ライフサイエンスコーパス: IkappaB kinase beta

1 nts of TRAF2, NIK, IkappaB kinase alpha, and IkappaB kinase beta.

2 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

3 wnstream kinases c-Jun N-terminal kinase and IkappaB kinase beta.

4 modulator (NEMO), and the catalytic subunit, IkappaB kinase beta.

5 ing the activation and intrinsic activity of IkappaB kinase-beta.

6 kappaB degradation) and was found to involve IkappaB-kinase beta.

7 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

8 of RelA/p65 in a manner that is dependent on IkappaB kinase beta activity and on the mitogen-activate

9 Manipulating the IkappaB kinase beta activity coupled with in vivo and in

10 ed LPS-dependent activation of NF-kappaB and IkappaB kinase beta activity, protected against LPS acti

11 [inhibitor of transcription factor NFkappaB (IkappaB) kinase beta; an upstream kinase responsible for

12 Additionally, IkappaB kinase beta and c-Jun N-terminal kinase 1 activa

13 r NF-kappaB due to spontaneous activation of IkappaB kinase beta and degradation of the NF-kappaB inh

14 ominant negative mutants of IkappaBalpha and IkappaB kinase beta and electrophoretic mobility shift a

15 FcepsilonRI-mediated activation of IkappaB kinase beta and IkappaBalpha phosphorylation and

16 plicating a possible link with the defective IkappaB kinase beta and IkappaBalpha phosphorylation in

17 splenic B cells are defective in BCR-induced IkappaB kinase beta and IkappaBalpha phosphorylation.

18 tracellular signal-regulated kinase 1/2, and IkappaB kinase beta appear to contribute to the anti-apo

19 -dead mutant of NF-kappaB-inducing kinase or IkappaB kinase-beta but not IkappaB kinase-alpha signifi

20 was inhibited by dominant-negative AP-1 and IkappaB kinase-beta, but stimulated by WT AP-1 and Ikapp

21 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

22 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

23 iciency also abrogated the formation of TAB1.IkappaB kinase beta complexes in 4T1 breast cancer cells

24 kinases, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta, components involved in IkappaBalpha

25 or of NF-kappaB expressed in C2C12 cells and IkappaB kinase beta-deficient embryonic mouse fibroblast

26 on of ABCA1 by TNFalpha is reduced by 65% in IkappaB kinase beta-deficient macrophages and by 30% in

27 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

28 t pathway involves NF-kappaB-inducing kinase-IkappaB kinase beta/gamma-dependent phosphorylation and

29 on of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade.

30 nsults activate a kinase complex composed of IkappaB kinase beta (IKK-beta), IKK-alpha, and IKK-gamma

31 oteins, IkappaB kinase alpha (IKK-alpha) and IkappaB kinase beta (IKK-beta), that are present in a tu

32 IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a ce

33 IkappaB kinase-beta (IKK-beta) activated NF-kappaB when

34 lective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described.

35 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

36 appaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encoded by Ikbkb) in the

37 nduces activation of inhibitor of NF-kappaB (IkappaB) kinase-beta (IKK-beta), a protein kinase that p

38 , IL-1 receptor-associated kinase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI),

39 eta-resistant variants, genetic depletion of IkappaB kinase beta (IKKbeta) (activated during hyperamm

40 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

41 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

42 cross-linking resulted in phosphorylation of IkappaB kinase beta (IKKbeta) and the phosphorylation an

43 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

44 Activation or overexpression of the IkappaB kinase beta (IKKbeta) attenuated insulin signali

45 The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction wa

46 sgenic mice expressing constitutively active IkappaB kinase beta (IKKbeta) in intestinal epithelial c

47 Here we examined the potential role of IkappaB kinase beta (IKKbeta) in mucus synthesis in vitr

48 -theta is mediated through the activation of IkappaB kinase beta (IKKbeta) in the absence of detectab

49 perrepressor and a dominant-negative form of IkappaB kinase beta (IKKbeta) inhibited NF-kappaB bindin

