ライフサイエンスコーパス: IgE receptor

1 lls transfected with the human high-affinity IgE receptor.

2 ctodomain shedding of CD23, the low affinity IgE receptor.

3 )CPX(2)CYX, for binding to the high-affinity IgE receptor.

4 ion of mast cells by the human high-affinity IgE receptor.

5 ilonRI, the mast cell/basophil high affinity IgE receptor.

6 in basophil expression of the high-affinity IgE receptor.

7 t not the gamma subunit of the high affinity IgE receptor.

8 s, including tryptase, Kit, and a functional IgE receptor.

9 r basophil by binding to their high affinity IgE receptors.

10 induction following aggregation of mast cell IgE receptors.

11 s and basophils through the cross-linking of IgE receptors.

12 antigen-induced aggregation of high affinity IgE receptors.

13 Both FCER2 and FCER1A encode subunits of IgE receptors.

14 endocytic vesicles containing the clustered IgE receptors.

15 downstream signaling processes activated by IgE receptors.

16 classical, antigen-induced cross-linking of IgE receptors.

17 nking of the high-affinity immunoglobulin E (IgE) receptor.

18 ncreased expression of the immunoglobulin E (IgE) receptor.

19 ressing a fully functional immunoglobulin E (IgE) receptor.

20 phorylated SHIP-Grb2-Dok that were lost upon IgE receptor activation but retained under conditions of

21 lls treated with chemoattractants, thrombin, IgE receptor agonists, or PMA.

22 but, upon activation via their high-affinity IgE receptor, alter their migratory kinetics to persist

23 wo genotypes showed comparable expression of IgE receptor and c-Kit.

24 e selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate

25 nstrate that IgE Abs can engage cell surface IgE receptors and activate effector cells against ovaria

26 very of IgE 50 y ago, followed by studies of IgE receptors and activation mechanisms, this review pro

27 allography interact differently with the two IgE receptors and suggest that temperature influences th

28 th factor, T cell, B cell, and high affinity IgE receptors and the receptor substrates IRS-1 (insulin

29 les, including Ras, PKCbeta activated by the IgE receptor, and Gbetagamma subunits released from acti

30 ecific IgE, nor the presence of a functional IgE receptor, and the clinical occurrence of some allerg

31 lergen exposure, decreases the expression of IgE receptors, and attenuates both immediate and delayed

32 MCs/Bs express high-affinity IgE receptors, and blocking their interactions with IgE

33 nteractions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively b

34 required for interactions with two distinct IgE receptors, and the structure suggests strategies for

35 idate the effect of rfhSP-D on high-affinity IgE receptor- and CD23-mediated, grass pollen-induced al

36 in response to allergens, anti-IgE, and anti-IgE receptor antibodies was assessed by Griess reagent,

37 Human high affinity IgE receptors are expressed as two different isoforms: t

38 ctors activated following stimulation of the IgE receptor as well as in ATP- and GTP-dependent intrac

39 emonstrated little or no cell surface IgE or IgE receptors as analyzed by immunofluorescence and flow

40 If they are present, are these IgE receptors associated with effector functions of eosi

41 By contrast, levels of IgE receptor-associated spleen tyrosine kinase, Syk, wer

42 of the antibody-binding domains of the human IgE receptor at 2.4 A resolution.

43 CD20, high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are

44 proteoform identification was performed and IgE receptor binding capacity and abundance in patient s

45 n-Barr virus gp350/220, and the low-affinity IgE receptor CD23) via the N-terminal two of fifteen or

46 nd to one of its receptors, the low-affinity IgE receptor CD23, which is expressed on activated B cel

47 ation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clearance of IgE a

48 ation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clearance of IgE a

49 The low affinity IgE receptor, CD23, is implicated in IgE regulation and

50 Additionally, cleavage of the low affinity IgE receptor, CD23, was profoundly impaired, but subsequ

51 ed IgE by direct binding to the low-affinity IgE receptor, CD23.

52 nd B cell surface levels of the low affinity IgE receptor, CD23.

53 The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and C

54 Comparison of the full IgE receptor complex with recent cryo-EM structures of t

55 and they inhibit endocytosis of crosslinked IgE receptor complexes, evidently by inhibiting pinching

56 Cross-linking of IgE-receptor complexes by antigen causes their coalescen

57 lency trigger degranulation by cross-linking IgE-receptor complexes, whereas smaller DNP-dendrimers a

58 ulation initiated by multivalent crossing of IgE-receptor complexes.

