ライフサイエンスコーパス: Ile

1 Ile-Pro-Ile-Gln-Tyr, Tyr-Pro-Tyr-Tyr and Leu-Pro-Tyr-Pro

2 The biased agonist [Sar(1),Ile(8)]AngII also showed a preference for the ground sta

3 e arrestin pathway-selective agonist [Sar(1)-Ile(4)-Ile(8)]AngII (SII), is blocked by shRNA silencing

4 f TM3 to extracellular loop 2, ECL2 (Thr-141/Ile-142) and ECL2 (Asn-148/Asp-149, Leu-150/Thr-151, Arg

5 e N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabiliz

6 mogens, pro-uPA (at consensus sites Lys(158)-Ile(159) and Lys(135)-Lys(136)) and plasminogen, yieldin

7 d 2 were well-tolerated, with Val(1)-Val(2), Ile(1)-Ala(2), and Leu(1)-Val(2) variants exhibiting Pro

8 n substitution and includes residues Arg-32, Ile-33, Met-34, and Val-35.

9 (Pre2), which is further attacked at Arg-320-Ile-321 to yield mature alphaT.

10 (Val-34, Leu-194, Phe-196, Phe-336, Thr-340, Ile-343, and Ile-344).

11 Specifically, Candida intermedia gxs1 Phe(38)Ile(39)Met(40), Scheffersomyces stipitis rgt2 Phe(38) an

12 tin pathway-selective agonist [Sar(1)-Ile(4)-Ile(8)]AngII (SII), is blocked by shRNA silencing of bet

13 four amino acid positions, Val-750, Ile-552, Ile-839, and Trp-500, located within a previously propos

14 nt of the alpha-helix by replacing Phe(604), Ile(608), or Ile(612) by Gln.

15 part of the pore: Ser(68), Ser(47), Thr(62)/Ile(66), Thr(56), Thr(32)/Gly(45), and Met(52).

16 Mutating SM residues Phe-35/Ser-37/Leu-65/Ile-69 into alanine, based on the key residues in Deg1,

17 by residues Ser-33, Leu-34, Ala-66, Lys-68, Ile-69, Leu-70, Ser-71, and Glu-72.

18 1 (Phe-40), helix 3 (Leu-63, Arg-68, Gln-69, Ile-72, Tyr-76), and C-terminal segment (Leu-81, Glu-84)

19 idues at gp120 positions 23, 45, 47, and 70 (Ile-Ala-Lys-Asn [I-A-K-N]) emerged as signatures of muco

20 revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14.Nav1.6 co

21 ncluding four amino acid positions, Val-750, Ile-552, Ile-839, and Trp-500, located within a previous

22 mutations in GyrA in addition to the Thr-86-Ile change.

23 ned in this study harbored the single Thr-86-Ile mutation in GyrA, FQ(R) C. jejuni isolates had other

24 ds Gly and Glu, and the essential amino acid Ile were more abundant in the scalp hair of diabetic pat

25 nel-based homology models predict amino acid Ile-1575 in domain IV segment 6 to be in close proximity

26 es whereas those of hydrophobic amino acids (Ile, Phe) deviate positively from the isotropic trend li

27 protein (65-74) fragment (H-Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-OH), following the solid-phase p

28 nt (with a C-terminal Gly, H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragme

29 ach containing either an allo-Thr or an allo-Ile residue.

30 Using validated allo-Thr and allo-Ile, both l-allo-ShK and d-allo-ShK polypeptide chains w

31 Ile and Thr residues, i.e. containing d-allo-Ile and d-allo-Thr along with d-amino acids and glycine.

32 d l-Ile (instead of d-Val, l-Lys, and l-allo-Ile) and is a hydroxylated brunsvicamide.

33 The three allo-Thr or allo-Ile-containing ShK polypeptides were able to fold into d

34 IP variant, comprising two disulfides and an Ile-to-Pro mutation of Env from strain BG505.

35 esaturase homologs which contained either an Ile or a Gly at this location and showed that only the G

36 ne or cysteine results in accumulation of an Ile(*) or Cys(*) radical, respectively.