50 otein kinase C-theta (PKC-theta), Bcl10, and IkappaB kinase beta (IKKbeta) into lipid rafts of the im

51 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

52 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

53 IkappaB kinase beta (IKKbeta) is an essential activator

54 IkappaB kinase beta (IKKbeta) is involved in tumor devel

55 IkappaB kinase beta (IKKbeta) is required for NF-kappaB

56 a) mice in which NF-kappaB signaling through IkappaB kinase beta (IKKbeta) is selectively ablated in

57 of Inhibitor of kappaB (IkappaB) proteins by IkappaB Kinase beta (IKKbeta) leads to IkappaB degradati

58 Overexpression of IkappaB kinase beta (IKKbeta) or p65-RHD causes nuclear

59 pression enhances LPA-induced MEKK3-mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kap

60 via the alternate pathway is accompanied by IkappaB kinase beta (IKKbeta) phosphorylation, IkappaBal

61 We show that the IkappaB kinase beta (IKKbeta) plays a crucial role in pr

62 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

63 t indomethacin, inhibited the activity of an IkappaB kinase beta (IKKbeta) that is required to activa

64 Tax expression increases the activity of IkappaB kinase beta (IKKbeta) to enhance phosphorylation

65 alpha), IkappaB kinase alpha (IKKalpha), and IkappaB kinase beta (IKKbeta) were measured.

66 IkappaB kinase beta (IKKbeta), a central coordinator of

67 IkappaB kinase beta (IKKbeta), a central coordinator of

68 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

69 Small molecule inhibitors of IkappaB kinase beta (IKKbeta), a key regulator of the NF

70 beta(Deltahep) mice, which specifically lack IkappaB kinase beta (IKKbeta), an activator of NF-kappaB

71 hances TNFalpha-induced RIP1 ubiquitination, IkappaB kinase beta (IKKbeta), and NF-kappaB phosphoryla

72 luding p65, IkappaB kinase alpha (IKKalpha), IkappaB kinase beta (IKKbeta), and NF-kappaB-inducing ki

73 trast, the phosphorylation of ERK, p38 MAPK, IkappaB kinase beta (IKKbeta), and nuclear NFkappaB acti

74 complex, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta), are required for NF-kappa

75 phosphorylation of IkappaBalpha by activated IkappaB kinase beta (IKKbeta), but the activities of oth

76 The majority of these proteins such as IkappaB kinase beta (IKKbeta), MKK3b, highly expressed i

77 fer marginally in their very poor binding to IkappaB kinase beta (IKKbeta), only wt NIK is able to bi

78 NF-kappaB pathway with UTC, an inhibitor of IkappaB kinase beta (IKKbeta), or transfection of CLL ce

79 IkappaB kinase beta (IKKbeta), required for NF-kappaB ac

80 lates sensitize insulin action by inhibiting IkappaB kinase beta (IKKbeta), the detailed mechanisms r

81 n of receptor-interaction proteins (RIP) and IkappaB kinase beta (IKKbeta), the key components of the

82 ownstream of the T-cell receptor (TCR) or of IkappaB kinase beta (IKKbeta), we demonstrate that NF-ka

83 We also demonstrate that IFN-gamma activates IkappaB kinase beta (IKKbeta)-dependent NF-kappaB to reg

84 a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act a

85 hysiological basis of canonical or classical IkappaB kinase beta (IKKbeta)-nuclear factor kappaB (NF-

86 ften resulting from constitutive activity of IkappaB kinase beta (IKKbeta).

87 on of TAp63gamma, but not DeltaNp63gamma, by IkappaB kinase beta (IKKbeta).

88 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

89 ng activation of NF-kappaB, which depends on IkappaB kinase beta (IKKbeta).

90 ced interleulin-8 production, and diminished IkappaB kinase beta (IKKbeta)/IKKgamma coimmunoprecipita

91 on loop that is essential for MEKK3-mediated IkappaB kinase beta (IKKbeta)/NF-kappaB activation.