59 IL-5 and TNF-alpha production in response to IgE receptor cross-linkage, implying a positive feedback

60 ot stimulus specific but is evident for both IgE receptor cross-linking and direct calcium influx.

61 Stimulation or RBL-2H3 cells through IgE receptor cross-linking caused plasma membrane recrui

62 Activation of primary human mast cells by IgE receptor cross-linking or activation of HMC-1 cells

63 Signal transduction cascades following IgE receptor cross-linking were compared in bone marrow-

64 rived mast cells stimulated by high affinity IgE receptor cross-linking, direct influx of calcium, an

65 e bone marrow MC (BMMC) after stimulation by IgE receptor cross-linking.

66 well as the secretion of serotonin following IgE receptor cross-linking.

67 tion and unique, cell-specific, responses to IgE-receptor cross-linking.

68 t mice to identify genes activated following IgE receptor crosslinking that were further modulated in

69 adapters that facilitate events initiated by IgE receptor-dependent activation of Src family protein

70 ulation of CD63 following stimulation of the IgE receptor, either specifically with peanut allergen o

71 In this study we show that IgE receptor engagement triggers activation of STAT6 in

72 After IgE receptor engagement, bone marrow mast cells from STA

73 Monocytes were essential IgE receptor-expressing effector cells that mediated the

74 sociated colitis was dependent on IgE, human IgE receptor-expressing effector cells, and the mediator

75 tic influence appeared central to regulating IgE receptor expression on basophils, whereas expression

76 nt regulation of high-affinity (FcepsilonRI) IgE receptor expression on basophils.

77 IgE receptor expression on lower airway plasmacytoid den

78 iants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have

79 lls transfected with the human high-affinity IgE receptor Fc epsilon RI, we demonstrate that ligands

80 to occur primarily through the high-affinity IgE receptor Fc epsilon RI.

81 Cross-linking the high affinity IgE receptor Fc epsilonRI of basophils and mast cells ac

82 RII or the alpha-chain of the high-affinity IgE receptor Fc-epsilon RI, but did detect transcripts t

83 lysis showed the absence of the low-affinity IgE receptor Fc-epsilon RII (CD23) and Mac-2 and the abs

84 of the high affinity immunoglobulin-epsilon (IgE) receptor Fc(epsilon)RI is defective.

85 nstrate that engagement of the high affinity IgE receptor (Fc epsilon R1) leads to the tyrosine phosp

86 Ag stimulation of mast cells via the IgE receptor (Fc epsilon RI) elicits production and rele

87 Activation of the high affinity IgE receptor (Fc epsilon RI) of mast cells, a member of

88 her hand, cross-linking of the high affinity IgE receptor (Fc epsilon RI) on mast cells induces a set

89 tions this past year to our understanding of IgE receptor (Fc epsilon RI) signaling in mast cells inc

90 IgE and allergens through the high affinity IgE receptor (Fc epsilon RI), play a prominent role in a

91 has revealed a biochemical event proximal to IgE receptor (Fc epsilon RI)-stimulated tyrosine phospho

92 Stimulation of the high affinity IgE receptor (FC epsilonRI) as well as a variety of stre

93 Aggregation of the high affinity IgE receptor (Fc epsilonRI), a member of the immune rece

94 IgE is rapidly bound by the high affinity IgE receptor (Fc epsilonRI), thereby sensitizing Fc epsi

95 pivotal role in mediating the high-affinity IgE receptor (Fc epsilonRI)-induced degranulation of mas

96 ation after stimulation of the high affinity IgE receptor (Fc epsilonRI).

97 by allergens through their highly expressed IgE receptor (Fc epsilonRI).

98 ve identified the gene for the high-affinity IgE receptor (FC(epsilon)RI) beta subunit as a candidate

99 mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated

100 The high affinity IgE receptor (Fc(epsilon)RI) plays a central role in the

101 The binding of IgE to high-affinity IgE receptors (Fc epsilon RI) on the surface of mast cel

102 h antigen receptors, including high-affinity IgE receptors (Fc epsilon RI), is thought to be mediated

103 hrough the cross-linking of the low affinity IgE receptors (Fc epsilon RIIb or CD23) by IgE-allergen

104 , when activated through their high affinity IgE receptors (Fc epsilonRI), release various granule me

105 g of immunoglobulin E (IgE) to high affinity IgE receptors (Fc(epsilon)RI) expressed on the surface o

