota cross-species-reactive IgA is a common aspect of SIgA-microbiota interactions i

215 Q) regimen also increased vaginal and rectal IgA antibodies to a greater extent.

216 and concomitantly elicited clonally related IgA(+) plasma cells in the small intestine.

217 h plaque scores, bleeding on probing, and RF-IgA.

218 RA patients displaying RF-IgA levels >75 IU/mL exhibited five-fold more abundant P

219 This association with RF-IgA levels appeared even more pronounced, by six-fold mo

220 Salivary IgA levels strongly correlated with increased convalesce

221 Salivary IgA levels strongly correlated with serum IgA titers and

222 in the study (n = 4), the level of salivary IgA correlated with the time elapsed from diagnosis and

223 pability, revealing the presence of salivary IgA in infected individuals.

224 he diagnostic/prognostic utility of salivary IgA in the context of large-scale screening to assess th

225 d outbreak or to monitor population salivary IgA.

226 een pre-existing influenza-specific salivary IgA concentrations and tonsillar TFH-cell responses, and

227 aft protein, by naturally acquired secretory IgA (sIgA).

228 In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota.

229 e further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that systemic IgA bin

230 a reduced luminal concentration of secretory IgA (SIgA) following infection with C rodentium.

231 When converted to secretory IgA, MAb326 also neutralizes authentic SARS-CoV-2 virus

232 While secretory IgA in healthy controls targeted a defined subset of the

233 idered to have celiac disease with selective IgA deficiency rather than seronegative celiac disease.

234 Seroconversion (IgA >= 20 U/mL) conferred substantial protection against

235 ell frequencies in the lung tissue and serum IgA while reducing serum IgE concentrations.

236 correlated with increased convalescent serum IgA titers and blockade antibodies.

237 egs, reduced body weight, and elevated serum IgA levels.

238 immune diseases, but the regulation of serum IgA effector functions is not well defined.

239 n multiple B-cell lineages and reduced serum IgA and elevated IgM levels across multiple ages.

240 ficant increase of SARS-CoV-2-specific serum IgA and IgG titers after symptom onset.

241 SARS-CoV-2-specific serum IgA titers in patients with mild COVID-19 were often tra

242 ery high titers of SARS-CoV-2-specific serum IgA were correlated with severe acute respiratory distre

243 munizations induced Chlamydia-specific serum IgA.

244 ry IgA levels strongly correlated with serum IgA titers and blockade antibodies and remained elevated

245 Peri-sinus IgA plasma cells increased with age and following a brea

246 was positive/equivocal in 21 (22%) (sixteen IgA, five IgG) versus four positives/equivocal in 102 co

247 Our results suggest that SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective im

248 proteins, we determined SARS-CoV-2-specific IgA and IgG in sera and mucosal fluids of 2 cohorts, inc

249 m antibody titers showed SARS-CoV-2-specific IgA in mucosal fluids with virus-neutralizing capacity i

250 ut may stimulate mucosal SARS-CoV-2-specific IgA secretion.

251 SARS-CoV-2-specific IgA titers in nasal fluids were inversely correlated wit

252 SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with S

253 as well as receptor binding domain-specific IgA; however, the frequency of pTfh responses to SARS-Co

254 n of novel Epstein-Barr virus (EBV)-specific IgA and IgG antibodies from a proteome array.

255 Nasal pollen-specific IgA and IgG isotypes are potentially protective within t

256 suppressed intestinal C. rodentium-specific IgA production as well as IgA(+)CD38(+)CD138(-) memory B

257 stemic 9cRA profoundly enhanced the specific IgA-secreting B-cell frequencies in the lung tissue and

258 show that the ability to induce or suppress IgA is characteristic of specific strains of Bacteroides

259 hat FCRL4 recognizes J chain-linked systemic IgA in the absence of heat aggregation.

260 is not recognized by FCRL4 and that systemic IgA binding can be competitively inhibited by recombinan

261 uggest a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for pIgR bindi

262 transglutaminase immunoglobulin A (anti-t-TG-IgA) titer was assessed.

263 healing even in the presence of negative TG2-IgA.

264 sIgAd subjects showed less specificity than IgA and bound a broader subset of the microbiota.

265 Taken together, these data demonstrate that IgA effector functions depend on subclass and glycosylat

266 nabled Ig affinity maturation, we found that IgA deposition and complement activation significantly i

267 d to develop IgA in the FRT, indicating that IgA response in the FRT relies on the FRT to gastrointes

268 These data suggest that IgA-Biome analyses can be used to identify novel microbi

269 rated broadly neutralizing activity, and the IgA fraction of M1214 plasma conferred neutralization.

270 Here, we assessed the IgA-inducing capacity of a diverse set of human gut micr

271 nstrated shifts in relative abundance in the IgA-Biome profiles between normoglycemic, prediabetic, o

272 Further analysis of the IgA response revealed an expansion of IgA(+) germinal ce

273 Ultimately, an understanding of the IgA-Biome may promote the development of novel strategie

274 This IgA-LFIA immunosensor could be useful for noninvasively

275 n memory B cells are constitutively bound to IgA.

276 n the portion of the microbiota not bound to IgA.

277 easing amount of attention has been given to IgA as a novel therapeutic antibody.

278 irect IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

279 ded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

280 Total IgA, IgG and aPL were measured with clinical diagnostic

281 nstrated by the detection of IL-1beta, total IgA, and IgA specific to Mycobacterium tuberculosis anti

282 Higher total IgA and IgA-aPL were consistently associated with severe

283 ignificantly associated with increased total IgA (sdCOVID, P=0.01; scCOVID, p-value<0.001), but not t

284 negative results from serologic tests, total IgA level should be measured; patients should also be te

285 In this study, we found the total IgA(+) B cells as well as CD38(+)CD138(-)IgA(+) memory B

286 COVID-19 is associated with a vigorous total IgA response and if IgA antibodies are associated with c

287 Patients with total IgA levels below the lower limit of detection and IgG ag

288 Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the

289 be tested for anti-tissue transglutaminase, IgA against deamidated gliadin peptide, and endomysial a

290 lations between CDAT categories and anti-tTG-IgA categories showed a significant correlation between

291 Here, we show that the two IgA subclasses (IgA1 and IgA2) differ in their effect on

292 Structures reveal two IgAs conjoined through four heavy-chain tailpieces and t

293 The two IgAs are bent and tilted with respect to each other, for

294 hort study, we compared 3963 biopsy-verified IgA nephropathy patients with 19,978 matched controls be

295 omplement C3 and fibronectin associated with IgA on immune complexes.

296 Treg proportions negatively correlated with IgA production and coating of gut commensals, traits als

297 -up of 12.6 years, 196 (4.95%) patients with IgA nephropathy and 330 (1.65%) matched controls develop

298 Patients with IgA nephropathy have an increased risk of inflammatory b

299 In addition, among patients with IgA nephropathy, comorbid inflammatory bowel disease ele

300 ed with increased ESKD risk in patients with IgA nephropathy.