37 Pro-82, Leu-94, Asp-145, and Ile-146 have a more differentiated role, suggesting that

38 ipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabilization of ful

39 Replacing Asn(7), Ser(8), Ala(19), and Ile(21) with the corresponding residues from RasGRP1/3 (

40 th the scaffold proteins beta-arrestin 2 and Ile Gln motif containing GTPase Activating Protein 1, a

41 g the idea, mutations in residues Ile-24 and Ile-25 of the MinD-interacting domain affect fibril form

42 sly suggested close proximity of Ser-281 and Ile-486 within the TSHR.

43 194, Phe-196, Phe-336, Thr-340, Ile-343, and Ile-344).

44 s URAT1 residues Cys-32, Ser-35, Phe-365 and Ile-481.

45 sp(399) and the di-isoleucines, Ile(402) and Ile(403).

46 ), Ala(16), Met(17), Gly(475), Val(477), and Ile(485) are more important for kinase domain closure an

47 Val(48) and Ile(328) are at the outer end of TM1 and TM2, respective

48 gest that an interaction between Val(48) and Ile(328) stabilizes the closed channel and that this is

49 pen-channel constriction sites (Gln-4933 and Ile-4937).

50 ent to the initially identified Gln(596) and Ile(597) residues.

51 iously identified two residues (Gln(596) and Ile(597)) in the helical domain of the catalytic subunit

52 ral side chains, such as Phe-57, Tyr-60, and Ile-77, that change their orientations to accommodate th

53 Additional mutations in residues Ile-72 and Ile-74 suggest a role of the C-terminal domain of MinE i

54 obic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, wh

55 idA proteins can preempt damage to BCAT3 and Ile biosynthesis by hydrolyzing the Ser-derived enamine/

56 ith the APC/C through their common C-box and Ile-Arg tail motifs, the mechanism underlying this diffe

57 with the binding sites of both the C-box and Ile-Arg tail motifs.

58 ntally verified contact of Ser-281 (ECD) and Ile-486 (TMD) was subsequently utilized in docking homol

59 fied to homogeneity functional Asn, Glu, and Ile tRNAs from the native E. coli tRNA mixture, and by c

60 exception of isoacceptors for Asn, Glu, and Ile, the majority of 48 synthetic Escherichia coli tRNAs

61 vealed that BCAT6 transaminates Val, Leu and Ile as well as the corresponding 2-oxo acids but also tr

62 (MS) for de novo protein sequencing, Leu and Ile have been generally considered to be indistinguishab

63 s spectrometer, to reliably identify Leu and Ile residues in proteins and peptides.

64 cid sequences, including identity of Leu and Ile residues, can be accurately obtained solely by means

65 by supplementation of LNAAs, such as Leu and Ile, with a strong affinity for the LNAA transporter typ

66 tion patches of ubiquitin (Ile(44) patch and Ile(36) patch, respectively, including Leu(8), which is

67 ShK protein revealed that diagnostic Thr and Ile signals were the same as for authentic d-ShK.

68 eu, Tyr-Pro-Tyr-Tyr, Leu-Pro-Tyr-Pro-Tyr and Ile-Pro-Ile) and a casein (CasH), whey (WPH) and lactofe

69 Ser-Val and Ile-Phe were shown to exhibit ACE inhibitory activity wi

70 Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly

71 f 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomo

72 3a (H-Dmt-d-Arg-Aba-beta-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) to mice resulted in potent and long lasting

73 hat tryptophan-containing dipeptides such as Ile-Trp or Val-Trp, which were recently found in food pr

74 The branched-chain amino acids (BCAAs) Ile, Val, and Leu are essential nutrients that humans an

75 Ser-112 and Lys-119, homologous to TGF-beta2 Ile-92 and Lys-97, on the inside of the fingers.

76 e hydrogen-bonded coassemblies formed by BTA Ile and the intrinsically achiral catalytic rhodium cata

77 BTA(PPh2) and the enantiopure comonomer BTA Ile as confirmed by various spectroscopic and scattering

78 The effect of the relative content of BTA Ile as compared to the ligand was investigated.

79 for mixtures containing high amounts of BTA Ile.

80 te" was modified by replacement of Asp372 by Ile.

81 s highly conserved in RF2 and substituted by Ile-196 in the corresponding position in RF1.

82 e quantum coherence (HMQC) spectrum of (13)C-Ile-labeled enzyme resembles the glucose-bound state.

83 se a model showing the interaction with CCR5 Ile(198).