106 Following Ag stimulation, the IgE-receptor (Fc(epsilon)RI ) accumulates within these d

107 ved the structure of the human high affinity IgE receptor, Fc epsilon RI alpha, in six different crys

108 ity through activation via the high-affinity IgE receptor, Fc epsilon RI, although many other functio

109 tion of Fc gamma RIIB with the high-affinity IgE receptor, Fc epsilon RI, leads to inhibition of Ag-i

110 Antigen stimulation of mast cells via the IgE receptor, Fc epsilon RI, results in recruitment of t

111 express the high-affinity immunoglobulin E (IgE) receptor, Fc epsilon receptor 1 (Fc epsilon RI), ha

112 /-) mice receiving bone marrow from Nhe1- or IgE receptor FcepsilonR1-deficient mice, blunted foam ce

113 dependent of activation of the high-affinity IgE receptor (FcepsilonR1) by antigen, as adenosine is e

114 cells (pDCs) impaired by IgE- high-affinity IgE receptor (FcepsilonR1) cross-linking to induce Tregs

115 s associated with baseline expression of the IgE receptor (FcepsilonR1).

116 ry (EM) Treg and increased expression of the IgE receptor, FcepsilonR1, on basophils.

117 ated whether activation of the high-affinity IgE receptor FcepsilonRI elicits release of mast-cell re

118 orescence microscopy to demonstrate that the IgE receptor FcepsilonRI in the plasma membrane can sign

119 The high-affinity IgE receptor FcepsilonRI is constitutively expressed in

120 ll (MC) activation through the high-affinity IgE receptor FcepsilonRI leads to the release of mediato

121 IgE to prevent its binding to high-affinity IgE receptor FcepsilonRI on basophils and mast cells is

122 E secretion and binding to the high-affinity IgE receptor FcepsilonRI on effector cells are responsib

123 Signaling through the high affinity IgE receptor FcepsilonRI on human basophils and rodent m

124 ific IgE, which sensitizes the high-affinity IgE receptor FcepsilonRI on mast cells and basophils and

125 inhibits the activation of the high affinity IgE receptor FcepsilonRI on mast cells and basophils by

126 igen-specific IgE bound to the high-affinity IgE receptor FcepsilonRI on mast cells and basophils.

127 d predominantly via IgG directed against the IgE receptor FcepsilonRI or FcepsilonRI-bound IgE.

128 For example, we find that the transmembrane IgE receptor FcepsilonRI preferentially segregates into

129 egranulation following DS, the high-affinity IgE receptor FcepsilonRI was still capable of transducin

130 a neuraminidase enzyme targeted towards the IgE receptor FcepsilonRI, and administering asialylated

131 , leading to activation of the high-affinity IgE receptor FcepsilonRI, and initiating a signaling cas

132 responses, IgE antibodies, the high-affinity IgE receptor FcepsilonRI, and mast cells can contribute

133 In signaling through the high affinity IgE receptor FcepsilonRI, the transmembrane adaptor call

134 c and asthmatic diseases is signaling by the IgE receptor FcepsilonRI, which depends on its interacti

135 stemic anaphylaxis in mice humanized for the IgE receptor FcepsilonRI.

136 E-dependent activation via the high-affinity IgE receptor FcepsilonRI.

137 rgen immune complexes (IgE-ICs) target the 2 IgE receptors FcepsilonRI and CD23, and we investigated

138 hagocytosis, acting respectively through the IgE receptors FcepsilonRI and CD23.

139 nking of the high-affinity immunoglobulin E (IgE) receptor FcepsilonRI.

140 on of the alpha subunit of the high affinity IgE receptor (FcepsilonRI(-/-)) were exposed on 10 conse

141 tyrosine-phosphorylated after high affinity IgE receptor (FcepsilonRI) aggregation in rat basophilic

142 eets, CD9 colocalized with the high-affinity IgE receptor (FcepsilonRI) and NTAL but not with LAT.

