ライフサイエンスコーパス: IkappaB kinase alpha

1 omoter after TNFalpha stimulation along with IkappaB kinase alpha.

2 complex, NF-kappaB-inducing kinase-dependent IkappaB kinase-alpha activation, and p52/RelB nuclear tr

3 ed Akt phosphorylation and the expression of IkappaB kinase alpha and beta (IKKalpha and beta) at bot

4 gulate the function of IkappaBalpha, such as IkappaB kinase alpha and beta and NF-kappaB-inducing kin

5 Breast milk appeared to suppress intestinal IkappaB kinase alpha and beta, resulting in inactivation

6 ngs point to constitutive phosphorylation of IkappaB kinase alpha and subsequent alterations in FANCD

7 IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta),

8 gnaling pathways in mice with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the inte

9 molecule to independently bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

10 by dominant negative mutants of TRAF2, NIK, IkappaB kinase alpha, and IkappaB kinase beta.

11 inases PCTAIRE-1 (PCTK1), PFTAIRE-1 (PFTK1), IkappaB kinase alpha, and MAP4K4/NIK.

12 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,

13 -regulated kinases (ERK; Thr(202)/Tyr(204)), IkappaB kinase alpha/beta (IKKalpha/beta; Ser(176)/(180)

14 nhibition of TGFbeta-associated kinase-1 and IkappaB kinase alpha/beta activities and reduced express

15 nuclear factor kappaB via downregulation of IkappaB kinase alpha/beta activity.

16 s associated with reductions in sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 ac

17 1 significantly increased phosphorylation of IkappaB kinase alpha/beta and IkappaBalpha resulting in

18 appaB activation are mediated by a TRAF2-NIK-IkappaB kinase alpha/beta signaling cascade but is MEKK1

19 by a TRAF2-MEKK1-MKK4 but not the TRAF2-NIK/IkappaB kinase alpha/beta signaling pathway.

20 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k

21 d kinase 1/2, Jun N-terminal protein kinase, IkappaB kinase alpha/beta, and Akt were unaltered, const

22 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor

23 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p

24 ukin 1 receptor-associated kinase (IRAK) and IkappaB kinase-alpha/beta.

25 Of several kinases examined, inhibition of IkappaB kinase alpha blocked STG28-mediated cytoplasmic

26 Subsequently, induction of IkappaB kinase-alpha by DeltaNp63alpha initiates epiderm

27 1beta), as well as activation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38, Akt, and

28 uently, others have identified two proteins, IkappaB kinase alpha (IKK-alpha) and IkappaB kinase beta

29 IkappaB kinase-alpha (IKK-alpha) and Mitogen- and Stress

30 IkappaB kinase-alpha (IKK-alpha) exhibits protein-kinase

31 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto

32 ction of NF-kappaB-inducing kinase (NIK) and IkappaB kinase-alpha (IKK-alpha).

33 through inhibitor of nuclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that

34 IkappaB kinase alpha (IKKalpha) activity is required for

35 fashion, associated with phosphorylation of IkappaB kinase alpha (IKKalpha) and degradation of Ikapp

36 We identified the two kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

37 Two subunits of this complex, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

38 nt insolubilization of the upstream kinases, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta,

39 tion of NF-kappaB requires calcium-dependent IkappaB kinase alpha (IKKalpha) and IKKbeta activation a

40 In NF-kappaB signaling cascades, IkappaB kinase alpha (IKKalpha) and IKKbeta are key mole

41 d NEMO-binding domain from the C terminus of IkappaB kinase alpha (IKKalpha) and IKKbeta can disrupt

42 Despite their homology, IkappaB kinase alpha (IKKalpha) and IKKbeta have diverge

43 Two related kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, phosphoryla

44 s targeting the NF-kappaB regulatory kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, we find tha

45 tes the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which norma

46 gers activation of cellular protein kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, which phosp

47 We reported recently a marked reduction in IkappaB kinase alpha (IKKalpha) expression in a large pr

48 We investigated the role of IkappaB kinase alpha (IKKalpha) in pancreatic homeostasi

49 Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative r

50 IkappaB kinase alpha (IKKalpha) is part of the cytoplasm

51 AA/AA) "knockin" mice in which activation of IkappaB kinase alpha (IKKalpha) is prevented by replacem

52 of NF-kappaB activation, we demonstrate that IkappaB kinase alpha (IKKalpha) is recruited to chromati

53 as independent of NIK's known function as an IkappaB kinase alpha (IKKalpha) kinase, because mice car

54 B essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent ni

55 We previously reported that IkappaB kinase alpha (IKKalpha), a component of the kina

56 We identified a role for IkappaB kinase alpha (IKKalpha), activated by receptor a

57 ion of inhibitor kappaBalpha (IkappaBalpha), IkappaB kinase alpha (IKKalpha), and IkappaB kinase beta

58 asal epidermal keratinocytes require nuclear IkappaB kinase alpha (IKKalpha), but not its protein kin

59 Deletions in the CHUK locus, coding for IkappaB kinase alpha (IKKalpha), correlate with reduced

60 ways of NF-kappaB activation, including p65, IkappaB kinase alpha (IKKalpha), IkappaB kinase beta (IK

61 We previously showed elevated activity of IkappaB kinase alpha (IKKalpha), IKKbeta, and protein ki

62 s that expresses a dominant negative form of IkappaB kinase alpha (IKKalpha), named IKKalpha-SA, with

63 IkappaB kinase alpha (IKKalpha), one of the two catalyti

64 cing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha), which requires the E3 l

65 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate

66 cing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha).

67 ppaB activation with a constitutively active IkappaB kinase alpha (IKKalpha).

68 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als

69 IkappaB kinase-alpha (IKKalpha) is required for splenic

70 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh

71 Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta, promot

72 such as inhibitor of nuclear factor kappa B (IkappaB) kinase alpha (IKKalpha), IKKbeta, and IKKepsilo

73 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c

74 ctivation of Akt(Thr-308), Akt(Ser-473), and IkappaB kinase alpha kinase.

75 xpression of either dominant-negative AKT or IkappaB kinase alpha mutant, IKKalphaT23A, containing a

76 linositol-3-OH kinase/protein kinase B (AKT)/IkappaB-kinase alpha/NF-kappaB signaling cascade.

77 miR-148a is an inhibitor of the IkappaB kinase alpha/NUMB/NOTCH pathway and an inducer o

78 sed differentiated phenotype and mediated by IkappaB kinase alpha/NUMB/NOTCH signaling.

79 B essential modifier-binding domain (NBD) of IkappaB kinase alpha or IkappaB kinase beta specifically

80 ducing kinase or IkappaB kinase-beta but not IkappaB kinase-alpha significantly inhibited the TWEAK-i

81 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr

82 Phosphorylation of IkappaB kinase alpha was observed within 30 minutes, whi

83 trovirally transduced with dominant negative IkappaB kinase alpha, we demonstrate that CXCL12 express