84 inge enables conserved nonpolar side chains (Ile(A2), Val(A3), Val(B12), Phe(B24), and Phe(B25)) to e

85 variant positions, and a triplet ATT codon (Ile) insertion within ATP synthase subunit 8, were uniqu

86 ctures of dimers of unliganded CodY and CodY-Ile derived from the tetramers showed a splaying of the

87 A conserved Ile Leu Leu sequence within the CWB2 repeats is essentia

88 Our analysis highlighted highly conserved Ile and Phe residues at the RfaH interdomain interface.

89 C20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.

90 siological conditions and that the conserved Ile-Met motif is mainly used to recover mistargeted rece

91 in PLCZ1, c.1465A>T; p.Ile489Phe, converting Ile 489 into Phe.

92 he pentapeptides Cys-Ile-His-Asn-Pro and Cys-Ile-Gln-Pro-Val while low response was achieved for the

93 peptides (cysteinylglycine, glutathione, Cys-Ile-His-Asn-Pro, Cys-Ile-Gln-Pro-Val, Cys-Arg-Gln-Val-Ph

94 ponse was obtained for the pentapeptides Cys-Ile-His-Asn-Pro and Cys-Ile-Gln-Pro-Val while low respon

95 ycine, glutathione, Cys-Ile-His-Asn-Pro, Cys-Ile-Gln-Pro-Val, Cys-Arg-Gln-Val-Phe) vs. 14 volatile co

96 n target of rapamycin signaling and decrease Ile Gln motif containing GTPase Activating Protein 1 pho

97 s ProT by inserting its N-terminal dipeptide Ile(1)-Val(2) into the ProT Ile(16) pocket, forming a sa

98 ids possessing two chiral centers such as dl-Ile or dl-Thr, only the epimerization of isomers with di

99 s show that Met(73) and, to a lesser extent, Ile(75) suppress excision activity when TAMs are present

100 By comparison, substitutions of Asn for Ile-136 (I136N) and Thr for Ile-142 (I142T) in a subdoma

101 trometer can provide sufficient evidence for Ile/Leu discrimination.

102 nslation of protein and an apparent role for Ile-585 in activation by particles.

103 An alanine substitution for Ile-85 specifically interfered with this interaction and

104 tions of Asn for Ile-136 (I136N) and Thr for Ile-142 (I142T) in a subdomain previously named the heli

105 her generation of a signature 69 Da ion from Ile or formation of unique w-ions employing MS(3) (ETD-H

106 t secondary structure are hydrophobic (e.g., Ile or Val) or only moderately polar (e.g., Thr).

107 peptides of the sequence EGAAXAASS (X = Gly, Ile, Tyr, Trp) through comparison of molecular dynamics

108 acetyltransferase uses a similar Gly-Asp-Gly-Ile motif to form the "cysteine synthase" complex with C

109 ositive bacteria lack C-terminal Gly-Tyr-Gly-Ile motifs, suggesting that they do not interact with Cy

110 CT(EC536) inserts its C-terminal Gly-Tyr-Gly-Ile peptide tail into the active-site cleft of CysK to a

111 h asthma at 18 years for children with GSTP1 Ile/Ile (odds ratio, 1.66; 95% CI, 1.07 to 2.57), but no

112 ing to AA was: Trp > norleucine > Phe, Leu > Ile > His >3,4-dihydroxyphenylalanine, Arg > Val > Lys,

113 The hierarchy Leu>Met>Ile>Val at the C-terminal position was determined for al

114 ate, thereby establishing the alpha-70(Val-->Ile) intermediate as a reliable guide to mechanism.

115 e-trapped intermediate of the alpha-70(Val-->Ile) MoFe protein as the Janus intermediate that stores

116 cid residues not present in MCM, namely HcmA Ile(A90) and Asp(A117).

117 s containing amino acids Ala, Asn, Gln, His, Ile, and Lys at positions equivalent to 782 and/or 786 i

118 Leu-Leu-Ala-Pro and Met-Ala-Gly-Val-Asp-His-Ile, with IC50 values in the range 43-159 muM were ident

119 UT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein confo

120 similarly to the wild type hSLC2A9; however, Ile-335 is necessary for urate/fructose trans-accelerati

121 d Met(40), and Saccharomyces cerevisiae hxt7 Ile(39)Met(40)Met(340) all exhibit this phenotype.

122 en a hydrophilic (Ser-109) or a hydrophobic (Ile-305) amino acid is mutated instead.