143 ur aim was to evaluate whether high-affinity IgE receptor (FcepsilonRI) and the related basophil func

144 ell activation through the IgE:high-affinity IgE receptor (FcepsilonRI) axis appears central to the d

145 ls of FAK and was defective in high affinity IgE receptor (FcepsilonRI) but not Ca2+ ionophore-mediat

146 beta and gamma subunits of the high affinity IgE receptor (FcepsilonRI) contain a consensus sequence

147 High-affinity IgE receptor (FcepsilonRI) cross-linking on mast cells (

148 to determine whether increased high-affinity IgE receptor (FcepsilonRI) expression and cross-linking

149 onRIbeta) to eliminate surface high-affinity IgE receptor (FcepsilonRI) expression and function, rend

150 Aggregation of the high affinity IgE receptor (FcepsilonRI) in a mast cell line resulted

151 rly and downstream signaling mediated by the IgE receptor (FcepsilonRI) in RBL mast cells utilizing s

152 To define the role of the high affinity IgE receptor (FcepsilonRI) in the development of AHR, mi

153 PIR-B coligation with the IgE receptor (FcepsilonRI) inhibited IgE-mediated mast c

154 n intact mast cells, including high affinity IgE receptor (FcepsilonRI) internalization and endosome

155 The human high affinity IgE receptor (FcepsilonRI) is a central component of the

156 st cell activation through the high affinity IgE receptor (FcepsilonRI) is a critical component of at

157 The high affinity IgE receptor (FcepsilonRI) is a multisubunit complex com

158 Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells activates a tyr

159 Cross-linking of the high affinity IgE receptor (FcepsilonRI) on mast cells induces secreti

160 Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells initiates signa

161 Cross-linking of the IgE receptor (FcepsilonRI) on mast cells plays a critica

162 Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cells with IgE and mu

163 Ligation of the high-affinity IgE receptor (FcepsilonRI) or of c-Kit stimulates cytoki

164 )-mediated crosslinking of the high-affinity IgE receptor (FcepsilonRI) resulted in genome-wide reorg

165 me thought to be essential for high-affinity IgE receptor (FcepsilonRI) signaling in human cells.

166 ng chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in

167 Engagement of the high affinity IgE receptor (FcepsilonRI) with a multimeric antigen lea

168 mast cells, cross-linking the high affinity IgE receptor (FcepsilonRI) with antigen activates cytoso

169 cell surface expression of the high affinity IgE receptor (FcepsilonRI), and eosinophilia.

170 In addition to the high-affinity IgE receptor (FcepsilonRI), MCs express numerous G prote

171 t the inflammatory response in high affinity IgE receptor (FcepsilonRI)-deficient mice.

172 5 min exposure to UA inhibited high affinity IgE receptor (FcepsilonRI)-mediated degranulation, calci

173 strate Gab2 may play a role in high affinity IgE receptor (FcepsilonRI)-mediated mast cell activation

174 ed SH2 domains to investigate where and when IgE receptor (FcepsilonRI)-mediated tyrosine phosphoryla

175 ed as well as occupancy of the high affinity IgE receptor (FcepsilonRI).

176 st cell activation through the high-affinity IgE receptor (FcepsilonRI).

177 mulation of mast cells via the high affinity IgE receptor (FcepsilonRI).

178 h the mRNA and protein for the high affinity IgE receptor (FcepsilonRI); it is speculated that this r

179 that expresses both native rat high affinity IgE receptors (FcepsilonRI) and functional human Fcepsil

180 IgE and IgE receptors (FcepsilonRI) are well-known inducers of a

181 ross-linking of the IgE-bound, high-affinity IgE receptors (FcepsilonRI) by allergens or Ags and the

182 tial observation that antigen stimulation of IgE receptors (FcepsilonRI) causes a significant change

183 pG DNA favors Th1 responses but also possess IgE receptors (FcepsilonRI) implicated in allergen prese

184 receptors in B lymphocytes and high-affinity IgE receptors (FcepsilonRI) in mast cells.

185 tivation mediated through both high-affinity IgE receptors (FcepsilonRI) on mast cells and basophils

186 gic diseases via activation of high-affinity IgE receptors (FcepsilonRI) resulting in release of proi

187 Cross-linking of mast cell (MC) IgE receptors (FcepsilonRI) triggers degranulation of se

188 Besides high-affinity IgE receptors (FcepsilonRI), human basophils express act

189 Basophils express high-affinity IgE receptors (FcepsilonRI), which play an essential rol

190 ivated by the cross-linking of high-affinity IgE receptors (FcepsilonRI).

