ライフサイエンスコーパス: Ir gene

1 ups of children for abnormalities in the IGF-IR gene.

2 in gamma-linolenate biosynthesis, and known IR genes.

3 T antigen to transform MEFs with deleted IGF-IR genes.

4 nate the effects of the class II and class I Ir genes.

5 hat the TCR locus can be an Immune response (Ir) gene.

6 e 1 insulin-like growth factor receptor (IGF-IR) genes.

7 ivo expression of heritable inverted-repeat (IR) genes.

8 42.7% had variants in 1 of the 5 most common IRD genes.

9 reported immune-responsive regulation of IGF-IR genes adds to an emerging body of evidence that suppo

10 Non-MHC Ir genes also contribute to the control of in vitro CTL

11 mice exhibited complete rearrangement of the IR gene and a more than 95% decrease in IR mRNA.

12 s including exon 11 of the Insulin Receptor (IR) gene and exon 5 of the cardiac Troponin T (cTNT) gen

13 e insulin-like growth factor I receptor (IGF-IR) genes) and R508 cells (derived from R- and with 15 x

14 inhibit transcription elongation of the IGF-IR gene, and emphasize the efficacy of triplex-mediated

15 There are over 270 causative IRD genes, and variants within the same gene can cause c

16 The former two IR genes are expressed in several neurons per sensillum,

17 arly establish that there are effects of the Ir gene associated with both biotypes of TcpA.

18 from a large cohort of patients, we identify IRD genes associated with myopia and hyperopia.

19 we have identified a novel mechanism of IGF-IR gene autoregulation in breast cancer cells.

20 Regulation of the IGF-IR gene by IGF-IR protein is mediated at the level of tr

21 her validated the functions of 3 new adipose IR genes by overexpression-based phenotypic rescue in th

22 ition to the effects of the classic class II Ir gene, class I (D, L) or nonclassical class I (Qa-2) m

23 We report that heritable IR genes confer potent and specific gene inactivation fo

24 ructure of insulin to study the mechanism of Ir gene control in H-2b mice, which respond to beef insu

25 With the rapid pace of IRD gene discovery, gene catalogs require frequent valid

26 Two ird genes encode components of the signaling pathways th

27 ith endothelial-specific inactivation of the IR gene (EndoIRKO), we find that in response to systemic

28 may provide for intricate regulation of IGF-IR gene expression at the translational level.

29 e a novel mechanism of autoregulation of IGF-IR gene expression by cellular IGF-IR, which is seemingl

30 s (1H7 and linsitinib) and knocking down IGF-IR gene expression had similar effects.

31 Thus, whereas IGF-IR stimulated IGF-IR gene expression, IR inhibited IGF-IR promoter activit

32 ossible mechanisms by which p53 may regulate IR gene expression, we show that p53 can repress the IR

33 fibroblast growth factor (bFGF) regulate IGF-IR gene expression.

34 Insulin-like growth factor-I receptor (IGF-IR) gene expression is regulated by various stimuli, inc

35 ase domains from six distinct members of the IR gene family were obtained, and sequence comparisons r

36 e conclude that there are at least two human Ir genes, HLA-DRB1*01 and HLA-DRB1*03, that confer a hig

37 We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was requir

38 We also examined the regulation of each IGF-IR gene in fish challenged by bacterial and viral infect

39 re/lox system to specifically inactivate the IR gene in rod photoreceptors.

40 nt was revealed by genetic disruption of the IR gene in the oncogene-expressing pancreatic beta cells

41 significantly higher number of OBP, OR, and IR genes in African malaria vectors compared to their In

42 ving KLH only, there was a greater change in IR genes in T cells in those receiving Id-KLH relative t

43 prominently express two Ionotropic Receptor (IR) genes, IR76b and IR25a, and we show that both these

44 eadipocyte knockout lines each with a single IR-gene knocked out by lentivirus-mediated CRISPR (clust

45 ys a key role in epitope immunodominance and Ir gene-linked unresponsiveness.

46 Immune response (Ir) gene-linked low responsiveness to protein Ags can be

47 ion and loss of the typical inverted repeat (IR), gene loss and repeat accumulation in both shared an

48 es to H-Y are controlled by immune response (Ir) genes mapping to the MHC.

49 To overcome the effects of the class II Ir gene, multiple TcpA peptides similar to peptides 4, 5

50 Immune response (Ir) genes, originally proposed by Baruj Benacerraf to ex

51 cells with a targeted disruption of the IGF-IR genes, R- cells, are refractory to transformation by

52 ived from well-characterized model Ags under Ir gene regulation has been very limited.

53 ly opposite activities in the context of IGF-IR gene regulation.

54 ole of IGF-IR in the specific context of IGF-IR gene regulation.

55 ental transcriptional regulation of each IGF-IR gene, revealing tight co-expression between the IGF-I

56 We disrupted the insulin receptor (IR) gene specifically in the theca-interstitial (TI) cel

57 d benchmarked 39 variant classifier tools on IRD genes, split by inheritance pattern.

58 n rates are, on average, 3.7 times slower in IR genes than in SC genes.

59 ote for point mutations in exon 2 of the IGF-IR gene that altered the amino acid sequence to Arg108Gl

60 Mutations in the IGF-IR gene that lead to abnormalities in the function or nu

61 demonstrated that Vbeta8.1 functioned as an Ir gene that was indispensable for immune reactivity aga

62 otential for effects of the immune response (Ir) gene that could complicate a peptide-based vaccine.

63 m survive: They express ionotropic receptor (Ir) genes that form IR complexes.

64 define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune respo

65 rage of both coding and noncoding regions in IRD genes to offer diagnoses in these patients.

66 AMP1 and LAMP1 inhibit Pol II-dependent IR gene transcription by suppressing ARGONAUTE 1 (AGO1)

67 F and IGF-I have differential effects on IGF-IR gene transcription, with the IGF-I response region as

68 structural gene can efficiently suppress IGF-IR gene transcription.

69 ing variants in inherited retinal dystrophy (IRD) genes, using genome sequencing (GS).

70 Complete sequencing of the IGF-IR gene was performed with DNA from nine children.

71 no other plausible disease variants in known IRD genes were identified.

72 to H-Y are controlled by MHC class I and II Ir genes, which-respectively, restrict CD8 and CD4 T cel

73 lower synonymous rates consistent with other IR genes, while genes moved from the IR into the SC exhi