ライフサイエンスコーパス: Indian hedgehog

1 separate requirements for Sonic hedgehog and Indian hedgehog.

2 tion in a similar manner as misexpression of Indian hedgehog.

3 ranscribed near cells making either Sonic or Indian hedgehog.

4 nic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions a

5 We show that Indian Hedgehog, a bone-derived signaling molecule, part

6 iately descended from their progenitors upon Indian hedgehog action and Runx2 expression.

7 (PTH)-related protein (PTHrP), regulated by Indian hedgehog and acting through the PTH/PTHrP recepto

8 zed, lacked maturing chondrocytes expressing Indian hedgehog and collagen X, and failed to undergo en

9 adjacent to the RPE expresses high levels of Indian Hedgehog and identified its downstream target as

10 Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-

11 e PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation

12 orter mice, we show that the two Hh ligands (Indian hedgehog and sonic hedgehog ligands) are expresse

13 Expression of col10a1, indian hedgehog, and patched was disrupted in mutants, r

14 cytochrome P450, glutathione S-transferase, Indian hedgehog, and solute carrier family genes.

15 We further demonstrate that misexpression of Indian hedgehog appears to directly upregulate BMP2 and

16 ), its receptor, the PTH/PTHrP receptor, and Indian hedgehog are implicated in the regulation of chon

17 We show that expression of Fibronectin and Indian Hedgehog are reduced in chato mutant yolk sacs.

18 parathyroid hormone-related peptide (PTHrP), Indian hedgehog, bone morphogenetic proteins and transfo

19 F9 cell lines expressing a full length Indian hedgehog cDNA express a number of characteristics

20 aturation and hypertrophy markers, including Indian hedgehog, collagen X and MMP-13.

21 Indian hedgehog (encoded by Ihh) has been shown to be ex

22 Joint development depends on signals from Indian hedgehog-expressing growth plate chondrocytes.

23 ondrocyte maturation was delayed, with fewer Indian hedgehog-expressing, prehypertrophic chondrocytes

24 Furthermore, GC treatment reduced Indian Hedgehog expression in growth plates of wild-type

25 d Ihh expression domains that the borders of Indian hedgehog expression in the chondrocytes are refle

26 is of Day 7.5 and 8.5 embryos indicates that Indian hedgehog expression is highest in the visceral yo

27 h plates adjacent to interphalangeal joints, Indian hedgehog expression is increased, whereas Collage

28 dition of retinoic acid and also upregulates Indian hedgehog expression.

29 of the parathyroid hormone-related protein, Indian hedgehog, fibroblast growth factor, bone morphoge

30 assessed the function of Sonic hedgehog and Indian hedgehog genes, which encode members of the Hedge

31 aled a significant increase in expression of Indian Hedgehog, glioma-associated oncogene homolog 1, W

32 Analysis of Indian hedgehog homolog a (ihha) mutants shows that the

33 We find that Runx2 directly up-regulates Indian Hedgehog (IHH) and colocalizes with Gli2, a Hedge

34 mice, accompanied by increased expression of Indian Hedgehog (Ihh) and hyperproliferation of surface

35 of Shh is accompanied by an up-regulation of Indian Hedgehog (Ihh) and maintenance of Hh pathway acti

36 ncrease in cell volume, and up-regulation of Indian hedgehog (Ihh) and of collagen type X--all indica

37 A signaling cascade involving Indian hedgehog (Ihh) and parathyroid hormone related pe

38 ulted in downregulation of expression of the Indian hedgehog (IHH) and parathyroid hormone-related pr

39 Indian hedgehog (Ihh) and Parathyroid Hormone-related Pr

40 d kinase (ERK) pathway activation, increased Indian hedgehog (Ihh) and parathyroid hormone-related pr

41 mmit to the osteogenic pathway and that both Indian hedgehog (IHH) and parathyroid hormone-related pr

42 Indian hedgehog (Ihh) and PTHrP signaling play crucial r

43 seal prehypertrophic chondrocytes expressing Indian hedgehog (Ihh) and were followed by mineralizing

44 velopmental stages, sonic hedgehog (Shh) and indian hedgehog (Ihh) are secreted by the endoderm of th

45 We identify Indian hedgehog (Ihh) as a novel downstream target of AR

46 The full-length mouse Indian hedgehog (Ihh) cDNA was cloned from an embryonic

47 Overexpression of Hip in cartilage, where Indian hedgehog (Ihh) controls growth, leads to a shorte

48 Indian hedgehog (Ihh) controls multiple aspects of endoc

49 Indian hedgehog (Ihh) controls multiple aspects of endoc

50 Indian hedgehog (Ihh) critically regulates multiple aspe

51 entally regulated and enhanced expression of Indian hedgehog (Ihh) during pregnancy and lactation.

52 Reduced Indian hedgehog (Ihh) expression was observed in prehype

53 skeletal tissue also demonstrated increased Indian hedgehog (IHH) expression.

54 paracrine signals Desert hedgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells.