191 ne kinase has been shown to be necessary for IgE-receptor (FcepsilonRI)-mediated mast cell activation

192 1[EMR1](+)MPs), mast cell MPs (high-affinity IgE receptor [FcepsilonRI](+)c-kit(+)MPs), and basophil

193 Immunoreceptors such as the high affinity IgE receptor, FcepsilonRI, and T-cell receptor-associate

194 induced cross-linking of their high affinity IgE receptor, FcepsilonRI, by releasing histamine and ot

195 step in the activation of the high affinity IgE receptor, FcepsilonRI, is the tyrosine phosphorylati

196 Cross-linking the high-affinity IgE receptor, FcepsilonRI, on mast cells activates signa

197 Antigen stimulation of mast cells via the IgE receptor, FcepsilonRI, results in the recruitment of

198 te that IgE antibodies and the high affinity IgE receptor, FcepsilonRI, were essential for such acqui

199 ion including that through the high-affinity IgE receptor, FcepsilonRI.

200 gered by signaling through the high-affinity IgE receptor, FcepsilonRI.

201 dent mast cells expressing the high-affinity IgE receptor, FcepsilonRI.

202 th decreased expression of the high-affinity IgE receptor, FcepsilonRI.

203 y induced by activation of the high affinity IgE receptor, FcepsilonRI.

204 activated by engagement of the high-affinity IgE receptor, FcepsilonRI.

205 ing of IgE antibodies bound to high-affinity IgE receptors, FcepsilonRI, on the surface of mast cells

206 ide GM1, palmitoylated LAT, and cross-linked IgE receptors, FcepsilonRI.

207 ling via the high-affinity immunoglobulin E (IgE) receptor, FcepsilonRI, leads to rapid degranulation

208 s, and its enzymatic activity is enhanced by IgE receptor/FcepsilonRI cross-linking.

209 Thus, JAK3 plays a pivotal role in IgE receptor/FcepsilonRI-mediated mast cell responses, a

210 against the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) or IgE on mast cells in

211 says and in vivo using a human high-affinity IgE receptor (FcepsilonRIalpha)-transgenic mouse model o

212 ic cell (DC) expression of the high-affinity IgE receptor (FcepsilonRIalpha).

213 t are transgenic for the human high-affinity IgE receptor (FcepsilonRIalpha).

214 ing of the beta-subunit of the high-affinity IgE receptor (FcepsilonRIbeta) to eliminate surface high

215 CD23, also known as the low affinity IgE receptor (FcepsilonRII), has been hypothesized to ha

216 on mast cells and basophils and low-affinity IgE receptors (FcepsilonRII) on B cells.

217 The low affinity IgE receptor, FcepsilonRII (CD23), is both a positive an

218 x ganglion neurons express the high-affinity IgE receptor FceR1, the levels of which increase in OVA-

219 E secretion and binding to the high-affinity IgE receptor FceRI on effector cells are responsible for

220 ross-linking of the IgE-bound, high-affinity IgE receptors (FceRI) by allergens or Ags and the bindin

221 t are transgenic for the human high-affinity IgE receptor (FceRIa).

222 IgG autoantibodies against the high-affinity IgE receptor, FceRIalpha, contribute the pathogenesis of

223 the membrane topography of the high-affinity IgE receptor, FcstraightepsilonRI, and its associated ty

224 t cells are major effectors in high-affinity IgE receptor (FcvarepsilonRI)-dependent allergic reactio

225 nkage of the high-affinity immunoglobulin E (IgE) receptor (FcvarepsilonRI) on mast cells by antigen

226 stromal lymphopoietin and the high-affinity IgE receptor, FcvarepsilonRI, were required to attain ma

227 peptide receptor (FPR) and the high-affinity IgE receptor (FepsilonRI).

228 , signal transduction from the high affinity IgE receptor for the secretion of histamine was similar

229 CD23, the low-affinity IgE receptor found on B lymphocytes and other cells, con

230 lerate the dissociation of the high-affinity IgE receptor from IgE.

231 , reversing basopenia and improving basophil IgE receptor function, reducing activity of IgG autoanti

232 phism in the high-affinity Immunoglobulin E (IgE) receptor (GC and non-GC haplotypes) that has sex-de

233 IgE receptors have been found on diverse inflammatory ce

234 xamine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in

235 e (BTK) is an emerging therapeutic target in IgE receptor (IgER)-cross-linked basophils.

236 hese mice express a tetrameric high affinity IgE receptor, in which the human alpha-chain associates

237 Similarly, cis-epoxysuccinate aggravated IgE-receptor-induced contraction of human bronchi, which

238 SUCNR1 amplifies IgE-receptor-induced mast cell activation and allergic b

239 Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of sub

240 vation of mast cells by aggregation of their IgE receptors induces rapid and transient synthesis of c

241 t contribute to their qualitatively distinct IgE-receptor inhibition profiles.