92 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

93 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

94 was abolished by a dominant-negative form of IkappaB kinase beta (IKKbeta, K44A) or a null mutation o

95 ells overexpressing a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM), the activation of NF-k

96 ble transfection of a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM).

97 We have previously shown that IkappaB kinase-beta (IKKbeta) interacts with the epithel

98 IkappaB kinase-beta (IKKbeta) mediates activation of the

99 IkappaB kinase-beta (IKKbeta) required for nuclear facto

100 f screening hits identified as inhibitors of IkappaB kinase-beta (IKKbeta), a key regulatory enzyme i

101 tween the carboxyl terminus of beta-ENaC and IkappaB kinase-beta (IKKbeta), the kinase that phosphory

102 ty of a recently identified cellular kinase, IkappaB kinase-beta (IKKbeta), was significantly elevate

103 NF-kappaB is regulated from the cytoplasm by IkappaB kinase-beta (IKKbeta), which earmarks inhibitors

104 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

105 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

106 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

107 conditional deficiency in those cells of the IkappaB-kinase beta (IKKbeta) subunit of IKK.

108 ty of a key kinase of the NF-kappaB cascade, IkappaB-kinase beta (IKKbeta) subunit, as a function of

109 The nuclear factor kappaB (NF-kappaB)/IkappaB-kinase-beta (IKKbeta) pathway has been shown to

110 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

111 sgenic mice expressing constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta

112 r, ubiquitin-dependent mechanism to activate IkappaB kinase-beta in response to TNF-alpha and TLR3 li

113 with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the intestinal epithelium.

114 NIK (NF-kappaB-inducing kinase) or IKKbeta (IkappaB kinase beta) inhibited the activity of NF-kappaB

115 ophagy in promoting obesity were reversed by IkappaB kinase beta inhibition in the brain.

116 and in vitro kinase assays demonstrated that IkappaB kinase beta is a key serine/threonine kinase act

117 Using brain-specific IkappaB kinase beta knockout mice, it was found that the

118 essive "alternative" phenotype that requires IkappaB kinase beta-mediated NF-kappaB activation.

119 -specific transgenic expression of activated IkappaB kinase beta (MIKK), causes profound muscle wasti

120 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

121 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

122 duced IL-32 was reduced by inhibition of the IkappaB kinase-beta/NF-kappaB and ERK pathways.

123 reporter was inhibited by dominant-negative IkappaB kinase beta or dominant-negative AP-1.

124 100 also requires IKKalpha, but not IKKbeta (IkappaB kinase beta) or IKKgamma (IkappaB kinase gamma).

125 ibitor of nuclear factor kappaB kinase beta (IkappaB kinase beta, or IKKbeta) has emerged as a key re

126 , PACAP, and VIP suppress phosphorylation of IkappaB kinase beta (P-IKKbeta), prevent degradation of

127 ivation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38, Akt, and extracellular recepto

128 including the activation of proinflammatory IkappaB kinase beta pathway.

129 uclear factor-kappaB-alpha level and reduced IkappaB kinase-beta phosphorylation, suggesting a suppre

130 IkappaB kinase beta plays a critical role in TNFR1 phosp

131 Notably, NF-kappaB signaling through IkappaB kinase beta protected crypt IECs but did not pro

132 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

133 of CD4+ T cells with the NF-kappaB-inducing IkappaB kinase beta showed that NF-kappaB activation is

134 ding domain (NBD) of IkappaB kinase alpha or IkappaB kinase beta specifically inhibit the induction o

135 B kinase-beta, but stimulated by WT AP-1 and IkappaB kinase-beta, suggesting that PKC-theta stimulate

136 es between TAK1-binding protein 1 (TAB1) and IkappaB kinase beta that enabled TGF-beta to activate p6

137 ting protein, NF-kappaB-inducing kinase, and IkappaB kinase beta was abolished by simvastatin.