123 After the addition of IDL (Ile-Asp-Leu) to the C terminus of CHR peptide WQ or MT-W

124 enzyme not only in Val but possibly also in Ile metabolism.

125 of a federal tertiary health institution in Ile-Ife, Nigeria.

126 28~Gln653, named CP), but with an innovative Ile-Asp-Leu tail (IDL) that dramatically increased the i

127 affolding protein, KIBRA, has an isoleucine (Ile-81) rather than a second conserved tryptophan and is

128 esidues (Xle): leucine (Leu) and isoleucine (Ile).

129 ain amino acids (BCAAs) leucine, isoleucine (Ile), and valine (Val) in the mitochondria efficiently a

130 their propensity to mistranslate isoleucine (Ile) in proteins.

131 Asp, as well as racemization of isoleucine (Ile) and phenylalanine (Phe) after 100 s of irradiation

132 f growth regulators includes the isoleucine (Ile) conjugate of jasmonic acid (JA-Ile) and its biosynt

133 fluenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).

134 JA-Ile metabolism has been studied intensively, but its cat

135 coronatine (COR), we demonstrate that (1) JA-Ile/COR-based signaling regulates corolla limb opening a

136 leucine (Ile) conjugate of jasmonic acid (JA-Ile) and its biosynthetic precursor 12-oxophytodienoic a

137 COR, MJ, and JA-Ile act through the canonical JA receptor COI1 in clock

138 ed accumulation of jasmonic acid (JA) and JA-Ile, elevated expression of over 2,200 different transcr

139 rofiling revealed significantly increased JA-Ile levels in OsJAZ9 OE lines under K deficiency.

140 ugh COI1; and (3) limb expansion involves JA-Ile-induced changes in limb fresh mass and carbohydrate

141 t recognizes both jasmonoyl-l-isoleucine (JA-Ile) and the bacterial-produced phytotoxin coronatine (C

142 nd that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in gua

143 Jasmonoyl-isoleucine (JA-Ile) is a phytohormone that orchestrates plant defenses

144 MJ and another JA agonist JA-isoleucine (JA-Ile) only affect some reporters.

145 The binding of jasmonoyl-L-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITIVE1 (COI1) is r

146 the plant hormone jasmonoyl-L-isoleucine (JA-Ile).

147 Enhanced bioactive JA (JA-Ile) accumulation in OsJAZ9 overexpressing rice helps pl

148 The loss of these JA/JA-Ile -dependent defense traits rendered them more attract

149 To assess the relative contribution of JA/JA-Ile and OPDA to insect resistance in tomato (Solanum lyc

150 JA/JA-Ile deficiency in OPR3-RNAi plants resulted in reduced t

151 we found that OPDA can substitute for JA/JA-Ile in the local induction of defense gene expression, b

152 nse, whereas the conversion of OPDA to JA/JA-Ile is not.

153 gene expression, but the production of JA/JA-Ile is required for a systemic response.

154 g the signaling activities of OPDA and JA/JA-Ile, we found that OPDA can substitute for JA/JA-Ile in

155 were complemented with methyl jasmonate, JA-Ile, and its functional homolog, coronatine (COR), we de

156 s had substantial reduction in content of JA-Ile, JA-Leu and JA-Val in florets.

157 important mechanism for the regulation of JA-Ile-mediated signaling is not well-understood.

158 ls of OPDA but failed to accumulate JA or JA-Ile after wounding.

159 Flower opening, by contrast, requires JA-Ile signaling-dependent changes in primary metabolism, w

160 ons of benzylacetone) and nectar requires JA-Ile/COR perception through COI1; and (3) limb expansion

161 trate a master regulatory function of the JA-Ile/COI1 duet for the main function of a sympetalous cor

162 es showed that jasmonic acid (JA), jasmonoyl-Ile, salicylic acid, abscisic acid, and indole-3-acetic

163 Mozamide A contains l-Val, d-Lys, and l-Ile (instead of d-Val, l-Lys, and l-allo-Ile) and is a h

164 iron and 2-oxoglutarate dependent enzymes, l-Ile 4-hydroxylase, l-Leu 5-hydroxylase and polyoxin dihy

165 hods of Marfey and Mosher indicated l-Glu, l-Ile, l-Phe and 1S-configurations, respectively; ROESY co

166 In contrast, the lactotripeptides Ile-Pro-Pro and Val-Pro-Pro, which were widely used as i

167 e conjugating jasmonic acid (JA) to at least Ile, Leu, Met, Phe, Trp and Val and both osjar1 alleles

168 Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine

169 The branched-chain amino acids (BCAAs) Leu, Ile, and Val are among nine essential amino acids that m

170 of Spo7, we identified a hydrophobic Leu-Leu-Ile (LLI) sequence comprising residues 54-56 as being re

171 highly stable dimers/oligomers through a Leu/Ile/Phe-rich domain.