55 al fibrosis through induction and release of Indian Hedgehog (IHH) from renal epithelial cells.

56 tiation, serving as a downstream mediator of Indian Hedgehog (IHH) function in both a local signaling

57 We identified the Indian hedgehog (Ihh) gene as a target of BMP signaling.

58 findings, we detected mRNA encoding SHH and Indian hedgehog (IHH) in both Nkx2.1(-/-) basal forebrai

59 tivates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes.

60 We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and th

61 roRNA in parallel to mechanical induction of Indian hedgehog (Ihh) in primary chicken chondrocytes cu

62 ning revealed a visceral endoderm pattern of Indian hedgehog (Ihh) in wild-type E6.5 embryos.

63 We now show that Indian hedgehog (Ihh) is a primitive endoderm-secreted s

64 Indian hedgehog (IHH) is an epithelial-derived signal in

65 Indian hedgehog (Ihh) is essential for chondrocyte and o

66 Indian hedgehog (Ihh) is essential for embryonic mandibu

67 g retina, albeit at very low levels, whereas Indian hedgehog (Ihh) is expressed in the developing and

68 Our previous studies have shown that Indian hedgehog (Ihh) is expressed in the visceral endod

69 Indian hedgehog (Ihh) is expressed normally in the growt

70 Indian hedgehog (Ihh) is indispensable for development o

71 Indian hedgehog (Ihh) is indispensable for osteoblast di

72 The expression of Indian hedgehog (Ihh) is markedly decreased, whereas the

73 olving endodermally secreted Sonic (Shh) and Indian hedgehog (Ihh) proteins that directly signal to a

74 aturing chondrocytes that also expressed the Indian hedgehog (Ihh) receptor and transcriptional targe

75 ing molecules in cartilage, most notably the Indian hedgehog (Ihh) receptor patched (Ptch), was lower

76 Indian Hedgehog (Ihh) regulates chondrocyte and osteobla

77 Indian hedgehog (Ihh) regulates endochondral ossificatio

78 Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage dev

79 Indian Hedgehog (Ihh) regulates tissue morphogenesis.

80 A null mutation in the morphogen Indian hedgehog (IHH) results in an embryonic lethal phe

81 Loss of Indian hedgehog (Ihh) results in reduction in pancreas s

82 s of bm limb growth plates showed diminished Indian hedgehog (Ihh) signaling and abnormal Ihh protein

83 Indian hedgehog (Ihh) signaling from prehypertrophic cho

84 We investigated the role of Disp1 in Indian hedgehog (Ihh) signaling in the developing bone b

85 Indian hedgehog (Ihh) signaling is indispensable for ost

86 of the spinal cord that most likely reflects Indian hedgehog (Ihh) signaling originating from the und

87 Significantly, FGFR3 downregulated the Indian hedgehog (Ihh) signaling pathway and Bmp4 express

88 of activated T cells 1 (Nfatc1), Runx3, and Indian hedgehog (Ihh) signaling pathways, although the m

89 athyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondr

90 e associated with reduced Ihh expression and Indian hedgehog (Ihh) signaling.

91 , and the endochondral skeleton, a target of Indian hedgehog (Ihh) signaling.

92 hyroid hormone-like hormone (Pthlh) inhibits Indian hedgehog (Ihh) to form a negative-feedback loop t

93 ment via expression of either Sonic (Shh) or Indian Hedgehog (Ihh) under control of the human Pax4-pr

94 In contrast, a second Hh family member, Indian hedgehog (Ihh) which maps close to Dbf, is ectopi

95 nomic analyses revealed that the promoter of Indian Hedgehog (IHH), a canonical driver of normal colo

96 expression of chondrogenic genes, including Indian hedgehog (Ihh), a critical mediator of mechanotra

97 n by IGFs interacts genetically with that by Indian hedgehog (Ihh), a locally produced growth signal

98 A chicken homolog of Indian hedgehog (Ihh), a member of the conserved Hedgeho

99 Indian hedgehog (Ihh), a member of the hedgehog (Hh) fam

100 Indian hedgehog (Ihh), a member of the vertebrate hedgeh

101 endoderm survival and production of VEGF-A, Indian hedgehog (IHH), and bFGF.

102 Mammalian Hhs include Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh).

103 the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with upregulation of the tran

104 Here we show that Indian hedgehog (Ihh), another hedgehog family member, a

105 pression but barely detectable expression of Indian hedgehog (Ihh), collagen X (Col10a1), Vegf (Vegfa

106 P normally functions in a feedback loop with Indian hedgehog (IHH), in which a reduction in one signa

107 Indian hedgehog (Ihh), one of the three mammalian hedgeh

108 ted with RNAs encoding Sonic hedgehog (Shh), Indian hedgehog (Ihh), or a dominant-negative regulatory

109 Indian hedgehog (Ihh), patched (Ptc), and Gli3 are expre

110 By contrast, the expression domains of Indian hedgehog (Ihh), patched, and noggin become restri

111 (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents premature hypertrophic d

112 meric mice, we provide in vivo evidence that Indian hedgehog (IHH), synthesized by prehypertrophic an

113 patched 1 (Ptch1), sonic hedgehog (Shh) and Indian hedgehog (Ihh), we demonstrate that Disp1 genetic

114 Indian hedgehog (Ihh), which is predominantly expressed

115 epiphyseal growth zone are regulated by the Indian hedgehog (IHH)-parathyroid hormone-related protei

116 s TAZ and the TAZ-induced profibrotic factor Indian hedgehog (IHH).