242 tion for therapeutic targeting approaches of IgE:receptor interactions to treat allergies.

243 Expression of high-affinity IgE receptor is increased and their function as major in

244 Signaling through the high affinity IgE receptor is initiated by noncovalently associated Ly

245 CD23, the low affinity IgE receptor, is up-regulated on the surface of IL-4-tre

246 of allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulat

247 pic controls, upregulated TSLP receptor upon IgE receptor ligation.

248 ains selectively suppressed the induction of IgE receptor-mediated calcium signals as well as the bin

249 to determine the role of STAT6 activation in IgE receptor-mediated mast cell responses using STAT6 kn

250 ed capacity to elicit high- and low-affinity IgE receptor-mediated responses compared to Ara h 2 or w

251 investigation to determine whether TLR9- and IgE receptor-mediated responses oppose one another in pD

252 mediated BP blister formation in a humanized IgE receptor mouse model of BP.

253 showed that aggregation of the high affinity IgE receptor on mast cells, FcepsilonRI, causes this imm

254 on induced by cross-linking of high-affinity IgE receptor on mast cells.

255 mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including mon

256 mediates cross-linking of the high-affinity IgE receptor on various cells, causing release of inflam

257 neutralizes almost all free IgE and reduces IgE receptors on basophils and mast cells.

258 more, the presence of trimeric high-affinity IgE receptors on leukocytes other than mast cells and ba

259 strate that perturbation of small numbers of IgE receptors on mast cells favors certain signals that

260 To investigate the expression of IgE receptors on murine eosinophils, they were purified

261 IgG autoantibody to IgE receptor or IgE itself causes urticarial lesions in

262 The affinity changes mediated by IgE receptor or interleukin-5 receptor persist longer.

263 nal transduction pathways, including EGF and IgE receptor pathways, have been proposed to be spatiall

264 eceptor tyrosine-based activation motif-free IgE receptor pool, which would fail to induce cell activ

265 The crystal structure of the IgE receptor provides a foundation for the development o

266 Syk SH2 domains selectively bind to Syk and IgE receptors, respectively.

267 soluble isoform of FceRI, the high-affinity IgE receptor (sFcepsilonRI), is a protein of the IgE net

268 tio-temporal dynamics of early events in the IgE receptor signal cascade.

269 CC-FCS data from studies of IgE receptor signaling challenge models of large stable

270 IgE receptor signaling events were also assessed in the

271 Our increasing understanding of IgE receptor signaling may lead to the development of no

272 0.22 +/- 0.01 at maximal association during IgE receptor signaling.

273 rafts," may act as functional platforms for IgE receptor signaling.

274 yzed a published model for immunoglobulin E (IgE) receptor signaling using synthetic qualitative and

275 d MC activation, including the high affinity IgE receptor, stem cell factor (SCF) receptor KIT/CD117,

276 ts of btk mutant mast cells in high-affinity IgE receptor-stimulated wild-type mast cells without aff

277 Inhibition of IgE-receptor-stimulated, PLD-catalysed phosphatidate for

278 naling proteins (including the high-affinity IgE receptor subunits, spleen tyrosine kinase, and phosp

279 t of antigen activation of the high-affinity IgE receptor, supports an important role for this nucleo

280 with immune cells and in particular with the IgE receptor system, which has been valuable for develop

281 Human eosinophils express IgE receptors that participate in an IgE-dependent eosin

282 Two well-known IgE receptors, the high-affinity FcepsilonRI and low-aff

283 calcium ionophore or by their high affinity IgE receptors, they degranulated in a pattern similar to

284 pDCs also express the high-affinity IgE receptor through which type I interferon production

285 plasma membrane signaling mechanism by which IgE receptors transiently associate with microdomains an

286 alpha and FcepsilonRIalpha (alpha subunit of IgE receptor type 1).

287 lonRIalpha (antibody to the alpha subunit of IgE receptor type I) stained for IL-13.

288 In studying the IgE receptor, we explored whether, in addition to their

289 caveolae microdomains, fluorescently labeled IgE receptors were found to be uniformly distributed in

290 ated reduced expression of the high affinity IgE receptor, which was restored to normal levels by the

291 ulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-couple

292 s to characterize stimulated interactions of IgE receptors with several signaling proteins, including