172 Additionally, the relationship between Leu/Ile and GDR was magnified in T2DM males.

173 omote and negate the association between Leu/Ile and insulin resistance, respectively.

174 In contrast, Leu/Ile was negatively associated with GDR in nonobese and T

175 elines we unambiguously identified every Leu/Ile residue in peptides containing up to five Leu/Ile re

176 nstrated, for the first time, that every Leu/Ile residue in the variable regions of a monoclonal anti

177 esidue in peptides containing up to five Leu/Ile residues and molecular masses up to 3000 Da.

178 is integrated, online LC-MS approach for Leu/Ile assignment can be applied to de novo sequencing of a

179 Positioning of incorrect Leu/Ile residues in variable domains, especially in CDRs (co

180 iation), followed by leucine/isoleucine (Leu/Ile) (negative association).

181 ids and the number of targeted isomeric (Leu/Ile) residues varied between 1 and 7.

182 ments were successful in all 22 cases of Leu/Ile residues, leaving no doubts in identification.

183 55 where Lys23 to Phe39 encompassing the Leu/Ile/Phe-rich domain forms an amphipathic alpha-helix.

184 In this work, the Leu/Ile/Phe-rich domain has been further characterized by NM

185 The merits and limitations of this Leu/Ile discrimination approach are evaluated.

186 This includes a Leu-Lys-Ile-Pro sequence (residues 125-128 of AKAP79) that occup

187 5)N-labeled Ras as well as [(13)C]methyl-Met,Ile-labeled Sos for observing site-specific details of R

188 with three participants ([1%]; all Met184Val/Ile) in the protease inhibitor group.

189 Moreover, Ile-48 and the phiX(D/E) motif are conserved in A55 orth

190 ely to account for the increased affinity of Ile-bound CodY for DNA.

191 3), as well as the hydrocarbon side chain of Ile(310) Our results suggest that placing methionine pro

192 de, whereas the strong positive deviation of Ile leads to prediction or fibril formation for the NINI

193 ociated with a large lateral displacement of Ile(328).

194 e same extent as ZnTerp upon Ala mutation of Ile-116(III:16/3.40), a residue that constrains the Trp-

195 revertants of K377C reveals that mutation of Ile-22 (in helix I) preserves Na(+) binding, whereas tha

196 for external QX-222 created by mutations of Ile-1575 was abolished by the additional mutation K1237E

197 Close proximity of Ile-207 and Ser-365 to the inserted RCL suggested that t

198 mprehensive (13)C-methyl relaxation study of Ile, Leu, and Val (ILV) residues of PTP1B, which, becaus

199 from the 4-fold channel axis and twisting of Ile-4937 at the channel constriction site out of the cha

200 on model for the southern fulmar breeding on Ile des Petrels, Antarctica.

201 NMR data for the methyl side chains on Ile, Leu, and Val residues showed changes in conformatio

202 n this model, OMR1 exerts primary control on Ile accumulation and functions independently of AHAS and

203 ha-helix by replacing Phe(604), Ile(608), or Ile(612) by Gln.

204 ta-ketosulfonamides derived from Val, Leu or Ile gave the expected beta-keto-alpha,alpha-difluorosulf

205 obic character; (3) ISDs tend to have Leu or Ile residues at their core; (4) ISDs are approximately e

206 X is any amino acid and Phi is Val, Leu, or Ile) endocytic motif that, when transferred to CD4, resu

207 e chain stereochemistry of individual Thr or Ile residues on the properties of the ShK protein.

208 e-chain stereochemistry of individual Thr or Ile residues.

209 For steric reasons, epoxyketones with Val or Ile at the P1 position are weak inhibitors of all active

210 ants if cultivated in the presence of Val or Ile but not in the presence of leucine.

211 interacted with the most hydrophobic peptide Ile-Asn-Tyr-Trp.