117 ich is caused by a deficiency in PSC-derived Indian hedgehog (Ihh).

118 largement accompanied by early activation of Indian hedgehog (Ihh).

119 a skeletogenic domain typically occupied by Indian hedgehog (Ihh).

120 mors and is accompanied by overexpression of Indian hedgehog (IHH).

121 erent chondrocyte zones independently of the Indian hedgehog (Ihh)/parathyroid hormone-related peptid

122 hormone-related peptide (PTHrP) receptor and Indian Hedgehog (IHH:), suggesting a new regulatory role

123 hedgehog proteins (sonic hedgehog [SHH] and Indian hedgehog [IHH]), Wnt proteins (Wnt-3a, Wnt-5a, an

124 the previous characterization of the role of Indian Hedgehog in bone morphogenesis, lead us to propos

125 s of the hedgehog pathway (purmorphamine and Indian hedgehog) in MC3T3 osteoblasts led to increased B

126 ng stimulates the expression and activity of Indian hedgehog, increases the expression of beta-cateni

127 Taken together, these data suggest that Indian hedgehog is involved in mediating differentiation

128 tures demonstrates that whereas little or no Indian hedgehog message is present in blastocysts, signi

129 We demonstrate here that the expression of Indian hedgehog mRNA and protein is upregulated dramatic

130 In situ hybridization analysis for Indian hedgehog mRNA expression demonstrates the presenc

131 Both Sonic hedgehog and Indian hedgehog mutant mice show reduced smooth muscle,

132 Indian hedgehog mutants show reduced epithelial stem cel

133 m the perichondrium, which is not typical of Indian hedgehog mutants.

134 hat synchondrosis development is abnormal in Indian hedgehog-null mice.

135 receptor gamma, matrix metalloproteinase 13, Indian hedgehog, osteocalcin, and the proapoptotic gene

136 and gene expression data suggested that the Indian Hedgehog-parathyroid hormone-related protein sign

137 Expression of Indian hedgehog, Patched-1, collagen X, and MMP-13 was r

138 Although Indian hedgehog, Patched1, parathyroid hormone-related p

139 esterone receptor target genes including the Indian Hedgehog pathway genes are significantly down-reg

140 tical mediator of progesterone action in the Indian Hedgehog pathway, by ChIP analysis.

141 nd 5 proteins that also affect the so-called Indian Hedgehog pathway, whose physical and functional t

142 spholipase D], APOE [apolipoprotein E], IHH [Indian hedgehog protein], ITIH4 [inter-alpha-trypsin inh

143 u hybridization showed reduced expression of Indian hedgehog, PTH/PTH-related peptide receptor (PTH,

144 erentiated mutant chondrocytes activates the Indian hedgehog/PTHrP axis and slows differentiation of

145 In vivo, mutating Indian Hedgehog results in a sex ratio bias against fema

146 ggrecan expression and increasing apoptosis, Indian hedgehog, Runx2, MMP13, and collagen type X expre

147 hic cell zones, a much wider distribution of Indian hedgehog signaling activity, and ectopic ossifica

148 ze the role of BMPs as possible mediators of Indian hedgehog signaling and use Noggin misexpression t

149 l ossification even though Runx2 expression, Indian hedgehog signaling, and osteoblastogenesis is int

150 eased Runx2 and Ihh expression and increased Indian hedgehog signaling.

151 ndrocyte proliferation, differentiation, and Indian hedgehog signaling.

152 attributable to abnormal sonic hedgehog and Indian hedgehog signalling, respectively.

153 Evidence is presented that Sonic and Indian hedgehog signals act together, through a Foxf1/Bm

154 ntiation (&agr; 1(II) collagen, Fgfr3, Osf2, Indian hedgehog, Sox9), as well as a chondrocyte-specifi

155 ression of dnPKA, but not by coexpression of Indian Hedgehog, suggesting that GiPs act upstream of PK

156 a signaling network with Sonic hedgehog and Indian hedgehog that are essential to anterior-posterior

157 ce suggests that the signaling is induced by Indian hedgehog that is produced by distal (ectoplacenta

158 ption-polymerase chain reaction experiments, Indian hedgehog transcript was first detected in the mou

159 icated by the presence of Sonic hedgehog and Indian hedgehog transcripts, by the pathway- and growth-

160 ng the regulatory landscape of IHH (encoding Indian hedgehog), which cause multiple, highly localized