212 Five casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro-Leu, Tyr-Pro-Tyr-Ty

213 interaction between milk bioactive peptides, Ile-Asn-Tyr-Trp, Leu-Asp-Gln-Trp, and Leu-Gln-Lys-Trp, a

214 Three novel DPP-IV inhibitory peptides, Ile-Leu-Ala-Pro, Leu-Leu-Ala-Pro and Met-Ala-Gly-Val-Asp

215 of TCam-2 cells with the peptide Leu-Asp-Phe-Ile (LDFI), a full leptin-receptor antagonist, completel

216 residues with Ile, one by one, and prepared Ile-1-(13)C amyloid of each mutant, seeding with amyloid

217 variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of EPIY

218 Pro-Tyr-Tyr, Leu-Pro-Tyr-Pro-Tyr and Ile-Pro-Ile) and a casein (CasH), whey (WPH) and lactoferrin hyd

219 e casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro-Leu, Tyr-Pro-Tyr-Tyr, Leu-P

220 Ile-Pro-Ile-Gln-Tyr, Tyr-Pro-Tyr-Tyr and Leu-Pro-Tyr-Pro-Tyr wer

221 rminal dipeptide Ile(1)-Val(2) into the ProT Ile(16) pocket, forming a salt bridge with ProT's Asp(19

222 e w-ions employing MS(3) (ETD-HCD) for rapid Ile/Leu distinction.

223 ed non-Hispanic white patients with the rare Ile 164 allele compared with non-Hispanic white patients

224 rimary and replication cohorts with the rare Ile 164 allele were more than twice as likely as Thr 164

225 anic white patients with or without the rare Ile 164 allele, 2.6 [SD 3.5] vs 1.1 [2.1] visits, p<0.00

226 Glutamate substitution of the A55 residue Ile-48, adjacent to the canonical phiX(D/E) Cul3-binding

227 e binding, although the MinD-binding residue Ile-25 is critical for this conformational transition.

228 Mutation of the Bw4 residue Ile(80) also disrupted this salt bridge, providing furth

229 xpected that the substitution of the residue Ile(105) for a serine, located within hydrogen-bonding d

230 1-binding proteins contain a Ser-any residue-Ile-Pro (SxIP) motif.

231 of ToPI1 via a peptide bond between residues Ile(1) and Lys(32).

232 Although Bw4 residues Ile(80) and Arg(83) directly interact with KIR3DL1*001,

233 g hydrophobic contacts between FtsZ residues Ile-374, Pro-375, and Leu-378 with ZapD residues Leu-74,

234 Supporting the idea, mutations in residues Ile-24 and Ile-25 of the MinD-interacting domain affect

235 Additional mutations in residues Ile-72 and Ile-74 suggest a role of the C-terminal domai

236 and binding studies indicated that residues Ile-701, Phe-705, and Trp-708 of the MyoB IQ motif are c

237 nce of three relay loop amino acid residues (Ile(508), Asn(509), and Asp(511)) in communicating with

238 2 peptides which possess two extra residues (Ile 41 &Ala 42) that the non-pathological strain (Abeta4

239 onal roles of two form II-specific residues (Ile(165) and Met(331)) near the active site were examine

240 proteome to a similar extent and at the same Ile positions.

241 The last 3 residues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that inte

242 Both peptides contain a putative 'SIP' (Ser-Ile-Pro) domain that is important for interactions with

243 To aid this process, several Ile methyl groups located in different binding sites of

244 Supplying Ile reversed the root growth defect.

245 g involves the hydrophobic patch surrounding Ile-44 in the parkin Ubl, a region that is highly conser

246 r null mutations or a deletion of the 14(th) Ile (LEP(I14)) in the mature LEP protein.

247 ximately 3 A formed by Gln-4933, rather than Ile-4937 in the closed-channel structure.

248 A positions are, in general, more rigid than Ile, Leu, and Val methyl probes in protein side chains.

249 C-terminal domain of primase, we found that Ile-85 is located at the interface in the NTD of DnaB th

250 al structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key

251 tutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the c

252 Chemical footprinting revealed that Ile-16 is significantly less protected from chemical mod

253 However, mutagenesis studies suggest that Ile-A10, Ser-A12, Leu-A13, and Glu-A17 also belong to in

254 The Ile(16) pocket in ProT(QQQ) appears to favor nonpolar, n

255 e concentrations were also available for the Ile-de-France region (including Paris).

256 ), and the association was reinforced in the Ile-de-France region when this indicator was combined wi

257 onserved hydrophobic residues, including the Ile at position 181 which was highly correlated with vac

258 eochemistry of the chiral side chains of the Ile and Thr residues, i.e. containing d-allo-Ile and d-a

259 es were obtained by the incorporation of the Ile residue at the P5 and P6 positions.

260 ion measurements of the methyl groups of the Ile, Leu, and Val residues at two static magnetic fields

261 Unexpectedly, the Ile/Thr80 dimorphism in the Bw4-motif did not categorica

262 olymorphism is functional in vitro, with the Ile allele leading to increased monoamine transport into

263 We converted the three Ile residues in Sup35NM to Leu and then replaced 16 sing

264 actions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to

265 A single amino acid (Asn to Ile) substitution in the homeodomain abolished the repre

266 fect can almost exclusively be attributed to Ile-Trp, the ACE inhibition by plant protein hydrolysate

267 etinal, we initially mutated this residue to Ile, the corresponding residue in rhodopsin.

268 These included a Thr-to-Ile substitution at SP1 residue 8 (T8I), which results i

269 mutant of Bacillus subtilis that allows tRNA(Ile) mischarging while retaining wild-type Ile-tRNA(Ile)

270 e essential function is to aminoacylate tRNA(Ile) with isoleucine.

271 ic binding to the cognate tRNA(Ile) and tRNA(Ile)-dependent structural rearrangements consistent with

272 r C(32) in the Saccharomyces cerevisiae tRNA(Ile)(IAU) anticodon stem and loop domain (ASL) negates w

273 strated specific binding to the cognate tRNA(Ile) and tRNA(Ile)-dependent structural rearrangements c

274 ileS T-box in complex with its cognate tRNA(Ile).

275 ed in which the essential gene encoding tRNA(Ile)-lysidine synthetase was deleted for the first time.

276 a determinant for the essential enzyme tRNA(Ile)-lysidine synthetase.

277 scharging while retaining wild-type Ile-tRNA(Ile) synthesis activity.

278 one and kinetically optimized isoleucyl-tRNA(Ile) synthesis under cellular conditions.

279 l-tRNA synthetases, IleRS can mischarge tRNA(Ile) and correct this misacylation through a separate po

280 A(Leu(UUR)) or with mutations in the mt-tRNA(Ile), both of which are aminoacylated by Class I mt-amin

281 consequently IleRS misaminoacylates Nva-tRNA(Ile) at slower rate than Val-tRNA(Ile).

282 g being optimized for hydrolysis of Nva-tRNA(Ile).

283 Here we show that tRNA(Ile) affects both the synthetic and editing reactions lo

284 s Nva-tRNA(Ile) at slower rate than Val-tRNA(Ile).

285 Finally, the extent to which tRNA(Ile) modulates activation and pre-transfer editing is in

286 ever, the molecular mechanisms by which tRNA(Ile) organizes the synthetic site to enhance pre-transfe

287 a mutant suppressor tRNA derived from tRNA1(Ile), in which G34 has been changed to U34.

288 strain, C34 at the wobble position of tRNA2(Ile) is expected to remain unmodified and cells depend o

289 agmatidine) at the wobble position of tRNA2(Ile) to base pair specifically with the A of the AUA cod

290 A(Ile) mischarging while retaining wild-type Ile-tRNA(Ile) synthesis activity.

291 -74) fragment (H-Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-OH), following the solid-phase peptide synth

292 secondary recognition patches of ubiquitin (Ile(44) patch and Ile(36) patch, respectively, including

293 s the weakest-binding analogs contained Val, Ile, and Leu substitutions.

294 The most potent inhibitory peptides were Ile-Gln-Ala (beta-CN f187-189) and Val-Glu-Pro (beta-CN

295 s showed a splaying of the wHTH domains when Ile was bound; splaying is likely to account for the inc

296 enoidosa (C) and Palmaria palmata (D), where Ile and Leu, respectively, were established.

297 f the VSD that form direct interactions with Ile(135) on the HCND.

298 eu and then replaced 16 single residues with Ile, one by one, and prepared Ile-1-(13)C amyloid of eac

299 sults suggest that SC variants other than WT Ile(1)-Val(2)-Thr(3) might emerge with similar ProT-acti

300 Ca(2+) -dependent complex with EB3 via Ser-x-Ile-Pro aminoacid motif and that disruption of STIM2-EB3